Ethyl 3,3,3-trifluoropyruvate Commercial product High purity ≥98.0% Customized product Our Key Technology: 1. Low Temperature Reactions 2. Coupling Reactions 3. Fluorine Chemistry 4. Asymmetric Hydrogenat
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inquiryProduct description: Product name Ethyl trifluoropyruvate CAS number 13081-18-0 Assay ≥99% Appearance Yellow to yellowish transparent liquid Capacity 200mt/year Application O
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inquiryTIANFUCHEM--13081-18-0--Ethyl trifluoropyruvate factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
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inquiryProduct Name Ethyl trifluoropyruvate Synonyms Ethyl trifluoropyruvate;Trifluoropyruvic acid ethyl ester CAS: 13081-18-0 MF: - MW: -
Cas:13081-18-0
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inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
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Cas:13081-18-0
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inquiryProduct name: Ethyl Trifluoropyruvate CAS No.: 13081-18-0 Molecule Formula:C4H3F3O3 Molecule Weight:156.06 Purity: 99.0% Package: 250kg/drum Description:Yellow to pale yellow clear liquid Manufacture Standards:Enterprise Standard
Cas:13081-18-0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:13081-18-0
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Product Name: Ethyl trifluoropyruvate CAS: 13081-18-0 MF: C5H5F3O3 MW: 170.09 EINECS: Mol File: 13081-18-0.mol Ethyl trifluoropyruvate Structure Ethyl trifluoropyruvate Chemical Properties Boiling point 42 °C(lit.) densit
Cas:13081-18-0
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With SbF5 | 83% |
With sulfuric acid; silica gel | |
With sulfuric acid; silica gel at 140℃; |
2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
A
1-fluoroethane
B
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
antimony pentafluoride In neat (no solvent) | A n/a B 83% |
ethyl 3,3,3-trifluoro-2-hydroxypropanoate
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With sodium hypochlorite pentahydrate In acetonitrile at 20℃; for 0.5h; Reagent/catalyst; Solvent; | 69% |
ethyl 3,3,3-trifluoropyruvate ethylhemiketal
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With sulfuric acid under 16.5017 - 49.505 Torr; | 67% |
Bromotrifluoromethane
oxalic acid diethyl ester
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With zinc In pyridine at 20℃; for 2h; other esters; other perfluoroalkyl iodide; | 38% |
With zinc In pyridine at 20℃; for 2h; | 38% |
With zinc In pyridine at 20℃; 1) pyridine, 20 deg C; | 38% |
ethanol
α,α-dihydroxyperfluoropropionic acid
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With hydrogenchloride Heating; |
allylbenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.5h; Ene reaction; | 100% |
With silver hexafluoroantimonate; (R)-(2,2'-bis(diphenylphosphanyl)biphenyl)dichloroplatinum(II) In dichloromethane at -20℃; for 1h; | 83% |
ethyl-3,3,3-trifluoropyruvate
methylenecyclohexane
Conditions | Yield |
---|---|
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.25h; Ene reaction; | 100% |
With silver hexafluoroantimonate; [(R)-BINAPHANE]PdCl2 In dichloromethane at 20℃; for 1h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 78% |
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.25h; Friedel-Crafts reaction; |
allylbenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.5h; Friedel-Crafts reaction; | 100% |
methanol
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
at 20℃; | 100% |
ethyl-3,3,3-trifluoropyruvate
1,2-diamino-benzene
3-(trifluoromethyl)quinoxalin-2-ol
Conditions | Yield |
---|---|
In tetrahydrofuran at 45℃; | 100% |
In tetrahydrofuran at 40 - 50℃; |
indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: indole In toluene at -78℃; for 4h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Catalytic behavior; Temperature; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 99.3% |
Stage #1: indole With C78H78N12O6 In tetrahydrofuran at -20℃; for 0.5h; Inert atmosphere; Stage #2: ethyl-3,3,3-trifluoropyruvate In tetrahydrofuran at -20℃; for 12h; Inert atmosphere; enantioselective reaction; | 92% |
With (3aS,11aS,14aR,16bR)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Schlenk technique; Inert atmosphere; enantioselective reaction; |
ethyl-3,3,3-trifluoropyruvate
5-chloro-1H-indole
Conditions | Yield |
---|---|
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 5-chloro-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 99% |
Stage #1: 5-chloro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 99.3% |
With cinchonidine In diethyl ether at -8℃; |
5-bromo-1H-indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
Stage #1: 5-bromo-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 99.1% |
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 5-bromo-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 96% |
With cinchonidine In diethyl ether at -8℃; | |
With cinchonidine In diethyl ether at -8℃; for 3h; enantioselective reaction; |
carbamic acid-(1-trichloromethyl-1-methyl-ethyl ester)
ethyl-3,3,3-trifluoropyruvate
Ethyl 2-(2,2,2-Trichloro-tert-butoxycarbonylamino)-2-hydroxy-3,3,3-trifluoropropionate
Conditions | Yield |
---|---|
In dichloromethane | 99% |
ethyl-3,3,3-trifluoropyruvate
benzamide
Ethyl 2-benzoylamino-2-hydroxy-3,3,3-trifluoropropionate
Conditions | Yield |
---|---|
In dichloromethane for 2h; Ambient temperature; | 99% |
indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 65 %ee; | 99% |
With gallium(III) triflate In dichloromethane at 20℃; for 2h; Friedel-Crafts hydroxyalkylation; | 98% |
With K-10 montmorillonite In toluene at 60℃; for 0.0666667h; Friedel-Crafts hydroxyalkylation; | 98% |
1-methylindole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With gallium(III) triflate In dichloromethane at 20℃; for 2h; Friedel-Crafts hydroxyalkylation; | 99% |
