DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:1878-68-8
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry4-Bromophenylacetic acid CAS No.:1878-68-8 Name: 4-Bromophenylacetic acid Synonyms: 2-(4-Bromophenyl)acetic acid Molecular Structure Molecular Formula: C8H7BrO2 Molecular Weight: 215.05
Cas:1878-68-8
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1878-68-8
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:1878-68-8
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryAbout Product Details
Cas:1878-68-8
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry4-Bromophenylacetic acid Basic information Product Name: 4-Bromophenylacetic acid Synonyms: Acetic acid, (p-bromophenyl)-;(p-bromophenyl)-aceticaci;4-bromo-benzeneaceticaci;4-Bromobenzeneaceticacid;4-Bromophenylacetic acid acid;Aceticacid,(p-br
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:1878-68-8
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inquiry4-Bromophenylacetic acid CAS:1878-68-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i
Cas:1878-68-8
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1878-68-8
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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Cas:1878-68-8
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:1878-68-8
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:1878-68-8
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:1878-68-8
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:1878-68-8
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With phosphonic Acid; methanesulfonic acid; sodium iodide In water at 95℃; for 72h; Inert atmosphere; | 98.7% |
(4-bromo-phenyl)-acetic acid methyl ester
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide for 2h; Heating; | 93% |
With sodium hydroxide In tetrahydrofuran; methanol; water at 23℃; for 12h; |
carbon monoxide
1-bromomethyl-4-bromobenzene
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 60℃; under 760 Torr; for 18h; Carbonylation; | 93% |
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Autoclave; | 93% |
Ethyl 4-bromophenylacetate
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14; | 93% |
carbon dioxide
hydrazone of p-bromobenzaldehyde
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction; | 88% |
Conditions | Yield |
---|---|
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Autoclave; | 88% |
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With bismuth(III) chloride; water In acetonitrile at 50℃; for 1h; | 85% |
Conditions | Yield |
---|---|
With Oxone; iodine In 1,2-dimethoxyethane; water at 20℃; for 4h; regioselective reaction; | 83% |
With D-glucose; oxygen In aq. phosphate buffer at 30℃; for 10h; pH=8; Green chemistry; Enzymatic reaction; regioselective reaction; | 71% |
carbon monoxide
1-bromomethyl-4-bromobenzene
A
para-bromotoluene
B
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave; | A 9 %Chromat. B 82% |
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; water In 1,4-dioxane at 175℃; for 0.5h; Microwave irradiation; Green chemistry; | 78% |
Conditions | Yield |
---|---|
With silver(I) acetate; sodium acetate; palladium dichloride at 130℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction; | 63% |
A
4-bromophenylacetic acid 2-deuterio-2,2-dichloroethyl ester
B
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With indium; deuterated ammonium chloride In tetrahydrofuran-d8; water-d2 at 20℃; for 40h; Reflux; chemoselective reaction; | A 3% B 54% |
carbon monoxide
1-bromomethyl-4-bromobenzene
A
4,4'-dibromobibenzyl
B
1,3-bis(4-bromophenyl)propan-2-one
C
(4-Bromo-phenyl)-acetic acid 4-bromo-benzyl ester
D
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
iron pentacarbonyl; tetrabutylammonium sulfate In sodium hydroxide; dichloromethane at 25℃; under 760 Torr; for 24h; | A 7% B 9% C 22% D 50% |
carbon dioxide
2-[(4-bromophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h; | 50% |
1-bromomethyl-4-bromobenzene
A
4,4'-dibromobibenzyl
B
1,3-bis(4-bromophenyl)propan-2-one
C
(4-Bromo-phenyl)-acetic acid 4-bromo-benzyl ester
D
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With calcium hydroxide In dichloromethane; water at 20℃; for 23h; | A 5 % Spectr. B 62 % Spectr. C 11 % Spectr. D 4% |
Conditions | Yield |
---|---|
With water; bromine; mercury(II) oxide |
phenylacetic acid
A
ortho-bromophenylacetic acid
B
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With bromine | |
With bromine; mercury(II) oxide | |
With water; bromine; mercury(II) oxide |
4-Bromophenylacetonitrile
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With sulfuric acid | |
With potassium hydroxide | |
With hydrogenchloride at 100℃; im Rohr; |
Conditions | Yield |
---|---|
With morpholine; sulfur Erwaermen des Reaktionsprodukts mit aethanol. Natronlauge; | |
