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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-4-Fluorotoluene supplier in China

Cas:1422-53-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $8.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Bromo-4-Fluorotoluene

Cas:1422-53-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

2-Bromo-4-Fluorotoluene CAS 1422-53-3

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 1422-53-3 with fast shipping

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 2-Bromo-4-fluorotoluene Synonyms: 2-Bromo-4-fluoro-1-methylbenzene CAS:1422-53-3 MF: C7H6BrF Appearance: colorless transparent liquid Storage: Preserve in well-closed, light-resistant and airtight containers. Package: 25kgs/drum Applicat

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Bromo-4-fluorotoluene 1422-53-3

Cas:1422-53-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-Bromo-4-fluorotoluene CAS: 1422-53-3 MF: C7H6BrF MW: 189.02 EINECS: 215-830-0 Mol File: 1422-53-3.mol 2-Bromo-4-fluorotoluene Structure 2-Bromo-4-fluorotoluene Chemical Properties Boiling point 170-172 °C (

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Bromo-4-fluorotoluene CAS:1422-53-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

2-Bromo-4-fluorotoluene CAS:1422-53-3

Cas:1422-53-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

2-Bromo-4-fluorotoluene CAS NO.1422-53-3

Cas:1422-53-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 1422-53-3 ,2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Bromo-4-Fluorotoluene

Cas:1422-53-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Bromo-4-fluorotoluene CAS NO.1422-53-3

Cas:1422-53-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

1422-53-3 C7H6BrF 2-Bromo-4-fluorotolueneAppearance:white powder Storage:Normal temperature Package:according to customers' requirements Application:Fluorin-contained toluene series;Aromatic Halides (substituted);Halogen toluene;Misc

1422-53-3 C7H6BrF 2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: 2-Bromo-4-Fluorotoluene CAS No.:1422-53-3 Molecule Formula:C7H6BrF Molecule Weight:189.02 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING IT

High Quality 2-Bromo-4-Fluorotoluene on stock

Cas:1422-53-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--1422-53-3--2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Metric Ton

FOB Price: $700.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-Bromo-4-fluorotoluene

Cas:1422-53-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

3-bromo-4-methylaniline
7745-91-7

3-bromo-4-methylaniline

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

Conditions
ConditionsYield
(i) NaNO2, aq. HCl, aq. HBF4, (ii) (pyrolysis); Multistep reaction;
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-6-fluoro-3-methylbenzaldehyde

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 0.5h; Reagent/catalyst; Temperature;
92%
Stage #1: 2-bromo-4-fluorotoluene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 1h;
91.3%
Stage #1: 2-bromo-4-fluorotoluene With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 2.16667h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 0.333333h;
84%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

2,3-Dimethylaniline
87-59-2

2,3-Dimethylaniline

5-fluoro-2,2',3'-trimethyl-diphenylamine
917241-99-7

5-fluoro-2,2',3'-trimethyl-diphenylamine

Conditions
ConditionsYield
With sodium t-butanolate; palladium diacetate; 2'-dicyclohexylphosphanyl-6-hydroxy-biphenyl-3-sulfonic acid In diethylene glycol dimethyl ether at 120℃; for 15h; Product distribution / selectivity;90%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

tert butyl 4-formylpiperidine-1-carboxylate
137076-22-3

tert butyl 4-formylpiperidine-1-carboxylate

tert-butyl 4-(5-fluoro-2-methylbenzoyl)piperidine-1-carboxylate

tert-butyl 4-(5-fluoro-2-methylbenzoyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With Quinuclidine; [nickel(II) (4,4'-di-tert-butyl-2,2'-bipyridine)(bromide)2]; [Ir(C6H2F2-C5H3NCF3)2(4,4′-di-tert-butyl-2,2′-dipyridyl)]; potassium carbonate In 1,4-dioxane at 20℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;90%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

1-chloro-1-methylsiletane
2351-34-0

1-chloro-1-methylsiletane

1-(2-bromo-6-fluoro-3-methylphenyl)-1-methylsiletane

1-(2-bromo-6-fluoro-3-methylphenyl)-1-methylsiletane

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃; Inert atmosphere; Schlenk technique;90%
methyl(tetramethylene)silyl chloride
2406-31-7

methyl(tetramethylene)silyl chloride

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

1-(2-bromo-6-fluoro-3-methylphenyl)-1-methylsilolane

1-(2-bromo-6-fluoro-3-methylphenyl)-1-methylsilolane

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃; Inert atmosphere; Schlenk technique;90%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

(1-acetylpiperidin-4-yl)acetic acid
78056-60-7

(1-acetylpiperidin-4-yl)acetic acid

2-(1-acetylpiperidin-4-yl)-1-(4-bromo-2-fluoro-5-methylphenyl)ethan-1-one

2-(1-acetylpiperidin-4-yl)-1-(4-bromo-2-fluoro-5-methylphenyl)ethan-1-one

Conditions
ConditionsYield
Stage #1: (1-acetylpiperidin-4-yl)acetic acid With thionyl chloride at 20℃;
Stage #2: 2-bromo-4-fluorotoluene With aluminum (III) chloride at 80℃; for 2h;
88%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

