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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Hecogenin Manufacturer/High quality/Best price/In stock

Cas:467-55-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% hecogenin 467-55-0 Producer

Cas:467-55-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hecogenin

Cas:467-55-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Hecogenin

Cas:467-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

ProName:High Quality 99% Hecogenin 467-55-0 GM... CasNo:467-55-0 Molecular Formula:Refer to COA Appearance:powder Application:API, pharmaceutical excipients, nutrit... DeliveryTime:Shiping within 3 working days after co... PackAge:1kg/bag; 25

Hecogenin 467-55-0

Cas:467-55-0

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 467-55-0 with competitive price

Cas:467-55-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:1kg/bag Application:Steroid saponins, betamethasone, dexamethasone and other corticosteroids. Transportation:Express/Sea/Air Port:Any port in china

Hot Sell Factory Supply Hecogenin CAS:467-55-0

Cas:467-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Spirostan-12-one,3-hydroxy-, (3b,5a,25R)- 467-55-0

Cas:467-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Hecogenin

Cas:467-55-0

Min.Order:10 Gram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Hecogenin CAS:467-55-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, st

Hecogenin CAS:467-55-0

Cas:467-55-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Spirostan-12-one,3-hydroxy-, (3b,5a,25R)-

Cas:467-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Hecogenin

Cas:467-55-0

Min.Order:0 Metric Ton

FOB Price: $7.0 / 10.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Spirostan-12-one,3-hydroxy-, (3b,5a,25R)-

Cas:467-55-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Hecogenin

Cas:467-55-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Hecogenin

Cas:467-55-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Hecogenin

Cas:467-55-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Hecogenin

Cas:467-55-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Tr

Spirostan-12-one,3-hydroxy-, (3b,5a,25R)-

Cas:467-55-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Hecogenin.99%

Cas:467-55-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Hecogenin

Cas:467-55-0

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Hecogenin

Cas:467-55-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Hecogenin

Cas:467-55-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

CAS467-55-0 Hecogenin

Cas:467-55-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Greenutra Resource Inc

hecogeninAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

hecogenin

Cas:467-55-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

hecogenin

Cas:467-55-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

hecogenin acetate
915-35-5

hecogenin acetate

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With methanol; potassium hydroxide In dichloromethane at 20℃; for 18h;99%
With methanol; potassium carbonate In tetrahydrofuran for 24h;97%
With potassium carbonate In tetrahydrofuran; methanol at 20℃; for 12h; Inert atmosphere;95%
(2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-8(2H)-one

(2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-8(2H)-one

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With sodium perborate tetrahydrate In tetrahydrofuran; water for 3h;79%
α-D-glucopyranosyl(1->4)α-D-glucopyranosyl(1->4)α-D-glucopyranosyl(1->3)hecogenin

α-D-glucopyranosyl(1->4)α-D-glucopyranosyl(1->4)α-D-glucopyranosyl(1->3)hecogenin

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With sulfuric acid44.8%
12-methylenetigogenin
108747-55-3

12-methylenetigogenin

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With sodium periodate; potassium carbonate; tert-butyl alcohol Reagens 4: Kaliumpermanganat;
3-oxo-5α-hecogenin
2137-20-4

3-oxo-5α-hecogenin

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With pyridine; sodium borate
With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether Behandeln des erhaltenen Reaktionsprodukts in Pyridin mit Bernsteinsaeure-anhydrid und mit Chrom(VI)-oxid und wss. Essigsaeure, danach mit methanol. Kalilauge;
Aspergillus niger;
3β-acetoxy-(25R)-5α-spirostan-12-one
4948-48-5

3β-acetoxy-(25R)-5α-spirostan-12-one

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride; ethanol
(25R)-12α-(Aminomethyl)-5α-spirostan-3β,12β-diol
78179-47-2

