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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Mesembrine Manufacturer/High quality/Best price/In stock

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

High quality and best price of Mesembrine from Henan Tianfu Chemical: Henan Tianfu Chemical Co.,LTD was built in 2009 with an ISO certificate in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had establishe

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Mesembrine 468-53-1

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Mesembrine CAS:468-53-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Mesembrine CAS:468-53-1

Cas:468-53-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Mesembrine CAS: 468-53-1 Specification Product Name: Mesembrine Synonyms: Mesembrine;(3aR,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyl-2,3,4,5,7,7a-hexahydroindol-6-one CAS: 468-53-1 MF: C17H23NO3

Factory supply Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Mesembrine

Cas:468-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : (3aR,7aR)-3a-(3,4-dimethoxyphenyl

Mesembrine

Cas:468-53-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

Tetradifon 468-53-1

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Lab/Research institutions

inquiry

Purestar Chem Enterprise Co.,Ltd

Kanna extract,Mesembrine Product Name: Kanna Extract, Lampranthus Spectabilis Extract Latin Name: Sceletium tortuosum Part Used: Whole Herb Appearance: Brown Yellow Powder Specification: 10:1, 20:1,98% Mesembrine Mesh size: 100% pass 80 Mesh

Kanna extract,Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $15.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Mesembrine

Cas:468-53-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Mesembrine

Cas:468-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

6H-Indol-6-one,3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aR,7aR)- factory

Cas:468-53-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Mesembrine((+)-Mesembrine Powder CAS 468-53-1

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Reliable Quality Mesembrine

Cas:468-53-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Mesembrine

Cas:468-53-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Mesembrine

Cas:468-53-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Mesembrine

Cas:468-53-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Mesembrine

Cas:468-53-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Mesembrine

Cas:468-53-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

6H-Indol-6-one,3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aR,7aR)-

Cas:468-53-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

6H-Indol-6-one,3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aR,7aR)-

Cas:468-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

6H-Indol-6-one,3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aR,7aR)-

Cas:468-53-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

Mesembrine

Cas:468-53-1

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

t-butyl 2-((S)-1-(3,4-dimethoxyphenyl)-4-oxocyclohex-2-enyl)ethylmethylcarbamate

t-butyl 2-((S)-1-(3,4-dimethoxyphenyl)-4-oxocyclohex-2-enyl)ethylmethylcarbamate

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 1.33333h;81%
(R)-3a-(3,4-dimethoxyphenyl)-1-methyl-1,2,3,3a,4,5-hexahydro-6H-indol-6-one

(R)-3a-(3,4-dimethoxyphenyl)-1-methyl-1,2,3,3a,4,5-hexahydro-6H-indol-6-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With ammonium hydroxide; lithium In tetrahydrofuran; tert-butyl alcohol for 0.5h; Birch Reduction; Inert atmosphere;77%
With ammonia; lithium In tetrahydrofuran; tert-butyl alcohol at -78℃; for 0.75h;77%
(3aR,8bS)-3a-(3,4-dimethoxyphenyl)-1,6-dimethyl-1,2,3,3a,4,5,6,8b-octahydro-8H-isoxazolo[3,4-g]indol-8-one
911847-34-2

(3aR,8bS)-3a-(3,4-dimethoxyphenyl)-1,6-dimethyl-1,2,3,3a,4,5,6,8b-octahydro-8H-isoxazolo[3,4-g]indol-8-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With hexacarbonyl molybdenum In water; acetonitrile for 12h; Heating;75%
(3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-ol
1427472-33-0

(3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-ol

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With dipyridinium dichromate In dichloromethane at 20℃; for 2h; Inert atmosphere;48%
(R)-2-(3,4-Dimethoxy-phenyl)-2-(2-methylamino-ethyl)-5-oxo-hexanal
99548-21-7

(R)-2-(3,4-Dimethoxy-phenyl)-2-(2-methylamino-ethyl)-5-oxo-hexanal

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With sodium hydroxide Ambient temperature;
C19H27NO4

