1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:378-44-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryStrict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detect
Cas:378-44-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryQuick Details ProName: Betamethasone CasNo: 378-44-9 Molecular Formula: C22H29FO5 Appearance: White crystalline powder Application: Anti-inflammatory, allergy, relieving ... DeliveryTime: Payment in advance af
Cas:378-44-9
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:378-44-9
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Items Standard Results Appearance White or almost white crystalline powder almost white crystalline powder
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Min.Order:1 Kilogram
FOB Price: $1300.0 / 1600.0
Type:Trading Company
inquirySuperiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best
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Min.Order:1 Kilogram
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Type:Other
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:378-44-9
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:0-6°C Packag
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum / 25kg/bag Application:active pharmaceutical ingredient Transportation:sea/air both ok
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Min.Order:1 Kilogram
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Name:Betamethasone CAS NO:378-44-9 Grade:Medical scientific research and export Molecular formula:C22H29FO5 Molecular weight: 392.4611 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da
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Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
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Type:Lab/Research institutions
inquiryName Betamethasone Molecular Formula C22H29FO5 Molecular Weight 392.461 CAS Registry Number 378-44-9 density
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Min.Order:100 Gram
Negotiable
Type:Other
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
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Min.Order:1 Kilogram
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Type:Trading Company
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;
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Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryConditions | Yield |
---|---|
With methanol; sodium methylate at 25℃; for 4h; | 90% |
Conditions | Yield |
---|---|
With hydrogen fluoride In water; N,N-dimethyl-formamide at -15℃; | 89% |
With hydrogen fluoride |
betamethasone
Conditions | Yield |
---|---|
Stage #1: C24H31FO5 In ethyl acetate at 0 - 10℃; Stage #2: With hydrogenchloride In water at 30 - 35℃; for 1h; | 45% |
betamethasone dipropionate
A
betamethasone
B
Betamethasone propionate
C
6β-hydroxybetamethasone
D
6β-hydroxybetamethasone 17-propionate
Conditions | Yield |
---|---|
With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat at 37℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo; | A 14.8 % Chromat. B 67.8 % Chromat. C 1.4 % Chromat. D 2.3 % Chromat. |
betamethasone
Conditions | Yield |
---|---|
With sodium methylate |
Conditions | Yield |
---|---|
With sulfuric acid In acetonitrile at 20℃; for 20h; Product distribution; Further Variations:; Temperatures; |
16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 95 percent / pyridine / 20 °C 2.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 3.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 4.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 4.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 5.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 5.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 6.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 7.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 8.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 9.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 2: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 3: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 4: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 1.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 2.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 2.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 3.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 4.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 5.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 6.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
3β-acetoxy-16α,17α-epoxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 2.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 2.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 3.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 3.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 4.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 5.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 6.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 7.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 2: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 1.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 2.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 3.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 4.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 5.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
20-oxo-5α-pregna-9(11),16-dien-3β-yl acetate
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C 2.1: 95 percent / pyridine / 20 °C 3.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 4.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 5.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 5.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 6.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 6.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 7.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 8.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 9.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 10.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: pyridine; ammonium chloride / 125 - 135 °C 1.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C 1.3: 57 percent / aluminium oxide / benzene / 2 h 2.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C 3.1: 95 percent / pyridine / 20 °C 4.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 5.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 6.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 6.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 7.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 7.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 8.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 9.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 10.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 11.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
3β-acetoxy-16α,17α-epoxy-5α-pregn-9(11)-en-20-one
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 2.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 3.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 3.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 4.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 4.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 5.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 6.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 7.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 8.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating 1.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C 2.1: pyridine; ammonium chloride / 125 - 135 °C 2.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C 2.3: 57 percent / aluminium oxide / benzene / 2 h 3.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C 4.1: 95 percent / pyridine / 20 °C 5.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 6.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 7.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 7.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 8.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 8.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 9.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 10.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 11.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 12.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 2: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 3: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1.1: 95 percent / pyridine / 20 °C 2.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating 3.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating 3.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C 4.1: pyridine; ammonium chloride / 125 - 135 °C 4.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C 4.3: 57 percent / aluminium oxide / benzene / 2 h 5.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C 6.1: 95 percent / pyridine / 20 °C 7.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 8.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 9.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 9.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 10.