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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Betamethasone 378-44-9 GMP manufacturer

Cas:378-44-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detect

Betamethasone Manufacturer

Cas:378-44-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Quick Details ProName: Betamethasone CasNo: 378-44-9 Molecular Formula: C22H29FO5 Appearance: White crystalline powder Application: Anti-inflammatory, allergy, relieving ... DeliveryTime: Payment in advance af

Betamethasone USP EP CAS 378-44-9

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Betamethasone CAS 378-44-9

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Results Appearance White or almost white crystalline powder almost white crystalline powder

High quality 378-44-9 Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

Betamethasone with best price and top quality

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Betamethasone CAS NO.378-44-9

Cas:378-44-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:0-6°C Packag

High quality Betamethasone CAS 378-44-9 of USP/EP standard

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1500.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High quality 99% Betamethasone powder cas:378-44-9

Cas:378-44-9

Min.Order:50 Gram

FOB Price: $0.99 / 1.26

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Betamethasone

Cas:378-44-9

Min.Order:1

Negotiable

Type:Other

inquiry

HANGZHOU CLAKE BIOTECH CO.,LTD

1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum / 25kg/bag Application:active pharmaceutical ingredient Transportation:sea/air both ok

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Betamethasone

Cas:378-44-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Betamethasone CAS NO:378-44-9 Grade:Medical scientific research and export Molecular formula:C22H29FO5 Molecular weight: 392.4611 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Betamethasone/ CAS:378-44-9/Betamethasone raw material/ high-quality

Cas:378-44-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

tianfu-chem_Betamethasone,378-44-9

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Betamethasone 378-44-9

Cas:378-44-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Betamethasone Corticosteroid Raw Powder

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Betamethasone/ LIDE PHARMA- Factory supply / Best price

Cas:378-44-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name Betamethasone Molecular Formula C22H29FO5 Molecular Weight 392.461 CAS Registry Number 378-44-9 density

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hu

Pharmaceutical Supplier Supply with cheap price CAS: 378-44-9 Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $850.0 / 900.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High purity Betamethasone99%

Cas:378-44-9

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Appearance:White Powder Storage:2 Years Package: according to customers' requirements Application:External skin material Transportation:International express delivery Port: China main port

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $100.0 / 110.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Betamethasone factory Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities

High quality Betamethasone factory

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

CAS 378-44-9 Betamethason Powder

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Betamethasone

Cas:378-44-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;

Adrenal Corticosteroids Pharmaceutical Material Beta-Methasone CAS 378-44-9

Cas:378-44-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
With methanol; sodium methylate at 25℃; for 4h;90%
17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
981-34-0

17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
With hydrogen fluoride In water; N,N-dimethyl-formamide at -15℃;89%
With hydrogen fluoride
C24H31FO5

C24H31FO5

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Stage #1: C24H31FO5 In ethyl acetate at 0 - 10℃;
Stage #2: With hydrogenchloride In water at 30 - 35℃; for 1h;
45%
betamethasone dipropionate
5593-20-4

betamethasone dipropionate

A

betamethasone
378-44-9

betamethasone

B

Betamethasone propionate
5534-13-4

Betamethasone propionate

C

6β-hydroxybetamethasone
24703-00-2

6β-hydroxybetamethasone

D

6β-hydroxybetamethasone 17-propionate
78144-00-0

6β-hydroxybetamethasone 17-propionate

Conditions
ConditionsYield
With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat at 37℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;A 14.8 % Chromat.
B 67.8 % Chromat.
C 1.4 % Chromat.
D 2.3 % Chromat.
21-acetoxy-9-fluoro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione/s

21-acetoxy-9-fluoro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione/s

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
With sodium methylate
betamethasone dipropionate
5593-20-4

betamethasone dipropionate

A

betamethasone
378-44-9

betamethasone

B

Betamethasone propionate
5534-13-4

Betamethasone propionate

C

betamethasone 21-monopropionate

betamethasone 21-monopropionate

Conditions
ConditionsYield
With sulfuric acid In acetonitrile at 20℃; for 20h; Product distribution; Further Variations:; Temperatures;
16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one
884488-47-5

16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 95 percent / pyridine / 20 °C
2.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
3.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
4.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
4.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
5.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
5.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
6.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
7.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
8.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
9.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione
37413-99-3

16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
2: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
3: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
4: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
884488-49-7