(25R)-12α-(Aminomethyl)-5α-spirostan-3β,12β-diol

A

(25R)-3β-Hydroxy-C-homo-5α-spirostan-12-on
72166-67-7

(25R)-3β-Hydroxy-C-homo-5α-spirostan-12-on

B

(25R)-3β-Hydroxy-C-homo-5α-spirostan-12-on
72166-68-8

(25R)-3β-Hydroxy-C-homo-5α-spirostan-12-on

C

(25R)-12α-(Azidomethyl)-5α-spirostan-3β,12β-diol

(25R)-12α-(Azidomethyl)-5α-spirostan-3β,12β-diol

D

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With sodium azide; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 100℃; for 3.5h;
3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

A

C39H62O14

C39H62O14

B

C45H72O19

C45H72O19

C

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In butan-1-ol at 70℃; for 2.5h;A 13.5 mg
B 16.5 mg
C 15 mg
3-O-<<β-D-xylopyranosyl(1->4)-β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

3-O-<<β-D-xylopyranosyl(1->4)-β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 100℃; for 3.5h;
Multi-step reaction with 2 steps
1: 20 mg / 1M HCl / butan-1-ol / 2.5 h / 70 °C
2: 2M HCl / ethanol / 3.5 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: 20 mg / 1M HCl / butan-1-ol / 2.5 h / 70 °C
2: 15 mg / 1M HCl / butan-1-ol / 2.5 h / 70 °C
View Scheme
3-O-<<β-D-xylopyranosyl(1->4)-β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

3-O-<<β-D-xylopyranosyl(1->4)-β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

A

C39H62O14

C39H62O14

B

C45H72O19

C45H72O19

C

3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

3-O-<<β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2> <β-D-xylopyranosyl(1->4)>-β-D-galactopyranosyl>-(25R)-5α-spirostan-12-one-3β-ol

D

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In butan-1-ol at 70℃; for 2.5h;A 10 mg
B 13.5 mg
C 20 mg
D 10 mg
25(R)-5α-spirostan-3β-ol-12-one 3-O-β-D-glucopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranoside
168960-81-4

25(R)-5α-spirostan-3β-ol-12-one 3-O-β-D-glucopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranoside

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; water for 2h; Heating;4.9 mg
(25R)-3β-[(O-β-D-glucopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-[O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one

(25R)-3β-[(O-β-D-glucopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-[O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one

A

D-Glucose
2280-44-6

D-Glucose

B

D-Galactose
10257-28-0

D-Galactose

C

L-rhamnose
73-34-7

L-rhamnose

D

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 100℃; for 3h; Product distribution; Hydrolysis;A 20.8 mg
B 8.1 mg
C 5.8 mg
D 11.8 mg
hydrogenchloride
7647-01-0

hydrogenchloride

20-isohecogenin
107492-88-6

20-isohecogenin

hecogenin
467-55-0

hecogenin

hydrogenchloride
7647-01-0

hydrogenchloride

3β-acetoxy-(25R)-5α-spirostan-12-one
4948-48-5

3β-acetoxy-(25R)-5α-spirostan-12-one

hecogenin
467-55-0

hecogenin

cyclopseudohecogenin

cyclopseudohecogenin

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride; methanol
hydrogenchloride
7647-01-0

hydrogenchloride

(25R)-3β-hydroxy-5α-spirostan-12-one-(2,4-dinitro-phenylhydrazone)
17990-60-2

(25R)-3β-hydroxy-5α-spirostan-12-one-(2,4-dinitro-phenylhydrazone)

tin (II)-chloride

tin (II)-chloride

hecogenin
467-55-0

hecogenin

(25R)-3β-[{O-β-D-xylopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl}oxy]-5α-spirostan-12-one

(25R)-3β-[{O-β-D-xylopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl}oxy]-5α-spirostan-12-one

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 98℃; for 2h;3.4 mg
(25R)-3β-hydroxy-5α-spirostan-12-one-3-O-β-xylopyranosyl(1->4)-[α-arabinopyranosyl(1->6)]-β-glucopyranoside

(25R)-3β-hydroxy-5α-spirostan-12-one-3-O-β-xylopyranosyl(1->4)-[α-arabinopyranosyl(1->6)]-β-glucopyranoside

