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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryPrice, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2.fast delivery by safe express way to all the country. 3.has a number of highly qualified engineers and experts to p
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry2(5H)-Furanone,5-(hydroxymethyl)-, (5R)- cas 112837-17-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
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inquiryDeliver Day : within 24 hours after get the payment Payment Terms : T/T, Western Union, MoneyGram, bank transfer Packaging: Safe and discreet packaging Shipment : UPS / DHL / FEDEX / EMS and Client's request Origin China Quality : High
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inquiryChinese name: (R) - (+) - 5 - hydroxy methyl - 2 (5 h) - furan ketone Chinese alias: English name: (R) - (+) - 5 - Hydroxymethyl - 2 (5 h) - furanone English nickname: CAS no. : 112837-17-9 Molecular formula: C5H6O3 Molecular weight: 11
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inquiryProName: 2(5H)-Furanone,5-(hydroxymethyl)-, (5R... CasNo: 112837-17-9 Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clients requirement Port: Shanghai
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inquiryAdequate stocks available,prompt shipment,Strictly control on quality,Timely after-sales Application:Intermediate
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inquiryHigh Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate
Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen
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inquiryhigh purity Application:Drug intermediates Materials intermediates and active molecules
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inquiry(R)-(+)-g-Hydroxymethyl-a,b-butenolide C5H6O3 CAS [112837-17-9] MW = 114.10
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inquiry(Z)-(-)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid at 25℃; for 3h; | 97% |
With Dowex 50-X2-100 ion-exchange resin In methanol at 20℃; Inert atmosphere; | 97% |
With sulfuric acid In methanol for 1.5h; Ambient temperature; | 91% |
With sulfuric acid In methanol; water for 2h; Ambient temperature; | 90% |
ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20℃; for 2.5h; Inert atmosphere; | 94% |
With sulfuric acid In methanol at 20℃; for 2h; Cyclization; | 66% |
(5R)-phenylseleno-5-methyldihydro-2(3H)-furanone
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With dihydrogen peroxide; acetic acid In water for 0.5h; | 83% |
C11H12O4S
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With calcium carbonate In toluene Inert atmosphere; Reflux; | 80% |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 12h; Ambient temperature; Yield given; |
5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5H-furan-2-one
A
(5S)-5-(hydroxymethyl)-5H-furan-2-one
B
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With pyridine hydrogenfluoride In tetrahydrofuran at 0℃; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
(+)-(R)-5-benzyloxymethylfuran-2(5H)-one
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 20℃; for 1h; |
5-benzyloxymethyl-3-phenylsulfanyl-dihydrofuran-2-one
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 50 percent / NaIO4 / aq. methanol / 20 °C 2: H2 / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C View Scheme |
5-benzyloxymethyl-3-phenylselanyl-dihydrofuran-2-one
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / NaIO4 / aq. methanol / 1 h / 20 °C 2: H2 / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C View Scheme |
methyl (R)-4,5-dihydroxy-2-butynoate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / Lindlar catalyst / ethyl acetate / 0.42 h / Ambient temperature 2: conc. aq. HCl / methanol / 12 h / Ambient temperature View Scheme |
methyl (R)-4,5-di-O-isopropylidene-4,5-dihydroxy-2-butynoate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90.4 percent / p-TsOH*H2O / methanol / 12 h / Ambient temperature 2: H2 / Lindlar catalyst / ethyl acetate / 0.42 h / Ambient temperature 3: conc. aq. HCl / methanol / 12 h / Ambient temperature View Scheme |
(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 46 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / -78 °C 2: 83 percent / 30percent hydrogen peroxide, acetic acid / H2O / 0.5 h View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium periodate / methanol; water / 0 °C / Inert atmosphere 2: calcium carbonate / toluene / Inert atmosphere; Reflux View Scheme |
ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere 1.2: 24 h / Inert atmosphere 2.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere 3.1: calcium carbonate / toluene / Inert atmosphere; Reflux View Scheme |
L-5,6-isopropylidene-gulono-1,4-lactone
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 1.2: 10 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 1.2: 10 h / 20 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere 2.2: 24 h / Inert atmosphere 3.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere 4.1: calcium carbonate / toluene / Inert atmosphere; Reflux View Scheme |
L-gulono-1,4-lactone
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 2.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 2.2: 10 h / 20 °C / Inert atmosphere 3.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 2.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 2.2: 10 h / 20 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere 3.2: 24 h / Inert atmosphere 4.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere 5.1: calcium carbonate / toluene / Inert atmosphere; Reflux View Scheme |
ascorbic acid
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: palladium 10% on activated carbon; hydrogen / water / 50 °C / 2585.81 Torr 2.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 3.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 3.2: 10 h / 20 °C / Inert atmosphere 4.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1.1: palladium 10% on activated carbon; hydrogen / water / 50 °C / 2585.81 Torr 2.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 3.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 3.2: 10 h / 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere 4.2: 24 h / Inert atmosphere 5.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere 6.1: calcium carbonate / toluene / Inert atmosphere; Reflux View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