2-bromo-4-fluorobenzyl bromide
61150-57-0

2-bromo-4-fluorobenzyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 70℃; for 18h;87%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 21h; Heating / reflux;87%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 2h; Heating / reflux;76%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

phenylboronic acid
98-80-6

phenylboronic acid

3-fluoro-6-methylbiphenyl
939771-54-7

3-fluoro-6-methylbiphenyl

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane at 80 - 120℃; for 0.666667h; Microwave irradiation;86%
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane at 80 - 120℃; for 0.666667h; Microwave;86%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

carbon dioxide
124-38-9

carbon dioxide

2-bromo-6-fluoro-3-methylbenzoic acid
1359857-60-5

2-bromo-6-fluoro-3-methylbenzoic acid

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With n-butyllithium; diisopropylamine In tetrahydrofuran Cooling with ice;
Stage #2: carbon dioxide In tetrahydrofuran for 0.333333h; Cooling with ice;
85%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

tris(5-fluoro-2-methylphenyl)phosphane

tris(5-fluoro-2-methylphenyl)phosphane

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With magnesium In tetrahydrofuran at 20 - 75℃;
Stage #2: With phosphorus trichloride In tetrahydrofuran for 1h; Heating;
82%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

2-bromo-4-fluorobenzoic acid
1006-41-3

2-bromo-4-fluorobenzoic acid

Conditions
ConditionsYield
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 60h; Irradiation;79%
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 60h; UV-irradiation;78.5%
With 2,2'-azobis(isobutyronitrile); oxygen; cobalt(II) diacetate tetrahydrate; acetic acid; sodium bromide at 130℃; under 9000.9 Torr; for 1.5h; Green chemistry;41%
With potassium permanganate; magnesium sulfate
With oxygen; cobalt(III) acetate
cis-dichlorobis(triphenylphosphine)platinum(II)
10199-34-5, 14056-88-3, 15604-36-1

cis-dichlorobis(triphenylphosphine)platinum(II)

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

cis-bis(2-methyl-5-fluorophenyl)bis(triphenylphosphane)platinum(II)

cis-bis(2-methyl-5-fluorophenyl)bis(triphenylphosphane)platinum(II)

Conditions
ConditionsYield
With n-butyl lithium In diethyl ether byproducts: LiCl; formation of Li-aryl compd. from BuLi and aryl compd. (room temp., 1 h), addn. of Pt complex in one portion to Li compd. soln. under inert gas, room temp.; stirring, 20°C, 0.5 h; hydrolysis of excess of Li compd. by ice-water; filtration; chromy. (silica gel, CH2Cl2); elem. anal.;77%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

N-cyano-N-phenyl-p-toluenesulfonamide
55305-43-6

N-cyano-N-phenyl-p-toluenesulfonamide

3-fluoro-6-methylbenzonitrile
77532-79-7

3-fluoro-6-methylbenzonitrile

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With magnesium; lithium chloride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: N-cyano-N-phenyl-p-toluenesulfonamide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
77%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

formic acid ethyl ester
109-94-4

formic acid ethyl ester

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-6-fluoro-3-methylbenzaldehyde

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.5h;
Stage #2: formic acid ethyl ester In tetrahydrofuran at -78℃; for 0.0833333h;
76.9%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

(2,6-dimethoxyphenyl)boronic acid
23112-96-1

(2,6-dimethoxyphenyl)boronic acid

5-fluoro-2',6'-dimethoxy-2-methylbiphenyl
1267964-65-7

5-fluoro-2',6'-dimethoxy-2-methylbiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 18h; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;76%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

3-fluoro-6-methylaniline
367-29-3

3-fluoro-6-methylaniline

Conditions
ConditionsYield
With ammonium sulfate; (R)-(-)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; bis(tri-ortho-tolylphosphine)palladium(0); sodium t-butanolate In 1,4-dioxane at 100℃; for 8h; Inert atmosphere; Glovebox;76%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

anthranil
271-58-9

anthranil

C14H10FNO

C14H10FNO

Conditions
ConditionsYield
With potassium acetate In N,N-dimethyl acetamide at 150℃; for 20h; Inert atmosphere;60%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

1-bromo-2-methyl-4-nitro-5-fluorobenzene
64695-96-1

1-bromo-2-methyl-4-nitro-5-fluorobenzene

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate at 0 - 25℃; for 2h; Inert atmosphere;54.3%
With nitric acid; Nitrogen dioxide
With potassium nitrite; sulfuric acid In water at 0 - 25℃; for 15.75h;
5-phenylimidazo[2,1-b][1,3,4]thiadiazole
25752-18-5

