Gemcitabine HCl CAS:122111-03-9 Gemcitabine Base CAS:95058-81-4 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on t
Cas:122111-03-9
Min.Order:100 Gram
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inquiryUSP34 we have got GMP,DMF.We registered in Russia. Appearance:white powder Storage:Room temperature Package:as required Application:used in medicine Transportation:by sea by air express Port:China main port
Cas:122111-03-9
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Type:Trading Company
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:122111-03-9
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Type:Trading Company
inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:122111-03-9
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:122111-03-9
Min.Order:1 Gram
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Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:122111-03-9
Min.Order:1 Gram
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Type:Manufacturers
inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Cas:122111-03-9
Min.Order:10 Metric Ton
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Type:Manufacturers
inquiryName:Gemcitabine Hydrochloride Other name:Gemcitabine HCl CAS:122111-03-9 Specification:USP Stock:Fresh Appearance:White or almost white powder Storage:dryer and cool Package:durm Application:API Transportation:
Cas:122111-03-9
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $15.0 / 16.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:122111-03-9
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FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:Gemcitabine Hydrochloride CAS NO:122111-03-9 Grade:Medical scientific research and export Molecular formula:C9H12ClF2N3O4 Molecular weight:299.6591 Product Quality 12 years of chemical raw materials Mature operation of the industry Sy
Cas:122111-03-9
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryGemcitabine hydrochloride Basic information Product Description Content Determination Distinguish Adverse reactions and side effects application Product Name: Gemcitabine hydrochloride
Cas:122111-03-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:122111-03-9
Min.Order:0
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Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or off-white crystalline powder Storage:Store in seale
Cas:122111-03-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiryUSDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re
Cas:122111-03-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:122111-03-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:122111-03-9
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $130.0 / 150.0
Type:Trading Company
inquiryGemcitabine hydrochloride CAS:122111-03-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ
Cas:122111-03-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:122111-03-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:122111-03-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:122111-03-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:White powder Storage:2-8°C Package:25kg/drum Application:Suitable for the treatment of inoperable advanced or metastatic pancreatic cancer and the treatment of locally advanced or metastatic non-small cell lung cancer, and the treatment
Cas:122111-03-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of
Cas:122111-03-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:122111-03-9
Min.Order:20 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:122111-03-9
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquirygemcitabine
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 20 - 70℃; | 93.4% |
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.5% |
With hydrogenchloride In isopropyl alcohol at 0 - 5℃; for 2h; pH=2; | 90% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.9% |
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.9% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.5% |
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.5% |
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: (2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate With ammonia In methanol at 20℃; for 6h; Inert atmosphere; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20℃; pH=2; Heating; | 90% |
With sodium methylate In methanol at 20℃; for 4h; Reagent/catalyst; | 90% |
Stage #1: (2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate With ammonium hydroxide In methanol at 20℃; for 16h; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20℃; | 78% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water; acetone at 0 - 5℃; Green chemistry; Industrial scale; | 88% |
3′,5′-O-bis(tert-butoxycarbonyl)-gemcitabine
A
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 24℃; for 4h; Hydrolysis; | A 10% B 85% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3',5'-di-O-benzoyl-β-2'-deoxy-2',2'-difluorocytidine With ammonium hydroxide; water In methanol for 6h; Reflux; Stage #2: With hydrogenchloride In methanol; water at 20℃; for 12h; pH=3; | 85% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-1-acetyl-2-deoxy-2,2-difluorocytidine 3,5-dicinnamonate With ammonia In methanol Stage #2: With hydrogenchloride In water | 80% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: C30H21Cl2F2N3O7 With ammonium hydroxide In methanol at 20℃; for 16h; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20℃; | 79% |