Multi-step reaction with 2 steps 1: BF3*O(C2H5)3, Pb(OAc)4 / benzene / 12 h / Ambient temperature 2: 93 percent / aq. NaOH / 2 h / Heating View Scheme | |
Stage #1: para-bromoacetophenone With morpholine; toluene-4-sulfonic acid; sulfur at 120℃; Stage #2: With tetrabutylammomium bromide; sodium hydroxide In ethanol; water at 100℃; for 4h; | |
Stage #1: para-bromoacetophenone With morpholine; toluene-4-sulfonic acid; sulfur at 120℃; Stage #2: With tetrabutylammomium bromide; sodium hydroxide at 100℃; |
1-(2,2,2-trichloroethyl)-4-bromobenzene
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With sulfuric acid | |
With sulfuric acid at 80 - 90℃; for 6h; Inert atmosphere; | 117.4 g |
A
phenylacetic acid
B
2-oxo-2-phenylethyl 2-phenylacetate
C
acetophenone
D
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With N,N-dimethyl-aniline In acetonitrile for 2h; Mechanism; Irradiation; sensitized deprotection; competing bromide and carboxylate elimination; |
phenylacetic acid
water
bromine
A
ortho-bromophenylacetic acid
B
2-(4-bromophenyl)-acetic acid
phenylacetic acid
N-Bromosuccinimide
water
A
ortho-bromophenylacetic acid
B
benzaldehyde
C
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-1-morpholinoethanethione
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 100℃; for 8h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: S; p-toluenesulfonic acid / 8 h / 120 - 130 °C 2: aq. NaOH; triethyl benzyl ammonium chloride / 8 h / 100 °C View Scheme |
3-(4-bromo-phenyl)-2-thioxo-propionic acid
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aqueous ethanol; hydroxylamine 3: ethanolic KOH-solution View Scheme |
3-(4-bromo-phenyl)-2-hydroxyimino-propionic acid
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: ethanolic KOH-solution View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Bromierung 2: ethanol 3: sulfuric acid View Scheme |
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)acetyl chloride
Conditions | Yield |
---|---|
With thionyl chloride | 100% |
With thionyl chloride In dichloromethane | 100% |
With thionyl chloride In toluene | 100% |
methanol
2-(4-bromophenyl)-acetic acid
(4-bromo-phenyl)-acetic acid methyl ester
Conditions | Yield |
---|---|
With chloro-trimethyl-silane for 15h; Ambient temperature; | 100% |
With hydrogenchloride for 1h; Heating; | 100% |
With hydrogenchloride for 3h; Heating; | 100% |
phenylboronic acid
2-(4-bromophenyl)-acetic acid
(4-biphenylyl)acetic acid
Conditions | Yield |
---|---|
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction; | 100% |
With carbon-doped cobalt; C118H94N4O7P8; palladium diacetate; sodium carbonate In tetrahydrofuran; water at 20 - 60℃; for 14h; Suzuki Coupling; Inert atmosphere; | 100% |
With palladium diacetate; potassium carbonate In water; toluene at 65℃; for 20h; Solvent; Suzuki-Miyaura Coupling; | 100% |
4-fluoroboronic acid
2-(4-bromophenyl)-acetic acid
2-(4'-fluoro-[1,1'-biphenyl]-4-yl)acetic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In toluene at 95℃; for 4h; Suzuki-Miyaura Coupling; | 100% |
With 2C2H5NO2*Pd(2+)*2Cl(1-); potassium carbonate In water at 20℃; for 6h; Suzuki-Miyaura Coupling; Green chemistry; | 96% |
With potassium carbonate In water at 20℃; for 4h; Suzuki-Miyaura Coupling; Green chemistry; | 96% |
Stage #1: 4-fluoroboronic acid; 2-(4-bromophenyl)-acetic acid With sodium carbonate; palladium 10% on activated carbon In water; isopropyl alcohol at 65 - 70℃; Suzuki Coupling; Stage #2: With sulfuric acid; water | 75% |
benzyl bromide
2-(4-bromophenyl)-acetic acid
benzyl 2-(4-bromophenyl)acetate
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; | 100% |
With potassium carbonate In acetone for 12h; Reflux; Inert atmosphere; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 0 - 100℃; Inert atmosphere; | 73% |
4-aminotetrahydropyran
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-N-(tetrahydropyran-4-yl)acetamide
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h; Cooling with ice; | 100% |
2-(3,4-dimethoxyphenyl)-ethylamine
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-N-(3,4-dimethoxyphenethyl)acetamide
Conditions | Yield |
---|---|
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; | 100% |
Stage #1: 2-(4-bromophenyl)-acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.166667h; Stage #2: 2-(3,4-dimethoxyphenyl)-ethylamine With triethylamine In dichloromethane at 20℃; | 90% |
Conditions | Yield |
---|---|
In methanol at 20℃; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-(4-bromophenyl)-acetic acid With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0 - 80℃; for 0.5h; | 99% |
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 0.25h; | 92% |
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; | 88% |
5,6-dimethoxy-2-(N-propylamino)indan
