4-(4-Aminophenyl)morpholin-3-one supplier

Name
4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
EINECS 610-147-8
CAS No. 438056-69-0
Article Data52
CAS DataBase
Density 1.268 g/cm³
Solubility 16.6g/L at 20℃
Melting Point 171.0 to 175.0 °C
Formula C₁₀H₁₂N₂O₂
Boiling Point 502.3 °C at 760 mmHg
Molecular Weight 192.217
Flash Point 257.6 °C
Transport Information
Appearance
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 4-(3-Oxo-4-morpholinyl)aniline;4-(4-Aminophenyl)-3-morpholinone;
PSA 55.56000
LogP 1.27820

Synthetic route

: 446292-04-2
4-(4-nitrophenyl)-3-morpholinone

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In ethanol at 60℃; under 3000.3 Torr; for 3h; Autoclave;	97.8%
With hydrogen In water; isopropyl alcohol at 50 - 55℃; under 7600.51 - 11400.8 Torr; for 5h; Temperature; Reagent/catalyst; Solvent; Pressure; Autoclave;	96.4%
With hydrogen; palladium on activated charcoal In methanol; water at 40℃; under 1500.15 Torr; for 17h;	95%

: 4-(4-aminophenyl)-3-morpholinone hydrochloride

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane at 0 - 20℃; for 2h;	96%

: 141-43-5
ethanolamine

: 446292-04-2
4-(4-nitrophenyl)-3-morpholinone

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With iron; acetic acid In acetonitrile at 30℃; for 3h;	95%

: 446292-04-2
4-(4-nitrophenyl)-3-morpholinone

A: 2-(2-((4-nitrophenyl)amino)ethoxy) acetohydrazide

B: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; water for 2h; Reflux;	A n/a B 93%

: N-(4-aminophenyl)-2-(2-chloroethoxy)acetamide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 5h; Concentration;	92.4%
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 3h;	92.4%
With tetrabutylammomium bromide; potassium carbonate In dichloromethane at 0 - 20℃; for 5h; Concentration;	35.2 g

: N-(tert-butoxycarbonyl)-4-(3-oxo-morpholinyl)aniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2h; Reflux;	92%

: 1313613-18-1
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 3h; Reflux;	90%

: 4-(4-nitrosophenyl)-3-morpholinone

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With ethanol; 5%-palladium/activated carbon; hydrogen at 40℃; under 2068.65 Torr; for 2h; Inert atmosphere; Heating;	89.5%

: 1252018-07-7
methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 4h; Reflux;	85%

: 109-11-5
morpholine-3-one

4-haloaniline: 4-haloaniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 110℃; for 2h; Ullmann Condensation; Microwave irradiation;	75%

: 109-11-5
morpholine-3-one

: 540-37-4
p-aminoiodobenzene

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With copper(l) iodide; 8-quinolinol; potassium carbonate In dimethyl sulfoxide at 130℃; for 12h; Inert atmosphere;	53.45%
With copper(l) iodide; N,N-dimethyl-formamide at 120℃; Inert atmosphere;	50%
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 110℃;
With potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃;
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃;

: 100-01-6
4-nitro-aniline

Boc-NH-L-Phe-L-Ala-NH-NH-C6H4-resinAc-X: Boc-NH-L-Phe-L-Ala-NH-NH-C6H4-resinAc-X

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene / 5 h / 95 °C 2: K2CO3 / acetonitrile / 8 h / 20 °C 3: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme

: 811450-82-5
4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: K2CO3 / acetonitrile / 8 h / 20 °C 2: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme

SnCl2 dihydrate: SnCl2 dihydrate

: 446292-04-2
4-(4-nitrophenyl)-3-morpholinone

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
In ethanol; ethyl acetate

: 122-98-5
2-Anilinoethanol

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale 2: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 3: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / isopropyl alcohol / 0 - 40 °C / pH 7 - 8 2: nitric acid; sulfuric acid / 1 h / -10 °C 3: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / ethanol; water 2: sulfuric acid; nitric acid / water 3: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C View Scheme

