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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Methylthiophenylacetic acid Manufacturer/High quality/Best price/In stock

Cas:16188-55-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Methylthiophenylaceticacid

Cas:16188-55-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Methylthio)-benzeneacetic acid

Cas:16188-55-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-Methylthiophenylacetic acid CAS 16188-55-9

Cas:16188-55-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 16188-55-9 with best quality

Cas:16188-55-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

4-Methylthiophenylacetic acid CAS NO 16188-55-9

Cas:16188-55-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzeneacetic acid,4-(methylthio)- 16188-55-9

Cas:16188-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Benzeneacetic acid,4-(methylthio)-/ LIDE PHARMA- Factory supply / Best price

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-(methylthio)phenylacetic acid 16188-55-9

Cas:16188-55-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Methylthiophenylaceticacid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

high purity 4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(methylthio)phenylacetic acid

Cas:16188-55-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzeneacetic acid,4-(methylthio)-

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzeneacetic acid,4-(methylthio)-

Cas:16188-55-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colorless transparent liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used in organic syn

4-Methylthiophenylacetic acid

Cas:16188-55-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-(Methylthio)phenylacetic acid cas no. 16188-55-9 98%

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

4-Methylthio phenyl acetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-(methylthio)phenylacetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(4-Methylsulfanylphenyl)acetic acid

Cas:16188-55-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-(4-(methylthio)phenyl)-2-oxoacetic acid
53066-99-2

2-(4-(methylthio)phenyl)-2-oxoacetic acid

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)-2-oxoacetic acid With sodium iodide In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With chloro-trimethyl-silane In dichloromethane at 20℃; for 2h; Inert atmosphere; regioselective reaction;
91%
Stage #1: 2-(4-(methylthio)phenyl)-2-oxoacetic acid With sodium hydroxide; hydrazine In water at 75℃; for 120h; Wolff-Kishner Reduction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1.5;
2-[4-(methylsulfanyl)phenyl]acetonitrile
38746-92-8

2-[4-(methylsulfanyl)phenyl]acetonitrile

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
Stage #1: 2-[4-(methylsulfanyl)phenyl]acetonitrile With potassium hydroxide; water for 8h; Reflux;
Stage #2: With hydrogenchloride; water at 20℃;
82%
With sodium hydroxide In ethylene glycol; ethyl acetate
With sulfuric acid; water for 1h; Reflux;
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
With copper(I) bromide In N,N-dimethyl-formamide at 130℃; for 24h; Inert atmosphere;79.3%
sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2-(4-bromophenyl)-acetic acid
1878-68-8

2-(4-bromophenyl)-acetic acid

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
With copper(I) bromide In N,N-dimethyl-formamide at 130℃; Inert atmosphere;76.1%
4-(Methylthio)acetophenone
1778-09-2

4-(Methylthio)acetophenone

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
With morpholine; sulfur for 20h; Heating;53%
Stage #1: 4-(Methylthio)acetophenone With morpholine; sulfur at 130℃; for 48h; Willgerodt reaction;
Stage #2: With sodium hydroxide; water at 130℃; for 24h;
Stage #3: With hydrogenchloride In water
(4-iodophenyl)acetic acid
1798-06-7

(4-iodophenyl)acetic acid

cuprous methylmercaptide
4856-13-7

cuprous methylmercaptide

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
With quinoline at 200℃;
morpholine
110-91-8

morpholine

4-(Methylthio)acetophenone
1778-09-2

4-(Methylthio)acetophenone

sulfur

sulfur

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
Erhitzen des Reaktionsgemisches mit wss. HCl;
1-<4-methylsulfanyl-phenyl>-ethanone-(1)

1-<4-methylsulfanyl-phenyl>-ethanone-(1)

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
With morpholine; sulfur Erhitzen des Reaktionsgemisches mit wss. Salzsaeure;
methyl-phenyl-thioether
100-68-5

methyl-phenyl-thioether

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / AlCl3 / CHCl3 / 0 - 5 °C
2: 53 percent / S8, Morpholin / 20 h / Heating
View Scheme
methanol
67-56-1

methanol

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(4-methylsulfanyl-phenyl)-acetic acid methyl ester
70290-37-8

(4-methylsulfanyl-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid at 50℃; for 16h;100%
With thionyl chloride at 0 - 20℃; for 48h;100%
With sulfuric acid for 19h; Heating / reflux;98%
With sulfuric acid In benzene at 0 - 80℃; for 16h; Inert atmosphere;83.1%
With hydrogenchloride
2-(phenyl)pyrrolidine
1006-64-0

2-(phenyl)pyrrolidine

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-(4-(methylthio)phenyl)-1-(2-phenylpyrrolidin-1-yl)ethan-1-one

2-(4-(methylthio)phenyl)-1-(2-phenylpyrrolidin-1-yl)ethan-1-one

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(4-methylsulfanyl-phenyl)-acetic acid methyl ester
70290-37-8