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 47 %ee; | 99% |
With K-10 montmorillonite In toluene at 60℃; for 0.0666667h; Friedel-Crafts hydroxyalkylation; | 95% |
2-methyl-1H-indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.416667h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 76 %ee; | 99% |
With K-10 montmorillonite In toluene at 60℃; for 0.0833333h; Friedel-Crafts hydroxyalkylation; | 97% |
With aluminum (III) chloride In dichloromethane at 20℃; Friedel-Crafts Acylation; | 93% |
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere; | 91% |
With N2,N2'-bis(pyridin-2-ylmethyl)-1,1'-binaphthyl-2,2'-diamine In dichloromethane at 0℃; for 24h; Friedel-Crafts Alkylation; enantioselective reaction; | 87% |
5-methoxylindole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 71 %ee; | 99% |
With K-10 montmorillonite In toluene at 60℃; for 0.0833333h; Friedel-Crafts hydroxyalkylation; | 97% |
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere; | 96% |
ethyl-3,3,3-trifluoropyruvate
3-phenylaminocyclohex-2-enone
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.5h; aldol condensation-cyclization; | 99% |
ethyl-3,3,3-trifluoropyruvate
5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.5h; aldol condensation-cyclization; | 99% |
ethyl-3,3,3-trifluoropyruvate
3-(benzylamino)cyclopent-2-en-1-one
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.5h; aldol condensation; | 99% |
indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With C32H40N4O4; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 99% |
Stage #1: indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 98% |
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper (I) trifluoromethane sulfonate toluene complex; C24H26N2O2 In diethyl ether at -98 - 20℃; for 0.333333h; Inert atmosphere; Stage #2: indole In diethyl ether at -98℃; for 1.5h; Friedel Crafts acylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 98% |
Stage #1: ethyl-3,3,3-trifluoropyruvate With 2,6-bis(1-[toluene-4-sulfonyl]-[4S,5S]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)benzene; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at -78℃; for 0.5h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: indole In dichloromethane at -78℃; for 3h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 95% |
With Cu(2+)*2C32H40N4O4; Cu(2+)*C32H40N4O4 at 0℃; for 1h; Friedel-Crafts Alkylation; Schlenk technique; Inert atmosphere; enantioselective reaction; |
5-fluoro-1H-indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 5-fluoro-1H-indole In toluene at -78℃; for 4h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 99% |
Stage #1: 5-fluoro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 98.6% |
Stage #1: 5-fluoro-1H-indole With C78H78N12O6 In tetrahydrofuran at -20℃; for 0.5h; Inert atmosphere; Stage #2: ethyl-3,3,3-trifluoropyruvate In tetrahydrofuran at -20℃; for 12h; Inert atmosphere; enantioselective reaction; | 87% |
5-iodo-1H-indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 5-iodo-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 98.6% |
With cinchonidine In diethyl ether at -8℃; |
ethyl-3,3,3-trifluoropyruvate
5-chloro-1H-indole
Conditions | Yield |
---|---|
Stage #1: 5-chloro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
Stage #1: ethyl-3,3,3-trifluoropyruvate With 2,6-bis(1-[toluene-4-sulfonyl]-[4S,5S]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)benzene; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at -78℃; for 0.5h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 5-chloro-1H-indole In dichloromethane at -78℃; for 19h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 95% |
With cinchonine In diethyl ether at -8℃; |
6-methylindole
ethyl-3,3,3-trifluoropyruvate
3,3,3-trifluoro-2-hydroxy-2-(6-methyl-1H-indol-3-yl)-propionic acid ethyl ester
Conditions | Yield |
---|---|
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere; | 99% |
With triethylamine In dichloromethane at 0℃; Friedel Crafts alkylation; | |
With copper(II) bis(trifluoromethanesulfonate) In chloroform at 25℃; for 16h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; |
7-methyl-1H-indole
ethyl-3,3,3-trifluoropyruvate
3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 7-methyl-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction; | 97.6% |
7-methyl-1H-indole
ethyl-3,3,3-trifluoropyruvate
3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester
Conditions | Yield |
---|---|
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere; | 99% |
With triethylamine In dichloromethane at 0℃; Friedel Crafts alkylation; | |
With copper(II) bis(trifluoromethanesulfonate) In chloroform at 25℃; for 16h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; |
5-fluoro-1H-indole
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
Stage #1: 5-fluoro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
7-ethyl-1H-indole
ethyl-3,3,3-trifluoropyruvate
3,3,3-trifluoro-2-hydroxy-2-(7-ethyl-1H-indol-3-yl)-propionic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 7-ethyl-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction; | 99% |
1-ethynyl-2-methylbenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction; | 99% |
1-ethynyl-3-methyl-benzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction; | 99% |
ethyl-3,3,3-trifluoropyruvate
phenylacetylene
(S)-ethyl 2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate
Conditions | Yield |
---|---|
With C54H48N5O7Rh In diethyl ether at 25℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale; enantioselective reaction; | 99% |
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction; | 95% |
1-[2-(4-methoxyphenyl)ethynyl]-4-nitrobenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; (S)-BINAP-PdCl2 In dichloromethane at 0℃; for 12h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 99% |
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