Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryName:3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester CAS NO:183322-16-9 Grade:Used as food additives, pharmaceutical intermediates, etc; Erotinib hydrochloride intermediate Product Quality 12 years of chemical raw materials Mature operation of
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/564.html Product Name Ethyl 3,4-bis(2-methoxyethoxy)be
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inquiryEthyl 3,4-bis(2-methoxyethoxy)benzoate Basic information Product Name: Ethyl 3,4-bis(2-methoxyethoxy)benzoate Synonyms: 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl e
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white or off-white powder Storage:Store in sealed containers
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryEthyl 3,4-bis(2-methoxyethoxy)benzoate CAS:183322-16-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:183322-16-9
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inquiryEthyl 3,4-bis(2-methoxyethoxy)benzoate;cas.183322-16-9;98%;ready stock, competitive priceAppearance:White powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:This product is an
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryProduct name: Erlotinib Intermediate I CAS No.: 183322-16-9 Molecule Formula:C15H22O6 Molecule Weight:298.33 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTI
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryEthyl 3,4-bis(2-methoxyethoxy)benzoate Basic information Product Name: Ethyl 3,4-bis(2-methoxyethoxy)benzoate Synonyms: 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester;Ethyl 3,4-bis(2-methoxyethoxy)benzoate;Thyl3,4-bis(2-methoxyethoxy)benzoat
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:183322-16-9
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryEthyl protocatechuate
2-Bromoethyl methyl ether
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetone at 60℃; for 19h; Inert atmosphere; | 100% |
With potassium carbonate In acetone at 20 - 70℃; for 24h; | 93% |
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 64h; Inert atmosphere; Reflux; | 93% |
3,4-bis(2-methoxyethoxy)-benzoic acid
ethanol
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With sulfuric acid Cooling with ice; Reflux; | 98% |
2-chloroethyl methyl ether
Ethyl protocatechuate
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With 4-(Methylamino)pyridine; potassium carbonate at 90 - 95℃; Temperature; Reagent/catalyst; | 95% |
With carbon dioxide; ammonia at 50℃; for 0.5h; Temperature; Reagent/catalyst; | 94.6% |
With potassium tert-butylate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 12h; | 87% |
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 120h; Heating; | |
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃; for 9h; | 95 %Chromat. |
2-methoxyethyl methanesulfonate
Ethyl protocatechuate
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In toluene for 6h; Reflux; | 95% |
With potassium tert-butylate; tetrabutylammomium bromide In N,N-dimethyl-formamide at 30 - 40℃; for 10h; | 90.5% |
Ethyl protocatechuate
2-methoxy-ethyl p-toluenesulfonyloxy ester
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 6h; Reflux; | 89% |
With potassium carbonate In acetonitrile for 6h; Reflux; | 89% |
Ethyl protocatechuate
2-Bromoethyl methyl ether
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetone |
3,4-Dihydroxybenzoic acid
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 10 h / 40 - 80 °C 2: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid In acetic acid at 20 - 70℃; for 2h; | 100% |
With sulfuric acid; nitric acid In acetic acid at 15 - 35℃; | 100% |
With sulfuric acid; nitric acid; acetic anhydride; acetic acid at 40℃; for 2h; Concentration; Large scale; | 98.3% |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester In tetrahydrofuran for 0.5h; Reflux; Stage #2: With peracetic acid; dinitrogen monoxide In tetrahydrofuran at 50℃; under 22502.3 Torr; for 2h; Reagent/catalyst; Temperature; Autoclave; | 95.2% |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
3,4-bis(2-methoxyethoxy)-benzoic acid
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 20℃; for 3h; | 90% |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 3: 84 percent / 12 h / 165 - 170 °C View Scheme | |
Multi-step reaction with 3 steps 1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 2: 94 percent / hydrogen / palladium on activated carbon / methanol 3: 62 percent / formamide / 3 h / 160 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid; nitric acid / 0 °C 2: hydrogen; palladium on activated charcoal / methanol 3: 165 - 170 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 3: 84 percent / 12 h / 165 - 170 °C 4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 2: 94 percent / hydrogen / palladium on activated carbon / methanol 3: 62 percent / formamide / 3 h / 160 °C 4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 3: 84 percent / 12 h / 165 - 170 °C 4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 5: pyridine / propan-2-ol View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 2.2: 20 °C 3.1: ammonium formate; triethylamine / 6 h / 160 °C 4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 5.1: methanol / 3 h / 20 - 30 °C 5.2: 3 h / 50 °C 6.