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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 184475-71-6 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol Gefinitinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below:

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-(3-Chloro-4-Fluoro-Phenylamino)-7- Methoxy-Quinazolin-6-Ol supplier in China

Cas:184475-71-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:184475-71-6/High quality/Factory supply

Cas:184475-71-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/571.html Product Name 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Gram

FOB Price: $53.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 184475-71-6 with competitive price

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

High quality 184475-71-6 Gefitinib iMpurity C with best price

Cas:184475-71-6

Min.Order:10 Gram

Negotiable

Type:Other

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Hangzhou Think Chemical Co. Ltd

Product: Gefitinib Intermediate Chemical name:4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol Batch NO: 20210405 Analysis Date: 2021-04-25 Expiry Date: 2023-04-24 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integ

4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $480.0 / 500.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy- 184475-71-6

Cas:184475-71-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Gefitinib intermediate, 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS:184475-71-6

Cas:184475-71-6

Min.Order:1 Kilogram

FOB Price: $51.0 / 58.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS:184475-71-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS:184475-71-6

Cas:184475-71-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-

Cas:184475-71-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

4-(3-chloro-4-fluorophenylami-no)-7-methoxyquinazolin-6-ol(CAS:184475-71-6) is an important pharmaceutical intermediate of Gefitinib and one of the most competitive products in our company. Please feel free to contact us for more details. Appearance:

4-(3-chloro-4-fluorophenylami-no)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-Ol

Cas:184475-71-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Our Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA can be supplied 2. Free

4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-OL

Cas:184475-71-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-(3-Chloro-4-Fluoro-Phenylamino)-7- Methoxy-Quinazolin-6-Ol

Cas:184475-71-6

Min.Order:10 Gram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol CAS No.: 184475-71-6 Molecule Formula:C15H11ClFN3O2 Molecule Weight:319.72 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Stand

Lower Price 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol on stock

Cas:184475-71-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Cas:184475-71-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
788136-89-0

4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 20℃; for 13h; Inert atmosphere;99%
With sodium methylate In methanol for 3h; Reflux;95.3%
With methanol; ammonium hydroxide at 20℃; for 3h;95%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

2-amino-5-hydroxy-4-methoxybenzonitrile

2-amino-5-hydroxy-4-methoxybenzonitrile

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
With acetic acid In toluene at 65℃; for 7h; Solvent; Temperature; Concentration; Reagent/catalyst; Inert atmosphere;97%
4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride

4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Stage #1: 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride With lithium hydroxide; water In methanol at 20℃; for 0.5h;
Stage #2: With acetic acid In methanol; water
94%
With lithium hydroxide; water In methanol at 20℃; for 0.5h;94%
Stage #1: 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride With methanol; lithium hydroxide; water at 20℃; for 0.5h;
Stage #2: With acetic acid In water
94%
6-(benzyloxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
913819-12-2

6-(benzyloxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
With methanesulfonic acid In chloroform for 5h; Reflux;91%
With trifluoroacetic acid at 75℃; for 4h;90%
With palladium 10% on activated carbon; hydrogen In methanol under 3102.97 Torr; for 24h;82%
N,N'-bis(3-chloro-4-fluorophenyl)formamidine
727658-04-0

N,N'-bis(3-chloro-4-fluorophenyl)formamidine

2-amino-5-hydroxy-4-methoxybenzonitrile

2-amino-5-hydroxy-4-methoxybenzonitrile

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 110℃; for 5h;84.2%
4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Stage #1: 4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt; 3-chloro-4-fluorophenylamine In N,N-dimethyl-formamide at 80℃; for 1h;
Stage #2: With ammonia; water In methanol for 2h; Reflux;
75%
C30H24ClFN3O4Pol

C30H24ClFN3O4Pol

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; not specified;44%
4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: propan-2-ol / 5 h / 90 °C
2: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene; isopropyl alcohol / 3 h / 20 - 65 °C
2: lithium hydroxide / water; methanol / 1 h / 20 °C
View Scheme
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
179688-53-0

