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Dayang Chem (Hangzhou) Co.,Ltd.

best service, quality and priceAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:1 Kilogram

FOB Price: $6.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2.fast delivery by safe express way to all the country. 3.has a number of highly qualified engineers and experts to p

Best price/RARECHEM AK HZ 0033

Cas:112837-17-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

112837-17-9---(R)-(+)-5-(HYDROXYMETHYL)-2(5H)-FURANONE

Cas:112837-17-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Best price/RARECHEM AK HZ 0033 CAS NO.112837-17-9

Cas:112837-17-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-(+)-5-(Hydroxymethyl)-2(5H)-furanone

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(R)-(+)-5-(Hydroxymethyl)-2(5H)-furanone, 98%

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)- cas 112837-17-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)- cas 112837-17-9

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Other

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

(R)-(+)-5-(HYDROXYMETHYL)-2(5H)-FURANONE

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-(+)-5-(HYDROXYMETHYL)-2(5H)-FURANONE

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Trading Company

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Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

Best price/RARECHEM AK HZ 0033 CAS NO.112837-17-9

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Trading Company

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Hebei MuHai biological technology co., LTD

Deliver Day : within 24 hours after get the payment Payment Terms : T/T, Western Union, MoneyGram, bank transfer Packaging: Safe and discreet packaging Shipment : UPS / DHL / FEDEX / EMS and Client's request Origin China Quality : High

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-CAS NO.: 112837-17-9

Cas:112837-17-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Trading Company

inquiry

SuZhou LaiTeou

Chinese name: (R) - (+) - 5 - hydroxy methyl - 2 (5 h) - furan ketone Chinese alias: English name: (R) - (+) - 5 - Hydroxymethyl - 2 (5 h) - furanone English nickname: CAS no. : 112837-17-9 Molecular formula: C5H6O3 Molecular weight: 11

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:1 Metric Ton

FOB Price: $100.0

Type:Trading Company

inquiry

Hangzhou Haiqiang Chemical Co.,Ltd.

ProName: 2(5H)-Furanone,5-(hydroxymethyl)-, (5R... CasNo: 112837-17-9 Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clients requirement Port: Shanghai

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Skyrun Industrial Co.,Ltd

Adequate stocks available,prompt shipment,Strictly control on quality,Timely after-sales Application:Intermediate

(R)-(+)-5-(HYDROXYMETHYL)-2(5H)-FURANONE

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

FT-0771760

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

(R)-(+)-5-Hydroxymethyl-2(5H)-furanone

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

(2R)-2-(hydroxymethyl)-2H-furan-5-one

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Camphor Technologies, Inc.

(R)-(+)-g-Hydroxymethyl-a,b-butenolide C5H6O3 CAS [112837-17-9] MW = 114.10

2(5H)-Furanone,5-(hydroxymethyl)-, (5R)-

Cas:112837-17-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(Z)-(-)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate
106757-56-6

(Z)-(-)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With camphor-10-sulfonic acid at 25℃; for 3h;97%
With Dowex 50-X2-100 ion-exchange resin In methanol at 20℃; Inert atmosphere;97%
With sulfuric acid In methanol for 1.5h; Ambient temperature;91%
With sulfuric acid In methanol; water for 2h; Ambient temperature;90%
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 2.5h; Inert atmosphere;94%
With sulfuric acid In methanol at 20℃; for 2h; Cyclization;66%
(5R)-phenylseleno-5-methyldihydro-2(3H)-furanone
112775-65-2, 112797-12-3

(5R)-phenylseleno-5-methyldihydro-2(3H)-furanone

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid In water for 0.5h;83%
C11H12O4S
1403352-72-6

C11H12O4S

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With calcium carbonate In toluene Inert atmosphere; Reflux;80%
(Z)-(R)-4,5-Dihydroxy-pent-2-enoic acid methyl ester

(Z)-(R)-4,5-Dihydroxy-pent-2-enoic acid methyl ester

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With hydrogenchloride In methanol for 12h; Ambient temperature; Yield given;
5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5H-furan-2-one
116561-10-5

