DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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Cas:183322-18-1
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inquiryName: 4-Chloro-6,7-(2-methoxyethoxy)quinazoline CAS NO:183322-18-1 Grade:Erotinib hydrochloride intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vu
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Cas:183322-18-1
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inquiry4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline CAS:183322-18-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAppearance:Pale yellow or off-white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common prod
Cas:183322-18-1
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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Cas:183322-18-1
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inquiry4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline;cas.183322-18-1;99% in stock,competitive priceAppearance:White powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:Erlotinib interm
Cas:183322-18-1
Min.Order:1 Gram
Negotiable
Type:Other
inquiry6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In toluene Heating; | 100% |
With triethylamine; trichlorophosphate In toluene at 70 - 80℃; for 3h; | 90% |
Stage #1: 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 6h; Reflux; Stage #2: With sodium hydroxide In dichloromethane at 20℃; for 0.5h; pH=7 - 8; | 89.5% |
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 6h; Reflux; | 89.5% |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 50℃; for 3h; | 99.3% |
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide for 1.5h; Heating; | 98% |
With oxalyl dichloride In dichloromethane Solvent; Reagent/catalyst; Temperature; Reflux; Large scale; | 97% |
With thionyl chloride In N,N-dimethyl-formamide at 60℃; Temperature; Concentration; | 95.6% |
C14H18N2O5
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With trichlorophosphate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 6h; Reagent/catalyst; | 97.1% |
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5 - 13h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: C14H18N2O5 With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5h; Heating / reflux; Stage #2: With sodium hydroxide In dichloromethane; water; N,N-dimethyl-formamide at 25℃; for 0.25 - 0.333333h; pH=7 - 8; | |
Stage #1: C14H18N2O5 With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5h; Heating / reflux; Stage #2: With sodium hydroxide In dichloromethane; water; N,N-dimethyl-formamide at 25℃; for 0.25 - 0.333333h; pH=7 - 8; | |
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 5 - 13h; Product distribution / selectivity; Heating / reflux; |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
92% | |
92% | |
With oxalyl dichloride; N,N-dimethyl-formamide In methanol for 1.5h; Reflux; | 92% |
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide for 1.5h; Heating / reflux; |
C13H19NO5
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: acetic anhydride / 110 °C 2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 81 percent / HCl / H2O / 90 - 130 °C 4.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme |
3,4-bis(2-methoxyethoxy) benzonitrile
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 81 percent / HCl / H2O / 90 - 130 °C 3.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: nitric acid 2: dihydrogen peroxide 3: palladium on activated charcoal; ammonium formate 4: water / 24 h / 130 °C 5: trichlorophosphate; triethylamine View Scheme |
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 1.2: 81 percent / HCl / H2O / 90 - 130 °C 2.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrazine hydrate / water / 3 h / 20 - 30 °C 2: trifluoroacetic acid / ethyl acetate / 4 h / Reflux 3: trichlorophosphate; N,N-dimethyl-formamide / ethyl acetate / 2 h / 70 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: dihydrogen peroxide 2: palladium on activated charcoal; ammonium formate 3: water / 24 h / 130 °C 4: trichlorophosphate; triethylamine View Scheme |
3,4-bis(2-methoxyethoxy)benzaldehyde
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C 5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1: hydroxylamine hydrochloride; acetic anhydride 2: nitric acid 3: dihydrogen peroxide 4: palladium on activated charcoal; ammonium formate 5: water / 24 h / 130 °C 6: trichlorophosphate; triethylamine View Scheme |
3,4-dihydroxybenzaldehyde
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C 2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 3.1: acetic anhydride / 110 °C 4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 81 percent / HCl / H2O / 90 - 130 °C 6.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme |
Ethyl protocatechuate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate; tetrabutylammonium iodide / acetone 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1: 68 percent / potassium carbonate; tetrabutylammonium iodide / acetone / 72 h / Heating 2: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 3: 94 percent / hydrogen / palladium on activated carbon / methanol 4: 62 percent / formamide / 3 h / 160 °C 5: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic acid; nitric acid / 24 h / 20 °C 2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 3: 84 percent / 12 h / 165 - 170 °C 4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 2: 94 percent / hydrogen / palladium on activated carbon / methanol 3: 62 percent / formamide / 3 h / 160 °C 4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water 2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 3.2: 0.5 h / 20 °C / pH 7 - 8 View Scheme |
