As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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Name:Gilenya CAS NO:162359-55-9 Grade:Medical scientific research and export Molecular formula:C19H33NO2 Molecular weight:307.47 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data sto
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryProduct name: Fingolimod CAS No.:162359-55-9 Molecule Formula:C19H33NO2 Molecule Weight:307.47 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPEC
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inquiry5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane
fingolimod
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 12h; | 96% |
Stage #1: 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane With water; trifluoroacetic acid In dichloromethane at 20℃; Stage #2: With sodium hydrogencarbonate In dichloromethane; water | 95% |
Stage #1: 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane With hydrogenchloride In methanol; water at 50℃; for 3h; Stage #2: With sodium hydroxide In water pH=8 - 9; | 69% |
fingolimod
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane | 95% |
2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol
fingolimod
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 20 - 50℃; under 750.075 - 26252.6 Torr; for 2.66667h; | 93% |
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 20 - 50℃; under 750.075 - 26252.6 Torr; for 2.66667h; | 93% |
With hydrogen; nickel | 82% |
With palladium 10% on activated carbon; hydrogen In methanol at 25 - 30℃; under 3000.3 - 3750.38 Torr; for 5h; Solvent; Temperature; Pressure; | 2 g |
With palladium 10% on activated carbon; ammonium formate In methanol at 20℃; for 5h; Reagent/catalyst; Temperature; Time; |
fingolimod
Conditions | Yield |
---|---|
Stage #1: C22H33NO4 With 5%-palladium/activated carbon; hydrogen In ethanol at 40 - 45℃; under 1500.15 - 2250.23 Torr; for 5h; Autoclave; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water at 60 - 65℃; for 4h; Reagent/catalyst; Temperature; Solvent; | 92.1% |
(3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol
fingolimod
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 100℃; under 26252.6 Torr; for 2h; | 86% |
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 100℃; under 26252.6 Torr; for 2h; | 86% |
diethyl 2-amino-2-(4-octylphenethyl)malonate
fingolimod
Conditions | Yield |
---|---|
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 0 - 20℃; Inert atmosphere; | 85% |
With lithium bromide; sodium borohydrid In ethanol; water |
5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / Et3N; CuI / Pd(PPh3)4 / dimethylformamide / 3 h / 20 °C 2: 99 percent / H2 / Pd/C / benzene / 5 h / 20 °C / 760 Torr 3: 96 percent / aq. TFA / CH2Cl2 / 12 h / 20 °C View Scheme |
4-chlorobenzaldehyde
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 71 percent / Ni(0) 2: 81 percent / diethyl ether / 0 °C 3: m-CPBA / CH2Cl2 / 20 °C 4: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating 5: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 6: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 7: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 8: 82 percent / H2 / Raney-Ni View Scheme |
1-octylzinc(II) iodide
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 71 percent / Ni(0) 2: 81 percent / diethyl ether / 0 °C 3: m-CPBA / CH2Cl2 / 20 °C 4: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating 5: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 6: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 7: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 8: 82 percent / H2 / Raney-Ni View Scheme |
4-octylbenzaldehyde
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 81 percent / diethyl ether / 0 °C 2: m-CPBA / CH2Cl2 / 20 °C 3: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating 4: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 5: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 6: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 7: 82 percent / H2 / Raney-Ni View Scheme |
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: m-CPBA / CH2Cl2 / 20 °C 2: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating 3: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 4: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 5: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 6: 82 percent / H2 / Raney-Ni View Scheme |
(4-octyl-phenyl)-oxiranyl-methanol
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating 2: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 3: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 4: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 5: 82 percent / H2 / Raney-Ni View Scheme |
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 2: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 3: 82 percent / H2 / Raney-Ni View Scheme |
1-(3-nitropropyl)-4-octylbenzene
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 2: 82 percent / H2 / Raney-Ni View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / methanol / 2 h / 68 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 25 - 30 °C / 3000.3 - 3750.38 Torr View Scheme |
3-nitro-1-(4-octyl-phenyl)-propane-1,2-diol
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C 2: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr 3: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h 4: 82 percent / H2 / Raney-Ni View Scheme |
n-octanoic acid chloride
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C 7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 8.1: 8.25 g / pyridine / 16 h / 20 °C 9.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 9 steps 1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr 3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C 5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere 6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C 7: hydrogenchloride / acetone / 2 h / 25 - 30 °C 8: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C 9: lithium hydroxide / methanol / 2 h / 25 - 30 °C / Reflux View Scheme | |