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 2: 94 percent / hydrogen / palladium on activated carbon / methanol View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / acetic acid / 15 - 35 °C 2: hydrogen; platinum on carbon / methanol / 20 - 40 °C / 760.05 Torr View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 2: 94 percent / hydrogen / palladium on activated carbon / methanol 3: 62 percent / formamide / 3 h / 160 °C 4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating 5: 53 percent / pyridine / propan-2-ol / 2 h / Heating View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; nitric acid / acetic acid / 15 - 35 °C 2.1: hydrogen; platinum on carbon / methanol / 20 - 40 °C / 760.05 Torr 3.1: N,N-dimethyl-formamide / 10 h / 130 - 140 °C 3.2: 65 - 80 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-chloro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: isopropyl alcohol / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 10 View Scheme | |
Multi-step reaction with 5 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: isopropyl alcohol / 4 h / Reflux 5: trichlorophosphate / 2 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-bromo-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: pyridine / acetonitrile / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 9 View Scheme | |
Multi-step reaction with 5 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: pyridine / acetonitrile / 4 h / Reflux 5: trichlorophosphate / 2 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / isopropyl alcohol; water 5.1: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: hydrogenchloride / isopropyl alcohol; water / 20 °C 5: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / Cooling with ice View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-ethynyl-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: pyridine / acetonitrile / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 9 6.1: hydrogenchloride / ethanol; water / Heating 7.1: triethylamine / triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux 8.1: sodium hydroxide / toluene / 6 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 8 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: pyridine / acetonitrile / 4 h / Reflux 5: trichlorophosphate / 2 h / Reflux 6: hydrogenchloride / ethanol / Heating 7: triethylamine; triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux 8: sodium hydroxide / toluene / 4 h / Resolution of racemate; Inert atmosphere View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-nitro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C 5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: hydrogenchloride / water; 1,4-dioxane / 7 h / 20 °C 5: triethylamine; methanesulfonyl chloride / chloroform / 20 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
9-amino-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C 5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice 6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: hydrogenchloride / water; 1,4-dioxane / 7 h / 20 °C 5: triethylamine; methanesulfonyl chloride / chloroform / 20 °C 6: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: isopropyl alcohol / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 10 6.1: hydrogenchloride / ethanol; water / Heating View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / isopropyl alcohol; water 5.1: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / cooling with ice 6.1: ethanol / 0.5 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: pyridine / acetonitrile / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 9 6.1: hydrogenchloride / ethanol; water / Heating 7.1: triethylamine / triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux 8.1: sodium hydroxide / toluene / 6 h / Inert atmosphere; Reflux 9.1: hydrogenchloride / ethanol View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C 5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice 6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux 7.1: hydrogen bromide / ethyl acetate; ethanol View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
C21H24ClN3O5
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: isopropyl alcohol / 4 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: isopropyl alcohol / 4 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
C21H24BrN3O5
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: pyridine / acetonitrile / 4 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: pyridine / acetonitrile / 4 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: pyridine / acetonitrile / 4 h / Reflux 5.1: trichlorophosphate / 2 h / Reflux 5.2: pH 9 6.1: hydrogenchloride / ethanol; water / Heating View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
C21H24FN3O5
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 4.1: hydrogenchloride / isopropyl alcohol; water View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice 2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 4: hydrogenchloride / isopropyl alcohol; water / 20 °C View Scheme |
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