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 84 percent / 12 h / 165 - 170 °C 2: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: 62 percent / formamide / 3 h / 160 °C 2: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 10 h / 130 - 140 °C 1.2: 65 - 80 °C 2.1: trichlorophosphate; triethylamine / toluene / 3 h / 70 - 80 °C View Scheme |
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 2: 84 percent / 12 h / 165 - 170 °C 3: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: 94 percent / hydrogen / palladium on activated carbon / methanol 2: 62 percent / formamide / 3 h / 160 °C 3: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux 2.2: 0.5 h / 20 °C / pH 7 - 8 View Scheme |
3,4-Dihydroxybenzoic acid
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 98 percent / H2SO4 / Heating 2: 99 percent / K2CO3; TBAI / acetone / Heating 3: 85 percent / HNO3; Ac2O / 20 °C 4: 100 percent / H2 / Pd/C / ethanol 5: 90 percent / 160 °C 6: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid / 10 h / 40 - 80 °C 2.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C 3.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 4.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 4.2: 20 °C 5.1: ammonium formate; triethylamine / 6 h / 160 °C 6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C View Scheme |
3,4-dihydroxybenzoic acid methyl ester
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 99 percent / K2CO3; TBAI / acetone / Heating 2: 85 percent / HNO3; Ac2O / 20 °C 3: 100 percent / H2 / Pd/C / ethanol 4: 90 percent / 160 °C 5: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme |
methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 85 percent / HNO3; Ac2O / 20 °C 2: 100 percent / H2 / Pd/C / ethanol 3: 90 percent / 160 °C 4: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; acetic anhydride; acetic acid / acetic acid / 0 - 5 °C 2: hydrogen / ethanol 3: ethanol / Reflux 4: thionyl chloride / N,N-dimethyl-formamide / Reflux View Scheme |
2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / 160 °C 2: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / Reflux 2: thionyl chloride / N,N-dimethyl-formamide / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: formamide / 160 - 165 °C 2: thionyl chloride / N,N-dimethyl-formamide / 0.67 h / 85 °C View Scheme |
methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / H2 / Pd/C / ethanol 2: 90 percent / 160 °C 3: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / ethanol 2: ethanol / Reflux 3: thionyl chloride / N,N-dimethyl-formamide / Reflux View Scheme |
2-methoxy-ethanol
4-chloro-6,7-dihydroxyquinazoline
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate In dichloromethane at 0 - 20℃; Mitsunobu reaction; |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 25 - 145 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 2: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 2: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: formic acid / 160 °C / Large scale 2: oxalyl dichloride / dichloromethane / Reflux; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: ammonium formate; triethylamine / 6 h / 160 °C 2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium hydroxide / methanol / 2 h / 20 °C 2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 3: sodium hydroxide / ethanol / 20 °C 4: ethanol / 1 h / Reflux 5: hydrogenchloride / water / 2 h / 100 - 105 °C 6: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
3,4-bis(2-methoxyethoxy)-benzoic acid
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C 2: triethylamine / dichloromethane / 0 - 20 °C 3: triethylamine; dmap / dichloromethane / 24 h / 20 °C 4: sodium hydroxide / methanol / 2 h / 20 °C 5: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 6: sodium hydroxide / ethanol / 20 °C 7: ethanol / 1 h / Reflux 8: hydrogenchloride / water / 2 h / 100 - 105 °C 9: trichlorophosphate / toluene / 4 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: sulfuric acid / Cooling with ice; Reflux 2: nitric acid; acetic acid / 24.5 h / 0 - 20 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 12 h 4: 12 h / 165 - 170 °C / Inert atmosphere 5: trichlorophosphate / 6 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: triethylamine; dmap / dichloromethane / 24 h / 20 °C 3: sodium hydroxide / methanol / 2 h / 20 °C 4: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 5: sodium hydroxide / ethanol / 20 °C 6: ethanol / 1 h / Reflux 7: hydrogenchloride / water / 2 h / 100 - 105 °C 8: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: triethylamine; dmap / dichloromethane / 24 h / 20 °C 2: sodium hydroxide / methanol / 2 h / 20 °C 3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 4: sodium hydroxide / ethanol / 20 °C 5: ethanol / 1 h / Reflux 6: hydrogenchloride / water / 2 h / 100 - 105 °C 7: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 2: sodium hydroxide / ethanol / 20 °C 3: ethanol / 1 h / Reflux 4: hydrogenchloride / water / 2 h / 100 - 105 °C 5: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / ethanol / 20 °C 2: ethanol / 1 h / Reflux 3: hydrogenchloride / water / 2 h / 100 - 105 °C 4: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 1 h / Reflux 2: hydrogenchloride / water / 2 h / 100 - 105 °C 3: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 2 h / 100 - 105 °C 2: trichlorophosphate / toluene / 4 h / Reflux View Scheme |
