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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

6-Chloropicolinic acid Manufacturer/High quality/Best price/In stock

Cas:4684-94-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Fluoropyridine-2-Carboxylic Acid with high purity

Cas:4684-94-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:

6-Chloropicolinic acid Cas 4684-94-0

Cas:4684-94-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

6-chloropyridine-2-carboxylic Acid

Cas:4684-94-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-Fluoropyridine-2-Carboxylic Acid

Cas:4684-94-0

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Chloro-2-pyridinecarboxylic acid

Cas:4684-94-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Leader Biochemical Group

Product Name: 6-Chloropicolinic acid Synonyms: OTAVA-BB BB5110090024;6-CHLORO-2-PYRIDINECARBOXYLIC ACID;6-CHLORO-2-PICOLINIC ACID;6-CHLOROPICOLINIC ACID;6-CHLOROPYRIDINE-2-CARBOXYLIC ACID;2-CHLORO-6-PYRIDINECARBOXYLIC ACID;2-C

China Biggest Factory & Manufacturer supply 6-Chloropicolinic acid CAS: 4684-94-0

Cas:4684-94-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--4684-94-0--High purity 6-Chloropicolinic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable

TIANFUCHEM--4684-94-0--High purity 6-Chloropicolinic acid factory price

Cas:4684-94-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 4684-94-0 with best quality

Cas:4684-94-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Crystalline Powder Storage:Keep in dark place, Sealed in dry, Room Temperature Package:50G; 25G; 5G Application:Pharmaceutical Intermediates Transportation:Express/Sea/Air Port:Any port in china

6-chloropicolinicacid at best price

Cas:4684-94-0

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry plac

6-chloro-picolinic acid CAS:4684-94-0

Cas:4684-94-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1803.html Product Name 6-Chloropicolinic acid CAS No. 4684-94-0

6-Chloropicolinic acid

Cas:4684-94-0

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 6-Chloropicolinic acid Synonyms: OTAVA-BB BB5110090024;6-CHLORO-2-PYRIDINECARBOXYLIC ACID;6-CHLORO-2-PICOLINIC ACID;6-CHLOROPICOLINIC ACID;6-CHLOROPYRIDINE-2-CARBOXYLIC ACID;2-CHLORO-6-PYRIDINECARBOXYLIC ACID;2-CHLOROPYRIDINE-6-CA

6-Chloropicolinic acid

Cas:4684-94-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2-Pyridinecarboxylicacid, 6-chloro-

Cas:4684-94-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyridinecarboxylicacid, 6-chloro-

Cas:4684-94-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6-Chloropicolinic Acid

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Chloropicolinic acid

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Chloro-6-pyridinecarboxylic acid

Cas:4684-94-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

6-Chloropicolinic acid

Cas:4684-94-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

6-Chloropicolinic acid/Manufacturer/High quality/Best price

Cas:4684-94-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

China Supplier 6-chloropicolinic acidAppearance:Colourless crystals Storage:Store in a cool .dry area. Package:according to customers' requirements Application:pesticide or pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT

China Supplier 6-chloropicolinic acid

Cas:4684-94-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

6-Chloropicolinic acid

Cas:4684-94-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

6-Chloropicolinic acidCAS NO.: 4684-94-0

Cas:4684-94-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

6-Chloropicolinicacid

Cas:4684-94-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

6-Chloro-2-Picolinic Acid

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4684-94-0 CAS NO.4684-94-0

Cas:4684-94-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2-Pyridinecarboxylicacid, 6-chloro-

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Chloro-6-pyridinecarboxylic acid

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-Chloro-6-pyridinecarboxylic acid