2-(4-bromophenyl)-acetic acid
2-(4-bromo-phenyl)-N-(5,6-dimethoxy-indan-2-yl)-N-propyl-acetamide
Conditions | Yield |
---|---|
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h; | 99% |
4-methoxyphenylboronic acid
2-(4-bromophenyl)-acetic acid
2-(4'-methoxy-[1,1'-biphenyl]-4-yl)acetic acid
Conditions | Yield |
---|---|
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction; | 99% |
With potassium carbonate In water at 20℃; for 4h; Suzuki-Miyaura Coupling; Green chemistry; | 97% |
With 2C2H5NO2*Pd(2+)*2Cl(1-); potassium carbonate In water at 20℃; for 6h; Suzuki-Miyaura Coupling; Green chemistry; | 92% |
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In toluene at 95℃; for 4h; Suzuki-Miyaura Coupling; | 52% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In methanol at 65℃; for 24h; |
1-methyl-piperazine
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 20h; | 99% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 19h; | 3.20 g |
ethanol
phenylboronic acid
2-(4-bromophenyl)-acetic acid
4-biphenylylacetic acid ethyl ester
Conditions | Yield |
---|---|
With tetra-butylammonium acetate; Pd EnCat-30TM In water at 120℃; for 0.166667h; Suzuki cross-coupling; microwave irradiation; | 99% |
6,7-dimethoxy-3-(4-methoxyphenyl)-1-(prop-2-en-1-yl)-1H-quinolin-2-one
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With caesium carbonate; triphenylphosphine; [Pd(OAc)2] In water; N,N-dimethyl-formamide at 120℃; for 16h; Heck reaction; | 99% |
methyl iodide
2-(4-bromophenyl)-acetic acid
(4-bromo-phenyl)-acetic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 60℃; | 99% |
With potassium carbonate In acetone at 60℃; | 99% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 20℃; for 2h; | 75% |
2-(4-bromophenyl)-acetic acid
Ethyl 4-bromophenylacetate
Conditions | Yield |
---|---|
With sulfuric acid In ethanol | 99% |
With toluene-4-sulfonic acid In diethyl ether; ethanol | |
Multi-step reaction with 2 steps 1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 20 °C / Inert atmosphere 2: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
1-(tert-butoxycarbonyl)-4-aminopiperidine
2-(4-bromophenyl)-acetic acid
4-[2-(4-bromophenyl)acetylamino]piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 99% |
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 1.25h; | 96.9% |
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h; Cooling with ice; | 96.9% |
Stage #1: 1-(tert-butoxycarbonyl)-4-aminopiperidine; 2-(4-bromophenyl)-acetic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.0833333h; Stage #2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dichloromethane at 20℃; for 3h; | 93% |
2-(4-bromophenyl)-acetic acid
2-(4-bromo-phenyl)-3-hydroxy-propenal
Conditions | Yield |
---|---|
With trichlorophosphate In N,N-dimethyl-formamide at 4 - 75℃; for 16h; Inert atmosphere; | 99% |
trifluoroacetic acid
1-t-Butoxycarbonylpiperazine
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
Stage #1: 1-t-Butoxycarbonylpiperazine; 2-(4-bromophenyl)-acetic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Stage #2: trifluoroacetic acid In dichloromethane at 20℃; for 1h; | 99% |
1-t-Butoxycarbonylpiperazine
2-(4-bromophenyl)-acetic acid
C17H23BrN2O3
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; | 98% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 98% |
Conditions | Yield |
---|---|
With acetic anhydride; triethylamine for 5h; Knoevenagel Condensation; Reflux; | 98% |
Conditions | Yield |
---|---|
With triethylamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 30℃; | 98% |
1-methyl-1-azaspiro<4.5>decan-10-amine
2-(4-bromophenyl)-acetic acid
2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In dichloromethane for 2h; | 97% |
Conditions | Yield |
---|---|
With sulfuric acid for 24h; Reflux; | 97% |
With toluene-4-sulfonic acid for 3h; Reflux; | 97% |
With toluene-4-sulfonic acid Inert atmosphere; | 96% |
2-(4-bromophenyl)-acetic acid
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In toluene at 20℃; for 0.25h; Inert atmosphere; | 97% |
With 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate In tetrahydrofuran for 0.0166667h; | |
With dicyclohexyl-carbodiimide In toluene at 20℃; for 0.25h; |
4-bromo-phenol
2-(4-bromophenyl)-acetic acid
4-bromophenyl 2-(4-bromophenyl)acetate
Conditions | Yield |
---|---|
With dmap In dichloromethane at 0 - 20℃; | 97% |
N-(7-amino-1,8-naphthyridin-2-yl)-2-ethylhexanamide
2-(4-bromophenyl)-acetic acid
N-(7-(2-(4-bromophenyl)acetamido)-1,8-naphthyridin-2-yl)-2-ethylhexanamide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃; Inert atmosphere; | 97% |
3-trifluoromethylaniline
2-(4-bromophenyl)-acetic acid
2-(4-bromo-phenyl)-N-(3-trifluoromethyl-phenyl)-acetamide
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 97% |
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