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inquiryassay above 99% Ritonavir APIs High purity In stock Ritonavir is an orally potent inhibitor of human immunodeficiency virus-1 (HIV-1) and human immunodeficiency virus-2 (HIV-2) aspartic proteases, blocking this enzyme promotes the production of mo
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiryItems Standard Result HPLC-content determination ≥98% 98.34% Appearance White floc
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiryUnique advantages for Ritonavir Cas 155213-67-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:-20°C Freezer Package:1kg/foil bag;25kg/drum
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inquiryRitonavir CAS No.:155213-67-5 Name: Ritonavir Synonyms: 1,3-Thiazol-5-ylmethyl N-[(2S,3S,5R)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]am
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inquiryRitonavir English name: Ritonavir Chemical name: 1,3-Thiazol-5-ylmethylN-[(2S,3S,5R)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diph
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Ritonavir CAS NO: 155213-67-5 Molecular formula:C37H48N6O5S2 Molecular weight:720.9442 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryOur company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry155213-67-5 Ritonavir product Name Ritonavir Synonyms 1,3-thiazol-5-ylmethyl n-[(2s,3s,5r)-3-hydroxy-5-[[(2s)-3-methyl-2-[[methyl-[(2-propan-2
Appearance:White to off-white powder Storage:Room temperature Package:1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in China
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiryBeluga chemical professional supply High-quality Ritonavir CAS 155213-67-5 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryCompany information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
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inquiryOur Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine
(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane
ritonavir
Conditions | Yield |
---|---|
Stage #1: N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine With N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide at 27℃; for 0.5h; Stage #2: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane for 7h; Temperature; | 91.5% |
With diethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In butanone at 41℃; for 0.666667h; Concentration; Temperature; | 87.4% |
With N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; 1-hydroxybenzotriazol-hydrate In tetrahydrofuran for 16h; Ambient temperature; Yield given; | |
Stage #1: N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine With pivaloyl chloride; triethylamine In dichloromethane at 0 - 10℃; Inert atmosphere; Large scale; Stage #2: With dmap In dichloromethane at 0 - 10℃; for 0.5h; Large scale; Stage #3: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane In dichloromethane at 25 - 35℃; Large scale; |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In ethyl acetate at 50 - 60℃; for 9h; | 85.29% |
Conditions | Yield |
---|---|
Stage #1: C37H53N5O5S With hydrogenchloride In water; ethyl acetate at 0 - 20℃; for 6h; Green chemistry; Stage #2: (5-thiazolyl)methyl 2,2,2-trichloroethanol carbonate With triethylamine In ethyl acetate at 0 - 20℃; for 12h; Green chemistry; | 79% |
ritonavir
Conditions | Yield |
---|---|
With PBS In ethanol pH=7.4; Kinetics; Further Variations:; pH-values; |
L-valine methylester hydrochloride
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4-methylmorpholine / CH2Cl2 / Ambient temperature 2: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 3: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature 4: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme |
((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 16 percent / tetrahydrofuran / 4 h / Ambient temperature 2: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme |
N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 2: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature 3: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 6 h / 50 - 60 °C / Green chemistry 2.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 3 h / 0 - 10 °C / Green chemistry 2.2: 6 h / 0 - 20 °C / Green chemistry 3.1: hydrogenchloride / ethyl acetate; water / 6 h / 0 - 20 °C / Green chemistry 3.2: 12 h / 0 - 20 °C / Green chemistry View Scheme |
N-<<(4-nitrophenyl)oxy>carbonyl>-L-valine methyl ester
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 2: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature 3: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme |
N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature 2: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme |