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C
2: propan-2-ol / 5 h / 90 °C
3: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: SOCl2
2: NH4OH / methanol
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / toluene / Reflux
2: pyridine / isopropyl alcohol / Reflux
3: water; sodium hydroxide / methanol
View Scheme
3H-6,7-dimethoxyquinazolin-4-one
13794-72-4

3H-6,7-dimethoxyquinazolin-4-one

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: L-methionine; methanesulfonic acid / 12 h / Heating
2: pyridine; 4-(dimethylamino)pyridine / 6 h / 100 °C
3: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C
4: propan-2-ol / 5 h / 90 °C
5: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: methionine; MeSO3H / 3 h / 100 °C
2: pyridine
3: SOCl2
4: NH4OH / methanol
View Scheme
Multi-step reaction with 5 steps
1: methanesulfonic acid; L-methionine / 120 °C
2: pyridine; dmap / 100 °C
3: trichlorophosphate / toluene / Reflux
4: pyridine / isopropyl alcohol / Reflux
5: water; sodium hydroxide / methanol
View Scheme
6-hydroxy-7-methoxyquinazolin-4(3H)-one
179688-52-9

6-hydroxy-7-methoxyquinazolin-4(3H)-one

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine; 4-(dimethylamino)pyridine / 6 h / 100 °C
2: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C
3: propan-2-ol / 5 h / 90 °C
4: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine
2: SOCl2
3: NH4OH / methanol
View Scheme
Multi-step reaction with 4 steps
1: pyridine; dmap / 100 °C
2: trichlorophosphate / toluene / Reflux
3: pyridine / isopropyl alcohol / Reflux
4: water; sodium hydroxide / methanol
View Scheme
6-acetoxy-4-chloro-7-methoxyquinazoline
230955-75-6

6-acetoxy-4-chloro-7-methoxyquinazoline

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH4OH / methanol
View Scheme
Multi-step reaction with 2 steps
1: pyridine / isopropyl alcohol / Reflux
2: water; sodium hydroxide / methanol
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / 5 h / 88 °C
2: water; sodium hydroxide / methanol / 6 h / 20 °C
View Scheme
2-carboethoxy-4,5-dimethoxyaniline
20323-74-4

2-carboethoxy-4,5-dimethoxyaniline

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 160 - 170 °C
2: methanesulfonic acid; L-methionine / 120 °C
3: pyridine; dmap / 100 °C
4: trichlorophosphate / toluene / Reflux
5: pyridine / isopropyl alcohol / Reflux
6: water; sodium hydroxide / methanol
View Scheme
Multi-step reaction with 6 steps
1: 165 - 170 °C
2: L-methionine; methanesulfonic acid
3: pyridine / 100 °C
4: thionyl chloride; N,N-dimethyl-formamide / 90 °C
5: isopropyl alcohol / Reflux
6: ammonia / water; methanol / 24 h / 20 °C
View Scheme
ethyl 2-nitro-4,5-dimethoxybenzoate
100905-33-7

ethyl 2-nitro-4,5-dimethoxybenzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: palladium on activated charcoal; hydrogen
2: 160 - 170 °C
3: methanesulfonic acid; L-methionine / 120 °C
4: pyridine; dmap / 100 °C
5: trichlorophosphate / toluene / Reflux
6: pyridine / isopropyl alcohol / Reflux
7: water; sodium hydroxide / methanol
View Scheme
Multi-step reaction with 7 steps
1: iron; hydrogenchloride / ethanol; water / Reflux
2: 165 - 170 °C
3: L-methionine; methanesulfonic acid
4: pyridine / 100 °C
5: thionyl chloride; N,N-dimethyl-formamide / 90 °C
6: isopropyl alcohol / Reflux
7: ammonia / water; methanol / 24 h / 20 °C
View Scheme
ethyl veratrate
3943-77-9

ethyl veratrate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: nitric acid; acetic acid / 0 - 5 °C
2: palladium on activated charcoal; hydrogen
3: 160 - 170 °C
4: methanesulfonic acid; L-methionine / 120 °C
5: pyridine; dmap / 100 °C
6: trichlorophosphate / toluene / Reflux
7: pyridine / isopropyl alcohol / Reflux
8: water; sodium hydroxide / methanol
View Scheme
Multi-step reaction with 8 steps
1: nitric acid / 0 °C
2: iron; hydrogenchloride / ethanol; water / Reflux
3: 165 - 170 °C
4: L-methionine; methanesulfonic acid
5: pyridine / 100 °C
6: thionyl chloride; N,N-dimethyl-formamide / 90 °C
7: isopropyl alcohol / Reflux
8: ammonia / water; methanol / 24 h / 20 °C
View Scheme
Veratric acid
93-07-2