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
4-(N-trimethylsilylacetamido)-2-trimethylsiloxypyrimidine
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: (2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate With triethylamine In tetrahydrofuran at 0 - 5℃; Stage #2: 4-(N-trimethylsilylacetamido)-2-trimethylsiloxypyrimidine With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0 - 5℃; Stage #3: In methanol at 40℃; | 50.5% |
α/β-1-(2-oxo-4-amino-1H-pyrimidin-1-yl)-2-desoxy-2,2'-difluororibose hydrochloride
gemcitabine hydrochloride
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 25℃; for 2h; Purification / work up; Resolution of anomeric mixture; |
2’-deoxy-2’,2’-difluoro-cytidine
A
2'-deoxy-2',2'-difluorocytidine hydrochloride
B
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at -4 - 60℃; for 6.5h; |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: C26H24F2N4O8 With ammonia; water In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In water at 0 - 5℃; for 4h; Product distribution / selectivity; | n/a |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: C26H24F2N4O8 With ammonia; water In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In water at 0 - 5℃; for 4h; Product distribution / selectivity; | n/a |
2’-deoxy-2’,2’-difluoro-cytidine
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; water at 10 - 68℃; for 1.5h; Product distribution / selectivity; | |
With hydrogenchloride In 1,2-dimethoxyethane; water at 10 - 68℃; for 1.5h; Product distribution / selectivity; |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3',5'-dicinnamoyl-2'-deoxy-2',2'-difluorocytidine With methanol; ammonia at 20℃; for 4 - 6h; Stage #2: With hydrogenchloride In dichloromethane; water Product distribution / selectivity; |
4-N-Acetylcytosine
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
A
2'-deoxy-2',2'-difluorocytidine hydrochloride
B
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 4-N-Acetylcytosine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In 1,2-dichloro-ethane for 3h; Heating / reflux; Stage #2: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20 - 75℃; for 14 - 16h; Heating / reflux; Stage #3: With hydrogenchloride In water; 1,2-dichloro-ethane |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water; ethyl acetate at 20℃; Product distribution / selectivity; |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / methanol / 3 h / 20 °C / pH Ca. 7 / Reflux 2.1: ammonium hydroxide; water / methanol / 6 h / Reflux 2.2: 12 h / 20 °C / pH 3 View Scheme |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / toluene; water / 3 h / 20 - 70 °C 2.1: triethylamine / methanol / 3 h / 20 °C / pH Ca. 7 / Reflux 3.1: ammonium hydroxide; water / methanol / 6 h / Reflux 3.2: 12 h / 20 °C / pH 3 View Scheme |
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 5 - 20 °C 2: 3 h / 120 °C / Heating 3: sodium t-butanolate / methanol / 2 h / 20 °C 4: hydrogenchloride / isopropyl alcohol; water / 20 - 70 °C View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 3 h / 120 °C / Heating 2: sodium t-butanolate / methanol / 2 h / 20 °C 3: hydrogenchloride / isopropyl alcohol; water / 20 - 70 °C View Scheme |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ethanol / 50 - 60 °C 2: 3 h / 120 °C / Heating 3: sodium t-butanolate / methanol / 2 h / 20 °C 4: hydrogenchloride / isopropyl alcohol; water / 20 - 70 °C View Scheme |
(erytro) ethyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxy propionate
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere; Industrial scale 2: diisobutylaluminium hydride / toluene; methanol / -50 - -20 °C / Inert atmosphere; Industrial scale 3: binaphthol phosphonate / N,N-dimethyl-formamide / 10 h / 20 °C / Industrial scale 4: hydrogenchloride / water; acetone; ethanol / 0 - 5 °C / Green chemistry; Industrial scale View Scheme |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: diisobutylaluminium hydride / toluene; methanol / -50 - -20 °C / Inert atmosphere; Industrial scale 2: binaphthol phosphonate / N,N-dimethyl-formamide / 10 h / 20 °C / Industrial scale 3: hydrogenchloride / water; acetone; ethanol / 0 - 5 °C / Green chemistry; Industrial scale View Scheme |
gemcitabine hydrochloride
Allyl chloroformate
4-allyloxycarbonylamino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Conditions | Yield |
---|---|
Stage #1: gemcitabine hydrochloride With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane In 1,4-dioxane for 2h; Heating; Stage #2: Allyl chloroformate With 1-methyl-1H-imidazole In dichloromethane at 20℃; for 4h; Stage #3: With triethylamine In methanol at 20℃; Further stages.; | 99% |
Stage #1: gemcitabine hydrochloride With pyridine; chloro-trimethyl-silane at 0℃; for 2h; Stage #2: Allyl chloroformate at 0 - 45℃; | 70% |
tert-butyldimethylsilyl chloride
gemcitabine hydrochloride
4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Conditions | Yield |
---|---|
at 20℃; | 98.5% |
With 1H-imidazole; triethylamine In N,N-dimethyl-formamide at 25℃; for 24h; | 95% |