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
In ethanol; sulfuric acid at 100℃; for 6h;2 mg
(25R)-12-ethylenedioxy-5α-spirostan-3β-ol
38673-31-3

(25R)-12-ethylenedioxy-5α-spirostan-3β-ol

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Jones' reagent
2: Aspergillus niger
View Scheme
C31H48O6

C31H48O6

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. KOH
2: Jones' reagent
3: Aspergillus niger
View Scheme
25R-spirost-4-ene-3,12-dione
6875-60-1

25R-spirost-4-ene-3,12-dione

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium/charcoal; dioxane; methanol. KOH-solution
2: sodium borate; pyridine
View Scheme
(23Ξ,25R)-23-bromo-spirost-4-ene-3,12-dione

(23Ξ,25R)-23-bromo-spirost-4-ene-3,12-dione

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol; acetic acid; zinc-powder
2: palladium/charcoal; dioxane; methanol. KOH-solution
3: sodium borate; pyridine
View Scheme
(23Ξ,25R)-2α,4α,23-tribromo-5α-spirostan-3,12-dione

(23Ξ,25R)-2α,4α,23-tribromo-5α-spirostan-3,12-dione

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium iodide; acetone / Behandeln des Reaktionsprodukts in Aceton und Dioxan mit Chrom(II)-chlorid in wss. Salzsaeure
2: ethanol; acetic acid; zinc-powder
3: palladium/charcoal; dioxane; methanol. KOH-solution
4: sodium borate; pyridine
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: ethanol; aqueous hydrochloric acid
View Scheme
(25R)-2α,3α-epoxy-5α-spirostan-12-one
28180-63-4

(25R)-2α,3α-epoxy-5α-spirostan-12-one

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene; diethyl ether; lithium alanate / Behandeln einer Loesung des Reaktionsprodukts in Essigsaeure mit Chrom(VI)-oxid und wss. Essigsaeure
2: tetrahydrofuran; lithium alanate; diethyl ether / Behandeln des erhaltenen Reaktionsprodukts in Pyridin mit Bernsteinsaeure-anhydrid und mit Chrom(VI)-oxid und wss. Essigsaeure, danach mit methanol. Kalilauge
View Scheme
(25R)-3β-[(O-β-D-glucopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one
1174898-06-6

(25R)-3β-[(O-β-D-glucopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With hydrogenchloride; water In 1,4-dioxane at 95℃; for 2h; Inert atmosphere;1.2 mg
(25R)-3β-[(O-α-L-arabinopyranosyl-(1 → 2)-O-[β-D-xylopyranosyl-(1 → 3)]-O-β-D-glucopyranosyl-(1 → 4)-O-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one
1499187-81-3

(25R)-3β-[(O-α-L-arabinopyranosyl-(1 → 2)-O-[β-D-xylopyranosyl-(1 → 3)]-O-β-D-glucopyranosyl-(1 → 4)-O-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one

A

D-xylose
58-86-6

D-xylose

B

L-arabinose
5328-37-0

L-arabinose

C

L-Rhamnose
3615-41-6

L-Rhamnose

D

D-glucose
50-99-7

D-glucose

E

D-Galactose
59-23-4

D-Galactose

F

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
With naringinase; potassium acetate; acetic acid In aq. buffer at 20℃; for 49h; pH=4.3; Enzymatic reaction;A n/a
B n/a
C n/a
D n/a
E n/a
F 3.1 mg
O-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-8-oxodocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)-1H-imidazole-1-carbothioate

