Hubei Vanz Pharm Co. Ltd. is the leading manufacture of APIs, supplements raw powder and some customization products. Located in Hubei province,China. We are one of the most professional company in medical/chemical industry for more than 10 years.
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $220.0
Type:Trading Company
inquiryHangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *W
Cas:183319-69-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Appearance Off-white to white crystalline powder White powder Assay(anhydrous)
Cas:183319-69-9
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryName Erlotinib hydrochloride Synonyms N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochlor
Cas:183319-69-9
Min.Order:1 Gram
FOB Price: $1.0
Type:Manufacturers
inquiryUnique advantages of Erlotinib hydrochloride Cas 183319-69-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Cool dry place
Cas:183319-69-9
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryErlotinib hydrochloride CAS No.:183319-69-9 Name: Erlotinib hydrochloride Synonyms: N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilin
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:183319-69-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
Cas:183319-69-9
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryMicafungin Verified By GMP,FDA,CEP,COS,ANDA Service 1, Professional Techincal Guidence 2, Free Sample can be supplied before commercial p
Cas:183319-69-9
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:183319-69-9
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:183319-69-9
Min.Order:1000 Gram
FOB Price: $500.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:183319-69-9
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryName: Erlotinib HCl CAS No.: 183319-69-9 Molecular Formula: C22H23N3O4.HCl Molecular Weight: 429.9 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:183319-69-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:183319-69-9
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediates, herbal
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:183319-69-9
Min.Order:1 Kilogram
FOB Price: $75.0 / 89.0
Type:Trading Company
inquiryErlotinib hydrochloride CAS:183319-69-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:183319-69-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:183319-69-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:183319-69-9
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:183319-69-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryErlotinib hydrochloride CAS: 183319-69-9 Specification Items Standard Result Appearance Off-white to white crystalline powder White powder Assay(anhydrou
Cas:183319-69-9
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:183319-69-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryerlotinib
erlotinib hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 0℃; for 1h; Product distribution / selectivity; Inert atmosphere; | 100% |
With hydrogenchloride In ethanol; water at 72℃; for 0.333333h; Solvent; Temperature; | 99% |
With hydrogenchloride In water; acetone at 10℃; for 2.5h; Solvent; Temperature; | 98.7% |
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: hydrochloric salt of m-aminophenylacetylene With sec.-butyllithium In tetrahydrofuran; cyclohexane at 0℃; for 0.5h; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; cyclohexane at 20℃; for 15h; Stage #3: With hydrogenchloride In tetrahydrofuran; cyclohexane; water at 20℃; for 1h; Product distribution / selectivity; | 100% |
Stage #1: hydrochloric salt of m-aminophenylacetylene With sec.-butyllithium In tetrahydrofuran; cyclohexane at 0℃; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; cyclohexane at 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; cyclohexane; water at 20℃; | 100% |
3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol for 18h; Heating; | 98% |
In iso-propanol (IPA) for 0.5h; Product distribution / selectivity; Heating / reflux; | 97% |
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In N,N-dimethyl-formamide; acetonitrile at 90℃; for 7h; Darkness; Stage #2: With hydrogenchloride In water at 15 - 30℃; Temperature; Solvent; | 97.6% |
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
3-acetylenephenylamine
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-acetylenephenylamine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 0℃; for 0.5h; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; for 15h; Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; ethylbenzene; water at 20℃; for 3h; Product distribution / selectivity; | 97% |
Stage #1: 3-acetylenephenylamine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 0℃; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; for 15h; Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; ethylbenzene; water at 20℃; Product distribution / selectivity; | 97% |
N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine
2-iodo-1-methoxyethane
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine; 2-iodo-1-methoxyethane With pyridine; tetrapropylammonium iodide In 1-methyl-pyrrolidin-2-one at 20℃; for 1h; Stage #2: With hydrogenchloride In water | 95.29% |
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
3-acetylenephenylamine
erlotinib hydrochloride
Conditions | Yield |
---|---|
for 3h; Temperature; Reflux; Large scale; | 95.1% |
4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib hydrochloride
Conditions | Yield |
---|---|
With 3-ethynylaniline In isopropyl alcohol for 15h; Heating; | 90% |
N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine
erlotinib hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; for 1h; | 90% |
3-acetylenephenylamine