With 1H-imidazole; triethylamine at 20℃; for 24h; Inert atmosphere; | 91% |
With 1-methyl-1H-imidazole; iodine In tetrahydrofuran; pyridine at 20℃; | 64% |
With 1H-imidazole In dichloromethane at 20℃; |
tert-butyldimethylsilyl chloride
gemcitabine hydrochloride
4-amino-1-((2R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 15h; | 98% |
With 1H-imidazole In N,N-dimethyl-formamide at 20 - 25℃; for 2h; | 93% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h; | 92% |
gemcitabine hydrochloride
p-toluenesulfonyl chloride
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-4-methylbenzenesulfonamide
Conditions | Yield |
---|---|
Stage #1: gemcitabine hydrochloride With pyridine; chloro-trimethyl-silane at 20℃; for 2h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride at 20 - 60℃; for 20h; Inert atmosphere; | 96% |
Stage #1: gemcitabine hydrochloride With pyridine; chloro-trimethyl-silane Stage #2: p-toluenesulfonyl chloride Stage #3: With ammonia In methanol |
di-tert-butyl dicarbonate
gemcitabine hydrochloride
(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 20℃; for 50h; | 95% |
With sodium carbonate In 1,4-dioxane; water at 20℃; for 48h; | 87% |
With sodium carbonate In 1,4-dioxane; water at 20℃; for 48h; | 87% |
gemcitabine hydrochloride
Deoxydifluorouridine
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In water at 20℃; for 48h; | 95% |
Multi-step reaction with 3 steps 1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme |
benzoyl chloride
gemcitabine hydrochloride
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
Conditions | Yield |
---|---|
With pyridine at 0 - 20℃; for 12h; Temperature; Inert atmosphere; | 93.5% |
With pyridine at 0 - 20℃; Inert atmosphere; | 93.5% |
With pyridine at 0 - 20℃; Inert atmosphere; | 93.5% |
Conditions | Yield |
---|---|
With pyridine In water at 30℃; for 22h; Inert atmosphere; | 91.2% |
di-tert-butyl dicarbonate
gemcitabine hydrochloride
3′,5′-O-bis(tert-butoxycarbonyl)-gemcitabine
Conditions | Yield |
---|---|
With potassium hydroxide In 1,4-dioxane at 24℃; Substitution; | 90% |
With potassium hydroxide In 1,4-dioxane at 22℃; for 2h; Inert atmosphere; | 71% |
With potassium hydroxide In 1,4-dioxane; water at 4 - 22℃; for 1h; Inert atmosphere; | 71% |
benzoyl chloride
gemcitabine hydrochloride
N4-benzoyl-2'-deoxy-2',2'-difluorocytidine
Conditions | Yield |
---|---|
Stage #1: gemcitabine hydrochloride With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 2.5h; Reflux; Stage #2: benzoyl chloride With 1-methyl-1H-imidazole In dichloromethane at 20℃; for 3h; Stage #3: With triethylamine In methanol; dichloromethane at 20℃; for 1.5h; | 83% |
Stage #1: gemcitabine hydrochloride With pyridine; chloro-trimethyl-silane at 0 - 20℃; for 0.5h; Stage #2: benzoyl chloride at 0 - 20℃; | 76% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With pyridine at 50℃; for 20h; Inert atmosphere; | 80.1% |
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: gemcitabine hydrochloride With water; bromine at 0 - 5℃; for 1h; Stage #2: With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine In hexane at 0 - 60℃; for 1h; Reagent/catalyst; Temperature; | 70.8% |
gemcitabine hydrochloride
11-azidoundecanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 65℃; Inert atmosphere; | 70% |
Conditions | Yield |
---|---|
With pyridine In dimethyl sulfoxide at 20℃; for 24h; | 68.6% |
(N-(methacryloyl)glycylphenylalanylleucylglycyl)thiazolidine-2-thione
gemcitabine hydrochloride
N-methacyloylglycylphenylalanylleucylglycyl-gemcitabine
Conditions | Yield |
---|---|
With pyridine at 50℃; for 12h; Inert atmosphere; | 66.1% |
With pyridine at 50℃; for 12h; Inert atmosphere; | 66.1% |
10-undecenoic acid
gemcitabine hydrochloride
4-N-(10-undecenoyl)-2'-deoxy-2',2'-difluorocytidine
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide; N,N-dimethyl-formamide at 20 - 65℃; Inert atmosphere; | 66% |
gemcitabine hydrochloride
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Conditions | Yield |
---|---|
Stage #1: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: gemcitabine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; | 65% |
3-(tert-butyloxycarbonylamino)propionic acid
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide; N,N-dimethyl-formamide Inert atmosphere; Heating; | 65% |
12-hydroxydodecanoic acid
4-Nitrophenyl chloroformate
gemcitabine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 12-hydroxydodecanoic acid; 4-Nitrophenyl chloroformate With pyridine; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 5h; Stage #2: gemcitabine hydrochloride With triethylamine In N,N-dimethyl-formamide for 24h; | 64.3% |
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 25℃; for 18h; Inert atmosphere; | 63% |
Stage #1: 3-(tritylthio) propanoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: gemcitabine hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 0.408333h; | 45% |
Conditions | Yield |
---|---|
Stage #1: gemcitabine hydrochloride With pyridine; chloro-trimethyl-silane In acetonitrile at 0 - 20℃; for 4h; Stage #2: hex-5-ynoic acid With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 60℃; for 18h; Stage #3: With ethanol at 45℃; for 4h; | 63% |
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