16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
1.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
2.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
2.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
3.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
4.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
5.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
6.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
3β-acetoxy-16α,17α-epoxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
884488-48-6

3β-acetoxy-16α,17α-epoxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
2.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
2.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
3.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
3.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
4.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
5.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
6.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
7.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one
37414-01-0

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
2: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione
14135-32-1

16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
1.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
2.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
3.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
4.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
5.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
20-oxo-5α-pregna-9(11),16-dien-3β-yl acetate
21650-83-9

20-oxo-5α-pregna-9(11),16-dien-3β-yl acetate

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
2.1: 95 percent / pyridine / 20 °C
3.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
4.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
5.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
5.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
6.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
6.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
7.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
8.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
9.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
10.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
Δ9(11)22-isoallospirosten-3β-ol
1106-20-3

Δ9(11)22-isoallospirosten-3β-ol

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: pyridine; ammonium chloride / 125 - 135 °C
1.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
1.3: 57 percent / aluminium oxide / benzene / 2 h
2.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
3.1: 95 percent / pyridine / 20 °C
4.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
5.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
6.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
6.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
7.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
7.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
8.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
9.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
10.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
11.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
3β-acetoxy-16α,17α-epoxy-5α-pregn-9(11)-en-20-one
113926-56-0

3β-acetoxy-16α,17α-epoxy-5α-pregn-9(11)-en-20-one

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
2.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
3.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
3.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
4.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
4.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
5.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
6.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
7.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
8.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
Δ9(11)22-isoallospirosten-3β-ol-12-one-3-acetate
989-73-1

Δ9(11)22-isoallospirosten-3β-ol-12-one-3-acetate

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
1.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C
2.1: pyridine; ammonium chloride / 125 - 135 °C
2.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
2.3: 57 percent / aluminium oxide / benzene / 2 h
3.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
4.1: 95 percent / pyridine / 20 °C
5.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
6.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
7.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
7.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
8.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
8.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
9.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
10.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
11.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
12.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
16β-methyl-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione
1879-77-2

16β-methyl-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
2: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
3: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
hecogenin
467-55-0

hecogenin

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: 95 percent / pyridine / 20 °C
2.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating
3.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
3.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C
4.1: pyridine; ammonium chloride / 125 - 135 °C
4.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
4.3: 57 percent / aluminium oxide / benzene / 2 h
5.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
6.1: 95 percent / pyridine / 20 °C
7.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
8.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
9.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
9.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
10.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
10.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
11.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
12.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
13.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
14.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
hecogenin acetate
915-35-5

hecogenin acetate

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating
2.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
2.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C
3.1: pyridine; ammonium chloride / 125 - 135 °C
3.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
3.3: 57 percent / aluminium oxide / benzene / 2 h
4.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
5.1: 95 percent / pyridine / 20 °C
6.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
7.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
8.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
8.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
9.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
9.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
10.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
11.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
12.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
13.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C
View Scheme
20-chloro-3-keto-16α-methylpregna-4,9(11),17(20)-triene-21-al

20-chloro-3-keto-16α-methylpregna-4,9(11),17(20)-triene-21-al

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
3.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
3.2: 0 - 5 °C
4.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
5.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
6.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
7.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
21-acetoxy-16-methylpregna-4,9(11),16-triene-3,20-dione

21-acetoxy-16-methylpregna-4,9(11),16-triene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
2.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
2.2: 0 - 5 °C
3.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
4.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
5.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
6.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
21-acetoxy-16(17)α-epoxy-16-methylpregna-4,9(11)-diene-3,20-dione

21-acetoxy-16(17)α-epoxy-16-methylpregna-4,9(11)-diene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
1.2: 0 - 5 °C
2.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
3.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
4.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
5.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
21-acetoxy-17α-hydroxy-16-methylenepregna-4,9(11)-diene-3,20-dione

21-acetoxy-17α-hydroxy-16-methylenepregna-4,9(11)-diene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
2: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
3: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
4: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
21-acetyloxy-17α-hydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione
18762-17-9

21-acetyloxy-17α-hydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
2: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
3: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
21-acetoxy-17α-hydroxy-9β,11β-epoxy-16β-methylpregna-4-ene-3,20-dione

