Recent work in our laboratory has shown that the highly substituted, electronically rich 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQ3CA) scaffold is a key building block for a novel class of promising anticoagulants.10 The synthesis of THIQ3CA analogs, especially containing specific, ...

A 4-kb fragment of the M. tuberculosis chromosome was identified which contains several genes including those involved in cell division and possibly macrophage survival. DNA sequence analysis revealed open reading frames (ORFs) encoding putative proteins bearing significant homology with protein...

A transposon mutant from Aeromonas hydrophila AH-3 was obtained which was highly resistant to opsonophagocytosis. The mutation was identified in the ftsE gene and we characterised the operon ftsY, E and X from this bacterium. These genes, as in enteric bacteria, are neighbours to rpoH. The A. hy...

Reactions between three diorganodithiophosphinates and diphenylantimony(V) bromide oxide (SbPh2OBr)2, led to antimony reduction while dithiophosphinate oxidation followed a complex path varying in detail with the nature of the organic groups on dithiophosphinate. Antimony(III) dithiophosphinates...

The microbiological transformations of 1-(2,2,3-trimethylcyclopent-3-en-yl)-propan-2-one (2a) and its four (2b–2e) homologues by Acremonium roseum were investigated. For 2a,b and e ketones Baeyer-Villiger oxydation was predominant reaction, but ketone 2c and d were mainly hydroxylated.

The first total synthesis of the 10,11-dihydro-12-ketoeicosatetraenoic acid (10,11-dihydro-12-KETE) 5, a proinflammatory metabolite of 12-KETE is reported. In addition, the total synthesis of two other potential metabolites of 12-KETE, namely 8,11-dihydro-12-KETE 6 and 8,9-dihydro-12-KETE 7, is ...

The need for simple, cheaper and high performance hospital effluent treatment system in Kete-Krachi District which is adjacent to the Lake Volta has necessitated this study. This study focuses on assessing, and treating Kete-Krachi District Hospital effluent using packed granular (GAC) and smoot...

Highly available and active photocatalysts and cocatalysts play key roles in the of efficient and stable visible-light-driven photocatalytic systems. In this work, a nickel phosphide (Ni2P)/red phosphorus (RP) heterojunction composite was fabricated for the first time by an in situ hydrothermal ...

Developing coordination complexes of earth abundant metals that can perform substrate oxidations under benign conditions is an ongoing challenge. Herein, the reactivity of two mononuclear Cu-complexes toward the oxidant H2O2 is reported. Both complexes displayed ligand oxidation upon reaction wi...

Al-doped zinc oxide (AZO) thin films were deposited at room temperature (RT) using reactive magnetron co-sputtering of two metallic Zn and Al targets in the presence of oxygen. The structural, optical and electrical properties of the AZO thin films were tailored by varying the Al content through...

BackgroundPast work suggests that individual differences in stress reactivity have implications for the development of psychopathology; in particular, females' stress reactivity appears more closely tied to internalizing symptoms than males' reactivity. Conversely, males who are under-...

The arsenic content in groundwater of the Red River floodplain decreases with the burial age of the aquifer sediment over a 6000 year period. This decrease is caused by diminishing reactivities of both sedimentary organic carbon, Fe-oxides as well as CaCO3. Here we present a 1-D reactive transpo...

Kynureninase from Pseudomonas fluorescens (Pfkynase) catalyzes the pyridoxal-5′-phosphate (PLP) dependent hydrolytic cleavage of L-kynurenine to give anthranilate and L-alanine. Asp-132 and Asp-201 are located in the structure near the pyridine NH of the PLP, with Asp-201 forming a hydrogen bon...

SummaryCultured human lymphocytes and fibroblasts accumulate methotrexate during 24 hours and synthesize methotrexate polyglutamates up to the hexaglutamate, with the triglutamate predominating. In the interval after incubation with methotrexate, drug is lost, metabolites are converted to longer...

Superparamagnetic Fe3O4@EDTA–Cu(II) nanoparticles were readily prepared and identified as an effective catalyst for the tandem transformation of benzyl alcohols and amine hydrochloride salts into the corresponding amides with tert-butyl hydroperoxide (TBHP) as an oxidant. After completion of th...

The effects of caissarone (C8H11N5O) on guinea-pig ileum and rat duodenum preparations are reported. Caissarone evoked, at first, a small response, as compared with that of applied acetylcholine. This effect was blocked by atropine, hexamethonium and slightly reduced by tetrodotoxin. The main ca...

On the basis of a methylation study of N6-benzyl-9-methyl-8-oxoadenine (8), the first synthesis of caissarone hydrochloride (1) has been achieved via a two-step route including methylation of the N6-methyl analogue (3).

Caissarone, a sea anemone iminopurine, produced an increase in the twitch response of the electrically stimulated guinea-pig ileum-myenteric plexus. In the same assay, caissarone reduced the inhibitory response to the endogenous neuromodulator, adenosine, the A1 adenosine receptor agonist, R-phe...

Based upon LX2421, a previously identified antiplatelet aggregation agent, a series of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives were designed, synthesized and evaluated. Among them, compounds LX14 and LX25 were identified as promising antiplatelet aggregation agents. The in vitro ...

All-trans-retinoic acid (ATRA), the biologically active metabolite of vitamin A, is used medicinally for the treatment of hyperproliferative diseases and cancers. However, it is easily metabolized. In this study, the leading compound S8 was found based on virtual screening. To improve the activi...