(4-methylsulfanyl-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid In methanol98%
With sulfuric acid In methanol98%
With sulfuric acid In methanol92%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

methyl iodide
74-88-4

methyl iodide

(4-methylsulfanyl-phenyl)-acetic acid methyl ester
70290-37-8

(4-methylsulfanyl-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With sodium hydrogencarbonate In N,N-dimethyl-formamide for 0.25h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 24h;
97%
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With sodium hydrogencarbonate In N,N-dimethyl-formamide for 0.25h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 24h;
97%
ethanol
64-17-5

ethanol

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

ethyl 4-methylthiophenylacetate
14062-27-2

ethyl 4-methylthiophenylacetate

Conditions
ConditionsYield
With sulfuric acid for 8h; Heating;96%
With sulfuric acid for 8h; Heating / reflux;96%
With sulfuric acid79%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

1,3-dioxoisoindolin-2-yl 2-(4-(methylthio)phenyl)acetate

1,3-dioxoisoindolin-2-yl 2-(4-(methylthio)phenyl)acetate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In tetrahydrofuran at 20℃; Inert atmosphere;96%
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 0.5h;72%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-[4-(methylmercapto)phenyl]-1-ethanol
81227-89-6

2-[4-(methylmercapto)phenyl]-1-ethanol

Conditions
ConditionsYield
With borane In tetrahydrofuran at 0℃; for 5h;94%
With sodium hydroxide In tetrahydrofuran; methanol; diethyl ether84.4%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-methoxy-N-methyl-4-(methylthio)benzeneacetamide

N-methoxy-N-methyl-4-(methylthio)benzeneacetamide

Conditions
ConditionsYield
In dichloromethane93%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-4-(methylthio)benzeneacetamide

N-methoxy-N-methyl-4-(methylthio)benzeneacetamide

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With 1,1'-Carbonyl-di-(1,2,4-triazole) In dichloromethane at 20℃; for 0.333333h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃;
93%
aqueous sodium chloride

aqueous sodium chloride

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(1R,2R)-pseudoephedrine
321-97-1

(1R,2R)-pseudoephedrine

pivaloyl chloride
3282-30-2

pivaloyl chloride

N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl-2-(4-methylsulfanyl-phenyl)-acetamide
436141-37-6

N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl-2-(4-methylsulfanyl-phenyl)-acetamide

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water; toluene92.6%
4-amino-3-(4-methylthiobenzyl)-5-mercapto-1,2,4-triazole

4-amino-3-(4-methylthiobenzyl)-5-mercapto-1,2,4-triazole

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

C19H18N4S3
1144110-74-6

C19H18N4S3

Conditions
ConditionsYield
With trichlorophosphate for 8h; Heating;91%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

monomethyl auristatin E

monomethyl auristatin E

C48H75N5O8S

C48H75N5O8S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dimethyl sulfoxide for 1h;90%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(4-methylthiophenyl)acetic acid hydrazide
1257393-74-0

(4-methylthiophenyl)acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 8h; Reflux;86%
Multi-step reaction with 2 steps
1: Acidic conditions
2: hydrazine hydrate / ethanol / 8 h / Reflux
View Scheme
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

dibenzylamine
103-49-1

dibenzylamine

N,N-dibenzyl-2-(4-(methylthio)phenyl)acetamide

N,N-dibenzyl-2-(4-(methylthio)phenyl)acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;86%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-(pyrimidin-5-yl)phenol

2-(pyrimidin-5-yl)phenol

2-(pyrimidin-5-yl)phenyl 2-(4-(methylthio)phenyl)acetate

2-(pyrimidin-5-yl)phenyl 2-(4-(methylthio)phenyl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; for 12h; Sealed tube;86%
di-tert-butyl-diazodicarboxylate
870-50-8

di-tert-butyl-diazodicarboxylate

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

di-tert-butyl 1-(4-(methylthio)benzyl)hydrazine-1,2-dicarboxylate

di-tert-butyl 1-(4-(methylthio)benzyl)hydrazine-1,2-dicarboxylate

Conditions
ConditionsYield
With iron(III) sulfate; bis[(2-pyridyl)methyl]amine In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation;86%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-bromo-1-(4-fluorophenyl)-1-butanone

2-bromo-1-(4-fluorophenyl)-1-butanone

5-ethyl-4-(4-fluoro-phenyl)-5-hydroxy-3-(4-methylsulfanyl-phenyl)-5H-furan-2-one

5-ethyl-4-(4-fluoro-phenyl)-5-hydroxy-3-(4-methylsulfanyl-phenyl)-5H-furan-2-one

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With potassium hydroxide In water; N,N-dimethyl-formamide at 25 - 30℃;
Stage #2: 2-bromo-1-(4-fluorophenyl)-1-butanone In water; N,N-dimethyl-formamide at 25 - 30℃;
83%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-(4-(methylsulfinyl)phenyl)acetic acid
118362-28-0

2-(4-(methylsulfinyl)phenyl)acetic acid

Conditions
ConditionsYield
With sodium periodate In methanol; water at 0 - 20℃; for 2h;82%
With perchloric acid; dihydrogen peroxide In ethanol; water at 25℃; Rate constant;
With sodium periodate In ethanol at 25℃; Rate constant;
With 3-chloro-benzenecarboperoxoic acid at 25℃; Rate constant; also in the presence α-cyclodextrin; pH 1.6;
Benzylidenemalononitrile
2700-22-3