21-acetoxy-17α-hydroxy-9β,11β-epoxy-16β-methylpregna-4-ene-3,20-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
2: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
androst-4,9(11)-dien-3,17-dione
1035-69-4

androst-4,9(11)-dien-3,17-dione

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere
2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide / tetrahydrofuran; hexane / 3 h / -40 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
3.2: 5 h / -45 - 20 °C / Inert atmosphere
4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
6.2: 0 - 5 °C
7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere
2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide / tetrahydrofuran / -40 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
3.2: 5 h / -45 - 20 °C / Inert atmosphere
4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
6.2: 0 - 5 °C
7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / -20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
3.2: 5 h / -45 - 20 °C / Inert atmosphere
4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
6.2: 0 - 5 °C
7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
3-ethoxyandrosta-3,5,9(11)-diene-17-one

3-ethoxyandrosta-3,5,9(11)-diene-17-one

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide / tetrahydrofuran; hexane / 3 h / -40 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
2.2: 5 h / -45 - 20 °C / Inert atmosphere
3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
5.2: 0 - 5 °C
6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
Multi-step reaction with 9 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide / tetrahydrofuran / -40 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
2.2: 5 h / -45 - 20 °C / Inert atmosphere
3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
5.2: 0 - 5 °C
6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / tetrahydrofuran / -20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
2.2: 5 h / -45 - 20 °C / Inert atmosphere
3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
5.2: 0 - 5 °C
6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
3-ethoxy-16α-methylandrosta-3,5,9(11)-diene-17-one

3-ethoxy-16α-methylandrosta-3,5,9(11)-diene-17-one

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere
1.2: 5 h / -45 - 20 °C / Inert atmosphere
2.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C
4.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C
4.2: 0 - 5 °C
5.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr
6.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C
7.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction
8.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C
View Scheme
C24H29FO5

C24H29FO5

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium borohydride; ethanol / dichloromethane / 0.5 h / 0 - 10 °C
2.1: phthalic acid peroxide; peroxide phthalic anhydride / ethyl acetate / 0 - 10 °C
2.2: 1 h / 30 - 35 °C
View Scheme
3-(tert-butyloxycarbonylamino)propionic acid
3303-84-2

3-(tert-butyloxycarbonylamino)propionic acid

betamethasone
378-44-9

betamethasone

Boc-β-alanine-betamethasone

Boc-β-alanine-betamethasone

Conditions
ConditionsYield
Stage #1: 3-(tert-butyloxycarbonylamino)propionic acid; betamethasone With dmap In dichloromethane; N,N-dimethyl-formamide
Stage #2: In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice;
100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 20℃; Cooling with ice;3.18 g
C8H14ClNO4

C8H14ClNO4

betamethasone
378-44-9

betamethasone

C30H41ClFNO8

C30H41ClFNO8

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice;100%
Fmoc-Orn(Boc)-OH

Fmoc-Orn(Boc)-OH

betamethasone
378-44-9

betamethasone

C47H57FN2O10

C47H57FN2O10

Conditions
ConditionsYield
With dmap In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice;99%
3-[(tert-butoxycarbonyl)amino]-2-fluoropropanoic acid

3-[(tert-butoxycarbonyl)amino]-2-fluoropropanoic acid

betamethasone
378-44-9

betamethasone

C30H41F2NO8

C30H41F2NO8

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 20℃; Cooling with ice;99%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃;99%
L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

betamethasone
378-44-9

betamethasone

21-Boc-alanyl-betamethasone

21-Boc-alanyl-betamethasone

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;98%
betamethasone
378-44-9

betamethasone

9α-fluoro-11β,17α-dihydroxy-16β-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
37926-75-3

9α-fluoro-11β,17α-dihydroxy-16β-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
With periodic acid In methanol; water at 20℃; for 16h;97%
In tetrahydrofuran; water
In tetrahydrofuran; water
With periodic acid In methanol
betamethasone
378-44-9

betamethasone

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

betamethasone 17-acetate
5534-12-3

betamethasone 17-acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature;96%
betamethasone
378-44-9

betamethasone

clobetasol

clobetasol

Conditions
ConditionsYield
With pyridine; dichlorohydantoin; sulfur dioxide In N,N-dimethyl-formamide at 5℃; for 2h;95.6%
C8H14BrNO4

C8H14BrNO4

betamethasone
378-44-9

betamethasone

C30H41BrFNO8

C30H41BrFNO8

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 8h;95%
N-Methylhydroxylamine
593-77-1

N-Methylhydroxylamine

betamethasone
378-44-9

betamethasone

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-3-methylimino-1,4-pregnadien-20-one N-oxide
84871-37-4