C19H27NO4

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
With acid Yield given;
[(S)-1-(3,4-Dimethoxy-phenyl)-3-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-4-oxo-cyclohex-2-enyl]-acetaldehyde
911847-30-8

[(S)-1-(3,4-Dimethoxy-phenyl)-3-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-4-oxo-cyclohex-2-enyl]-acetaldehyde

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C
2: 190 mg / NaBH3CN / 1,2-dichloro-ethane / 6 h / 20 °C
3: 60 percent / ethanol / 6 h / Heating
4: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
(S)-4-(3,4-Dimethoxy-phenyl)-2-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-4-{2-[(E)-methylimino]-ethyl}-cyclohex-2-enone

(S)-4-(3,4-Dimethoxy-phenyl)-2-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-4-{2-[(E)-methylimino]-ethyl}-cyclohex-2-enone

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 190 mg / NaBH3CN / 1,2-dichloro-ethane / 6 h / 20 °C
2: 60 percent / ethanol / 6 h / Heating
3: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
((R)-1-allyl-5-(3,4-dimethoxyphenyl)-2-methoxycyclohexa-2,5-dienyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone
911847-24-0

((R)-1-allyl-5-(3,4-dimethoxyphenyl)-2-methoxycyclohexa-2,5-dienyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 95 percent / HCl / methanol / 15 h / 20 °C
2.1: 80 percent / 1,2-dichloro-benzene / 10 h / Heating
3.1: O3; Sudan III / methanol / 0.03 h / -78 °C
3.2: dimethyl sulfide / methanol / 7 h / 20 °C
4.1: triethylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C
5.1: 190 mg / NaBH3CN / 1,2-dichloro-ethane / 6 h / 20 °C
6.1: 60 percent / ethanol / 6 h / Heating
7.1: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
(S)-4-allyl-4-(3,4-dimethoxyphenyl)-2-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)cyclohex-2-en-1-one
911847-28-4

(S)-4-allyl-4-(3,4-dimethoxyphenyl)-2-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)cyclohex-2-en-1-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: O3; Sudan III / methanol / 0.03 h / -78 °C
1.2: dimethyl sulfide / methanol / 7 h / 20 °C
2.1: triethylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C
3.1: 190 mg / NaBH3CN / 1,2-dichloro-ethane / 6 h / 20 °C
4.1: 60 percent / ethanol / 6 h / Heating
5.1: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
(R)-2-allyl-4-(3,4-dimethoxyphenyl)-2-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)cyclohex-3-en-1-one
911847-26-2

(R)-2-allyl-4-(3,4-dimethoxyphenyl)-2-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)cyclohex-3-en-1-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 80 percent / 1,2-dichloro-benzene / 10 h / Heating
2.1: O3; Sudan III / methanol / 0.03 h / -78 °C
2.2: dimethyl sulfide / methanol / 7 h / 20 °C
3.1: triethylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C
4.1: 190 mg / NaBH3CN / 1,2-dichloro-ethane / 6 h / 20 °C
5.1: 60 percent / ethanol / 6 h / Heating
6.1: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
(3aR,7aR)-3a-(3,4-dimethoxyphenyl)-7-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)-1-methylhexahydro-1H-indol-6(2H)-one
911847-32-0

(3aR,7aR)-3a-(3,4-dimethoxyphenyl)-7-((S)-2-(methoxymethyl)pyrrolidin-1-carbonyl)-1-methylhexahydro-1H-indol-6(2H)-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / ethanol / 6 h / Heating
2: 75 percent / Mo(CO)6 / acetonitrile; H2O / 12 h / Heating
View Scheme
2-(but-3'-ynyl)-2-methyl-1,3-dioxolane
42541-87-7

2-(but-3'-ynyl)-2-methyl-1,3-dioxolane

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: EtMgBr / diethyl ether; toluene
2: 1.) n-BuLi, 2.) CuBr
3: 1.) Zn-Cu, 2.) Zn, AcOH / 1.) THF, 0 deg C, 2.) RT, 1 h
4: aq. AcOH / 2 h / 60 °C
5: K2CO3 / methanol
6: methanol
7: 83 percent / tetrahydrofuran / Heating
8: PTS
9: LiAlH4 / tetrahydrofuran
10: acid
View Scheme
(3aR,7aR)-3a-(3,4-Dimethoxy-phenyl)-1-methyl-hexahydro-indole-2,6-dione
151764-32-8