: 29518-11-4
4-phenyl-3-morpholinone

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C View Scheme

: 109-11-5
morpholine-3-one

: 106-40-1
4-bromo-aniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene Inert atmosphere; Reflux;
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene Inert atmosphere;

: 108-86-1
bromobenzene

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: copper(l) iodide; potassium carbonate / water / 15 h / 80 °C 2.1: hydrogenchloride; sodium nitrite / water / 5 h / 0 - 5 °C / Cooling 3.1: triethylamine / tetrahydrofuran / 4.6 h / Cooling with ice 3.2: 1.3 h / 35 °C / Heating 4.1: ethanol; 5%-palladium/activated carbon; hydrogen / 2 h / 40 °C / 2068.65 Torr / Inert atmosphere; Heating View Scheme

: 52671-43-9
4-nitroso-N-2-hydroxyethylaniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine / tetrahydrofuran / 4.6 h / Cooling with ice 1.2: 1.3 h / 35 °C / Heating 2.1: ethanol; 5%-palladium/activated carbon; hydrogen / 2 h / 40 °C / 2068.65 Torr / Inert atmosphere; Heating View Scheme

: 586-78-7
para-nitrophenyl bromide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme

: 100-00-5
4-chlorobenzonitrile

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 6 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate / 3 h / 100 - 105 °C / Green chemistry 2: hydrogen / water; isopropyl alcohol / 4 h / 50 - 55 °C / 2280.15 - 3040.2 Torr / Autoclave; Green chemistry 3: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / 100 - 110 °C / Green chemistry View Scheme

: 350-46-9
4-Fluoronitrobenzene

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C View Scheme
Multi-step reaction with 4 steps 1.1: caesium carbonate / acetonitrile / 0.5 h / 10 - 20 °C / Inert atmosphere 1.2: 5 h / 20 - 80 °C 2.1: caesium carbonate / 1,4-dioxane / Reflux 3.1: potassium tert-butylate / toluene / 5 h / 100 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 70 °C / 2280.15 Torr View Scheme
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.83 h / 10 - 20 °C / Inert atmosphere 1.2: 10 h / 20 - 35 °C 2.1: potassium carbonate / 1,4-dioxane / Reflux 3.1: caesium carbonate / toluene / 10 h / 70 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 70 °C / 2280.15 Torr View Scheme

: 2-(2-((methylsulfonyl)oxy)ethoxy)-N-phenylacetamide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme

: 103-84-4
Acetanilid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C 2.1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 3.1: potassium carbonate / acetonitrile / 6 h / Reflux 4.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 5.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 5.2: 5 h / Cooling; Reflux View Scheme

: 100-01-6
4-nitro-aniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 2.1: potassium carbonate / acetonitrile / 6 h / Reflux 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme
Multi-step reaction with 3 steps 1: toluene / 6.5 h / 5 - 98 °C 2: potassium carbonate / acetonitrile / 10 h / 20 °C 3: 5%-palladium/activated carbon; hydrogen / methanol View Scheme

: 2-(2-chloroethoxy)-N-phenylacetamide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 6 h / Reflux 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme

: 62-53-3
aniline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 4 h / 0 - 25 °C 2.1: potassium carbonate / acetonitrile / 6 h / Reflux 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 4 h / 0 - 5 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme
Multi-step reaction with 4 steps 1.1: triethylamine / tert-butyl methyl ether / 4 h / 0 - 5 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 3.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 4.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 4.2: 5 h / Cooling; Reflux View Scheme

: 2-(2-((benzenesulfonyl)oxy)ethoxy)-N-phenylacetamide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 2.1: acetic anhydride; nitric acid / 5 h / 0 - 25 °C 3.1: iron(III) chloride hexahydrate; pyrographite / methanol / 0.5 h / Reflux 3.2: 5 h / Cooling; Reflux View Scheme