tert-butylchlorodiphenylsilane
(R)-(+)-5-(tert-butyldiphenylsilanyloxymethyl)-5H-furan-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.916667h; Inert atmosphere; Cooling with ice; | 97% |
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; | 94% |
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere; | 94% |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
tert-butyldimethylsilyl chloride
(R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-5H-furan-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane 0 deg C, 15 min; rt, 20 min; | 96% |
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature; | 92% |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
trityl chloride
(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone
Conditions | Yield |
---|---|
In pyridine; ethanol | 90% |
With pyridine |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
phenylboronic acid
(4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triethylamine In 1,4-dioxane; water at 25℃; for 18h; Inert atmosphere; diastereoselective reaction; | 90% |
4-fluoroboronic acid
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(4S,5R)-4-(4-fluorophenyl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With barium dihydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane; water at 25℃; for 18h; Inert atmosphere; diastereoselective reaction; | 85% |
O-benzyl 2,2,2-trichloroacetimidate
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(+)-(R)-5-benzyloxymethylfuran-2(5H)-one
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 0 - 20℃; for 2.16667h; Addition; | 84% |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
(5'-oxo-2',5'-dihydrofuran-2'-yl)methyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside
Conditions | Yield |
---|---|
With silver nitrate In dichloromethane for 48h; Koenigs-Knorr synthesis; Inert atmosphere; | 29% |
diazomethane
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(+)-(R)-umbelactone
Conditions | Yield |
---|---|
1.) THF/ether; 2.) dioxane, 50 h, reflux; Yield given. Multistep reaction; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(1S,4R,5R)-4-benzoyloxymethyl-6,6-dimethyl-3-oxabicyclo<3.1.0>hexan-2-one
Conditions | Yield |
---|---|
Multistep reaction; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
pivaloyl chloride
2,2-Dimethyl-propionic acid (R)-5-oxo-2,5-dihydro-furan-2-ylmethyl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane Ambient temperature; Yield given; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
ethylenediamine
Conditions | Yield |
---|---|
In water 80 deg C, 15 min; RT, 3 h; Yield given. Yields of byproduct given; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
isopropyl alcohol
(4R,5R)-5-hydroxymethyl-4-(1-hydroxy-1-methylethyl)tetrahydrofuran-2-one
Conditions | Yield |
---|---|
for 48h; Irradiation; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Cysteamine
Conditions | Yield |
---|---|
In water 80 deg C, 15 min; RT, 3 h; Yield given. Yields of byproduct given; |
pyrrolidine
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
With chromenone receptor In chloroform-d1 at 20℃; Product distribution; var. chromanone receptors: determination t1/2 and products ratio; | |
With chromanone receptor In chloroform-d1 at 20℃; Title compound not separated from byproducts; |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C 2.1: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C 3.1: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C 4.1: 4.41 g / Ag2O / CH2Cl2 / 48 h / Heating 5.1: O3 / CH2Cl2 / -78 °C 5.2: 83 percent / PPh3 / CH2Cl2 / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere 2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 2.2: 0.67 h / Inert atmosphere; Cooling 3.1: diisobutylaluminium hydride / diethyl ether; toluene / 1 h / -78 °C / Inert atmosphere 4.1: silver(l) oxide / dichloromethane / 48 h / Inert atmosphere; Reflux 5.1: ozone / dichloromethane / 0.17 h / -78 °C / Inert atmosphere 5.2: 0 °C / Inert atmosphere View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C 2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C 3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C 4: Ag2O / CH2Cl2 / 48 h / Heating View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
tert-butyl (((2R,3S,5R)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C 2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C 3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C 4: 4.41 g / Ag2O / CH2Cl2 / 48 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere 2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 2.2: 0.67 h / Inert atmosphere; Cooling 3.1: diisobutylaluminium hydride / diethyl ether; toluene / 1 h / -78 °C / Inert atmosphere 4.1: silver(l) oxide / dichloromethane / 48 h / Inert atmosphere; Reflux View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C 2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C 3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(4S,5R)-(-)-5-(tert-butyldiphenylsilanyloxymethyl)-4-vinyldihydrofuran-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C 2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere 2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 2.2: 0.67 h / Inert atmosphere; Cooling View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
(4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,4-diol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 84 percent / trifluoromethanesulfonic acid / CH2Cl2; cyclohexane / 2.17 h / 0 - 20 °C 2.1: Li / tetrahydrofuran / 0 °C / sonication 2.2: CuCN / tetrahydrofuran / 0.5 h / -45 °C 2.3: 90 percent / tetrahydrofuran / 1 h / -45 °C 3.1: 65 percent / AcOOH/AcOH; Br2 / 5 h / 20 °C 4.1: 60 percent / 2-methyl-2-butene; BH3 / tetrahydrofuran / 24 h / 20 °C 5.1: 80 percent / formic acid / 10 percent Pd/C / methanol / 1 h / 20 °C View Scheme |
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 84 percent / trifluoromethanesulfonic acid / CH2Cl2; cyclohexane / 2.17 h / 0 - 20 °C 2.1: Li / tetrahydrofuran / 0 °C / sonication 2.2: CuCN / tetrahydrofuran / 0.5 h / -45 °C 2.3: 90 percent / tetrahydrofuran / 1 h / -45 °C 3.1: 65 percent / AcOOH/AcOH; Br2 / 5 h / 20 °C 4.1: 60 percent / 2-methyl-2-butene; BH3 / tetrahydrofuran / 24 h / 20 °C View Scheme |
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