4-Iodophenol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
4-(4-iodo-phenoxy)-6,7-bis-(2-methoxy-ethoxy)-quinazoline
Conditions | Yield |
---|---|
With potassium carbonate In isopropyl alcohol Heating; | 100% |
3-Iodoaniline
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-iodo-phenyl)-amine
Conditions | Yield |
---|---|
With isopropyl alcohol Heating; | 100% |
p-aminoiodobenzene
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine
Conditions | Yield |
---|---|
With isopropyl alcohol Heating; | 100% |
2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
Conditions | Yield |
---|---|
In acetonitrile at 25℃; for 5h; Inert atmosphere; Reflux; | 100% |
In acetonitrile for 5h; Inert atmosphere; Reflux; | 100% |
1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
Stage #1: 1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In 1,2-dichloro-ethane; tert-butyl alcohol at 90℃; for 1h; Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; tert-butyl alcohol at 20℃; for 0.166667h; | 99% |
3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol for 18h; Heating; | 98% |
In iso-propanol (IPA) for 0.5h; Product distribution / selectivity; Heating / reflux; | 97% |
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In N,N-dimethyl-formamide; acetonitrile at 90℃; for 7h; Darkness; Stage #2: With hydrogenchloride In water at 15 - 30℃; Temperature; Solvent; | 97.6% |
1,2-dimethylindole
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube; | 98% |
1-ethyl-2-phenyl-1H-indole
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube; | 98% |
4-methoxy-aniline
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
6,7-bis(2-methoxyethoxy)-N-(4-methoxyphenyl)quinazolin-4-amine
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 0.666667h; Temperature; | 97.21% |
In water; isopropyl alcohol |
3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib
Conditions | Yield |
---|---|
In isopropyl alcohol Concentration; Reflux; | 96.6% |
In isopropyl alcohol Temperature; Reflux; | 96.6% |
In isopropyl alcohol at 20℃; Concentration; Temperature; Reflux; | 96.6% |
2-(3-aminophenyl)ethan-1-ol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With pyridine In isopropyl alcohol for 4h; Reflux; Inert atmosphere; | 96% |
ethyl (E)-3-(3-aminophenyl)acrylate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
ethyl (E)-3-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)acrylate
Conditions | Yield |
---|---|
In isopropyl alcohol for 5h; Reflux; | 93.6% |
3-biphenyl amine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
[6,7-di(2-methoxyethoxy)quinazolin-4-yl]-(biphenyl-3'-yl)amine hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 0.25h; Microwave irradiation; | 93% |
m-ethylaniline
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Conditions | Yield |
---|---|
In water; ethyl acetate; isopropyl alcohol | 90% |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
In isopropyl alcohol for 2h; Reflux; | 89% |
(2-amino-6-bromophenyl)methanol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C21H24BrN3O5
Conditions | Yield |
---|---|
With pyridine In acetonitrile for 4h; Reflux; | 88.89% |
With pyridine In acetonitrile for 4h; Reflux; | 88.89% |
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
6,7-bis(2-methoxyethoxy)-N-[3-[(trimethylsilyl)ethynyl]phenyl]-4-quinazolinamine, monohydrochloride
Conditions | Yield |
---|---|
With aniline In isopropyl alcohol | 88% |
(2-amino-6-chlorophenyl)methanol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C21H24ClN3O5
Conditions | Yield |
---|---|
In isopropyl alcohol for 4h; Reflux; | 87.63% |
In isopropyl alcohol for 4h; Reflux; | 87.63% |
methyl 3-amino-1H-pyrrole-2-carboxylate
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
methyl 3-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate
Conditions | Yield |
---|---|
In isopropyl alcohol for 4h; Reflux; | 87% |
1-(2-amino-4-chlorophenyl)pentyl-1-alcohol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C25H32ClN3O5
Conditions | Yield |
---|---|
With sulfuric acid In isopropyl alcohol at 20℃; | 86.67% |
2-amino-6-nitrobenzyl alcohol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C21H24N4O7
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; water at 20℃; for 7h; | 86.46% |
With hydrogenchloride In 1,4-dioxane; water at 20℃; for 7h; | 86.46% |
2-amino-6-cyanobenzyl alcohol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C22H24N4O5
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃; | 86.3% |
(2-amino-6-methoxyphenyl)methanol
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
C22H27N3O6
Conditions | Yield |
---|---|
In acetonitrile at 20℃; | 86.24% |
1-methylindole
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube; | 86% |
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