Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:114457-94-2
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryBortezomib Intermediate N-(2-Pyrazinylcarbonyl)-L-phenylalanine[CAS:114457-94-2] Identification Name N-(2-Pyrazinylcarbonyl)-L-phenylalanine Molecular Structure Molecular F
Cas:114457-94-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Manufacturers
inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:114457-94-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $100.0 / 102.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:114457-94-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:114457-94-2
Min.Order:1 Gram
FOB Price: $9.0
Type:Lab/Research institutions
inquiryProduct Name: (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID CAS: 114457-94-2 MF: C14H13N3O3 MW: 271.27 EINECS: Mol File: 114457-94-2.mol (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Structure (S)-3-PH
Cas:114457-94-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:114457-94-2
Min.Order:1 Kilogram
FOB Price: $25.0 / 30.0
Type:Trading Company
inquiry(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID CAS:114457-94-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s
Cas:114457-94-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:114457-94-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryN-(2-Pyrazinylcarbonyl)-L-phenylalanine China CAS: 114457-94-2 Specification Appearance White to off-white powder Assay 98~102% 100.1% Melting Point 175~18
Cas:114457-94-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe provide tailor-made photoinitiator solutions for different performances by custom synthesisi.blends or other technical supports low-odor uv formulations non-yellowing uv formulations benzene-free uv formulations polymeric uv formul
Cas:114457-94-2
Min.Order:100 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:114457-94-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryFandaChem,a China-based chemical company, specialize in exporting N-(2-Pyrazinylcarbonyl)-L-phenylalanine ,S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID,Bortezomib intermediate,cas 114457-94-2 Please contact us by email freely. Appe
Cas:114457-94-2
Min.Order:1 Gram
Negotiable
Type:Other
inquiryL Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air Port:Qingdao/Shanghai,China
Cas:114457-94-2
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:114457-94-2
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:114457-94-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:114457-94-2
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:114457-94-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide interm
Cas:114457-94-2
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/246.html Product Name N-(2-Pyrazinylcarbonyl)-L-phenylalanine
Cas:114457-94-2
Min.Order:1 Gram
FOB Price: $34.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:114457-94-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Cas:114457-94-2
Min.Order:0
Negotiable
Type:Trading Company
inquiry(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 0℃; for 2h; | 99% |
L-phenylalanine
(1H-benzo[d][1,2,3]triazol-1-yl)(pyrazin-2-yl)methanone
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With trialkylamine In water; acetonitrile at 20℃; | 98% |
N,O-bis(trimethylsilyl)phenylalanine
pyrazinecarboxylic acid imidazolide
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: N,O-bis(trimethylsilyl)phenylalanine; pyrazinecarboxylic acid imidazolide In dichloromethane at -40 - 20℃; for 19.5h; Stage #2: With water; citric acid In dichloromethane | 97% |
In dichloromethane at -40 - 20℃; for 16.5h; | 0.96 g |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; | 96% |
N-(2-pyrazinylcarbonyl)-L-phenylalanine methyl ester
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In acetone pH=12 - Ca. 13; Cooling with ice; | 93.6% |
With lithium hydroxide In tetrahydrofuran; water at 0℃; for 1h; | 93% |
With sodium hydroxide In 1,4-dioxane; methanol for 1h; | 69% |
diphenylmethylsilanecarboxylic acid
2-iodopyrazine
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: Phe-Wang resin; diphenylmethylsilanecarboxylic acid; 2-iodopyrazine With potassium fluoride; C39H32OP2*C13H12N(1-)*Pd(2+)*CH3O3S(1-); triethylamine In N,N-dimethyl-formamide at 20℃; for 15h; wang polystyrene resin; Sealed tube; Inert atmosphere; Stage #2: With triethylsilane; trifluoroacetic acid In water at 20℃; for 2h; Sealed tube; Inert atmosphere; | 82% |
pyrazinoyl chloride
L-phenylalanine
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: pyrazinoyl chloride; L-phenylalanine With sodium carbonate In water; toluene at 10 - 25℃; for 3h; Stage #2: With hydrogenchloride In methanol; water at 15 - 20℃; pH=3; | 36% |
With sodium carbonate In water; toluene at 10 - 25℃; | 36% |
velcade
B
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=12.0; Kinetics; Product distribution; Oxidation; hydrolysis; | |
With sodium hydroxide; oxygen at 70℃; for 48h; pH=12; Oxidation; hydrolysis; |
velcade
B
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
C
Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide
Conditions | Yield |
---|---|
With dihydrogen peroxide In water at 20℃; for 1h; Kinetics; Product distribution; Further Variations:; Solvents; Oxidation; hydrolysis; |
velcade
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=1.0; Kinetics; Product distribution; Oxidation; hydrolysis; | |
With hydrogenchloride; oxygen at 70℃; for 120h; pH=1.0; Oxidation; hydrolysis; |
2-pyrazylcarboxylic acid
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BOP; DiPEA / dimethylformamide / 0.25 h 1.2: 70 percent / dimethylformamide / 1 h 2.1: 69 percent / aq. NaOH / dioxane; methanol / 1 h View Scheme | |
Multi-step reaction with 2 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / dichloromethane; acetonitrile / 5 h / -15 - 25 °C 2.1: triethylamine; water; lithium bromide / acetonitrile / 5.17 h / 0 - 20 °C 2.2: 0 - 2 °C / pH 3 - 4 View Scheme |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BOP; DiPEA / dimethylformamide / 0.25 h 1.2: 70 percent / dimethylformamide / 1 h 2.1: 69 percent / aq. NaOH / dioxane; methanol / 1 h View Scheme | |
Multi-step reaction with 2 steps 1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / dichloromethane; acetonitrile / 5 h / -15 - 25 °C 2.1: triethylamine; water; lithium bromide / acetonitrile / 5.17 h / 0 - 20 °C 2.2: 0 - 2 °C / pH 3 - 4 View Scheme | |
Multi-step reaction with 2 steps 1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / -15 - 20 °C 2: lithium hydroxide; water / tetrahydrofuran / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 2: lithium hydroxide monohydrate / methanol / 14 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.67 h / 0 °C 1.2: 12 h 2.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C View Scheme |