Veratric acid

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: sulfuric acid / Reflux
2: nitric acid; acetic acid / 0 - 5 °C
3: palladium on activated charcoal; hydrogen
4: 160 - 170 °C
5: methanesulfonic acid; L-methionine / 120 °C
6: pyridine; dmap / 100 °C
7: trichlorophosphate / toluene / Reflux
8: pyridine / isopropyl alcohol / Reflux
9: water; sodium hydroxide / methanol
View Scheme
Multi-step reaction with 9 steps
1: sulfuric acid
2: nitric acid / 0 °C
3: iron; hydrogenchloride / ethanol; water / Reflux
4: 165 - 170 °C
5: L-methionine; methanesulfonic acid
6: pyridine / 100 °C
7: thionyl chloride; N,N-dimethyl-formamide / 90 °C
8: isopropyl alcohol / Reflux
9: ammonia / water; methanol / 24 h / 20 °C
View Scheme
2-Amino-4,5-dimethoxybenzoic acid
5653-40-7

2-Amino-4,5-dimethoxybenzoic acid

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: trimethyl orthoformate / methanol / 4 h / 70 °C / Reflux
2.1: methanesulfonic acid; DL-methionine / 3 h / 130 °C / Cooling with ice
2.2: pH 7
3.1: pyridine / 3 h / 20 - 100 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C
5.1: isopropyl alcohol / 5 h / 88 °C
6.1: water; sodium hydroxide / methanol / 6 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: trimethyl orthoformate / methanol / 4 h / 70 °C
2: DL-methionine; methanesulfonic acid / 3 h / 130 °C
3: pyridine / 3 h / 100 °C
4: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C
5: isopropyl alcohol / 5 h / 88 °C
6: sodium hydroxide; methanol / 6 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: water / Microwave irradiation
2: magnesium sulfate; methanesulfonic acid
3: pyridine / 20 °C
4: triethylamine; trichlorophosphate / acetonitrile / 80 °C
5: 1,4-dioxane
6: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C
View Scheme
methyl 2-amino-4,5-dimethoxybenzoate
26759-46-6

methyl 2-amino-4,5-dimethoxybenzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: formamide / 2 h / 190 - 200 °C
2: methanesulfonic acid; L-methionine / 5 h / 150 - 160 °C
3: pyridine / 3 h / Heating / reflux
4: trichlorophosphate / 3 h / Heating / reflux
5: isopropyl alcohol / 3 h / Heating / reflux
6: methanol; lithium hydroxide; water / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: methanol; N,N-dimethyl-formamide / Inert atmosphere
2: methanesulfonic acid; DL-methionine / Inert atmosphere
3: pyridine / Inert atmosphere
4: thionyl chloride / N,N-dimethyl-formamide / Inert atmosphere
5: isopropyl alcohol / Inert atmosphere
6: ammonium hydroxide / 3 h / Inert atmosphere; Reflux
View Scheme
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; trichlorophosphate / toluene / 20 - 60 °C
1.2: 2 h / 65 °C
2.1: lithium hydroxide; water / methanol / 0.5 h / 20 °C
View Scheme
6-(benzyloxy)-4-chloro-7-methoxyquinazoline
286371-65-1