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 10.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 11.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 12.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 13.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 14.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating 2.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating 2.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C 3.1: pyridine; ammonium chloride / 125 - 135 °C 3.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C 3.3: 57 percent / aluminium oxide / benzene / 2 h 4.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C 5.1: 95 percent / pyridine / 20 °C 6.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C 7.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C 8.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating 8.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C 9.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling 9.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling 10.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C 11.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C 12.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating 13.1: 90 percent / sodium methoxide; methanol / 4 h / 25 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 3.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 3.2: 0 - 5 °C 4.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 5.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 6.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 7.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 2.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 2.2: 0 - 5 °C 3.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 4.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 5.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 6.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 1.2: 0 - 5 °C 2.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 3.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 4.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 5.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 2: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 3: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 4: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
21-acetyloxy-17α-hydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 2: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 3: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 2: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere 2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide / tetrahydrofuran; hexane / 3 h / -40 - 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 3.2: 5 h / -45 - 20 °C / Inert atmosphere 4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 6.2: 0 - 5 °C 7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme | |
Multi-step reaction with 10 steps 1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere 2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide / tetrahydrofuran / -40 - 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 3.2: 5 h / -45 - 20 °C / Inert atmosphere 4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 6.2: 0 - 5 °C 7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme | |
Multi-step reaction with 10 steps 1.1: toluene-4-sulfonic acid / ethanol / 4 h / 40 °C / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / -20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 3.2: 5 h / -45 - 20 °C / Inert atmosphere 4.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 6.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 6.2: 0 - 5 °C 7.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 8.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 9.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 10.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide / tetrahydrofuran; hexane / 3 h / -40 - 20 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 2.2: 5 h / -45 - 20 °C / Inert atmosphere 3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 5.2: 0 - 5 °C 6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide / tetrahydrofuran / -40 - 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 2.2: 5 h / -45 - 20 °C / Inert atmosphere 3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 5.2: 0 - 5 °C 6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: potassium tert-butylate / tetrahydrofuran / -20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 2.2: 5 h / -45 - 20 °C / Inert atmosphere 3.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 5.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 5.2: 0 - 5 °C 6.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 7.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 8.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 9.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -45 - -30 °C / Inert atmosphere 1.2: 5 h / -45 - 20 °C / Inert atmosphere 2.1: alkali metal acetate / N,N-dimethyl-formamide / 2 h / 115 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C 4.1: hydrogen bromide / 1,4-dioxane / 5 h / 35 °C 4.2: 0 - 5 °C 5.1: Wilkinson's catalyst; hydrogen / ethyl acetate / 60 - 65 °C / 760.05 Torr 6.1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetone / 2.5 h / 0 - 5 °C 7.1: D-Glucose / aq. phosphate buffer / 76 h / Microbiological reaction 8.1: hydrogen fluoride / water; N,N-dimethyl-formamide / -15 °C View Scheme |
betamethasone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium borohydride; ethanol / dichloromethane / 0.5 h / 0 - 10 °C 2.1: phthalic acid peroxide; peroxide phthalic anhydride / ethyl acetate / 0 - 10 °C 2.2: 1 h / 30 - 35 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: 3-(tert-butyloxycarbonylamino)propionic acid; betamethasone With dmap In dichloromethane; N,N-dimethyl-formamide Stage #2: In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice; | 100% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 20℃; Cooling with ice; | 3.18 g |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice; | 100% |
Conditions | Yield |
---|---|
With dmap In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice; | 99% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 20℃; Cooling with ice; | 99% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; | 99% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 98% |
betamethasone
9α-fluoro-11β,17α-dihydroxy-16β-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
Conditions | Yield |
---|---|
With periodic acid In methanol; water at 20℃; for 16h; | 97% |
In tetrahydrofuran; water | |
In tetrahydrofuran; water | |
With periodic acid In methanol |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature; | 96% |
betamethasone
Conditions | Yield |
---|---|
With pyridine; dichlorohydantoin; sulfur dioxide In N,N-dimethyl-formamide at 5℃; for 2h; | 95.6% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 8h; | 95% |
N-Methylhydroxylamine
betamethasone
9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-3-methylimino-1,4-pregnadien-20-one N-oxide
Conditions | Yield |
---|---|
With pyridine at 40℃; | 87% |
Conditions | Yield |
---|---|
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 87% |
N-(tert-butyloxycarbonyl)-L-isoleucine
betamethasone
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 0 - 20℃; | 87% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 4h; Heating; | 85% |
Conditions | Yield |
---|---|
With hydrogenchloride In chloroform at 30℃; for 3h; Temperature; | 84.4% |
Conditions | Yield |
---|---|
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 82% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water; N,N-dimethyl-formamide at 0 - 20℃; | 82% |
betamethasone
Conditions | Yield |
---|---|
With bithmuth(III) triflate hydrate In 1,4-dioxane at 80℃; chemoselective reaction; | 68% |
betamethasone
(aminooxy)acetic acid hemihydrochloride
betamethasome-3-(O-carboxymethy)oxime
Conditions | Yield |
---|---|
With pyridine In ethanol for 8h; Ambient temperature; | 55% |
Conditions | Yield |
---|---|
With sodium hydride In benzene for 24h; Cyclocondensation; | 50% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; trichloroacetic acid In dichloromethane at 20℃; | 49% |
Conditions | Yield |
---|---|
With dmap In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 18% |
6-Aminopenicillanic Acid
betamethasone
chloroformic acid ethyl ester
6β-(9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxo-pregna-1,4-dien-21-yloxycarbonylamino)-penicillanic acid
Conditions | Yield |
---|---|
(i) Et3N, THF, (ii) /BRN= 15080/, aq. KHCO3; Multistep reaction; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature; |
1,1,1-trimethoxybutane
betamethasone
9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-butyrate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; benzene for 1.25h; Ambient temperature; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran for 12h; Ambient temperature; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran for 12h; Ambient temperature; |
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