2-pyrazylcarboxylic acid
L-phenylalanine sodium salt
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: 2-pyrazylcarboxylic acid With chloroformic acid ethyl ester; triethylamine In acetone at -5 - 30℃; for 3.5h; Stage #2: L-phenylalanine sodium salt In water; acetone at 0 - 30℃; for 18h; Product distribution / selectivity; |
methyl (2S)-2-amino-3-phenylpropanoate
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C 2: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C 2: sodium hydroxide / methanol; water / 20 °C View Scheme |
L-phenylalanine
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dichloromethane / 16 h / 20 °C 2: dichloromethane / 16.5 h / -40 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride 2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / -15 - 10 °C 3: sodium hydroxide / water View Scheme |
L-phenylalanine tert-butyl ester hydrochloride
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 0.08 h / 20 °C 1.2: 18 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: C17H19N3O3 With sodium hydroxide In water Stage #2: With hydrogenchloride In water |
2-amino-3-phenyl-propionic acid isopropyl ester
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / -15 - 10 °C 2: sodium hydroxide / water View Scheme |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
(S)-methyl 3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)-propanoate
Conditions | Yield |
---|---|
With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 2h; pH=12 - Ca. 13; | 95.6% |
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.666667h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 4-methyl-morpholine In tetrahydrofuran for 12h; | 81% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide) at -5 - 0℃; for 1h; Stage #2: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With 4-methyl-morpholine In DMF (N,N-dimethyl-formamide) at 0℃; pH=7; | 95.5% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; tert-butyl methyl ether at 0 - 20℃; for 12h; Reagent/catalyst; Solvent; Temperature; Large scale; | 93% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 24h; Large scale; | 93% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In hexane; dichloromethane at 0 - 20℃; for 12h; Large scale; | 93% |
1-amino-3-methylbutane
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; | 91% |
With 6,6'-diselanediylbis(N-(2-(dimethylamino)ethyl)-N-methyl-3-nitrobenzamide); triethyl phosphite In acetonitrile at 50℃; for 16h; Molecular sieve; | 78% |
1,2,3-Benzotriazole
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In dichloromethane for 0.5h; Stage #2: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid In dichloromethane at -15℃; | 90% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With ammonium chloride In N,N-dimethyl-formamide at 20℃; for 12h; Reagent/catalyst; Solvent; | 88.3% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
bortezomib pinacol ester
Conditions | Yield |
---|---|
With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; triethylamine In dichloromethane; ethyl acetate at 0 - 20℃; for 12h; Large scale; | 88% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at -10 - -5℃; for 3h; | 77% |
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 5℃; for 2.5h; Large scale; |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
Conditions | Yield |
---|---|
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; acetonitrile at -15 - 25℃; for 1.5h; | 86% |
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - 20℃; optical yield given as %de; | 84% |
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane at 25 - 30℃; for 0.166667 - 0.333333h; Stage #2: (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate With N-ethyl-N,N-diisopropylamine In dichloromethane at 25 - 30℃; for 2 - 3h; Product distribution / selectivity; | |
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 0℃; for 0.25h; Stage #2: (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate With N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 30℃; for 1h; Product distribution / selectivity; |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
bortezomib pinacol ester
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 0 - 80℃; for 8h; Large scale; | 86% |
methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
(S)-methyl 3-(naphthalen-2-yl)-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)-propanamido) propanoate
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.666667h; Stage #2: methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride With 4-methyl-morpholine In tetrahydrofuran for 12h; | 83% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; |
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol In dichloromethane for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.25h; Stage #3: C20H30BNO2*ClH With N-ethyl-N,N-diisopropylamine In dichloromethane | 79.3% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol In dichloromethane at -5℃; for 0.333333h; Stage #2: (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -15 - 20℃; for 3h; | 79% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at -10 - -5℃; for 3h; | 72% |
water
copper(II) acetate monohydrate
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
In sodium hydroxide; acetonitrile aq. NaOH; High Pressure; mixt. of Cu(OAc)2*H2O, aq. NaOH, ligand, CH3CN and water sealed in Teflon-lined autoclave and heated at 120°C for 4 d and then autoclave slowly cooled; crystals filtered off, washed with water and dried in air; elem. anal.; | 78% |
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol In dichloromethane for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.25h; Stage #3: C18H26BNO2*ClH With N-ethyl-N,N-diisopropylamine In dichloromethane | 77.9% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h; | 73% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; | 71% |
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With benzotriazol-1-ol In dichloromethane for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.25h; Stage #3: C16H30BNO2*ClH With N-ethyl-N,N-diisopropylamine In dichloromethane | 70.6% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 0.166667h; | 53% |
L-leucine tert-butyl ester hydrochloride
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: L-leucine tert-butyl ester hydrochloride; (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride at 20℃; for 3h; | 38% |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
Stage #1: (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane Stage #2: leucine vinyl sulfone trifluoroacetate In dichloromethane for 4h; Further stages.; | 19% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View