Background and aimLignosus rhinocerus (LR) is an edible mushroom with a variety of medicinal properties such as neurostimulation, immunomodulation, anti-inflammation, anti-oxidation, anti-proliferation, anti-diabetes and especially antiviral activity. Human immunodeficiency virus type-1 (HIV-1) ...
We present a detailed investigation of the effect of the crystallographic structure of the HIV-1 protease (PR) on the binding energy of different classes of inhibitors obtained from docking simulations. The crystal structures of 222 HIV-1 proteases (in wild-type and mutant forms) and 202 inhibit...
Individual drug concentration data can be a valuable tool for the clinical management of antiretroviral therapy (ART) for the treatment of HIV infection. High performance liquid chromatography (HPLC) based assays are currently the gold standard for drug measurement but its high cost and requirem...
A key target in the treatment of HIV-1/AIDS has been the viral protease. Here we first studied in silico the evolution of protease resistance. Primary active site resistance mutations were found to weaken interactions between protease and both inhibitor and substrate P4-P4′ residues. We next st...
The Ca2+ indicator, arsenazo III, binds to subcellular fractions of rabbit skeletal muscle with sufficient affinity that in living muscle containing 1–2 mM arsenazo III, the estimated free arsenazo III concentration is only 50–200 μM; 80–90% of the bound arsenazo III is associated with solub...
The viability of the separation of lanthanides and uranium(VI) in the form of strongly absorbing complexes with arsenazo III (AIII) was studied with the aim to increase the sensitivity of absorbance detection in determination of these metals by capillary electrophoresis (CE). Special attention w...
A novel method is proposed for the computation of formation constants of complexes. It makes use essentially of the data from the first stages of the titration and is based on the Taylor expansion of the concentration of the ligand as a function of the titrant concentration. The applicability of...
Silica based sorbent sequentially modified with polyhexamethylene guanidine and 2-(1,8-dihydroxy-3,6-disulfo-2-naphthylazo)benzenearsonic acid (Arsenazo I) was developed and studied in the present work. Conditions for immobilizing Arsenazo I on the aminated silica surface were studied: optimal e...
The present study devoted to description of efficient removal of radioactive UO22+ ions (U(IV)) via complexation with Arsenazo III (ARS III) accelerated by ultrasound-assisted adsorption onto the Au-NPs supported on carbon nanotubes (Au-NPs-CNTs), which were characterized by conventional techniq...
A fibre-optic sensor based on the use of 2,7-bis(2-arsenophenylazo) 1,8-dihydroxynaphthalene-3,6-disulphonic acid, commonly called Arsenazo III (ASA III) immobilized onto XAD-16, has been developed for the rapid reflectance spectrometric determination of lead (II). The measurements were carried ...
A short, sensitive and reliable spectrophotometric method, which has advantages over all known “wet chemistry” methods for uranium determination with regard to tolerance to common interferences, has been developed for the determination of uranium. Selectivity, molar absorptivity and the determ...
Clinoptilolite nanoparticles (NClin) modified with hexadecyltrimethyl ammonium bromide surfactant (HDTMABr) and Arsenazo III (ARS) was used for the modification of carbon paste electrode. The modified electrode was used for voltammetric determination of Cesium. The peak current of semi-reversibl...
A modified PVC (polyvinyl chloride) membrane with clinoptilolite nanoparticles/hexadecyltrimethyl ammonium bromide surfactant (HDTMABr)/Arsenazo III: (NSMZ-ARS), was used for construction of Al(III) –selective electrode. The raw and modified samples were characterized by XRD, FTIR, SEM and TEM ...
A sorbent of zirconia with covalently immobilized Arsenazo III has been obtained by the sorption of the organic reagent from aqueous solutions, and its properties have been defined.
The influence of diverse methoxyphenyl substitution patterns on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold is herein explored in order to modulate the A3 adenosine receptor antagonistic profile. As a result, novel ligands exhibiting excellent potency (Ki on A3 AR
A bimodal imaging Gd–Zpy probe based on magnetic resonance imaging and fluorescence sensing has been synthesized and characterized. Gd–Zpy features a bright green emission and a turn-on fluorescent response manner with high sensitivity for Zn2+ in aqueous solution and is able to luminescent im...
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly...
The search for novel, generally applicable and highly efficient delivery tools is a major activity in the biotechnology arena. Using highly optimized microwave based solid-phase chemistry a series of fluorescein-labelled cationic peptoid conjugates were synthesized within 24 h and cellular uptak...
Unmodified fluorescein (1) behaves as a fluorescent chemosensor for F− detection, where the F−-induced fluorescence enhancement is driven by a transfer of the phenolic OH protons to F−.
This study describes the development of a novel fluorescent tag, O-2-[aminoethyl]fluorescein, for the separation of sugars by capillary electrophoresis with fluorescence detection using an argon ion laser. The tag was synthesised using three consecutive steps namely: esterification, alkylation a...
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