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 6,7-dimethoxy quinazolin-4-one With triethylamine; trichlorophosphate In toluene at 70 - 80℃; for 3h; Stage #2: 3-acetylenephenylamine In toluene; acetonitrile at 20 - 80℃; for 2h; | 88% |
3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride With sodium hydroxide In water; butan-1-ol pH=10 - 12; Inert atmosphere; Stage #2: With sodium hydroxide In butan-1-ol at 115 - 120℃; for 24h; Stage #3: With hydrogenchloride In water; butan-1-ol at 20 - 25℃; | 74% |
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
3-acetylenephenylamine
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-acetylenephenylamine; 4-(dimethoxymethylene)morpholine With acetic acid In toluene Reflux; Stage #2: 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile In toluene Reflux; Stage #3: With hydrogenchloride In water; toluene at 15 - 20℃; | 63% |
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 95 percent / P2S5 / pyridine / 24 h / Heating 2.1: aq. NaOH / methanol / 0.5 h / 20 °C 2.2: 86 percent / methanol; H2O / 5 h / 25 °C 3.1: 90 percent / 3-ethynylaniline / propan-2-ol / 15 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 2: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 2: pyridine / propan-2-ol View Scheme |
6,7-bis(2-methoxyethoxy)quinazoline-4(3H)-thione
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aq. NaOH / methanol / 0.5 h / 20 °C 1.2: 86 percent / methanol; H2O / 5 h / 25 °C 2.1: 90 percent / 3-ethynylaniline / propan-2-ol / 15 h / Heating View Scheme |
C13H19NO5
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetic anhydride / 110 °C 2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 81 percent / HCl / H2O / 90 - 130 °C 4.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 5.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme |
3,4-bis(2-methoxyethoxy) benzonitrile
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 81 percent / HCl / H2O / 90 - 130 °C 3.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 4.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: nitric acid / acetic acid / 4 h / 0 °C 2.1: sodium dithionite / water / 3 h / 50 °C 2.2: 0.5 h / 65 °C 3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 4.1: acetic acid / toluene / 5 h / 60 °C 5.1: toluene / 5 h / 125 °C 6.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 4 h / 0 °C 2.1: sodium dithionite / water / 3 h / 50 °C 2.2: 0.5 h / 65 °C 3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 4.1: acetic acid / toluene / 125 - 130 °C 5.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: acetic acid / 20 °C 1.2: 5 - 55 °C 2.1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr 3.1: 3 h / 20 °C / Reflux 4.1: acetic acid / 2 h / Reflux 5.1: hydrogenchloride / water; methanol / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: nitric acid 2: dihydrogen peroxide 3: palladium on activated charcoal; ammonium formate 4: water / 24 h / 130 °C 5: trichlorophosphate; triethylamine 6: hydrogenchloride / water; N,N-dimethyl-formamide View Scheme |
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 1.2: 81 percent / HCl / H2O / 90 - 130 °C 2.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 3.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium dithionite / water / 3 h / 50 °C 1.2: 0.5 h / 65 °C 2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 3.1: acetic acid / toluene / 5 h / 60 °C 4.1: toluene / 5 h / 125 °C 5.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium dithionite / water / 3 h / 50 °C 1.2: 0.5 h / 65 °C 2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 3.1: acetic acid / toluene / 125 - 130 °C 4.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzaldehyde
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C 5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 6.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme | |
Multi-step reaction with 7 steps 1: hydroxylamine hydrochloride; acetic anhydride 2: nitric acid 3: dihydrogen peroxide 4: palladium on activated charcoal; ammonium formate 5: water / 24 h / 130 °C 6: trichlorophosphate; triethylamine 7: hydrogenchloride / water; N,N-dimethyl-formamide View Scheme |
3,4-dihydroxybenzaldehyde
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C 2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 3.1: acetic anhydride / 110 °C 4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 81 percent / HCl / H2O / 90 - 130 °C 6.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 7.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme |
Ethyl protocatechuate
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 6: pyridine / propan-2-ol View Scheme | |
Multi-step reaction with 6 steps 1: potassium carbonate; tetrabutylammonium iodide / acetone 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 6: pyridine / propan-2-ol View Scheme | |
Multi-step reaction with 7 steps 1.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C 2.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 3.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 3.2: 20 °C 4.1: ammonium formate; triethylamine / 6 h / 160 °C 5.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 6.1: methanol / 3 h / 20 - 30 °C 6.2: 3 h / 50 °C 7.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 3: 84 percent / 12 h / 165 - 170 °C 4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 5: pyridine / propan-2-ol View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 2.2: 20 °C 3.1: ammonium formate; triethylamine / 6 h / 160 °C 4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 5.1: methanol / 3 h / 20 - 30 °C 5.2: 3 h / 50 °C 6.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C View Scheme |