O-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-8-oxodocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)-1H-imidazole-1-carbothioate

hecogenin
467-55-0

hecogenin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / N,N-dimethyl acetamide; 1,4-dioxane / 48 h / Inert atmosphere; Schlenk technique; Irradiation
1.2: 2 h / Inert atmosphere; Schlenk technique; Irradiation
2.1: sodium perborate tetrahydrate / tetrahydrofuran; water / 3 h
View Scheme
hecogenin
467-55-0

hecogenin

3-oxo-5α-hecogenin
2137-20-4

3-oxo-5α-hecogenin

Conditions
ConditionsYield
With Jones reagent In acetone at 20℃; for 0.333333h;99%
Multi-step reaction with 4 steps
1: pyridine / Ambient temperature
2: BF3-Et2O / CH2Cl2 / Ambient temperature
3: aq. KOH
4: Jones' reagent
View Scheme
With pyridinium chlorochromate In dichloromethane at 0 - 20℃; for 3h;
acetic anhydride
108-24-7

acetic anhydride

hecogenin
467-55-0

hecogenin

hecogenin acetate
915-35-5

hecogenin acetate

Conditions
ConditionsYield
With pyridine at 20℃;95%
Conditions
ConditionsYield
With ammonia; lithium In tetrahydrofuran at -78 - -33℃; for 5h; Reduction;95%
With diethyl ether; acetic acid; platinum Hydrogenation;
Stage #1: hecogenin With sodium tetrahydroborate In tetrahydrofuran; methanol at 0℃; for 2h;
Stage #2: With hydrogenchloride In tetrahydrofuran; methanol; water stereoselective reaction;
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

hecogenin
467-55-0

hecogenin

(25R)-12-oxo-5α-spirostan-3β-yl tosylate
60433-68-3

(25R)-12-oxo-5α-spirostan-3β-yl tosylate

Conditions
ConditionsYield
With pyridine In dichloromethane at 4℃; for 24h;94%
With pyridine at 20℃;93%
With pyridine
With pyridine
1,2-bis(tert-butyldimethylsilyl)hydrazine
10000-20-1

1,2-bis(tert-butyldimethylsilyl)hydrazine

hecogenin
467-55-0

hecogenin

C39H72N2O3Si2
690275-05-9

C39H72N2O3Si2

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In chloroform at 55℃; for 20h;93%
2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate
149707-75-5

2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate

hecogenin
467-55-0

hecogenin

hecogenyl 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside
1373440-74-4

hecogenyl 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h; Inert atmosphere; Molecular sieve;91%
acetic anhydride
108-24-7

acetic anhydride

hecogenin
467-55-0

hecogenin

(25R)-23-acetyl-22,26-epoxy-12-oxo-5α-cholesta-22-ene-3β,16β-diyl diacetate
245124-65-6

(25R)-23-acetyl-22,26-epoxy-12-oxo-5α-cholesta-22-ene-3β,16β-diyl diacetate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 20℃; for 0.833333h; Ring cleavage; acetylation;87%
With boron trifluoride diethyl etherate at 20℃; for 0.166667h;87%
2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1→3)-2-O-acetyl-4-O-triethylsilyl-α,β-L-arabinopyranosyl trichloroacetimidate
321125-08-0

2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1→3)-2-O-acetyl-4-O-triethylsilyl-α,β-L-arabinopyranosyl trichloroacetimidate

hecogenin
467-55-0

hecogenin

hecogenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-3-O-triethylsilyl-α-L-arabinopyranoside

hecogenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-3-O-triethylsilyl-α-L-arabinopyranoside

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; 4 Angstroem MS In dichloromethane at -20℃;86%
acetic anhydride
108-24-7

acetic anhydride

hecogenin
467-55-0

hecogenin

(25R)-26-hydroxy-12,22-dioxo-5α-cholestan-3β,16β-diyl diacetate
1228298-02-9

(25R)-26-hydroxy-12,22-dioxo-5α-cholestan-3β,16β-diyl diacetate

Conditions
ConditionsYield
Stage #1: acetic anhydride; hecogenin With boron trifluoride diethyl etherate In dichloromethane at 0℃;
Stage #2: With water In dichloromethane Cooling with ice;
86%
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.25h;86%
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.5h;
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

hecogenin
467-55-0

hecogenin

(25R)-3β-(tert-butyl(dimethyl)silyloxy)-5α-spirostan-12-one
909880-00-8

(25R)-3β-(tert-butyl(dimethyl)silyloxy)-5α-spirostan-12-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 3h;84%
O-carboxymethylhydroxylamine hydrochloride
20295-82-3

