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Cas:24065-33-6
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inquiryProduct Name 5-Chlorothiophene-2-carboxylic acid CAS No 24065-33-6 Batch No RIBA2170816
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inquiryRivaroxaban Intermediates 5-Chlorothiophene-2-Carboxylic Acid[CAS:24065-33-6] 4-(4-Aminophenyl)Morpholin-3-One[CAS:438056-69-0] (S)-(+)-N-(2,3-Epoxypropyl)phthalimide[CAS:161596-47-0] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) i
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inquiryFactory direct sales, accept customization. 5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following: rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders 5-chloro-4-nitrothiophene-2-car
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inquiryProduct Description Product Name 5-Chlorothiophene-2-carboxylic acid CAS No. 24065-33-6 Appearance Yellowish powder Assay ≥99% Capacity 100mt/year Min.packing 1gr
Cas:24065-33-6
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inquiryItems Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che
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inquiryHigh quality 5-Chlorothiophene-2-carboxylic acid CAS 24065-33-6 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediat
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiry5-Chlorothiophene-2-Carboxylic Acid CAS NO.: 24065-33-6 Formula: C5H3ClO2S Molecular Weight: 162.59 Characteristic It is off-white powder Usage: It is pharmaceutical intermediate. Package It is packed in 25kg fiber drum with PE
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryName: 5-Chlorothiophene-2-carboxylic acid Synonyms: 5-Chloro-2-thiophenecarboxylic acid CAS:24065-33-6 MF: C5H2ClO2S Appearance: White To Brown Powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Interm
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inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:24065-33-6
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inquiry5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID CAS: 24065-33-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual
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inquiry5-Chloro-2-thiophenecarboxaldehyde
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-Chloro-2-thiophenecarboxaldehyde With sodium hydroxide at -5 - 0℃; for 2h; Large scale; Stage #2: With chlorine at 15 - 30℃; for 8h; Large scale; | 98.8% |
With tert.-butylhydroperoxide In dichloromethane at 35 - 40℃; for 4h; Reagent/catalyst; Temperature; | 96% |
With 1,4-dithio-D,L-threitol; recombinant aldehyde dehydrogenase from bovine lens; water‐forming NADH oxidase from Streptococcus mutans; NAD In aq. phosphate buffer at 40℃; for 4h; pH=8.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; chemoselective reaction; |
5-bromo-2-chlorothiophene
carbon dioxide
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-chlorothiophene With iodine; magnesium In tetrahydrofuran at 22 - 28℃; Inert atmosphere; Stage #2: carbon dioxide With hydrogenchloride In water at -15℃; for 1.5h; | 96.7% |
Multistep reaction; |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In toluene at 20℃; for 2h; Reagent/catalyst; Solvent; | 95% |
2-acetyl-5-chlorothiophene
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium chlorite; potassium dihydrogenphosphate In water; acetone at 0 - 30℃; for 22h; | 84.9% |
With bromine; sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; | 76.1% |
With sodium hydroxide; potassium permanganate; water |
2-thiophenylcarboxylic acid
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With trichloroisocyanuric acid; sulfuric acid at -5 - 5℃; for 4h; Reagent/catalyst; Temperature; | 82.2% |
With chlorine; acetic acid |
Conditions | Yield |
---|---|
Stage #1: 2-thienyl chloride With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 0.000833333h; Flow reactor; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 0.000138889h; Flow reactor; Stage #3: With water; acetic acid In tetrahydrofuran at 20℃; under 7500.75 Torr; Flow reactor; | 77% |
With ethylaluminum dichloride In hexane; chlorobenzene at 100℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere; regioselective reaction; | 41% |
Stage #1: 2-thienyl chloride With n-butyllithium In tetrahydrofuran; hexane at 0℃; Stage #2: carbon dioxide In tetrahydrofuran; hexane Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 0℃; | > 70 %Chromat. |
2-thienyl chloride
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With palladium diacetate; sodium persulfate In acetic acid for 7h; Heating; | 19.6% |
With n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid; |
ethyl acetoacetate
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere; | 3% |
Conditions | Yield |
---|---|
With sodium amalgam Behandeln der Reaktionsloesung mit festem Kohlendioxid; | |
With sodium Behandeln der Reaktionsloesung mit festem Kohlendioxid; |
2,5-diclorothiophene
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid; |
2-thiophenylcarboxylic acid
A
2,5-diclorothiophene
B
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With alkaline aqueous sodium hypochlorite solution anschliessend Erwaermen mit wss. Salzsaeure; |
5-chlorothiophene-2-carbonyl chloride
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
5-chloro-2-thiophenecarboxylic acid N-methylamide
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With water |
2-thiophenylcarboxylic acid
water
chlorine
acetic acid
5-Chlorothiophene-2-carboxylic acid
2-thiophenylcarboxylic acid
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
und anschl. mit wss. HCl; |
5-chloro-2-acetylthiophene oxime
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / sodium hydroxide / acetone; H2O 2: 35 percent / anhydrous sodium acetate / H2O; methanol / 60 - 70 °C 3: water View Scheme |
5-chloro-2-acetylthiophene oxime benzenesulfonate
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 35 percent / anhydrous sodium acetate / H2O; methanol / 60 - 70 °C 2: water View Scheme |