: 106-50-3
1,4-phenylenediamine

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 5 h / 10 - 20 °C 2: tetrabutylammomium bromide; potassium carbonate / dichloromethane / 5 h / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 3 h / 10 - 20 °C 2: potassium carbonate; tetrabutylammomium bromide / dichloromethane / 3 h / 0 - 20 °C View Scheme

: 57044-25-4
(R)-oxiranemethanol

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1447919-65-4
4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one

Conditions

Conditions	Yield
In methanol for 14h; Reflux;	100%

: 501-53-1
benzyl chloroformate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1313613-18-1
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone; toluene at 0 - 30℃; for 4h;	98%
With sodium hydrogencarbonate In water; acetone; toluene at 0 - 20℃; for 4h;	98%
With sodium hydrogencarbonate In water; acetone at 0℃; for 3.5h;	96.2%

: 112-05-0
nonanoic acid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C19H28N2O3

Conditions

Conditions	Yield
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;	98%

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: N-[4-(3-morpholinon-4-yl)phenyl]-5-chloro-2-thiophenecarboxamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 5h;	97.5%

: 111-14-8
oenanthic acid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C17H24N2O3

Conditions

Conditions	Yield
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;	97%

: 124-07-2
Octanoic acid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C18H26N2O3

Conditions

Conditions	Yield
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;	97%

: C10H11Cl2NO4S

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 366789-02-8
Rivaroxaban

Conditions

Conditions	Yield
In ethanol at 36℃; for 7h; Solvent;	96.4%

: 2937-50-0
Allyl chloroformate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C14H16N2O4

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 0 - 10℃;	96.1%

: 161596-47-0
(S)-N-glycidylphthalimide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 446292-07-5
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 15h; Solvent; Temperature;	95%
In ethanol; water for 27h; Heating;	92%
In methanol; water at 65 - 70℃; for 32h;	92%

: 51594-55-9
(R)-(-)-epichlorohydrin

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1252018-10-2
4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one

Conditions

Conditions	Yield
In ethanol for 12h; Reflux;	95%
In water; isopropyl alcohol at 25 - 35℃; for 17h; Solvent; Time;	90%
In isopropyl alcohol for 12h; Reflux;	90%

: 79-22-1
methyl chloroformate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1252018-07-7
methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate

Conditions

Conditions	Yield
Stage #1: methyl chloroformate; 4-(4-aminophenyl)morpholin-3-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.3h; Stage #2: methyl chloroformate In dichloromethane for 1.16667h;	95%

: 142-62-1
hexanoic acid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C16H22N2O3

Conditions

Conditions	Yield
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;	95%

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C10H10(2)H2N2O2

Conditions

Conditions	Yield
With C40H51ClIrN3; potassium carbonate; deuterium In dichloromethane at 50℃; under 760.051 Torr; for 12h; Sealed tube; Inert atmosphere; regioselective reaction;	95%

: 103723-94-0
3-methylbut-2-enyl chloroformate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C16H20N2O4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 10℃;	94.8%

: 161596-47-0
(S)-N-glycidylphthalimide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 2-((2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
In water; toluene at 30 - 85℃; Solvent; Temperature;	94.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: N-(tert-butoxycarbonyl)-4-(3-oxo-morpholinyl)aniline

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)morpholin-3-one With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 3h;	94.2%

: 24460-74-0
n-dodecyl chloroformate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1414932-71-0
dodecyl (4-(3-oxomorpholin)phenyl)carbamate

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)morpholin-3-one With sodium carbonate In water; acetone at 0℃; for 0.166667h; Stage #2: n-dodecyl chloroformate at 20℃; for 4h;	94%
Stage #1: 4-(4-aminophenyl)morpholin-3-one With sodium carbonate In water; acetone at 0℃; for 0.166667h; Stage #2: n-dodecyl chloroformate In water; acetone at 20℃; for 4h;	94%

: 41994-44-9
5-chloro-2-nitrobenzoyl chloride

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 5-chloro-2-nitro-N-(4-(3-oxomorpholino)phenyl)benzamide

