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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Etoricoxib CAS:202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Etoricoxib

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Etoricoxib CAS NO.202409-33-4

Cas:202409-33-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Etoricoxib Cas 202409-33-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:1kg/foill bag;25kg

Manufacturer supply Etoricoxib Cas 202409-33-4 with high quality and best price

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Etoricoxib CAS No.:202409-33-4 Name: Etoricoxib Synonyms: 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine Molecular Structure Molecular Formula: C18H15ClN2O2S Molecular Weight: 358.84 CA

High purity Etoricoxib CAS No.:202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Etoricoxib

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Etoricoxib manufacturer with low price

Cas:202409-33-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Etoricoxib 202409-33-4 GMP Manufacturer

Cas:202409-33-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Etoricoxib

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Etoricoxib

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 202409-33-4 with best quality

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High Purity Etoricoxib CAS: 202409-33-4

Cas:202409-33-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Etoricoxib CAS202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Item Name Etoricoxib CAS NO. 202409-33-4 Apparence White Powder

5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

Cas:202409-33-4

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to light yellow crystalline powder Storage:R.T Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in China

Etoricoxib powder cas 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Etoricoxib CAS NO 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Etoricoxib 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Etoricoxib CAS:202409-33-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Etoricoxib CAS:202409-33-4

Cas:202409-33-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Etoricoxib

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Good quality Etoricoxib CAS NO.202409-33-4

Cas:202409-33-4

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Etoricoxib

Cas:202409-33-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Manufacturer supply Etoricoxib CAS 202409-33-4 AKS

Cas:202409-33-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd is China-based top1 exporter and supplier of Etoricoxib, Algix, Arcoxia, Etobrix, Etocox, CAS: 202409-33-4,please contact for price of Etoricoxib, Algix, Arcoxia, Etobrix, Etocox, CAS: 202409-33-4 and also you can sen

Top1 supplier and exporter of Etoricoxib, CAS: 202409-33-4 in China

Cas:202409-33-4

Min.Order:25 Gram

FOB Price: $16.5

Type:Other

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Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Etoricoxib

Cas:202409-33-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

high purity Etoricoxib API

Cas:202409-33-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Etoricoxib

Cas:202409-33-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Etoricoxib CAS 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Hefei Zhaobo Technology Co., Ltd.

Etoricoxib cas 202409-33-4 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syst

Etoricoxib cas 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Etoricoxib

Cas:202409-33-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Etoricoxib CAS 202409-33-4 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 P

Etoricoxib CAS 202409-33-4

Cas:202409-33-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Synthetic route

etoricoxib hydrochloride
202409-40-3

etoricoxib hydrochloride

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 10 - 20℃; for 0.5h; Reagent/catalyst; Large scale;96.5%
4-(5-chloro-6'-methyl-[2,3'-bipyridin]-3-yl)benzenesulfinic acid

4-(5-chloro-6'-methyl-[2,3'-bipyridin]-3-yl)benzenesulfinic acid

methyl iodide
74-88-4

methyl iodide

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Stage #1: 4-(5-chloro-6'-methyl-[2,3'-bipyridin]-3-yl)benzenesulfinic acid With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 65℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran at 65℃; for 2h; Cooling with liquid nitrogen;
95%
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
292067-97-1

5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With sodium molybdate; sulfuric acid; dihydrogen peroxide In methanol at 55℃; for 0.25h;94%
With oxygen; uranyl(VI) acetate dihydrate In o-xylene; water; acetonitrile at 20℃; under 760.051 Torr; Schlenk technique; Irradiation;91%
With diethylene glycol dibutyl ether; oxygen at 110℃; for 20h; Green chemistry;78%
5-chloro-1,2,3-triazine

5-chloro-1,2,3-triazine

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With potassium hydroxide In acetonitrile at 80℃; for 8h; Concentration; Inert atmosphere;89%
With caesium carbonate In tetrahydrofuran at 20℃; for 3h;82%
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V)

N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V)