5-Chlorothiophene-2-carboxylic acid
5-chlorothiophene-2-carbonyl chloride
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 16h; Heating / reflux; | 100% |
With oxalyl dichloride In dichloromethane for 16h; Reflux; | 100% |
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 40℃; for 4h; Solvent; Reagent/catalyst; Temperature; | 100% |
5-Chlorothiophene-2-carboxylic acid
benzyl 3-amino-tetrahydro-furan-3-carboxylate
3-[(5-chloro-thiophen-2-yl)-carbonylamino]-tetrahydro-furan-3-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 20h; Product distribution / selectivity; | 100% |
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 20h; | 100% |
5-Chlorothiophene-2-carboxylic acid
4-bromo-5-chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With iron(III) chloride; bromine In acetic acid at 25℃; for 168h; Heating / reflux; | 100% |
5-Chlorothiophene-2-carboxylic acid
methyl 2-(aminomethyl)benzoate hydrochloride salt
methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 28h; | 100% |
methanol
5-Chlorothiophene-2-carboxylic acid
methyl 5-chloro-2-thiophenecarboxylate
Conditions | Yield |
---|---|
With sulfuric acid at 50 - 55℃; for 12 - 20h; | 99% |
With sulfuric acid at 50℃; for 20h; | 95% |
With hydrogenchloride at 60℃; for 16h; | 94.1% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane Reflux; Stage #2: 4-isopropyl-1-methylcyclohex-3-en-1-amine With triethylamine In dichloromethane; N,N-dimethyl-formamide Reflux; | 98.87% |
5-Chlorothiophene-2-carboxylic acid
tert-butyl D-alaninate
(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid tert-butyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In tetrahydrofuran at 20℃; for 2h; | 98% |
5-Chlorothiophene-2-carboxylic acid
(bromomethylcyclohexane)
cyclohexyl-methyl 5-chlorothiophene-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate at 85℃; for 72h; Inert atmosphere; | 97% |
With potassium carbonate at 85℃; for 72h; Inert atmosphere; | 97% |
5-Chlorothiophene-2-carboxylic acid
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 34℃; for 4h; | 96.3% |
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2.83333h; Reagent/catalyst; Cooling with ice; | 95.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; pH=8 - 9; Large scale; | 94.7% |
5-Chlorothiophene-2-carboxylic acid
(R)-amino-phenyl-acetic acid ethyl ester
(2R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-2 phenyl-acetic acid ethyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In tetrahydrofuran at 20℃; for 2h; | 96% |
5-Chlorothiophene-2-carboxylic acid
(9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-yl)(1,2,3,4-tetrahydroisoquinolin-7-yl)methanone
(5-chlorothiophen-2-yl)(7-(9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-carbonyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In tetrahydrofuran at 25℃; for 0.5h; Inert atmosphere; Stage #2: (9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-yl)(1,2,3,4-tetrahydroisoquinolin-7-yl)methanone With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 25℃; for 15h; | 96% |
5-Chlorothiophene-2-carboxylic acid
tert-butyl glycidyl ether
(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With oxalyl dichloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 0 - 20℃; for 2h; Stage #2: tert-butyl glycidyl ether With triethylamine In tetrahydrofuran at 0 - 20℃; for 2h; | 95.56% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h; | 95.2% |
With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark; | 85% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 68.9% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; | 95% |
Conditions | Yield |
---|---|
With diisopropyl-carbodiimide; dmap In chloroform at 0 - 20℃; | 94% |
With dmap; diisopropyl-carbodiimide In chloroform at 0 - 20℃; | 94% |
With dmap; diisopropyl-carbodiimide In chloroform at 0 - 20℃; | 94% |
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid; 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 10 - 25℃; for 12.5h; Stage #2: With water In ethyl acetate for 1h; | 94% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-[5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl]aniline With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; Inert atmosphere; Stage #2: 5-Chlorothiophene-2-carboxylic acid In dichloromethane at 20℃; Inert atmosphere; | 94% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 3h; | 94% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 3h; | 93.8% |
5-Chlorothiophene-2-carboxylic acid
(3R,4S)-3-amino-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester trifluoroacetic acid salt
(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran at 20℃; | 93% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 100℃; Sealed tube; | 93% |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In ethanol; water at 60℃; for 3h; Stage #2: 5-Chlorothiophene-2-carboxylic acid With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In ethanol; water at 25℃; for 12h; Solvent; Temperature; | 92.8% |
5-Chlorothiophene-2-carboxylic acid
(S)-4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)benzonitrile
(S)-5-chloro-N-((3-(4-cyanophenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 91.2% |
With 4-hydroxybenzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 15h; | 82% |
5-Chlorothiophene-2-carboxylic acid
dimethyl amine
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With thionyl chloride In N,N-dimethyl-formamide for 3h; Inert atmosphere; Reflux; Stage #2: dimethyl amine With triethylamine In diethyl ether; water at 0℃; for 1h; Inert atmosphere; | 91% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; | 91% |
5-Chlorothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; | 91% |
5-Chlorothiophene-2-carboxylic acid
2-thienyl chloride
Conditions | Yield |
---|---|
With triethylsilane; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane In toluene at 160℃; for 15h; chemoselective reaction; | 91% |
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