Cas:4684-94-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

6-Chloropyridine-2-carboxylicacid

Cas:4684-94-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Synthetic route

6-chloro-2-picoline
18368-63-3

6-chloro-2-picoline

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
at 30℃; for 16h; with Pseudomonas putida ATCC 33015; other heteroarenes; enzymatical, selective oxidation of methylgroups of heteroarenes;90%
at 30℃; for 16h; Pseudomonas putida ATCC 33015;90%
With potassium permanganate In water Heating;51%
With sodium permanganate; water
With potassium permanganate In water at 70 - 80℃; for 24h; Large scale;
nitrapyrin
1929-82-4

nitrapyrin

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
With sulfuric acid; water at 100℃; for 8h;90%
With sulfuric acid at 100℃; for 6h; Time;90%
2-bromo-6-chloro-pyridine
5140-72-7

2-bromo-6-chloro-pyridine

Acetic formic anhydride
2258-42-6

Acetic formic anhydride

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
Stage #1: 2-bromo-6-chloro-pyridine; formyl acetic anhydride With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80 - 90℃; for 3h; Inert atmosphere;
Stage #2: With hydrogenchloride In water pH=Ca. 4 - 6;
75%
2-bromo-6-chloro-pyridine
5140-72-7

2-bromo-6-chloro-pyridine

carbon dioxide
124-38-9

carbon dioxide

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
Stage #1: 2-bromo-6-chloro-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 1h; Metallation;
Stage #2: carbon dioxide In diethyl ether; hexane at -78℃; for 1h; Carboxylation;
67%
2,6-dichloropyridine
2402-78-0

2,6-dichloropyridine

carbon dioxide
124-38-9

carbon dioxide

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique;
Stage #2: 2,6-dichloropyridine With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 10h; Schlenk technique; Sealed tube;
45%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.416667h; Schlenk technique;
Stage #2: 2,6-dichloropyridine With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 10h; Schlenk technique;
45%
6-oxy-pyridine-carboxylic acid-(2)

6-oxy-pyridine-carboxylic acid-(2)

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate at 100℃; Zerlegen des Reaktionsprodukts mit Eis;
C6H3Cl2NO2

C6H3Cl2NO2

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Conditions
ConditionsYield
With water; potassium carbonate
methanol
67-56-1

methanol

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

methyl 6-chloropicolinate
6636-55-1

methyl 6-chloropicolinate

Conditions
ConditionsYield
With thionyl chloride at 0 - 50℃; for 6.75h;100%
Stage #1: methanol; 6-chloropicolinic acid With hydrogenchloride for 15h; Heating / reflux;
Stage #2: With sodium hydroxide In water
95%
With hydrogenchloride In water at 80℃; for 48h;
With hydrogenchloride In water at 80℃; for 48h;
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

4-((2-aminobenzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide

4-((2-aminobenzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide

6-chloro-N-(6-((2-(methylcarbamoyl)pyridin-4-yl)oxy)benzo[d]thiazol-2-yl)picolinamide

6-chloro-N-(6-((2-(methylcarbamoyl)pyridin-4-yl)oxy)benzo[d]thiazol-2-yl)picolinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;100%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

[5-(6-methylpyrazin-2-yl)pyrazin-2-yl]methanamine dihydrochloride

[5-(6-methylpyrazin-2-yl)pyrazin-2-yl]methanamine dihydrochloride

6-chloro-N-[[5-(6-methylpyrazin-2-yl)pyrazin-2-yl]methyl]pyridine-2-carboxamide

6-chloro-N-[[5-(6-methylpyrazin-2-yl)pyrazin-2-yl]methyl]pyridine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;97%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl 6-chloropyridine-2-carboxylate
1280786-59-5

tert-butyl 6-chloropyridine-2-carboxylate

Conditions
ConditionsYield
With pyridine; p-toluenesulfonyl chloride at 20℃;96%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

4-(2-fluorophenyl)piperidine
180161-17-5

4-(2-fluorophenyl)piperidine

(6-chloro-pyridin-2-yl)-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone
1175689-41-4

(6-chloro-pyridin-2-yl)-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h;95%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

