Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:183321-74-6
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inquiryItems Standard Result Assay 98%min ---------------------------------------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryErlotinib CAS 183321-74-6 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing t
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inquiryErlotinib[CAS:183321-74-6] 3-Aminophenylacetylene[CAS:54060-30-9] 2-Bromoethyl Methyl Ether[CAS:6482-24-2] 3-Aminophenylacetylene HCL[CAS:207726-02-6] 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline[CAS:183322-18-1] 6,7-Bis-(2-methoxye
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Name:Erlotinib The alias:4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazolin CAS NO: 183321-74-6 Molecular formula:C22H23N3O4 Molecular weight:393.44 Product Quality 12 years of chemical raw materials Mature operation of the industry
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudo
Erlotinib (OSI-744; NSC 718781; R1415) is an EGFR inhibitor . Chemical Properties: Cas No. 183321-74-6 Storage Please store the product under the recommended conditions
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
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inquiryProduct Name: Erlotinib Synonyms: ERLOTINIB;ERLOTINIB HCL;ERLOTINIB HCL SALT;4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline;n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine;Erlotinib Hydrochloirde;4-Quinazolinam
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:183321-74-6
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inquiryErlotinib CAS: 183321-74-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
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inquiryErlotinib CAS: 183321-74-6 Specification APPEARANCE ALMOST WHITE TO PALE YELLOW POWDER CONFORM IDENTIFICATION H-NMR MS CONFORM LOSS ON DRYING &
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Nanjing Fred Technology Co., Ltd is a high-tech enterprise engaged in the R&D, production and sales of pharmaceutical intermediates. With our own R&D center and production sites, we specialize in the kg to hundred kgs scale synthesis of compl
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inquiry3-acetylenephenylamine
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
erlotinib
Conditions | Yield |
---|---|
In isopropyl alcohol Concentration; Reflux; | 96.6% |
In isopropyl alcohol Temperature; Reflux; | 96.6% |
In isopropyl alcohol at 20℃; Concentration; Temperature; Reflux; | 96.6% |
erlotinib hydrochloride
erlotinib
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=5 - 12; Product distribution / selectivity; | 96.3% |
With ammonia In water for 2h; pH=9.4; Product distribution / selectivity; | 94.3% |
With sodium hydroxide In water; ethyl acetate at 20℃; Product distribution / selectivity; |
N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine
3-acetylenephenylamine
erlotinib
Conditions | Yield |
---|---|
With acetic acid In N,N-dimethyl-formamide at 125℃; for 1h; | 91.5% |
With acetic acid In toluene at 125 - 130℃; | 66% |
With acetic acid at 125 - 130℃; for 3h; | 66% |
Stage #1: N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine; 3-acetylenephenylamine With acetic acid at 125℃; for 3h; Stage #2: With sodium hydrogencarbonate In water at 0℃; |
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
erlotinib
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 110℃; for 5h; Temperature; Solvent; | 88.2% |
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
3-acetylenephenylamine
erlotinib
Conditions | Yield |
---|---|
With titanium tetrachloride; methoxybenzene In 1,4-dioxane for 4h; Inert atmosphere; Reflux; | 82% |
Stage #1: 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate In toluene at 20 - 65℃; Inert atmosphere; Stage #2: 3-acetylenephenylamine In isopropyl alcohol; toluene for 2.5h; Inert atmosphere; | 64% |
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
3-acetylenephenylamine
erlotinib
Conditions | Yield |
---|---|
Stage #1: 3-acetylenephenylamine In tetrahydrofuran; toluene at 0℃; for 0.5h; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; toluene at 20℃; for 4h; Product distribution / selectivity; | 70% |