(3aR,7aR)-3a-(3,4-Dimethoxy-phenyl)-1-methyl-hexahydro-indole-2,6-dione

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PTS
2: LiAlH4 / tetrahydrofuran
3: acid
View Scheme
3'a-(3,4-dimethoxy-phenyl)-1'-methyl-hexahydro-spiro[[1,3]dioxolane-2,6'-indol]-2'-one
21104-36-9, 80515-96-4

3'a-(3,4-dimethoxy-phenyl)-1'-methyl-hexahydro-spiro[[1,3]dioxolane-2,6'-indol]-2'-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran
2: acid
View Scheme
2-Methyl-2-[4-((S)-toluene-4-sulfinyl)-but-3-ynyl]-[1,3]dioxolane
151670-66-5

2-Methyl-2-[4-((S)-toluene-4-sulfinyl)-but-3-ynyl]-[1,3]dioxolane

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 1.) n-BuLi, 2.) CuBr
2: 1.) Zn-Cu, 2.) Zn, AcOH / 1.) THF, 0 deg C, 2.) RT, 1 h
3: aq. AcOH / 2 h / 60 °C
4: K2CO3 / methanol
5: methanol
6: 83 percent / tetrahydrofuran / Heating
7: PTS
8: LiAlH4 / tetrahydrofuran
9: acid
View Scheme
[(S)-1-(3,4-Dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-acetic acid

[(S)-1-(3,4-Dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-acetic acid

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: methanol
2: 83 percent / tetrahydrofuran / Heating
3: PTS
4: LiAlH4 / tetrahydrofuran
5: acid
View Scheme
[(S)-1-(3,4-Dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-acetic acid methyl ester
151764-31-7

[(S)-1-(3,4-Dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-acetic acid methyl ester

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / tetrahydrofuran / Heating
2: PTS
3: LiAlH4 / tetrahydrofuran
4: acid
View Scheme
2-[(E)-3-(3,4-Dimethoxy-phenyl)-4-((R)-toluene-4-sulfinyl)-but-3-enyl]-2-methyl-[1,3]dioxolane
151670-58-5

2-[(E)-3-(3,4-Dimethoxy-phenyl)-4-((R)-toluene-4-sulfinyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1.) Zn-Cu, 2.) Zn, AcOH / 1.) THF, 0 deg C, 2.) RT, 1 h
2: aq. AcOH / 2 h / 60 °C
3: K2CO3 / methanol
4: methanol
5: 83 percent / tetrahydrofuran / Heating
6: PTS
7: LiAlH4 / tetrahydrofuran
8: acid
View Scheme
(4R,5R)-4-(3,4-Dimethoxy-phenyl)-4-(3-oxo-butyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

(4R,5R)-4-(3,4-Dimethoxy-phenyl)-4-(3-oxo-butyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: K2CO3 / methanol
2: methanol
3: 83 percent / tetrahydrofuran / Heating
4: PTS
5: LiAlH4 / tetrahydrofuran
6: acid
View Scheme
(4R,5R)-4-(3,4-Dimethoxy-phenyl)-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-5-p-tolylsulfanyl-dihydro-furan-2-one

(4R,5R)-4-(3,4-Dimethoxy-phenyl)-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-5-p-tolylsulfanyl-dihydro-furan-2-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: aq. AcOH / 2 h / 60 °C
2: K2CO3 / methanol
3: methanol
4: 83 percent / tetrahydrofuran / Heating
5: PTS
6: LiAlH4 / tetrahydrofuran
7: acid
View Scheme
(3aR,5aR,8S,9aR)-3a-(3,4-Dimethoxy-phenyl)-8-isopropyl-1,5a-dimethyl-decahydro-oxazolo[3,2-a]pyrrolo[3,2-e]pyridine
99548-20-6