5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5H-furan-2-one

A

(5S)-5-(hydroxymethyl)-5H-furan-2-one
78508-96-0

(5S)-5-(hydroxymethyl)-5H-furan-2-one

B

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With pyridine hydrogenfluoride In tetrahydrofuran at 0℃; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(+)-(R)-5-benzyloxymethylfuran-2(5H)-one
85428-26-8

(+)-(R)-5-benzyloxymethylfuran-2(5H)-one

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate at 20℃; for 1h;
5-benzyloxymethyl-3-phenylsulfanyl-dihydrofuran-2-one
364373-27-3

5-benzyloxymethyl-3-phenylsulfanyl-dihydrofuran-2-one

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 50 percent / NaIO4 / aq. methanol / 20 °C
2: H2 / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C
View Scheme
5-benzyloxymethyl-3-phenylselanyl-dihydrofuran-2-one
364373-24-0

5-benzyloxymethyl-3-phenylselanyl-dihydrofuran-2-one

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / NaIO4 / aq. methanol / 1 h / 20 °C
2: H2 / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C
View Scheme
methyl (R)-4,5-dihydroxy-2-butynoate
174599-52-1

methyl (R)-4,5-dihydroxy-2-butynoate

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Lindlar catalyst / ethyl acetate / 0.42 h / Ambient temperature
2: conc. aq. HCl / methanol / 12 h / Ambient temperature
View Scheme
methyl (R)-4,5-di-O-isopropylidene-4,5-dihydroxy-2-butynoate
174599-51-0

methyl (R)-4,5-di-O-isopropylidene-4,5-dihydroxy-2-butynoate

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90.4 percent / p-TsOH*H2O / methanol / 12 h / Ambient temperature
2: H2 / Lindlar catalyst / ethyl acetate / 0.42 h / Ambient temperature
3: conc. aq. HCl / methanol / 12 h / Ambient temperature
View Scheme
(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone
52813-63-5

(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / -78 °C
2: 83 percent / 30percent hydrogen peroxide, acetic acid / H2O / 0.5 h
View Scheme
(S)-5-hydroxymethyl-4-phenylsulfanyldihydro-furan-2-one

(S)-5-hydroxymethyl-4-phenylsulfanyldihydro-furan-2-one

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium periodate / methanol; water / 0 °C / Inert atmosphere
2: calcium carbonate / toluene / Inert atmosphere; Reflux
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere
1.2: 24 h / Inert atmosphere
2.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere
3.1: calcium carbonate / toluene / Inert atmosphere; Reflux
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
1.2: 10 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
1.2: 10 h / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere
2.2: 24 h / Inert atmosphere
3.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere
4.1: calcium carbonate / toluene / Inert atmosphere; Reflux
View Scheme
L-gulono-1,4-lactone
1128-23-0

L-gulono-1,4-lactone

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice
2.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
2.2: 10 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice
2.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
2.2: 10 h / 20 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere
3.2: 24 h / Inert atmosphere
4.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere
5.1: calcium carbonate / toluene / Inert atmosphere; Reflux
View Scheme
ascorbic acid
50-81-7

ascorbic acid

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / water / 50 °C / 2585.81 Torr
2.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice
3.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
3.2: 10 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / ethanol; water / 2.5 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: palladium 10% on activated carbon; hydrogen / water / 50 °C / 2585.81 Torr
2.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice
3.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice
3.2: 10 h / 20 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere
4.2: 24 h / Inert atmosphere
5.1: sodium periodate / methanol; water / 0 °C / Inert atmosphere
6.1: calcium carbonate / toluene / Inert atmosphere; Reflux
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(R)-(+)-5-(tert-butyldiphenylsilanyloxymethyl)-5H-furan-2-one
110171-24-9

(R)-(+)-5-(tert-butyldiphenylsilanyloxymethyl)-5H-furan-2-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.916667h; Inert atmosphere; Cooling with ice;97%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;94%
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere;94%
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-5H-furan-2-one
171595-14-5

