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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/223.html Product Name 4-(4-Aminophenyl)morpholin-3-one CAS No.
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryTIANFUCHEM--438056-69-0-- 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable bus
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inquiryWe are the manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, AlityGroup is your best choice. Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName: 4-(4-AMinophenyl)-3-Morpholinone Synonyms: 4-(4-Aminophenyl)Morpholin-3-One CAS: 438056-69-0 MF: C10H12N2O2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Intermediates Tran
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inquiryAppearance:White powder Storage:ln stock Package:25kg/Barrel Application:Rivaroxaban intermediate Transportation:Express/Sea/Air Port:Any port in china
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiry4-(4-Aminophenyl)morpholin-3-one CAS NO.:438056-69-0 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the mark
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
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inquiry4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Basic information Product Name: 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Synonyms: Rivaroxaban Intermediate 1;Rivaroxaban InterMediate;4-(4-aMinophenyl) Morpholinone;3-Morpholinone, 4-(4-aminophenyl)-;4-(4-Aminophenyl)m
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiry4-(4-AMINOPHENYL)MORPHOLIN-3-ONE CAS: 438056-69-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit
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inquiry4-(4-Aminophenyl)morpholin-3-one CAS: 438056-69-0 Specification product name 4-(4-aminophenyl)morpholin-3-one cas no. 438056-69-0 appearance yellowish powder assay ≥99% capacity 200
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inquiry4-(4-nitrophenyl)-3-morpholinone
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In ethanol at 60℃; under 3000.3 Torr; for 3h; Autoclave; | 97.8% |
With hydrogen In water; isopropyl alcohol at 50 - 55℃; under 7600.51 - 11400.8 Torr; for 5h; Temperature; Reagent/catalyst; Solvent; Pressure; Autoclave; | 96.4% |
With hydrogen; palladium on activated charcoal In methanol; water at 40℃; under 1500.15 Torr; for 17h; | 95% |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane at 0 - 20℃; for 2h; | 96% |
ethanolamine
4-(4-nitrophenyl)-3-morpholinone
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With iron; acetic acid In acetonitrile at 30℃; for 3h; | 95% |
4-(4-nitrophenyl)-3-morpholinone
B
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; water for 2h; Reflux; | A n/a B 93% |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 5h; Concentration; | 92.4% |
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 3h; | 92.4% |
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 5h; Concentration; | 35.2 g |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 2h; Reflux; | 92% |
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 3h; Reflux; | 90% |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With ethanol; 5%-palladium/activated carbon; hydrogen at 40℃; under 2068.65 Torr; for 2h; Inert atmosphere; Heating; | 89.5% |
methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 4h; Reflux; | 85% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 110℃; for 2h; Ullmann Condensation; Microwave irradiation; | 75% |
Conditions | Yield |
---|---|
With copper(l) iodide; 8-quinolinol; potassium carbonate In dimethyl sulfoxide at 130℃; for 12h; Inert atmosphere; | 53.45% |
With copper(l) iodide; N,N-dimethyl-formamide at 120℃; Inert atmosphere; | 50% |
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 110℃; | |
With potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃; | |
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃; |
4-nitro-aniline
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 5 h / 95 °C 2: K2CO3 / acetonitrile / 8 h / 20 °C 3: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme |
4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: K2CO3 / acetonitrile / 8 h / 20 °C 2: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme |
4-(4-nitrophenyl)-3-morpholinone
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
In ethanol; ethyl acetate |
2-Anilinoethanol