(3aR,5aR,8S,9aR)-3a-(3,4-Dimethoxy-phenyl)-8-isopropyl-1,5a-dimethyl-decahydro-oxazolo[3,2-a]pyrrolo[3,2-e]pyridine

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Bu4NH2PO4 / ethanol
2: 4N NaOH / Ambient temperature
View Scheme
[(3S,6R,8aR)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-5-oxo-hexahydro-oxazolo[3,2-a]pyridin-6-yl]-acetaldehyde

[(3S,6R,8aR)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-5-oxo-hexahydro-oxazolo[3,2-a]pyridin-6-yl]-acetaldehyde

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: CNBH3(-)
2: LiAl(OEt)H3 / 1,2-dimethoxy-ethane; toluene / -20 °C
3: Bu4NH2PO4 / ethanol
4: 4N NaOH / Ambient temperature
View Scheme
(3S,6R,8aR)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-6-(2-methylamino-ethyl)-hexahydro-oxazolo[3,2-a]pyridin-5-one
99548-18-2

(3S,6R,8aR)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-6-(2-methylamino-ethyl)-hexahydro-oxazolo[3,2-a]pyridin-5-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiAl(OEt)H3 / 1,2-dimethoxy-ethane; toluene / -20 °C
2: Bu4NH2PO4 / ethanol
3: 4N NaOH / Ambient temperature
View Scheme
(S)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
99548-16-0, 99603-20-0, 99603-21-1, 99603-22-2

(S)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / s-BuLi / tetrahydrofuran / -20 °C
2: OsO4, NaIO4 / diethyl ether; H2O / 8 h / 25 °C
3: CNBH3(-)
4: LiAl(OEt)H3 / 1,2-dimethoxy-ethane; toluene / -20 °C
5: Bu4NH2PO4 / ethanol
6: 4N NaOH / Ambient temperature
View Scheme
(3S,6R,8aR)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
99548-17-1

(3S,6R,8aR)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: OsO4, NaIO4 / diethyl ether; H2O / 8 h / 25 °C
2: CNBH3(-)
3: LiAl(OEt)H3 / 1,2-dimethoxy-ethane; toluene / -20 °C
4: Bu4NH2PO4 / ethanol
5: 4N NaOH / Ambient temperature
View Scheme
(3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-amine
853761-21-4

(3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-amine

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Stage #1: (3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-amine With 3,5-di-tert-butyl-o-benzoquinone In tetrahydrofuran; methanol for 1h;
Stage #2: With oxalic acid In tetrahydrofuran; methanol; water
Stage #3: With potassium hydroxide In tetrahydrofuran; methanol; water
1-(3,4-Dimethoxy-phenyl)-1-methyl-iminomethyl-cyclopropan
20802-17-9

1-(3,4-Dimethoxy-phenyl)-1-methyl-iminomethyl-cyclopropan

methyl vinyl ketone
78-94-4

methyl vinyl ketone

A

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Stage #1: 1-(3,4-Dimethoxy-phenyl)-1-methyl-iminomethyl-cyclopropan With chloro-trimethyl-silane; sodium iodide In DMF (N,N-dimethyl-formamide) at 90℃; for 3h;
Stage #2: With hydrogenchloride In diethyl ether; dichloromethane
Stage #3: methyl vinyl ketone With sodium hydroxide more than 3 stages;
2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide
1427435-77-5

2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one
468-53-1

(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 15 h / 0 - 20 °C
2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 15 h / 40 °C
3.1: palladium diacetate; triphenylphosphine; potassium carbonate / N,N-dimethyl-formamide / 15 h / 110 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C
4.2: 15 h / 0 - 20 °C
5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 19 h / 20 °C / 760.05 Torr
6.1: 3-chloro-benzenecarboperoxoic acid / chloroform-d1; water-d2 / 48 h / 20 °C
7.1: lithium; ammonia / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
7.2: 4 h / 20 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux
9.1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C / Inert atmosphere
View Scheme

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