Stage #1: 3-acetylenephenylamine With n-butyllithium In tetrahydrofuran; toluene at 0℃; Inert atmosphere; Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; toluene at 0 - 20℃; for 4.16667h; Product distribution / selectivity; | 70% |
3,4-bis(2-methoxyethoxy) benzonitrile
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid / acetic acid / 4 h / 0 °C 2.1: sodium dithionite / water / 3 h / 50 °C 2.2: 0.5 h / 65 °C 3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 4.1: acetic acid / toluene / 5 h / 60 °C 5.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: nitric acid / acetic acid / 4 h / 0 °C 2.1: sodium dithionite / water / 3 h / 50 °C 2.2: 0.5 h / 65 °C 3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 4.1: acetic acid / toluene / 125 - 130 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: acetic acid / 20 °C 1.2: 5 - 55 °C 2.1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr 3.1: 3 h / 20 °C / Reflux 4.1: acetic acid / 2 h / Reflux View Scheme |
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium dithionite / water / 3 h / 50 °C 1.2: 0.5 h / 65 °C 2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 3.1: acetic acid / toluene / 5 h / 60 °C 4.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium dithionite / water / 3 h / 50 °C 1.2: 0.5 h / 65 °C 2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 3.1: acetic acid / toluene / 125 - 130 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium dithionite / water / 2.5 h / 50 °C 2: acetic acid / toluene / 3 h / 105 °C / Dean-Stark 3: acetic acid / 3 h / 125 - 130 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrazine hydrate / water / 3 h / 20 - 30 °C 2: trifluoroacetic acid / ethyl acetate / 4 h / Reflux 3: trichlorophosphate; N,N-dimethyl-formamide / ethyl acetate / 2 h / 70 °C / Inert atmosphere 4: ethanol / 3 h / 40 - 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr 2: 3 h / 20 °C / Reflux 3: acetic acid / 2 h / Reflux View Scheme |
erlotinib
Conditions | Yield |
---|---|
In toluene at 125℃; for 5h; | 47 g |
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: water; potassium hydroxide / methanol / 4 h / 20 °C 2.1: urea / 0.5 h / 220 °C 3.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 4.1: nitric acid / acetic acid / 4 h / 0 °C 5.1: sodium dithionite / water / 3 h / 50 °C 5.2: 0.5 h / 65 °C 6.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 7.1: acetic acid / toluene / 5 h / 60 °C 8.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: water; potassium hydroxide / methanol / 4 h / 20 °C 2.1: urea / 0.5 h / 220 °C 3.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 4.1: nitric acid / acetic acid / 4 h / 0 °C 5.1: sodium dithionite / water / 3 h / 50 °C 5.2: 0.5 h / 65 °C 6.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 7.1: acetic acid / toluene / 125 - 130 °C View Scheme |
3,4-bis(2-methoxyethoxy)-benzamide
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 2.1: nitric acid / acetic acid / 4 h / 0 °C 3.1: sodium dithionite / water / 3 h / 50 °C 3.2: 0.5 h / 65 °C 4.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 5.1: acetic acid / toluene / 5 h / 60 °C 6.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 2.1: nitric acid / acetic acid / 4 h / 0 °C 3.1: sodium dithionite / water / 3 h / 50 °C 3.2: 0.5 h / 65 °C 4.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 5.1: acetic acid / toluene / 125 - 130 °C View Scheme |
3,4-bis(2-methoxyethoxy)-benzoic acid
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: urea / 0.5 h / 220 °C 2.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 3.1: nitric acid / acetic acid / 4 h / 0 °C 4.1: sodium dithionite / water / 3 h / 50 °C 4.2: 0.5 h / 65 °C 5.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 6.1: acetic acid / toluene / 5 h / 60 °C 7.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: urea / 0.5 h / 220 °C 2.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 3.1: nitric acid / acetic acid / 4 h / 0 °C 4.1: sodium dithionite / water / 3 h / 50 °C 4.2: 0.5 h / 65 °C 5.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 6.1: acetic acid / toluene / 125 - 130 °C View Scheme | |
Multi-step reaction with 10 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C 2: triethylamine / dichloromethane / 0 - 20 °C 3: triethylamine; dmap / dichloromethane / 24 h / 20 °C 4: sodium hydroxide / methanol / 2 h / 20 °C 5: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 6: sodium hydroxide / ethanol / 20 °C 7: ethanol / 1 h / Reflux 8: hydrogenchloride / water / 2 h / 100 - 105 °C 9: trichlorophosphate / toluene / 4 h / Reflux 10: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme |
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 2: acetic acid / toluene / 5 h / 60 °C 3: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid / toluene / 3 h / 105 °C / Dean-Stark 2: acetic acid / 3 h / 125 - 130 °C View Scheme |
N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid / toluene / 5 h / 60 °C 2: toluene / 5 h / 125 °C View Scheme |
3,4-Dihydroxybenzoic acid
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C 1.2: 50 - 85 °C 2.1: water; potassium hydroxide / methanol / 4 h / 20 °C 3.1: urea / 0.5 h / 220 °C 4.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 5.1: nitric acid / acetic acid / 4 h / 0 °C 6.1: sodium dithionite / water / 3 h / 50 °C 6.2: 0.5 h / 65 °C 7.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 8.1: acetic acid / toluene / 5 h / 60 °C 9.1: toluene / 5 h / 125 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C 1.2: 50 - 85 °C 2.1: water; potassium hydroxide / methanol / 4 h / 20 °C 3.1: urea / 0.5 h / 220 °C 4.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux 5.1: nitric acid / acetic acid / 4 h / 0 °C 6.1: sodium dithionite / water / 3 h / 50 °C 6.2: 0.5 h / 65 °C 7.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C 8.1: acetic acid / toluene / 125 - 130 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sulfuric acid / 10 h / 40 - 80 °C 2.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C 3.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 4.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 4.2: 20 °C 5.1: ammonium formate; triethylamine / 6 h / 160 °C 6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 7.1: methanol / 3 h / 20 - 30 °C 7.2: 3 h / 50 °C View Scheme |
Ethyl protocatechuate
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C 2: potassium hydroxide / ethanol; water / 3 h / 20 °C 3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C 5: triethylamine; dmap / dichloromethane / 24 h / 20 °C 6: sodium hydroxide / methanol / 2 h / 20 °C 7: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 8: sodium hydroxide / ethanol / 20 °C 9: ethanol / 1 h / Reflux 10: hydrogenchloride / water / 2 h / 100 - 105 °C 11: trichlorophosphate / toluene / 4 h / Reflux 12: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 64 h / Inert atmosphere; Reflux 2: acetic acid; nitric acid / 24 h / 5 °C 3: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr 4: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 5: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere 6: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 64 h / Inert atmosphere; Reflux 2: acetic acid; nitric acid / 24 h / 5 °C 3: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr 4: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 5: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux 6: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C 2.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 3.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 3.2: 20 °C 4.1: ammonium formate; triethylamine / 6 h / 160 °C 5.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 6.1: methanol / 3 h / 20 - 30 °C 6.2: 3 h / 50 °C View Scheme |
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: potassium hydroxide / ethanol; water / 3 h / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C 3: triethylamine / dichloromethane / 0 - 20 °C 4: triethylamine; dmap / dichloromethane / 24 h / 20 °C 5: sodium hydroxide / methanol / 2 h / 20 °C 6: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 7: sodium hydroxide / ethanol / 20 °C 8: ethanol / 1 h / Reflux 9: hydrogenchloride / water / 2 h / 100 - 105 °C 10: trichlorophosphate / toluene / 4 h / Reflux 11: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: acetic acid; nitric acid / 24 h / 5 °C 2: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr 3: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 4: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere 5: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: acetic acid; nitric acid / 24 h / 5 °C 2: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr 3: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere 4: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux 5: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness 2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C 2.2: 20 °C 3.1: ammonium formate; triethylamine / 6 h / 160 °C 4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C 5.1: methanol / 3 h / 20 - 30 °C 5.2: 3 h / 50 °C View Scheme |