6-(benzyloxy)-4-chloro-7-methoxyquinazoline

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
2: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / Reflux
2: trifluoroacetic acid / 1 h / Reflux
View Scheme
isovanillin
621-59-0

isovanillin

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: aminosulfonic acid; sodium chlorite / water / 2 h / 5 - 8 °C
2.1: hydrogenchloride / 4 h / 50 - 55 °C
3.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C
3.2: Reflux
4.1: nitric acid; acetic acid / 14 h / 25 - 35 °C
5.1: acetic acid; iron / 50 - 60 °C
6.1: ethyl acetate / 12 h / Reflux
7.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
8.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
9.1: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 7 steps
1: sodium formate; formic acid; hydroxyammonium sulfate / 85 °C
2: potassium carbonate / acetonitrile / 1.5 h / Reflux
3: acetic acid; nitric acid / 1 h / Cooling with ice
4: tin(ll) chloride; hydrogenchloride / water; acetic acid / 1 h / 60 °C
5: acetic acid / benzene / 2 h / 105 °C / Dean-Stark
6: acetic acid / 3 h / 130 - 140 °C
7: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr
View Scheme
Isovanillic acid
645-08-9

Isovanillic acid

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: hydrogenchloride / 4 h / 50 - 55 °C
2.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C
2.2: Reflux
3.1: nitric acid; acetic acid / 14 h / 25 - 35 °C
4.1: acetic acid; iron / 50 - 60 °C
5.1: ethyl acetate / 12 h / Reflux
6.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
7.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
8.1: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 8 steps
1: sulfuric acid / methanol / Reflux
2: potassium carbonate / butanone / Reflux
3: nitric acid; acetic acid / 30 °C
4: iron; ammonium chloride / methanol; water / Reflux
5: acetic acid; formamide / Reflux
6: trichlorophosphate; N,N-dimethyl-formamide / Reflux
7: isopropyl alcohol / Reflux
8: trifluoroacetic acid / 1 h / Reflux
View Scheme
3-hydroxy-4-methoxybenzoate
6702-50-7

3-hydroxy-4-methoxybenzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C
1.2: Reflux
2.1: nitric acid; acetic acid / 14 h / 25 - 35 °C
3.1: acetic acid; iron / 50 - 60 °C
4.1: ethyl acetate / 12 h / Reflux
5.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
7.1: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate / butanone / Reflux
2: nitric acid; acetic acid / 30 °C
3: iron; ammonium chloride / methanol; water / Reflux
4: acetic acid; formamide / Reflux
5: trichlorophosphate; N,N-dimethyl-formamide / Reflux
6: isopropyl alcohol / Reflux
7: trifluoroacetic acid / 1 h / Reflux
View Scheme
methyl 3-(benzyloxy)-4-methoxy-benzoate
57535-57-6

methyl 3-(benzyloxy)-4-methoxy-benzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: nitric acid; acetic acid / 14 h / 25 - 35 °C
2: acetic acid; iron / 50 - 60 °C
3: ethyl acetate / 12 h / Reflux
4: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
6: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1: nitric acid; acetic acid / 30 °C
2: iron; ammonium chloride / methanol; water / Reflux
3: acetic acid; formamide / Reflux
4: trichlorophosphate; N,N-dimethyl-formamide / Reflux
5: isopropyl alcohol / Reflux
6: trifluoroacetic acid / 1 h / Reflux
View Scheme
methyl 5-(benzyloxy)-4-methoxy-2-nitrobenzoate
164161-49-3

methyl 5-(benzyloxy)-4-methoxy-2-nitrobenzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic acid; iron / 50 - 60 °C
2: ethyl acetate / 12 h / Reflux
3: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
5: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: iron; ammonium chloride / methanol; water / Reflux
2: acetic acid; formamide / Reflux
3: trichlorophosphate; N,N-dimethyl-formamide / Reflux
4: isopropyl alcohol / Reflux
5: trifluoroacetic acid / 1 h / Reflux
View Scheme
methyl 2-amino-5-(benzyloxy)-4-methoxybenzoate
855793-63-4

methyl 2-amino-5-(benzyloxy)-4-methoxybenzoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethyl acetate / 12 h / Reflux
2: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
4: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: acetic acid; formamide / Reflux
2: trichlorophosphate; N,N-dimethyl-formamide / Reflux
3: isopropyl alcohol / Reflux
4: trifluoroacetic acid / 1 h / Reflux
View Scheme
6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one
286371-64-0

6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
3: methanesulfonic acid / chloroform / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate; N,N-dimethyl-formamide / Reflux
2: isopropyl alcohol / Reflux
3: trifluoroacetic acid / 1 h / Reflux
View Scheme
C18H19N3O2

