Aqueous solutions of the industrially important chelating agent N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine exhibit basic properties. The proton dissociation constants were determined to be 8.99 ± 0.04 (pK1) and 4.30 ± 0.04 (pK2) by potentiometric titration at 25° in 0.15M so...
The use of inductive adsorption chromatography for enantiomer resolution involves a chiral additive to the mobile phase, the so-called inductive agent, which has the same chemical nature as the enantiomers to be resolved. In this way, (±)-2-aminoheptane enantiomers were partially resolved on a ...
A modified nanoprecipitation (interfacial polymer deposition following solvent displacement) method was used to produce nanoparticles from low molecular weight poly(l-lactic acid). Model drugs, either salbutamol sulphate or beclomethasone dipropionate, were encapsulated in the particles. The inf...
Beclomethasone dipropionate (BDP) liposomes were prepared from various lipids, dilauroyl phosphatidylcholine (DLPC), dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and hydrogenated soybean phosphatidylcholine (Epikuron 200 SH). A lipid with a low transition tempe...
Methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL) polymeric micelles (PMs) open a promising avenue through which ocular drug delivery with superior efficacy and tolerability can be potentially obtained. Methazolamide (MTZ) is an anti-glaucoma drug exhibiting poor corneal penetrati...
The aim of this study was to characterize the physical properties of spray dried lactose in the presence of different polyethylene glycols (PEG 400, PEG 3000 and PEG 6000) and to evaluate their performance as carriers for dry powder inhaler (DPI) formulations. The efficiency of spray dried lacto...
Oral beclomethasone dipropionate (BDP) has been extensively studied in the management of ulcerative colitis in clinical practice in recently years. However, the effective bioavailability and absorption of BDP are limited by its poor water solubility when administered orally. Herein, we report a ...
This study was performed to achieve two primary goals: First, a microemulsion containing betamethasone dipropionate was optimized using the quality by design approach. Second, a hydrogel-containing microemulsion was developed using cellulose derivatives, and its anti-inflammatory and skin irrita...
The partitioning of active pharmaceutical ingredients (API) in emulsions is influenced by various factors, such as composition of the phases, emulsifier type and concentration, and temperature. Therefore, the chemical stability of the API can be influenced by its partitioning into the aqueous ph...
A total of 136 food packaging materials were analysed for the presence of six phthalate esters and one adipate ester. All of the sample materials were manufactured from either synthetic polymers or from wood pulp and most were in immediate contact with their food contents. The esters in the pack...
The present work reports on an efficient and simple one pot synthetic approach for aluminium nanoflakes and nanoparticles based on the intensification using ultrasound and provides a comparison with the conventional approach to establish the cutting edge process benefits. In situ passivation of ...
Poly(glycerol adipate) (PGA) was synthesized by enzymatic polymerization and grafted with different amounts of oleoyl chloride. A series of graft copolymers PGA-g-Ox was obtained where O represents the oleate side chains and x is the degree of grafting (mol% of the pendant OH groups of PGA ester...
Food grade PVC film containing 28.3% dioctyl adipate (DOA) plasticizer was brought in one side contact with olive oil and was irradiated with y-radiation (80Co) at 4 and 9 KGy doses corresponding to “cold pasteurization”. Irradiation was carried out at 8-–10°C and samples were subsequently s...
A strategy for the nickel-catalyzed reductive coupling of α-aminoaldehydes with silyl alkynes has been developed. The process proceeds with exceptional regiocontrol and diastereoselectivity. A variety of protected serinal derivatives were examined, and Garner aldehyde afforded the highest chemi...
In the present study, we studied N,N-dimethyl-d-erythro-sphingosine (DMS)-induced cell death and its signaling mechanism in U937 human monocytes. We found that DMS induced cell death in a concentration-dependent manner, while sphingosine 1-phoshate did not. DMS also induced DNA fragmentation, nu...
The synthesis presented provides rapid access to an orthogonally protected d-(+)-erythro-sphingosine: 1-methoxymethyl, 2-azido, 3-benzoyl. After selective deprotection the resulting sphingosine derivative is suitable for coupling to a wide variety of saccharides or other molecules at either the ...
d-erythro-Sphingosine (1) and d-erythro-2-azidosphingosine (2) are both prepared from commercially available and cheap d-ribo-phytosphingosine (3) in a yield of 58% and 70%, respectively. A key transformation in the synthesis of d-erythro-sphingosine (1) is the palladium catalyzed regiospecific ...
Starting from a single suitable functionalised epoxide, a highly efficient stereoselective synthesis of d-erythro-sphingosine and d-lyxo-phytosphingosine is described. The approach allows the formal preparation of all stereoisomers of these sphingoid structures.
D-erythro-sphingosine and D-erythro-sphinganine can be produced in protected form from serine by a synthetic approach in which the normal biological intermediate 3-ketosphinganine in protectyed form, is a key synthetic intermediate. The sequence is short and convergent, proceeds in good overall ...
From the perspective of synthesis, ynones are compounds of considerable interest because of their occurrence in a wide variety of biologically active molecules and as key synthetic intermediates. In this context, a facile and highly efficient synthesis of ynones was developed based on the high r...
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