2-chloro-6-pyridinecarboxamide
70593-61-2

2-chloro-6-pyridinecarboxamide

Conditions
ConditionsYield
With endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; ammonium chloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;94%
With endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;94%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

ethanol
64-17-5

ethanol

6-chloropyridine-2-carboxylic acid ethyl ester
21190-89-6

6-chloropyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid; ethanol With sulfuric acid In toluene for 3h; Reflux;
Stage #2: With potassium carbonate In water; ethyl acetate
94%
With sulfuric acid for 16h; Inert atmosphere; Reflux;85%
Stage #1: 6-chloropicolinic acid; ethanol With thionyl chloride at 0℃; Reflux; Inert atmosphere;
Stage #2: With water; potassium carbonate In ethanol
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole
63478-10-4

2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

6-chloro-N-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)picolinamide

6-chloro-N-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)picolinamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;93%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

4-((2-aminoquinolin-5-yl)oxy)-N-methylpicolinamide

4-((2-aminoquinolin-5-yl)oxy)-N-methylpicolinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;91.7%

Conditions
ConditionsYield
at 30℃; for 16h; with Pseudomonas putida ATCC 33015; other heteroarenes; enzymatical, selective oxidation of methylgroups of heteroarenes;90%
at 30℃; for 16h; Pseudomonas putida ATCC 33015;90%
With potassium permanganate In water Heating;51%
With sodium permanganate; water
With potassium permanganate In water at 70 - 80℃; for 24h; Large scale;
6-chloropicolinic acid

6-chloropicolinic acid

tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate
960535-17-5

tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate

tert-butyl 4-(6-chloropicolinoyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate
960535-98-2

tert-butyl 4-(6-chloropicolinoyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid; tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide
Stage #2: With sodium hydroxide In water; N,N-dimethyl-formamide for 1h;
90%
4-methylpiperidin
626-58-4

4-methylpiperidin

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

C12H15ClN2O
912934-67-9

C12H15ClN2O

Conditions
ConditionsYield
With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;88%
With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide at 20℃; for 18h;88%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

1,1-dimethylethyl (2S)-4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate
865314-22-3

1,1-dimethylethyl (2S)-4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

6-chloro-N-({3'-[((3S)-4-{[(1,1-dimethylethyl)-oxy]carbonyl}-3-methyl-1-piperazinyl)methyl]-6-fluoro-3-biphenylyl}methyl)-2-pyridinecarboxamide
1179343-96-4

6-chloro-N-({3'-[((3S)-4-{[(1,1-dimethylethyl)-oxy]carbonyl}-3-methyl-1-piperazinyl)methyl]-6-fluoro-3-biphenylyl}methyl)-2-pyridinecarboxamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 19h;84%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

(cis-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno[3,2-c]pyrazole hydrochloride

(cis-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno[3,2-c]pyrazole hydrochloride

cis-(6-chloropyridin-2-yl)-(2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)methanone

cis-(6-chloropyridin-2-yl)-(2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 1h;84%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Methyl trichloroacetate
598-99-2

Methyl trichloroacetate

methyl 6-chloropicolinate
6636-55-1

methyl 6-chloropicolinate

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate at 90 - 150℃; for 2h;83%
2-Picolinic acid
98-98-6

2-Picolinic acid

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

water
7732-18-5

water

zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

[Zn(6-chloropicolinic acid)(2-picolinic acid)(H2O)2]

[Zn(6-chloropicolinic acid)(2-picolinic acid)(H2O)2]

Conditions
ConditionsYield
In ethanol at 60℃; for 3h; Sealed tube;82.8%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

6-chloropicolinoyl chloride
80099-98-5

6-chloropicolinoyl chloride

4-fluoroaniline
371-40-4

4-fluoroaniline

6-chloro-N-(4-fluorophenyl)pyridin-2-amide
137640-94-9

6-chloro-N-(4-fluorophenyl)pyridin-2-amide

Conditions
ConditionsYield
In thionyl chloride; diethyl ether; water82%
In thionyl chloride; diethyl ether; water75%
4-aminopyridine
504-24-5