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale 2: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 3: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / isopropyl alcohol / 0 - 40 °C / pH 7 - 8 2: nitric acid; sulfuric acid / 1 h / -10 °C 3: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / ethanol; water 2: sulfuric acid; nitric acid / water 3: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C View Scheme |
4-phenyl-3-morpholinone
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C View Scheme |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene Inert atmosphere; Reflux; | |
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene Inert atmosphere; |
bromobenzene
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: copper(l) iodide; potassium carbonate / water / 15 h / 80 °C 2.1: hydrogenchloride; sodium nitrite / water / 5 h / 0 - 5 °C / Cooling 3.1: triethylamine / tetrahydrofuran / 4.6 h / Cooling with ice 3.2: 1.3 h / 35 °C / Heating 4.1: ethanol; 5%-palladium/activated carbon; hydrogen / 2 h / 40 °C / 2068.65 Torr / Inert atmosphere; Heating View Scheme |
4-nitroso-N-2-hydroxyethylaniline
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / tetrahydrofuran / 4.6 h / Cooling with ice 1.2: 1.3 h / 35 °C / Heating 2.1: ethanol; 5%-palladium/activated carbon; hydrogen / 2 h / 40 °C / 2068.65 Torr / Inert atmosphere; Heating View Scheme |
para-nitrophenyl bromide
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme |
4-chlorobenzonitrile
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 6 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / 3 h / 100 - 105 °C / Green chemistry 2: hydrogen / water; isopropyl alcohol / 4 h / 50 - 55 °C / 2280.15 - 3040.2 Torr / Autoclave; Green chemistry 3: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / 100 - 110 °C / Green chemistry View Scheme |
4-Fluoronitrobenzene
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: caesium carbonate / acetonitrile / 0.5 h / 10 - 20 °C / Inert atmosphere 1.2: 5 h / 20 - 80 °C 2.1: caesium carbonate / 1,4-dioxane / Reflux 3.1: potassium tert-butylate / toluene / 5 h / 100 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 70 °C / 2280.15 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.83 h / 10 - 20 °C / Inert atmosphere 1.2: 10 h / 20 - 35 °C 2.1: potassium carbonate / 1,4-dioxane / Reflux 3.1: caesium carbonate / toluene / 10 h / 70 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 70 °C / 2280.15 Torr View Scheme |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme |
Acetanilid
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C 2.1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 3.1: potassium carbonate / acetonitrile / 6 h / Reflux 4.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 5.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 5.2: 5 h / Cooling; Reflux View Scheme |
4-nitro-aniline
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 2.1: potassium carbonate / acetonitrile / 6 h / Reflux 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: toluene / 6.5 h / 5 - 98 °C 2: potassium carbonate / acetonitrile / 10 h / 20 °C 3: 5%-palladium/activated carbon; hydrogen / methanol View Scheme |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 6 h / Reflux 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme |
aniline
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 4 h / 0 - 25 °C 2.1: potassium carbonate / acetonitrile / 6 h / Reflux 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 4 h / 0 - 5 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / tert-butyl methyl ether / 4 h / 0 - 5 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme |
1,4-phenylenediamine
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 5 h / 10 - 20 °C 2: tetrabutylammomium bromide; potassium carbonate / dichloromethane / 5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 3 h / 10 - 20 °C 2: potassium carbonate; tetrabutylammomium bromide / dichloromethane / 3 h / 0 - 20 °C View Scheme |
(R)-oxiranemethanol
4-(4-aminophenyl)morpholin-3-one
4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one
Conditions | Yield |
---|---|
In methanol for 14h; Reflux; | 100% |
benzyl chloroformate
4-(4-aminophenyl)morpholin-3-one
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetone; toluene at 0 - 30℃; for 4h; | 98% |
With sodium hydrogencarbonate In water; acetone; toluene at 0 - 20℃; for 4h; | 98% |