C18H19N3O2

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / 3 h / 130 - 140 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr
View Scheme
2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / acetonitrile / 1.5 h / Reflux
2: acetic acid; nitric acid / 1 h / Cooling with ice
3: tin(ll) chloride; hydrogenchloride / water; acetic acid / 1 h / 60 °C
4: acetic acid / benzene / 2 h / 105 °C / Dean-Stark
5: acetic acid / 3 h / 130 - 140 °C
6: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / methanol / 1 h / 65 °C / Inert atmosphere
2: nitric acid; acetic acid / 0 - 25 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C / 1520.1 - 2280.15 Torr
4: acetic acid / toluene / 7 h / 65 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / methanol / 1 h / 65 °C / Inert atmosphere
2: nitric acid; acetic acid / 0 - 25 °C / Inert atmosphere
3: tetrabutylammomium bromide; sodium dithionite; water / methanol / 30 °C / Inert atmosphere
4: acetic acid / 110 °C / Inert atmosphere
5: trifluoroacetic acid / 4 h / 75 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C
1.2: 5 h / Reflux
2.1: acetic acid; nitric acid / 1 h / Cooling with ice
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2327.23 Torr
4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
View Scheme
propargyl bromide
106-96-7

propargyl bromide

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

4-(3'-chloro-4'-fluoroanilino)-6-(prop-2-ynyloxy)-7-methoxyquinazoline
1214731-77-7

4-(3'-chloro-4'-fluoroanilino)-6-(prop-2-ynyloxy)-7-methoxyquinazoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;99%
tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate
217817-01-1

tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

3-(2-(2-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)tert-butyl propionate

3-(2-(2-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)tert-butyl propionate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;98.5%
(E)-methyl 3-(4-(2-(tosyloxy)ethoxy)phenyl)acrylate
1012057-56-5

(E)-methyl 3-(4-(2-(tosyloxy)ethoxy)phenyl)acrylate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate
1012057-57-6

(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;98%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;98%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;98%
trifluoroacetic acid
76-05-1

trifluoroacetic acid

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

tert-butyl 4-(3-bromopropyl)-piperazine-1-carboxylate
655225-02-8

tert-butyl 4-(3-bromopropyl)-piperazine-1-carboxylate

C27H33ClFN5O4*C2HF3O2

C27H33ClFN5O4*C2HF3O2

Conditions
ConditionsYield
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline; tert-butyl 4-(3-bromopropyl)-piperazine-1-carboxylate With potassium carbonate In N,N-dimethyl-formamide at 80℃;
Stage #2: trifluoroacetic acid In methanol; water
97%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

4-(3'-chloro-4'-fluorophenylamino)-7-methoxy-6-(trifluoromethanesulfonyloxy)quinazoline
451494-86-3

4-(3'-chloro-4'-fluorophenylamino)-7-methoxy-6-(trifluoromethanesulfonyloxy)quinazoline

Conditions
ConditionsYield
With pyridine at 0 - 20℃; Inert atmosphere;94%
With pyridine at -6 - 20℃;62%
N-phthaloylglycine chloride
6780-38-7

N-phthaloylglycine chloride

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

C25H16ClFN4O5

C25H16ClFN4O5

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 4.5h; Inert atmosphere; Cooling with ice;93.2%
1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

6-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)hexan-1-ol
1012057-92-9

6-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)hexan-1-ol

Conditions
ConditionsYield
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.166667h;
Stage #2: 1-bromo-6-hexanol In N,N-dimethyl-formamide at 60℃; for 6h;
93%
methanesulfonic acid 2-[2-(2-{2-[3-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxy)-2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester
939056-49-2

methanesulfonic acid 2-[2-(2-{2-[3-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxy)-2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-((18,18,18-trifluoro-14,14-bis(((1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl)oxy)methyl)-17,17-bis(trifluoromethyl)-3,6,9,12,16-pentaoxaoctadecyl)oxy)quinazolin-4-amine

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-((18,18,18-trifluoro-14,14-bis(((1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl)oxy)methyl)-17,17-bis(trifluoromethyl)-3,6,9,12,16-pentaoxaoctadecyl)oxy)quinazolin-4-amine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h;93%
10-(3-chloropropyl)-1,4,7,10-tetraazacyclododecan-1,4,7-tricarboxylic acid tri-tert-butyl ester