Benzylidenemalononitrile

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-(2-(4-(methylthio)phenyl)-1-phenylethyl)malononitrile

2-(2-(4-(methylthio)phenyl)-1-phenylethyl)malononitrile

Conditions
ConditionsYield
With iron(III) sulfate; bis[(2-pyridyl)methyl]amine In 1,2-dichloro-ethane at 20℃; for 12h; Inert atmosphere; Sealed tube; Irradiation;81%
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 2-(4-(methylthio)phenyl)-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)acetate

methyl 2-(4-(methylthio)phenyl)-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)acetate

Conditions
ConditionsYield
Stage #1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2-(4-(methylthio)phenyl)acetic acid With N4,N4,N7,N7-tetramethyl-1,10-phenanthroline-4,7-diamine; iron(II) acetate In tetrahydrofuran at 60℃; for 24h; Molecular sieve; Inert atmosphere; Schlenk technique;
Stage #2: diazomethyl-trimethyl-silane With methanol In tetrahydrofuran; hexane for 1h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran; hexane; ethyl acetate chemoselective reaction;
81%
phthalic anhydride
85-44-9

phthalic anhydride

2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(Z)-3-(4-methylsulfanylbenzylidene)isobenzofuran-1-one

(Z)-3-(4-methylsulfanylbenzylidene)isobenzofuran-1-one

Conditions
ConditionsYield
With sodium acetate In benzene at 230 - 240℃;80%
With sodium acetate Heating;65%
With sodium acetate Heating;
With sodium acetate In toluene at 210 - 245℃; Inert atmosphere;
With sodium acetate In toluene at 210 - 245℃; Dean-Stark; Inert atmosphere;
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-bromo-1-(4-methoxyphenyl)butan-1-one
881-43-6

2-bromo-1-(4-methoxyphenyl)butan-1-one

A

5-ethyl-4-hydroxy-4-(4-methoxy-phenyl)-3-(4-methylsulfanyl-phenyl)-dihydro-furan-2-one

5-ethyl-4-hydroxy-4-(4-methoxy-phenyl)-3-(4-methylsulfanyl-phenyl)-dihydro-furan-2-one

B

5-ethyl-5-hydroxy-4-(4-methoxy-phenyl)-3-(4-methylsulfanyl-phenyl)-5H-furan-2-one

5-ethyl-5-hydroxy-4-(4-methoxy-phenyl)-3-(4-methylsulfanyl-phenyl)-5H-furan-2-one

Conditions
ConditionsYield
With potassium hydroxide In water; N,N-dimethyl-formamide at 25℃; for 6h; Product distribution; Further Variations:; Temperatures; Reagents; substrate/reagent ratios, inert/O2 atmosphere;A 16%
B 79%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2-bromo-1-phenylbutan-1-one
877-35-0

2-bromo-1-phenylbutan-1-one

5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone
503174-32-1

5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With potassium hydroxide In water; N,N-dimethyl-formamide at 25 - 30℃;
Stage #2: 2-bromo-1-phenylbutan-1-one In water; N,N-dimethyl-formamide at 25 - 30℃;
77%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-amino-2,2-dimethyl-1,3-dioxane
1400872-56-1

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-amino-2,2-dimethyl-1,3-dioxane

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-{N-[(4-methylthiobenzyl)carboximido]}-2,2-dimethyl-1,3-dioxane
1400872-58-3

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-{N-[(4-methylthiobenzyl)carboximido]}-2,2-dimethyl-1,3-dioxane

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 24h; Inert atmosphere;76%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

2,4-Dihydroxybenzaldehyde
95-01-2

2,4-Dihydroxybenzaldehyde

3-(4-methylthiophenyl)-7-hydroxycoumarin

3-(4-methylthiophenyl)-7-hydroxycoumarin

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid; 2,4-Dihydroxybenzaldehyde With sodium acetate; acetic anhydride at 160℃; for 10h; Inert atmosphere;
Stage #2: With lithium hydroxide In tetrahydrofuran; methanol; water for 3h;
74.2%
2-(4-(methylthio)phenyl)acetic acid
16188-55-9

2-(4-(methylthio)phenyl)acetic acid

(1R,2R)-pseudoephedrine
321-97-1

(1R,2R)-pseudoephedrine

pivaloyl chloride
3282-30-2

pivaloyl chloride

N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl-2-(4-methylsulfanyl-phenyl)-acetamide
436141-37-6

N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl-2-(4-methylsulfanyl-phenyl)-acetamide

Conditions
ConditionsYield
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With potassium carbonate In tetrahydrofuran at 25 - 26℃; for 0.5h;
Stage #2: pivaloyl chloride In tetrahydrofuran at -10 - -5℃; for 1h;
Stage #3: (1R,2R)-pseudoephedrine at -10 - 0℃; for 3.25h;
73.1%

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