Conditions

Conditions	Yield
With dmap; potassium carbonate In tetrahydrofuran for 2h; Reflux;	94%

: 51673-84-8
dimethoxyacetaldehyde

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: N-4-[(2,2-dimethoxyethylamino)phenyl]morpholine-3-one

Conditions

Conditions	Yield
Stage #1: dimethoxyacetaldehyde; 4-(4-aminophenyl)morpholin-3-one In dichloromethane; water at 20℃; for 2h; Molecular sieve; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane; water at 20℃; for 1h;	94%

: 64057-79-0
bis(2-methylallyl) carbonate

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: C15H18N2O4

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane Reflux;	93.7%

: 135042-12-5
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 773889-47-7
(2R,4R)-4-hydroxy-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In toluene at 20℃; for 18h;	93.2%

: 610-14-0
2-nitrobenzyl chloride

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 2-nitro-N-(4-(3-oxomorpholino)phenyl)benzamide

Conditions

Conditions	Yield
With dmap; potassium carbonate In tetrahydrofuran for 2h; Reflux;	93%

: 50-00-0
formaldehyd

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 4-[4-(methylideneamino)phenyl]morpholin-3-one

Conditions

Conditions	Yield
In dichloromethane at 20 - 30℃; for 2h; Time;	92.1%
In dichloromethane at 20 - 30℃; for 2h; Time;	92.1%
In dichloromethane at 20 - 30℃; for 5h; Concentration;	92.1%
In dichloromethane at 20 - 30℃; for 5h; Solvent;	185.4 g
In dichloromethane at 20 - 30℃; for 2h; Time;	188.1 g

: 348626-26-6
5-chloro-N-(oxiran-2-ylmethyl)thiophene-2-carboxamide

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 721401-53-2
5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide

Conditions

Conditions	Yield
ytterbium(III) triflate In tetrahydrofuran at 20 - 60℃;	92%
With magnesium(II) perchlorate In acetone at 50℃; for 18h; Inert atmosphere;	76%

: 1412905-05-5
2-[(2-oxo-2H-chromen-4-yl)oxy]propanoic acid

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1412905-15-7
2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide

Conditions

Conditions	Yield
With HATU In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	92%

4-(4-Aminophenyl)morpholin-3-one Chemical Properties

Following is the structure of 4-(4-Aminophenyl)morpholin-3-one (CAS NO.438056-69-0):

Empirical Formula: C₁₀H₁₂N₂O₂
Molecular Weight: 192.2145
Molar Refractivity: 52.42 cm³
Molar Volume: 151.5 cm³
Density: 1.268 g/cm³
Flash Point: 257.6 °C
Index of Refraction: 1.608
Surface Tension: 55.8 dyne/cm
Enthalpy of Vaporization: 77.12 kJ/mol
Boiling Point: 502.3 °C at 760 mmHg
Vapour Pressure of 4-(4-Aminophenyl)morpholin-3-one (CAS NO.438056-69-0): 3.23E-10 mmHg at 25 °C
Product Categories of 4-(4-Aminophenyl)morpholin-3-one (CAS NO.438056-69-0): Amines and Anilines; Heterocycles
SMILES: O=C2N(c1ccc(N)cc1)CCOC2
InChI: InChI=1/C10H12N2O2/c11-8-1-3-9(4-2-8)12-5-6-14-7-10(12)13/h1-4H,5-7,11H2
InChIKey: MHCRLDZZHOVFEE-UHFFFAOYAC

4-(4-Aminophenyl)morpholin-3-one Specification

4-(4-Aminophenyl)morpholin-3-one , its cas register number is 438056-69-0. It also can be called 3-Morpholinone, 4-(4-aminophenyl)- .

Product Name

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

Synthetic route

4-(4-Aminophenyl)morpholin-3-one Chemical Properties

4-(4-Aminophenyl)morpholin-3-one Specification

Related Products

Hot Products