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-3-methylimino-1,4-pregnadien-20-one N-oxide

Conditions
ConditionsYield
With pyridine at 40℃;87%
N-(t-butoxycarbonyl)-isoleucine
13139-16-7

N-(t-butoxycarbonyl)-isoleucine

betamethasone
378-44-9

betamethasone

C33H48FNO8

C33H48FNO8

Conditions
ConditionsYield
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;87%
N-(tert-butyloxycarbonyl)-L-isoleucine
13139-16-7

N-(tert-butyloxycarbonyl)-L-isoleucine

betamethasone
378-44-9

betamethasone

21-(Boc-isoleucyl)-betamethasone

21-(Boc-isoleucyl)-betamethasone

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 0 - 20℃;87%
betamethasone
378-44-9

betamethasone

1-(13-cis-Retinoyl)imidazole
85610-79-3

1-(13-cis-Retinoyl)imidazole

C43H53FO7

C43H53FO7

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 4h; Heating;85%
formaldehyd
50-00-0

formaldehyd

betamethasone
378-44-9

betamethasone

C24H31FO6

C24H31FO6

Conditions
ConditionsYield
With hydrogenchloride In chloroform at 30℃; for 3h; Temperature;84.4%
BOC-glycine
4530-20-5

BOC-glycine

betamethasone
378-44-9

betamethasone

21-Boc-glycyl-betamethasone

21-Boc-glycyl-betamethasone

Conditions
ConditionsYield
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;82%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 0 - 20℃;82%
betamethasone
378-44-9

betamethasone

9α-fluoro-11β-hydroxy-16β-methylandrosta-1,4-diene-3,17-dione

9α-fluoro-11β-hydroxy-16β-methylandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
With bithmuth(III) triflate hydrate In 1,4-dioxane at 80℃; chemoselective reaction;68%
betamethasone
378-44-9

betamethasone

(aminooxy)acetic acid hemihydrochloride
2921-14-4, 7776-18-3, 20295-82-3

(aminooxy)acetic acid hemihydrochloride

betamethasome-3-(O-carboxymethy)oxime
61600-49-5, 88378-32-9

betamethasome-3-(O-carboxymethy)oxime

Conditions
ConditionsYield
With pyridine In ethanol for 8h; Ambient temperature;55%
betamethasone
378-44-9

betamethasone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

C26H31FO7

C26H31FO7

Conditions
ConditionsYield
With sodium hydride In benzene for 24h; Cyclocondensation;50%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

betamethasone
378-44-9

betamethasone

betamethasone 21-butyrate

betamethasone 21-butyrate

Conditions
ConditionsYield
With toluene-4-sulfonic acid; trichloroacetic acid In dichloromethane at 20℃;49%
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid
4530-18-1

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

betamethasone
378-44-9

betamethasone

C36H46FNO8

C36H46FNO8

Conditions
ConditionsYield
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;18%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

betamethasone
378-44-9

betamethasone

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

6β-(9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxo-pregna-1,4-dien-21-yloxycarbonylamino)-penicillanic acid
19763-57-6, 19774-84-6

6β-(9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxo-pregna-1,4-dien-21-yloxycarbonylamino)-penicillanic acid

Conditions
ConditionsYield
(i) Et3N, THF, (ii) /BRN= 15080/, aq. KHCO3; Multistep reaction;
trimethoxypropane
24823-81-2

trimethoxypropane

betamethasone
378-44-9

betamethasone

Betamethasone propionate
5534-13-4

Betamethasone propionate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature;
1,1,1-trimethoxybutane
43083-12-1

1,1,1-trimethoxybutane

betamethasone
378-44-9

betamethasone

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-butyrate
5534-14-5

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-butyrate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature;
trimethyl orthovalerate
13820-09-2

trimethyl orthovalerate

betamethasone
378-44-9

betamethasone

betamethasone-valerate
2152-44-5

betamethasone-valerate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature;
2-chloro-1,1,1-triethoxyethane
51076-95-0

2-chloro-1,1,1-triethoxyethane

betamethasone
378-44-9

betamethasone

C26H34ClFO6

C26H34ClFO6

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran for 12h; Ambient temperature;
triethyl 2-methoxyorthoacetate
58995-66-7

triethyl 2-methoxyorthoacetate

betamethasone
378-44-9

betamethasone

C27H37FO7

C27H37FO7

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran for 12h; Ambient temperature;

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