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 84 percent / 12 h / 165 - 170 °C 2: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 3: pyridine / propan-2-ol View Scheme |
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 2: 84 percent / 12 h / 165 - 170 °C 3: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 4: pyridine / propan-2-ol View Scheme | |
Multi-step reaction with 4 steps 1.1: tin(II) chloride dihdyrate / methanol / 25 - 35 °C 1.2: 0 - 30 °C 2.1: 25 - 145 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux 4.1: isopropyl alcohol / 4 h / 25 - 45 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 1.2: 20 °C 2.1: ammonium formate; triethylamine / 6 h / 160 °C 3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 4.1: methanol / 3 h / 20 - 30 °C 4.2: 3 h / 50 °C 5.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C View Scheme |
2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / toluene / 1 h / Heating 2: 98 percent / propan-2-ol / 18 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere 2: toluene; acetonitrile / 25 °C / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: acetonitrile / 5 h / 25 °C / Inert atmosphere; Reflux 2.1: sodium hydroxide / butan-1-ol; water / pH 10 - 12 / Inert atmosphere 2.2: 24 h / 115 - 120 °C 2.3: 20 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 5 h / Inert atmosphere; Reflux 2: sodium hydroxide; water / butan-1-ol / pH 10 - 12 / Inert atmosphere View Scheme |
3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
B
erlotinib hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol for 1.5 - 2h; Product distribution / selectivity; Heating / reflux; |
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
3-acetylenephenylamine
orthoformic acid triethyl ester
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile; 3-acetylenephenylamine; orthoformic acid triethyl ester; acetic acid In isopropyl alcohol for 4h; Reflux; Stage #2: With hydrogenchloride In isopropyl alcohol at 20℃; pH=3.0 - 4.0; Product distribution / selectivity; |
erlotinib trifluoroacetate
erlotinib hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 25 - 30℃; Product distribution / selectivity; |
4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline
3-acetylenephenylamine
erlotinib hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol for 15h; Reflux; | |
In isopropyl alcohol for 15h; Reflux; |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 1 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0.5 h / 0 - 40 °C 3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / 0 °C / Inert atmosphere 3.2: 15 h / 20 °C 3.3: 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 1 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0.5 h / 0 - 40 °C 3.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 15 h / 20 °C 3.3: 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0 - 40 °C 3.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0 °C / Inert atmosphere 3.2: 20 °C 3.3: 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0 - 40 °C 3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0 °C / Inert atmosphere 3.2: 15 h / 20 °C 3.3: 20 °C View Scheme | |
With hydrogenchloride In water; N,N-dimethyl-formamide |
3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
A
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
B
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h; Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃; for 1h; Product distribution / selectivity; | |
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h; Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃; |
methanesulfonic acid
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate at 60 - 70℃; pH=10 - 11; Stage #2: methanesulfonic acid In ethyl acetate Heating / reflux; | 100% |
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate pH=8 - 9; Stage #2: In isopropyl alcohol Stage #3: methanesulfonic acid at 62 - 70℃; for 34h; | 93% |
Stage #1: erlotinib hydrochloride With sodium hydrogencarbonate In dichloromethane; water Stage #2: In isopropyl alcohol Stage #3: methanesulfonic acid | 69% |
Stage #1: erlotinib hydrochloride With 50percent NaOH In water; ethyl acetate at 50℃; for 0.25h; Stage #2: methanesulfonic acid at 50℃; for 4h; Further stages.; | 111.76 g |
sodium docusate
erlotinib hydrochloride
Conditions | Yield |
---|---|
In dichloromethane; water at 20℃; | 98% |
erlotinib hydrochloride
erlotinib
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=5 - 12; Product distribution / selectivity; | 96.3% |
With ammonia In water for 2h; pH=9.4; Product distribution / selectivity; | 94.3% |
With sodium hydroxide In water; ethyl acetate at 20℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 45℃; Temperature; | 92.5% |
maleic acid
erlotinib hydrochloride
Conditions | Yield |
---|---|
Stage #1: erlotinib hydrochloride With ammonium hydroxide In water; ethyl acetate at 50℃; for 0.5h; Stage #2: maleic acid In ethanol; ethyl acetate at 20℃; for 24h; | 89% |
erlotinib hydrochloride
Conditions | Yield |
---|---|
With sulfuric acid at 50℃; Reagent/catalyst; Temperature; Cooling with ice; | 84% |
Adipic acid
erlotinib hydrochloride
[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate
Conditions | Yield |
---|---|
Stage #1: erlotinib hydrochloride With ammonium hydroxide In water; ethyl acetate at 50℃; for 0.5h; Stage #2: Adipic acid In ethanol; ethyl acetate for 24h; Cooling with ice; | 72% |
Conditions | Yield |
---|---|
Stage #1: erlotinib hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: ethylenediamine platinum(II) nitrate In N,N-dimethyl-formamide at 65℃; for 17h; | 29% |
cis-Pt(ethylenediamine)nitrate-chloride
erlotinib hydrochloride
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 65℃; for 17h; | 22% |
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