New derivatives of thiacalix[4]arene, tri- and tetrasubstituted at the lower rim by N-(4-nitrophenyl)acetamide and 1-amidoanthraquinone fragments were synthesized. Their ability for recognition and binding of some anions (F–, Cl–, Br–, I–, MeCO2-, H2PO4-, NO3-) was examined by UV spectroscop...

The phenolysis of 3-nitrophenyl 4-cyanophenyl thionocarbonate (1) and 4-nitrophenyl 4-cyanophenyl thionocarbonate (2) are subjected to a kinetic investigation in order to evaluate the nucleofugality of the corresponding leaving groups. For the reaction of 2 only 4-nitrophenoxide is obtained as l...

1-Phenyl-2,3,4,5-tetramethylphosphole reacts with [Mo(CO)6] to give the mono- and bis(phosphole) complexes [Mo(CO)5L] and cis- and trans-[Mo(CO)4L2], where L=C4Me4PPh (tmpPh). The new complexes have been characterised by spectroscopic methods, supplemented by single-crystal X-ray analyses in the...

The title polymer of Kdn was detected in biological object for the first time.

N-Acetylneuraminate pyruvate lyase accepts as substrates varied non-nitrogeneous sugars. Condensation of pyruvate with D-mannose yields 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) a component of rainbow trout egg polysialoglycoprotein. From some easily available monosaccharides were pre...

We have examined the tissues of several species of fish and found that the liver of the loach (Misgurnus fossilis) contains a novel sialidase capable of efficiently hydrolyzing 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) from the 4-methylumbelliferyl α-ketoside of KDN, KDNα2 → 3Galβ...

Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a liquid-liquid miscibility gap has been observed with pure water, isotonic and hypertoni...

Pseudomonas aeruginosa ATCC 27853 was cultured on media containing long odd-chain fatty acids. Heptadecanoic, nonadecanoic, and heneicosanoic acids sustained cell growth and resulted in polyhydroxyalkanoate (PHA) accumulation when culturing was conducted under nitrogen starvation conditions. No ...

The chemical synthesis of 4-methylnicotinamide adenine dinucleotide from 3-carbamoyl-1-(2,3-O-isopropylidine-d-ribofuranosyl)-4-methyl pyridinium chloride is presented, and some properties of the modified coenzyme are described with particular reference to its potential as a cofactor for the gly...

Derivatisation of racemic ethylene-bridged bis(4,5,6,7tetrahydro-1-indenyl)-titanium and -zirconium dichlorides with O-acetyl-r-mandelic acid affords diastereomers which can be separately crystallised. Crystal and molecular structures of these diastereomers reveal different chelate ring conforma...

New aromatic diamine with cyclohexane cardo group substituted with trifluoromethyl group in the side chain, 1,1-bis[4-(4-amino-2-trifluoromethylphenoxy)phenyl]cyclohexane (II), was prepared through the nucleophilic substitution reaction of 1,1-bis(4-hydroxyphenyl)cyclohexane and 2-chloro-5-nitro...

1,1-bis(4-Hydroxyphenyl)-2-phenylpent-1-ene (5) and 1,1,2-tris(4-hydroxyphenyl)pent-1-ene (6) derivatives with terminal CN (5a, 6a), NH2 (5b, 6b), NHCOCH3 (5c, 6c), NHCOC2H5 (5d, 6d) groups at the C2-propyl chain were synthesized and assayed in vitro for estrogen receptor (ER) binding affinity (...

Copolyethers based on 3,3-bis(chloromethyl)oxetane and several bisphenols [4,4′-dihydroxyazobenzene, bisphenol A and 1,1-bis-(4-hydroxyphenyl)ethane] were synthesized. The influence of chain geometry and flexibility on the possible appearance of liquid crystalline behavior was investigated. Pol...

A new series of fluorine-containing polyarylates were synthesized by interfacial or high-temperature solution polymerization of 1,1-bis(4-hydroxyphenyl)-1-phenyl-2,2,2-trifluoroethane with six aromatic diacyl chlorides. These polyarylates had inherent viscosities ranging from 0.47 to 1.37 dl/g t...

Monoalkylated bis(4-hydroxyphenyl)methanes (e.g., 1) are reported to show weak binding affinity for estrogen receptor (ER). We hypothesized that introduction of appropriately located hydrophobic substituents in these compounds would increase the binding affinity. Indeed, we found that bis(4-hydr...

1, 2-O, O-Diacetyllycorine (DALY) is one of the lycorine derivatives which has various biological properties. However, the bioavailability and clinical application of DALY was restrained because of its low water solubility and moderate antitumor activities. In order to improve its physicochemica...

New 3-O-branched 1, 6-anhydro glucopyranose disaccharide monomers, 1, 6-anhydro-2, 4-di-O- benzyl-3-O-(2′, 3′, 4′, 6'-tetra-O-benzyl-α-D-mannopyranosyl)- (LGM 6) and -glucopyranosyl)-β-D- glucopyranose (LGG 7), and a trisaccharide monomer, 1, 6-anhydro-2, 4-di-O-benzyl-3-O-α-(2′, 3′...

Direct 6-thiophosphorylation of mannopyranoside gave both the wanted S- as well as the undesired O-phosphates. This required sequential protecting group syntheses to give mannopyranoside6-phosphate and 6-thiophosphate as well as 6-deoxy-6-thio-mannopyranoside6-phosphate, which were transformed i...

Thermal rearrangement of 4-allyl-, 4-dimethylallyl-, and 4-propargyl-isopyrazoles proceed by [3,3]-sigmatropic processes to pyrazoles. The migration terminus is the C(3) Me group, if present, and the rearrangement is preceded by imine-enamine tautomerism. When enamine formation is not possible t...

The reaction between 3-aminocrotonates and 3-acetonylideneoxindole in refluxing toluene resulted in 2-pyrrolo-3′-yloxindoles in high yields (around 90%). At room temperature the 2-pyrrolo-3′-yloxindoles exists as keto–enol tautomers. Treatment with POCl3 yielded the 2-chloro-3-pyrrolyl indole...