With sodium hydrogencarbonate In water; acetone at 0℃; for 3.5h; | 96.2% |
Conditions | Yield |
---|---|
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; | 98% |
5-chlorothiophene-2-carbonyl chloride
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 5h; | 97.5% |
Conditions | Yield |
---|---|
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
In ethanol at 36℃; for 7h; Solvent; | 96.4% |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water at 0 - 10℃; | 96.1% |
(S)-N-glycidylphthalimide
4-(4-aminophenyl)morpholin-3-one
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
In ethanol; water at 20℃; for 15h; Solvent; Temperature; | 95% |
In ethanol; water for 27h; Heating; | 92% |
In methanol; water at 65 - 70℃; for 32h; | 92% |
(R)-(-)-epichlorohydrin
4-(4-aminophenyl)morpholin-3-one
4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one
Conditions | Yield |
---|---|
In ethanol for 12h; Reflux; | 95% |
In water; isopropyl alcohol at 25 - 35℃; for 17h; Solvent; Time; | 90% |
In isopropyl alcohol for 12h; Reflux; | 90% |
methyl chloroformate
4-(4-aminophenyl)morpholin-3-one
methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate
Conditions | Yield |
---|---|
Stage #1: methyl chloroformate; 4-(4-aminophenyl)morpholin-3-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.3h; Stage #2: methyl chloroformate In dichloromethane for 1.16667h; | 95% |
Conditions | Yield |
---|---|
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; | 95% |
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With C40H51ClIrN3; potassium carbonate; deuterium In dichloromethane at 50℃; under 760.051 Torr; for 12h; Sealed tube; Inert atmosphere; regioselective reaction; | 95% |
3-methylbut-2-enyl chloroformate
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 10℃; | 94.8% |
(S)-N-glycidylphthalimide
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
In water; toluene at 30 - 85℃; Solvent; Temperature; | 94.6% |
di-tert-butyl dicarbonate
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: 4-(4-aminophenyl)morpholin-3-one With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 3h; | 94.2% |
n-dodecyl chloroformate
4-(4-aminophenyl)morpholin-3-one
dodecyl (4-(3-oxomorpholin)phenyl)carbamate
Conditions | Yield |
---|---|
Stage #1: 4-(4-aminophenyl)morpholin-3-one With sodium carbonate In water; acetone at 0℃; for 0.166667h; Stage #2: n-dodecyl chloroformate at 20℃; for 4h; | 94% |
Stage #1: 4-(4-aminophenyl)morpholin-3-one With sodium carbonate In water; acetone at 0℃; for 0.166667h; Stage #2: n-dodecyl chloroformate In water; acetone at 20℃; for 4h; | 94% |
5-chloro-2-nitrobenzoyl chloride
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With dmap; potassium carbonate In tetrahydrofuran for 2h; Reflux; | 94% |
dimethoxyacetaldehyde
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: dimethoxyacetaldehyde; 4-(4-aminophenyl)morpholin-3-one In dichloromethane; water at 20℃; for 2h; Molecular sieve; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane; water at 20℃; for 1h; | 94% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane Reflux; | 93.7% |
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline
4-(4-aminophenyl)morpholin-3-one
(2R,4R)-4-hydroxy-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In toluene at 20℃; for 18h; | 93.2% |
2-nitrobenzyl chloride
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With dmap; potassium carbonate In tetrahydrofuran for 2h; Reflux; | 93% |
formaldehyd
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
In dichloromethane at 20 - 30℃; for 2h; Time; | 92.1% |
In dichloromethane at 20 - 30℃; for 2h; Time; | 92.1% |
In dichloromethane at 20 - 30℃; for 5h; Concentration; | 92.1% |
In dichloromethane at 20 - 30℃; for 5h; Solvent; | 185.4 g |
In dichloromethane at 20 - 30℃; for 2h; Time; | 188.1 g |
5-chloro-N-(oxiran-2-ylmethyl)thiophene-2-carboxamide
4-(4-aminophenyl)morpholin-3-one
5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide
Conditions | Yield |
---|---|
ytterbium(III) triflate In tetrahydrofuran at 20 - 60℃; | 92% |
With magnesium(II) perchlorate In acetone at 50℃; for 18h; Inert atmosphere; | 76% |
2-[(2-oxo-2H-chromen-4-yl)oxy]propanoic acid
4-(4-aminophenyl)morpholin-3-one
2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide
Conditions | Yield |
---|---|
With HATU In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 92% |
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