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: triethylamine; dmap / dichloromethane / 24 h / 20 °C 3: sodium hydroxide / methanol / 2 h / 20 °C 4: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 5: sodium hydroxide / ethanol / 20 °C 6: ethanol / 1 h / Reflux 7: hydrogenchloride / water / 2 h / 100 - 105 °C 8: trichlorophosphate / toluene / 4 h / Reflux 9: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme |
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: triethylamine; dmap / dichloromethane / 24 h / 20 °C 2: sodium hydroxide / methanol / 2 h / 20 °C 3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 4: sodium hydroxide / ethanol / 20 °C 5: ethanol / 1 h / Reflux 6: hydrogenchloride / water / 2 h / 100 - 105 °C 7: trichlorophosphate / toluene / 4 h / Reflux 8: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme |
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere 2: sodium hydroxide / ethanol / 20 °C 3: ethanol / 1 h / Reflux 4: hydrogenchloride / water / 2 h / 100 - 105 °C 5: trichlorophosphate / toluene / 4 h / Reflux 6: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme |
erlotinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide / ethanol / 20 °C 2: ethanol / 1 h / Reflux 3: hydrogenchloride / water / 2 h / 100 - 105 °C 4: trichlorophosphate / toluene / 4 h / Reflux 5: pyridine / isopropyl alcohol / 4 h / Reflux View Scheme |
erlotinib
erlotinib hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 0℃; for 1h; Product distribution / selectivity; Inert atmosphere; | 100% |
With hydrogenchloride In ethanol; water at 72℃; for 0.333333h; Solvent; Temperature; | 99% |
With hydrogenchloride In water; acetone at 10℃; for 2.5h; Solvent; Temperature; | 98.7% |
erlotinib
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; dichloromethane at 15 - 30℃; for 3.08333h; Product distribution / selectivity; | 100% |
With hydrogenchloride In 1,4-dioxane; isopropyl alcohol at 0 - 70℃; for 1.5h; Solvent; Temperature; | 97.2% |
With hydrogenchloride In water; butanone at 30 - 35℃; | 93.13% |
With hydrogenchloride In isopropyl alcohol at 20 - 65℃; for 1h; Time; Concentration; | 30.0 g |
With hydrogenchloride In diethyl ether; chloroform | 90 mg |
Conditions | Yield |
---|---|
In isopropyl alcohol at 20 - 25℃; for 0.0416667h; Product distribution / selectivity; | 95.43% |
erlotinib
Conditions | Yield |
---|---|
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 40℃; for 48h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; water at 20℃; for 24h; | 93% |
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; ethanol; water at 20℃; for 24h; | 93% |
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 40℃; for 5h; Inert atmosphere; | 54% |
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 60℃; for 3h; Inert atmosphere; |
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 60℃; for 3h; Inert atmosphere; | 91% |
tert-butyl N-(3-azidopropyl)carbamate
erlotinib
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 60℃; Inert atmosphere; | 90% |
erlotinib
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In dimethyl sulfoxide at 20℃; for 12h; | 90% |
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; chloroform; water for 24h; Darkness; | 89% |
benzyl azide
erlotinib
Conditions | Yield |
---|---|
With [(1-phenylisoquinoline)2Ir(acetylacetonate)] In dichloromethane at 20℃; Irradiation; regioselective reaction; | 87% |
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 70℃; | 0.41 g |
carbon monoxide
erlotinib
Conditions | Yield |
---|---|
With dimanganese decacarbonyl In toluene at 100℃; under 760.051 Torr; for 16h; Schlenk technique; Sealed tube; | 86% |
erlotinib
Conditions | Yield |
---|---|
With cobalt(II) acetate; sodium pivalate at 23℃; for 16h; Inert atmosphere; Electrolysis; | 85% |
erlotinib
1-azido-1-deoxy-β-D-glucopyranoside tetraacetate
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol for 24h; | 83% |
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; chloroform; water for 24h; Darkness; | 82% |
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