O-carboxymethylhydroxylamine hydrochloride

hecogenin
467-55-0

hecogenin

(25R)-12E-[O-(carboxymethyl)oximino]-5α-spirostan-3β-ol

(25R)-12E-[O-(carboxymethyl)oximino]-5α-spirostan-3β-ol

Conditions
ConditionsYield
With pyridine at 20℃;84%
3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-(α/β)-D-glucopyranosyl trichloroacetimidate
146728-55-4

3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-(α/β)-D-glucopyranosyl trichloroacetimidate

hecogenin
467-55-0

hecogenin

hecogenin 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
869884-28-6

hecogenin 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20℃; for 1h; Molecular sieve;82%
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

hecogenin
467-55-0

hecogenin

C39H70O4Si2
1246949-40-5

C39H70O4Si2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;80%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;80%
hecogenin
467-55-0

hecogenin

(25R)-3α-amino-5α-spirostan-12-one
1432631-48-5

(25R)-3α-amino-5α-spirostan-12-one

Conditions
ConditionsYield
Stage #1: hecogenin With methanesulfonyl chloride; triethylamine In dichloromethane
Stage #2: With sodium azide In dimethyl sulfoxide at 70℃;
Stage #3: With 10 wt% Pd(OH)2 on carbon; hydrogen
79%
Multi-step reaction with 3 steps
1: pyridine
2: sodium azide / 60 °C
3: triphenylphosphine; water / tetrahydrofuran / 20 °C
View Scheme
1,1'-Thiocarbonyldiimidazole
6160-65-2

1,1'-Thiocarbonyldiimidazole

hecogenin
467-55-0

hecogenin

O-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-8-oxodocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)-1H-imidazole-1-carbothioate

O-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyl-8-oxodocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)-1H-imidazole-1-carbothioate

Conditions
ConditionsYield
With dmap In dichloromethane at 55℃; for 3h;79%
4-Phenyl-3-thiosemicarbazide
5351-69-9

4-Phenyl-3-thiosemicarbazide

hecogenin
467-55-0

hecogenin

3β-hydroxy-5α,25R-spirostan-12-(phenyl thiosemicarbazone)

3β-hydroxy-5α,25R-spirostan-12-(phenyl thiosemicarbazone)

Conditions
ConditionsYield
With pyridine at 20℃;78%
In ethanol at 20℃;
N-(2-(trifluoromethyl)phenyl)hydrazinecarbothioamide
38901-29-0

N-(2-(trifluoromethyl)phenyl)hydrazinecarbothioamide

hecogenin
467-55-0

hecogenin

3β-hydroxy-5α,25R-spirostan-12-(3'-trifluoromethylphenyl thiosemicarbazone)

3β-hydroxy-5α,25R-spirostan-12-(3'-trifluoromethylphenyl thiosemicarbazone)

Conditions
ConditionsYield
With pyridine at 20℃;75%
4-(2-methylphenyl)-3-thiosemicarbazide
614-10-8

4-(2-methylphenyl)-3-thiosemicarbazide

hecogenin
467-55-0

hecogenin

3β-hydroxy-5α,25R-spirostan-12-(3'-methylphenyl thiosemicarbazone)

3β-hydroxy-5α,25R-spirostan-12-(3'-methylphenyl thiosemicarbazone)

Conditions
ConditionsYield
With pyridine at 20℃;75%
4-(2'-nitrophenyl)-3-thiosemicarbazide
73305-12-1

4-(2'-nitrophenyl)-3-thiosemicarbazide

hecogenin
467-55-0

hecogenin

3β-hydroxy-5α,25R-spirostan-12-(3'-nitrophenyl thiosemicarbazone)

3β-hydroxy-5α,25R-spirostan-12-(3'-nitrophenyl thiosemicarbazone)