(R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-5H-furan-2-one

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane 0 deg C, 15 min; rt, 20 min;96%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;92%
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

trityl chloride
76-83-5

trityl chloride

(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone
101758-68-3

(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

Conditions
ConditionsYield
In pyridine; ethanol90%
With pyridine
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

phenylboronic acid
98-80-6

phenylboronic acid

(4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one
950838-18-3

(4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triethylamine In 1,4-dioxane; water at 25℃; for 18h; Inert atmosphere; diastereoselective reaction;90%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(4S,5R)-4-(4-fluorophenyl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one
950838-19-4

(4S,5R)-4-(4-fluorophenyl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With barium dihydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane; water at 25℃; for 18h; Inert atmosphere; diastereoselective reaction;85%
O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(+)-(R)-5-benzyloxymethylfuran-2(5H)-one
85428-26-8

(+)-(R)-5-benzyloxymethylfuran-2(5H)-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 0 - 20℃; for 2.16667h; Addition;84%
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

(5'-oxo-2',5'-dihydrofuran-2'-yl)methyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside
85846-73-7

(5'-oxo-2',5'-dihydrofuran-2'-yl)methyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

Conditions
ConditionsYield
With silver nitrate In dichloromethane for 48h; Koenigs-Knorr synthesis; Inert atmosphere;29%
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(+)-(R)-umbelactone
69534-86-7

(+)-(R)-umbelactone

Conditions
ConditionsYield
1.) THF/ether; 2.) dioxane, 50 h, reflux; Yield given. Multistep reaction;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(1S,4R,5R)-4-benzoyloxymethyl-6,6-dimethyl-3-oxabicyclo<3.1.0>hexan-2-one
136374-69-1

(1S,4R,5R)-4-benzoyloxymethyl-6,6-dimethyl-3-oxabicyclo<3.1.0>hexan-2-one

Conditions
ConditionsYield
Multistep reaction;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

pivaloyl chloride
3282-30-2

pivaloyl chloride

2,2-Dimethyl-propionic acid (R)-5-oxo-2,5-dihydro-furan-2-ylmethyl ester
130245-25-9

2,2-Dimethyl-propionic acid (R)-5-oxo-2,5-dihydro-furan-2-ylmethyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane Ambient temperature; Yield given;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

ethylenediamine
107-15-3

ethylenediamine

A

7-(1,2-dihydroxyethyl)-<1,4>-diazepan-5-one

7-(1,2-dihydroxyethyl)-<1,4>-diazepan-5-one

B

7-(1,2-dihydroxyethyl)-<1,4>-diazepan-5-one

7-(1,2-dihydroxyethyl)-<1,4>-diazepan-5-one

Conditions
ConditionsYield
In water 80 deg C, 15 min; RT, 3 h; Yield given. Yields of byproduct given;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

isopropyl alcohol
67-63-0

isopropyl alcohol

(4R,5R)-5-hydroxymethyl-4-(1-hydroxy-1-methylethyl)tetrahydrofuran-2-one
136265-80-0

(4R,5R)-5-hydroxymethyl-4-(1-hydroxy-1-methylethyl)tetrahydrofuran-2-one

Conditions
ConditionsYield
for 48h; Irradiation;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

Cysteamine
60-23-1

Cysteamine

A

(αS,7R)-7-(1,2-dihydroxyethyl)-<1,4>-thiazepan-5-one

(αS,7R)-7-(1,2-dihydroxyethyl)-<1,4>-thiazepan-5-one

B

(αS,7S)-7-(1,2-dihydroxyethyl)-<1,4>-thiazepan-5-one

(αS,7S)-7-(1,2-dihydroxyethyl)-<1,4>-thiazepan-5-one

Conditions
ConditionsYield
In water 80 deg C, 15 min; RT, 3 h; Yield given. Yields of byproduct given;
pyrrolidine
123-75-1

pyrrolidine

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

A

(4R,5R)-5-Hydroxymethyl-4-pyrrolidin-1-yl-dihydro-furan-2-one

(4R,5R)-5-Hydroxymethyl-4-pyrrolidin-1-yl-dihydro-furan-2-one

B

5-Hydroxy-1-pyrrolidin-1-yl-pentane-1,4-dione

5-Hydroxy-1-pyrrolidin-1-yl-pentane-1,4-dione

Conditions
ConditionsYield
With chromenone receptor In chloroform-d1 at 20℃; Product distribution; var. chromanone receptors: determination t1/2 and products ratio;
With chromanone receptor In chloroform-d1 at 20℃; Title compound not separated from byproducts;
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(2R,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-carbaldehyde