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2O / 1 h 2: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 3: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature 4: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature View Scheme |
N-[[N-methyl-N-[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl]-L-valinyl hydroxysuccinimide ester
(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane
ritonavir
Conditions | Yield |
---|---|
In ethyl acetate at 0 - 20℃; for 18h; | |
In ethyl acetate at 0 - 20℃; for 18h; |
(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane
ritonavir
Conditions | Yield |
---|---|
In ethyl acetate Solvent; | 55.7 g |
(2S,3S,5S)-5-(t-butyloxycarbonylamino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water; ethyl acetate / 3 h / 50 °C 2: ethyl acetate View Scheme |
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane / 1 h / 10 °C 2: hydrogenchloride / ethyl acetate; water / 4 h / 10 - 20 °C 3: sodium hydrogencarbonate / ethyl acetate / 9 h / 50 - 60 °C View Scheme |
N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 10 °C 2: dichloromethane / 1 h / 10 °C 3: hydrogenchloride / ethyl acetate; water / 4 h / 10 - 20 °C 4: sodium hydrogencarbonate / ethyl acetate / 9 h / 50 - 60 °C View Scheme |
(S)-3-methyl-2-[(2,2,2-trichloroethoxy)carbonylamino]butyric acid
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 6 h / 50 - 60 °C / Green chemistry 2.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 3 h / 0 - 10 °C / Green chemistry 2.2: 6 h / 0 - 20 °C / Green chemistry 3.1: hydrogenchloride / ethyl acetate; water / 6 h / 0 - 20 °C / Green chemistry 3.2: 12 h / 0 - 20 °C / Green chemistry View Scheme |
dimethylsulfide
ritonavir
N1-((1S,3S,4S)-1-benzyl-3-[(methylthio)methoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide
Conditions | Yield |
---|---|
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 84% |
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 84% |
4-((di-tert-butoxyphosphoryl)oxy)-3,3-dimethylbutanoic acid
ritonavir
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 86h; | 81% |
dibenzyl N,N-diethylphosphoramidite
ritonavir
N1-((1S,3S,4S)-1-benzyl-3-{[bis(benzyloxy)phosphoryl]oxy}-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide
Conditions | Yield |
---|---|
Stage #1: dibenzyl N,N-diethylphosphoramidite; ritonavir With 1H-tetrazole In tetrahydrofuran at 20℃; for 4h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; Dichlorodifluoromethane at -45 - 20℃; for 1h; | 76% |
diethyl sulphide
ritonavir
N1-((1S,3S,4S)-1-benzyl-3-[1-(ethylthio)ethoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide
Conditions | Yield |
---|---|
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 75% |
With dibenzoyl peroxide In acetonitrile at 0℃; for 3h; | 75% |
diisobutyl sulfide
ritonavir
N1-((1S,3S,4S)-1-benzyl-3-[1-(isobutylthio)-2-methylpropoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide
Conditions | Yield |
---|---|
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 75% |
With dibenzoyl peroxide In acetonitrile at 0℃; for 1.5h; | 75% |
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 72% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h; | 70.3% |
Dibutyl sulfide
ritonavir
N1-((1S,3S,4S)-1-benzyl-3-[1-(butylthio)butoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide
Conditions | Yield |
---|---|
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 68% |
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 7h; | 68% |
Conditions | Yield |
---|---|
In 1,2-dichloro-ethane at 75℃; for 6h; |
ritonavir
Conditions | Yield |
---|---|
With Dess-Martin periodane In dichloromethane at 20℃; for 6h; | |
With Dess-Martin periodane |
Conditions | Yield |
---|---|
With 1H-tetrazole In tetrahydrofuran at 20℃; for 4h; |
Conditions | Yield |
---|---|
With human CYP3A4; NADPH; NADPH-cytochrome P450 reductase In aq. phosphate buffer at 37℃; for 0.333333h; pH=7.7; Enzymatic reaction; | |
With cytochrome P450 monooxygenases from Actinosynnema mirum at 25℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With human CYP2B6; NADPH; NADPH-cytochrome P450 reductase In aq. phosphate buffer at 37℃; for 0.333333h; pH=7.7; Enzymatic reaction; |
Conditions | Yield |
---|---|
With human CYP3A4; NADPH; NADPH-cytochrome P450 reductase In aq. phosphate buffer at 37℃; for 0.333333h; pH=7.7; Enzymatic reaction; |
ritonavir
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate Concentration; Temperature; Solvent; Inert atmosphere; |
ritonavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 °C 2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / 115 °C View Scheme |
Conditions | Yield |
---|---|
at 75℃; |
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