5-phenylimidazo[2,1-b][1,3,4]thiadiazole

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

2-((5-fluoro-2-methylphenyl)thio)-4-phenyl-1H-imidazole

2-((5-fluoro-2-methylphenyl)thio)-4-phenyl-1H-imidazole

Conditions
ConditionsYield
With copper acetylacetonate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 2h; Microwave irradiation;53%
trifluoroacetonitrile
353-85-5

trifluoroacetonitrile

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

A

2-(5-fluoro-2-methylphenyl)-2,4,6-tris(trifluoromethyl)-1,2-dihydro-1,3,5-triazine

2-(5-fluoro-2-methylphenyl)-2,4,6-tris(trifluoromethyl)-1,2-dihydro-1,3,5-triazine

B

2,2,2-trifluoro-1-(5-fluoro-2-methylphenyl)ethanimine

2,2,2-trifluoro-1-(5-fluoro-2-methylphenyl)ethanimine

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With magnesium In diethyl ether
Stage #2: trifluoroacetonitrile In diethyl ether Further stages.;
A 23%
B 49%
1-phenylmethyl-4-piperidone
3612-20-2

1-phenylmethyl-4-piperidone

hexane-EtOAc

hexane-EtOAc

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

1-benzyl-4-(4-fluoro-2-methylphenyl)piperidin-4-ol
216311-09-0

1-benzyl-4-(4-fluoro-2-methylphenyl)piperidin-4-ol

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran46%
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

2-bromo-4-fluorobenzaldehyde
59142-68-6

2-bromo-4-fluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluorotoluene With N-Bromosuccinimide; dibenzoyl peroxide In ethyl acetate at 80℃; for 1h;
Stage #2: With hexamethylenetetramine In water; acetic acid at 100℃; for 1h;
Stage #3: With hydrogenchloride In water for 1h;
41%
With chromium(VI) oxide; acetic anhydride
(E)-2,7-dimethyl-2,6-octadienal
72172-57-7

(E)-2,7-dimethyl-2,6-octadienal

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

(E)-4-(5-fluoro-2-methylphenyl)-2,7-dimethylocta-2,6-dienal

(E)-4-(5-fluoro-2-methylphenyl)-2,7-dimethylocta-2,6-dienal

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; tricyclohexylphosphine In N,N-dimethyl-formamide at 110 - 120℃; Inert atmosphere;28%
t-butylnitrite
917-95-3

t-butylnitrite

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

N-tert-Butyl-N-(5-fluoro-2-methyl-phenyl)-hydroxylamine
53104-10-2

N-tert-Butyl-N-(5-fluoro-2-methyl-phenyl)-hydroxylamine

Conditions
ConditionsYield
(i) Mg, BrCH2CH2Br, (ii) /BRN= 1737613/; Multistep reaction;
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

3-Brom-4-methyl-2.6-dinitrophenol
64695-95-0

3-Brom-4-methyl-2.6-dinitrophenol

Conditions
ConditionsYield
(i) NO2/HNO3, (ii) aq. NaOH, CHCl3; Multistep reaction;
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

ethyl acrylate
140-88-5

ethyl acrylate

Ethyl 3-(5'-fluoro-2'-methylphenyl)propanoate
137466-12-7

Ethyl 3-(5'-fluoro-2'-methylphenyl)propanoate

Conditions
ConditionsYield
With magnesium; copper(l) chloride 1.) diethyl ether, reflux, 2h, 2.) -17 deg C; Yield given. Multistep reaction;
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

succinic acid monomethylester chloride
1490-25-1

succinic acid monomethylester chloride

methyl 3-(5-fluoro-2-methylbenzoyl)propionate
97072-91-8

methyl 3-(5-fluoro-2-methylbenzoyl)propionate

Conditions
ConditionsYield
With magnesium; cadmium(II) chloride 1.) diethyl ether; 2.) benzene, Et2O, 45 min, reflux; 3.) benzene, reflux, 1.5 h; overnight, RT; Yield given. Multistep reaction;
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

4-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
174603-56-6

4-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 62 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating; IR illumination
2.1: sodium hydride / 1,2-dimethoxy-ethane / 1 h / 20 °C
2.2: 40 percent / 1,2-dimethoxy-ethane / 1.5 h / Heating
3.1: aq. KOH / 4.5 h / Heating
3.2: 91 percent / aq. H2SO4 / 18 h / Heating
4.1: oxalyl chloride / CH2Cl2 / 18 h / 20 °C
5.1: aluminum chloride / CH2Cl2 / 2 h / Heating
View Scheme
2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

3-(2-bromo-4-fluorophenyl)propionyl chloride

3-(2-bromo-4-fluorophenyl)propionyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 62 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating; IR illumination
2.1: sodium hydride / 1,2-dimethoxy-ethane / 1 h / 20 °C
2.2: 40 percent / 1,2-dimethoxy-ethane / 1.5 h / Heating
3.1: aq. KOH / 4.5 h / Heating
3.2: 91 percent / aq. H2SO4 / 18 h / Heating
4.1: oxalyl chloride / CH2Cl2 / 18 h / 20 °C
View Scheme

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