Conditions
ConditionsYield
With pyridine at 20℃;72%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

hecogenin
467-55-0

hecogenin

3β-O-(furoyl)-5α,25R-spirostan-12-one

3β-O-(furoyl)-5α,25R-spirostan-12-one

Conditions
ConditionsYield
Stage #1: hecogenin With pyridine; dmap; triethylamine at 20℃; for 0.333333h;
Stage #2: 2-furancarbonyl chloride
71%
2-Methoxybenzoyl chloride
21615-34-9

2-Methoxybenzoyl chloride

hecogenin
467-55-0

hecogenin

3β-O-(4'-chlorobenzoyl)-5α,25R-spirostan-12-one

3β-O-(4'-chlorobenzoyl)-5α,25R-spirostan-12-one

Conditions
ConditionsYield
Stage #1: hecogenin With pyridine; dmap; triethylamine at 20℃; for 0.333333h;
Stage #2: 2-Methoxybenzoyl chloride
70%
N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

hecogenin
467-55-0

hecogenin

12-Z,E-methyloximehecogenin
1033264-82-2

12-Z,E-methyloximehecogenin

Conditions
ConditionsYield
With pyridine In toluene at 20 - 50℃;69.5%
hecogenin
467-55-0

hecogenin

(25R)-C-homo-12a-oxa-3β-hydroxy-5α-spirostan-12-one
469-13-6

(25R)-C-homo-12a-oxa-3β-hydroxy-5α-spirostan-12-one

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 120h; Baeyer-Villiger oxidation; Darkness;69%
hecogenin
467-55-0

hecogenin

(25R)-5α-spirostan-3β,12β-diol diacetate
10007-76-8

(25R)-5α-spirostan-3β,12β-diol diacetate

Conditions
ConditionsYield
With sodium tetrahydroborate In 1,4-dioxane; methanol at 10℃; for 0.5h;68%
Multi-step reaction with 2 steps
1: 95 percent / liquid NH3; Li / tetrahydrofuran / 5 h / -78 - -33 °C
2: 90 percent / NEt3; DMAP / CH2Cl2 / 5.5 h
View Scheme
Multi-step reaction with 2 steps
1: NaBH4 / dioxane; methanol / 0.5 h / 10 °C
2: 8.2 g / pyridine
View Scheme
Multi-step reaction with 2 steps
1: platinum; acetic acid; diethyl ether / Hydrogenation
View Scheme
4-cyanobenzoyl chlorIde
6068-72-0

4-cyanobenzoyl chlorIde

hecogenin
467-55-0

hecogenin

3β-O-(5'-cyanobenzoyl)-5α,25R-spirostan-12-one

3β-O-(5'-cyanobenzoyl)-5α,25R-spirostan-12-one

Conditions
ConditionsYield
Stage #1: hecogenin With pyridine; dmap; triethylamine at 20℃; for 0.333333h;
Stage #2: 4-cyanobenzoyl chlorIde
68%
4-(2'-chlorophenyl)-3-thiosemicarbazide
42135-75-1

4-(2'-chlorophenyl)-3-thiosemicarbazide

hecogenin
467-55-0

hecogenin

3β-hydroxy-5α,25R-spirostan-12-(3'-chlorophenyl thiosemicarbazone)

3β-hydroxy-5α,25R-spirostan-12-(3'-chlorophenyl thiosemicarbazone)

Conditions
ConditionsYield
With pyridine at 20℃;65%
ortho-iodophenyl chlorothionoformate

ortho-iodophenyl chlorothionoformate

hecogenin
467-55-0

hecogenin

C34H45IO5S

C34H45IO5S

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃;64%
4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

hecogenin
467-55-0

hecogenin

3β-O-(5'-nitrobenzoyl)-5α,25R-spirostan-12-one

3β-O-(5'-nitrobenzoyl)-5α,25R-spirostan-12-one

Conditions
ConditionsYield
Stage #1: hecogenin With pyridine; dmap; triethylamine at 20℃; for 0.333333h;
Stage #2: 4-nitro-benzoyl chloride
63%
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