(2R,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C
2.1: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C
3.1: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C
4.1: 4.41 g / Ag2O / CH2Cl2 / 48 h / Heating
5.1: O3 / CH2Cl2 / -78 °C
5.2: 83 percent / PPh3 / CH2Cl2 / 0 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.67 h / Inert atmosphere; Cooling
3.1: diisobutylaluminium hydride / diethyl ether; toluene / 1 h / -78 °C / Inert atmosphere
4.1: silver(l) oxide / dichloromethane / 48 h / Inert atmosphere; Reflux
5.1: ozone / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
5.2: 0 °C / Inert atmosphere
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

tert-butyl (((2R,3S,5S)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane

tert-butyl (((2R,3S,5S)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C
2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C
3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C
4: Ag2O / CH2Cl2 / 48 h / Heating
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

tert-butyl (((2R,3S,5R)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane
909395-03-5

tert-butyl (((2R,3S,5R)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C
2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C
3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C
4: 4.41 g / Ag2O / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.67 h / Inert atmosphere; Cooling
3.1: diisobutylaluminium hydride / diethyl ether; toluene / 1 h / -78 °C / Inert atmosphere
4.1: silver(l) oxide / dichloromethane / 48 h / Inert atmosphere; Reflux
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-vinyl-tetrahydro-furan-2-ol

(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-vinyl-tetrahydro-furan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C
2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C
3: DIBAL-H / toluene; diethyl ether / 1 h / -78 °C
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(4S,5R)-(-)-5-(tert-butyldiphenylsilanyloxymethyl)-4-vinyldihydrofuran-2-one
160308-93-0

(4S,5R)-(-)-5-(tert-butyldiphenylsilanyloxymethyl)-4-vinyldihydrofuran-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / imidazole / dimethylformamide / 0 - 20 °C
2: CuCl; LiCl / tetrahydrofuran / -78 - -50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.1: copper(l) chloride; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.67 h / Inert atmosphere; Cooling
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

(4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,4-diol
29780-54-9

(4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,4-diol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 84 percent / trifluoromethanesulfonic acid / CH2Cl2; cyclohexane / 2.17 h / 0 - 20 °C
2.1: Li / tetrahydrofuran / 0 °C / sonication
2.2: CuCN / tetrahydrofuran / 0.5 h / -45 °C
2.3: 90 percent / tetrahydrofuran / 1 h / -45 °C
3.1: 65 percent / AcOOH/AcOH; Br2 / 5 h / 20 °C
4.1: 60 percent / 2-methyl-2-butene; BH3 / tetrahydrofuran / 24 h / 20 °C
5.1: 80 percent / formic acid / 10 percent Pd/C / methanol / 1 h / 20 °C
View Scheme
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one
112837-17-9

(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

α,β-(4R,5S)-(-)-5-benzyloxymethyltetrahydrofuran-2,4-diol

α,β-(4R,5S)-(-)-5-benzyloxymethyltetrahydrofuran-2,4-diol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 84 percent / trifluoromethanesulfonic acid / CH2Cl2; cyclohexane / 2.17 h / 0 - 20 °C
2.1: Li / tetrahydrofuran / 0 °C / sonication
2.2: CuCN / tetrahydrofuran / 0.5 h / -45 °C
2.3: 90 percent / tetrahydrofuran / 1 h / -45 °C
3.1: 65 percent / AcOOH/AcOH; Br2 / 5 h / 20 °C
4.1: 60 percent / 2-methyl-2-butene; BH3 / tetrahydrofuran / 24 h / 20 °C
View Scheme

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