4-aminopyridine

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

6-chloro-N-(pyridin-4-yl)pyridine-2-carboxamide
1026136-67-3

6-chloro-N-(pyridin-4-yl)pyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h;
Stage #2: 4-aminopyridine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
81.7%
Stage #1: 6-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 0.5h;
Stage #2: 4-aminopyridine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h;
81.7%
Stage #1: 6-chloropicolinic acid With thionyl chloride at 25℃; for 1h;
Stage #2: 4-aminopyridine With triethylamine In dichloromethane at 25℃; for 18h;
Stage #1: 6-chloropicolinic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 15 - 25℃; for 1h;
Stage #2: 4-aminopyridine With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; for 3h;
Stage #1: 6-chloropicolinic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 15 - 25℃; for 1h;
Stage #2: 4-aminopyridine With triethylamine In dichloromethane; N,N-dimethyl-formamide at 15 - 25℃; for 3h;
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

1-(2-amino-4-ethynylphenyl)propan-1-one

1-(2-amino-4-ethynylphenyl)propan-1-one

6-chloro-N-(5-ethynyl-2-propionylphenyl)picolinamide

6-chloro-N-(5-ethynyl-2-propionylphenyl)picolinamide

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid With N-ethyl-N,N-diisopropylamine; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 1-(2-amino-4-ethynylphenyl)propan-1-one In N,N-dimethyl-formamide at 150 - 154℃; for 0.5h; Microwave irradiation;
81%
pyridin-3-ylamine
462-08-8

pyridin-3-ylamine

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

6-chloro-N-(pyridin-3-yl)picolinamide

6-chloro-N-(pyridin-3-yl)picolinamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 13h;78%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

4-heptafluoroisopropyl-2,6-dimethylaniline
273735-43-6

4-heptafluoroisopropyl-2,6-dimethylaniline

N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-chloropyridine-2-carboxylic acid amide
847622-55-3

N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-chloropyridine-2-carboxylic acid amide

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 80℃; for 3h; Heating / reflux;
Stage #2: 4-heptafluoroisopropyl-2,6-dimethylaniline With pyridine In tetrahydrofuran at 20℃; for 2h;
Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water; ethyl acetate
77%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

Cyclopropylamine
765-30-0

Cyclopropylamine

C9H9ClN2O
149527-07-1

C9H9ClN2O

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;77%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

3-Trifluoromethylphenol
98-17-9

3-Trifluoromethylphenol

6-(3-α,α,α-trifluoromethylphenoxy)picolinic acid
137640-84-7

6-(3-α,α,α-trifluoromethylphenoxy)picolinic acid

Conditions
ConditionsYield
With potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 140℃; for 6h;75%
With potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 140℃; for 8h; Solvent; Temperature; Reagent/catalyst;75%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

methyl 2-(2-aminophenyl)acetate hydrochloride
49851-36-7

methyl 2-(2-aminophenyl)acetate hydrochloride

methyl 2-(2-(6-chloropicolinamido)phenyl)acetate

methyl 2-(2-(6-chloropicolinamido)phenyl)acetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2.5h;71%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2.5h; Inert atmosphere;
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(6-Chloro-pyridin-2-yl)-1H-benzoimidazole

2-(6-Chloro-pyridin-2-yl)-1H-benzoimidazole

Conditions
ConditionsYield
With PPA at 160℃; for 4h;70%
6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

(3S,6S)-3-((1H-indol-3-yl)methyl)-6-(3-aminopropyl)piperazine-2,5-dione

(3S,6S)-3-((1H-indol-3-yl)methyl)-6-(3-aminopropyl)piperazine-2,5-dione

N-(3-((2S,5S)-5-((1H-indol-3-yl)methyl)-3,6-dioxopiperazin-2-yl)propyl)-6-chloropicolinamide

N-(3-((2S,5S)-5-((1H-indol-3-yl)methyl)-3,6-dioxopiperazin-2-yl)propyl)-6-chloropicolinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;69%

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