Multi-step reaction with 9 steps 1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr 3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C 5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere 6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C 7: methanesulfonic acid / methanol / 2 h / 25 - 30 °C / Reflux 8: hydrogen; palladium / methanol / 2585.81 - 3102.97 Torr 9: lithium hydroxide / methanol / 2 h / 25 - 30 °C / Reflux View Scheme | |
Multi-step reaction with 9 steps 1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr 3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C 4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C 5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere 6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C 7: methanesulfonic acid / methanol / 2 h / 25 - 30 °C / Reflux 8: lithium hydroxide / methanol / 2 h / Reflux 9: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 6.2: 0.4 - 0.45 °C / Inert atmosphere 7.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 7.2: 0.01 h / 0 - 0.5 °C 7.3: 0 h / 0.15 - 0.5 °C 8.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme |
acetic acid phenethyl ester
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C 7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 8.1: 8.25 g / pyridine / 16 h / 20 °C 9.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 6.2: 0.4 - 0.45 °C / Inert atmosphere 7.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 7.2: 0.01 h / 0 - 0.5 °C 7.3: 0 h / 0.15 - 0.5 °C 8.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme |
diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 2: 8.25 g / pyridine / 16 h / 20 °C 3: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: lithium chloride; ethanol; sodium tetrahydroborate / tetrahydrofuran / 72.5 h / 0 - 20 °C 2: sodium hydroxide / methanol / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 1.2: 0.01 h / 0 - 0.5 °C 1.3: 0 h / 0.15 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme |
1-(2-iodoethyl)-4-octylbenzene
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: 8.25 g / pyridine / 16 h / 20 °C 4.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 1.2: 0.4 - 0.45 °C / Inert atmosphere 2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 2.2: 0.01 h / 0 - 0.5 °C 2.3: 0 h / 0.15 - 0.5 °C 3.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux 2.1: calcium chloride / ethanol; water 2.2: 10 - 15 °C 2.3: Reflux View Scheme |
2-(4-Octylphenyl)ethyl alcohol
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 5.1: 8.25 g / pyridine / 16 h / 20 °C 6.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 2.2: 0.4 - 0.45 °C / Inert atmosphere 3.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 3.2: 0.01 h / 0 - 0.5 °C 3.3: 0 h / 0.15 - 0.5 °C 4.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme |
acetic acid 2-(4-octylphenyl)ethyl ester
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 2.1: Et3N / CH2Cl2 / 1 h / 20 °C 3.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 4.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 4.2: 61 percent / ethanol / 3 h / 65 °C 5.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 6.1: 8.25 g / pyridine / 16 h / 20 °C 7.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 2.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 3.2: 0.4 - 0.45 °C / Inert atmosphere 4.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 4.2: 0.01 h / 0 - 0.5 °C 4.3: 0 h / 0.15 - 0.5 °C 5.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme |
acetic acid
fingolimod
2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol acetate
Conditions | Yield |
---|---|
In ethyl acetate at 75℃; Product distribution / selectivity; | 99.4% |
propionic acid
fingolimod
2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol propionate
Conditions | Yield |
---|---|
In ethyl acetate at 70℃; Product distribution / selectivity; | 96.9% |
fingolimod
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 30 - 35℃; for 4h; | 96.5% |
With hydrogenchloride In methanol at 25 - 55℃; for 0.5h; | 93.88% |
With hydrogenchloride In n-heptane; isopropyl alcohol at 0 - 50℃; for 0.416667h; | 91% |
malonic acid
fingolimod
Conditions | Yield |
---|---|
In isopropyl alcohol at 82℃; Product distribution / selectivity; | 92.3% |
fingolimod
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃; | 5% |
Stage #1: fingolimod With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃; Stage #2: With trifluoroacetic acid In water; acetonitrile Stage #3: With sodium hydroxide In methanol | 2% |
With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃; | 2% |
benzyl chloroformate
fingolimod
2-(benzyloxycarbonyl)amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In water; ethyl acetate at 20℃; for 2h; Schotten-Baumann reaction; | 5.29 g |
With potassium hydrogencarbonate In water; ethyl acetate |
benzyl chloroformate
fingolimod
(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium hydroxide at 20℃; for 48h; |
Triethyl orthoacetate
fingolimod
{2-methyl-4-[2-(4-octylphenyl)ethyl]-4,5-dihydro-1,3-oxazol-4-yl}methanol
Conditions | Yield |
---|---|
With N,N-diethyl-N-isopropylamine |
fingolimod
4-benzyloxymethyl-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iPrN(Et)2 2: NaH / tetrahydrofuran View Scheme |
fingolimod
2-amino-2-benzyloxymethyl-4-(4-octyl-phenyl)-butan-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: iPrN(Et)2 2: NaH / tetrahydrofuran 3: HCl View Scheme |
fingolimod
octanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iPrN(Et)2 2.1: NaH / tetrahydrofuran 3.1: HCl 4.1: pyridine; chlorotrimethylsilane / 20 °C 4.2: 20 °C View Scheme |
fingolimod
hexadecanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iPrN(Et)2 2.1: NaH / tetrahydrofuran 3.1: HCl 4.1: pyridine; chlorotrimethylsilane / 20 °C 4.2: 20 °C View Scheme |
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: iPrN(Et)2 2.1: NaH / tetrahydrofuran 3.1: HCl 4.1: pyridine; chlorotrimethylsilane / 20 °C 4.2: 20 °C 5.1: 37 percent / SnCl2; AgClO4; molecular sieves 4 Angstroem / H2O; diethyl ether 6.1: 53 percent / H2 / Pd/C / ethanol View Scheme |
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: iPrN(Et)2 2.1: NaH / tetrahydrofuran 3.1: HCl 4.1: pyridine; chlorotrimethylsilane / 20 °C 4.2: 20 °C 5.1: 74 percent / SnCl2; AgClO4; molecular sieves 4 Angstroem / H2O; diethyl ether 6.1: 76 percent / H2 / Pd/C / ethanol View Scheme |
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