10-(3-chloropropyl)-1,4,7,10-tetraazacyclododecan-1,4,7-tricarboxylic acid tri-tert-butyl ester

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

10-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)-1,4,7,10-tetraazacyclododecan-1,4,7-tricarboxylic acid tri-tert-butyl ester

10-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)-1,4,7,10-tetraazacyclododecan-1,4,7-tricarboxylic acid tri-tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h;92.8%
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h;66%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 3h; Reagent/catalyst; Temperature;92%
With tetrabutylammomium bromide; sodium carbonate; potassium iodide In iso-butanol Reflux;90%
In N,N-dimethyl-formamide at 80 - 90℃; Concentration;88%
1-chloro-3-hydroxypropane
627-30-5

1-chloro-3-hydroxypropane

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

M 527301
1221965-74-7

M 527301

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 12h; Reflux;91%
7-(3-chloropropyl)-1,4,7-triazacyclononan-1,4-dicarboxylic acid di-tert-butyl ester

7-(3-chloropropyl)-1,4,7-triazacyclononan-1,4-dicarboxylic acid di-tert-butyl ester

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

7-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)-1,4,7-triazacyclononan-1,4-dicarboxylic acid di-tert-butyl ester

7-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)-1,4,7-triazacyclononan-1,4-dicarboxylic acid di-tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h;89.8%
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h;66%
3-morpholinopropyl 4-methylbenzenesulfonate
957621-67-9

3-morpholinopropyl 4-methylbenzenesulfonate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature;89.5%
methanesulfonic acid 3-morpholin-4-yl-propyl ester
1018895-28-7

methanesulfonic acid 3-morpholin-4-yl-propyl ester

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature;89.2%
1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
912556-91-3

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40℃; for 6h;89%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40℃; for 6h;89%
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h;
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h; Heating;Ca. 330 mg
ethyl 5-bromovalerate
14660-52-7

ethyl 5-bromovalerate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

ethyl 4-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

ethyl 4-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h;88%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

ethylene glycol
107-21-1

ethylene glycol

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib ethylene glycol

gefitinib ethylene glycol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 8h;85.9%
allyl bromide
106-95-6

allyl bromide

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

(6-allyloxy-7-methoxy-quinazolin-4-yl)-(3-chloro-4-fluoro-phenyl)-amine

(6-allyloxy-7-methoxy-quinazolin-4-yl)-(3-chloro-4-fluoro-phenyl)-amine

Conditions
ConditionsYield
With potassium carbonate In acetone at 90℃; for 4h;82%
4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

ethyl 4-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)butanoate
1012057-14-5

ethyl 4-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)butanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h;81%
ethyl 17-[[(4-methylbenzene)sulfonyl]oxy]-3,6,9,12,15-pentaoxaheptadecanoate

ethyl 17-[[(4-methylbenzene)sulfonyl]oxy]-3,6,9,12,15-pentaoxaheptadecanoate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

ethyl 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl]-1,4,7,10,13,16-hexaoxaoctadecan-18-oate

ethyl 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl]-1,4,7,10,13,16-hexaoxaoctadecan-18-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;80%
4-benzyl-6-(3-chloropropyl)octahydropyrrolo[3,4-b][1,4]oxazine

4-benzyl-6-(3-chloropropyl)octahydropyrrolo[3,4-b][1,4]oxazine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

6-(3-(4-benzylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)propoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
1438075-59-2

6-(3-(4-benzylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)propoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h;79.59%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h;79.59%
2-bromoethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside
86651-36-7

2-bromoethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside

2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside

Conditions
ConditionsYield
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: 2-bromoethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;
79%
4 (3-bromopropyl)-morpholine
125422-83-5

4 (3-bromopropyl)-morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h;78%
2-(3-chloropropyl)octahydrocyclopenta[c]pyrrole
1438081-50-5

2-(3-chloropropyl)octahydrocyclopenta[c]pyrrole

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine
1438073-01-8

N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h;75.59%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere;

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