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 0.25h; Inert atmosphere;
Stage #2: N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V) With acetic acid In tetrahydrofuran at 20 - 25℃; for 2.5h; Inert atmosphere;
Stage #3: With ammonium hydroxide In tetrahydrofuran at 60 - 65℃; for 1.5h; Inert atmosphere;
84.4%
With methanesulfonic acid; ammonium acetate; propionic acid In toluene at 25 - 75℃; for 14 - 16h; Reflux;
2,5-dichloro-3-[4-(methylsulfonyl)phenyl]pyridine
202409-86-7

2,5-dichloro-3-[4-(methylsulfonyl)phenyl]pyridine

C15H27BNO3(1-)*Li(1+)

C15H27BNO3(1-)*Li(1+)

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
palladium79%
2-chloro-1,3-(bis-piperidinyl)trimethinium hexafluorophosphate

2-chloro-1,3-(bis-piperidinyl)trimethinium hexafluorophosphate

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone With potassium tert-butylate In tetrahydrofuran at 25 - 30℃; for 1h;
Stage #2: 2-chloro-1,3-(bis-piperidinyl)trimethinium hexafluorophosphate In tetrahydrofuran at 30 - 55℃; Product distribution / selectivity;
75.9%
2-chloro-3-hydroxyacrylaldehyde

2-chloro-3-hydroxyacrylaldehyde

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With methanesulfonic acid In 1,2-dichloro-ethane at 80 - 100℃; for 24h;73%
(2Z,4Z)-4-Chloro-5-dimethylamino-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-penta-2,4-dien-1-one

(2Z,4Z)-4-Chloro-5-dimethylamino-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-penta-2,4-dien-1-one

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran at 60 - 65℃; Inert atmosphere;72.1%
With ammonium hydroxide In tetrahydrofuran for 5h; cyclocondensation; Heating;
5-chloro-3-(4-(methylsulfonyl)phenyl)pyridin-2-yl fluorosulfate

5-chloro-3-(4-(methylsulfonyl)phenyl)pyridin-2-yl fluorosulfate

(6-methylpyridin-3-yl)boronic acid
659742-21-9

(6-methylpyridin-3-yl)boronic acid

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 80℃; for 8h; Suzuki Coupling; chemoselective reaction;71%
5-bromo-2-methylpyridine
3430-13-5

5-bromo-2-methylpyridine

2-(allylsulfonyl)-5-chloro-3-[4-(methylsulfonyl)phenyl]pyridine

2-(allylsulfonyl)-5-chloro-3-[4-(methylsulfonyl)phenyl]pyridine

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate In 1,4-dioxane at 120℃; for 18h; Inert atmosphere;69%
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

2-chloroaminoacrolein

2-chloroaminoacrolein

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With methanesulfonic acid; propionic acid In toluene at 114℃; for 12h; Heating / reflux;65%
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

chloromalonaldehyde

chloromalonaldehyde

A

3,5-dichloropyridine
2457-47-8

3,5-dichloropyridine

B

etoricoxib
202409-33-4

etoricoxib

C

1-(6-methyl-3-pyridinyl)-3-(4-methanesulfonylphenyl)furan

1-(6-methyl-3-pyridinyl)-3-(4-methanesulfonylphenyl)furan

Conditions
ConditionsYield
With ammonium acetate In propionic acid at 125℃;A n/a
B 62%
C 15%
5-chloro-3-[4-(methylsulfonyl)phenyl]pyridin-2-yl trifluoromethanesulfonate

5-chloro-3-[4-(methylsulfonyl)phenyl]pyridin-2-yl trifluoromethanesulfonate

(6-methylpyridin-3-yl)boronic acid
659742-21-9

(6-methylpyridin-3-yl)boronic acid

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With palladium diacetate; sodium hydrogencarbonate; tricyclohexylphosphine In 1,4-dioxane; water at 80℃; for 1.5h; Suzuki-Miyaura Coupling; Sealed tube; Inert atmosphere; Schlenk technique;60%
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 80℃; for 3h; Inert atmosphere; Schlenk technique; Sealed tube;52%
2,3-dichloroacrolein
99414-75-2

2,3-dichloroacrolein

Lithium; (Z)-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethenolate

Lithium; (Z)-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethenolate

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Stage #1: 2,3-dichloroacrolein; Lithium; (Z)-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethenolate In tetrahydrofuran
Stage #2: With ammonia In tetrahydrofuran Heating; Further stages.;
58%
2-bromo-5-chloro-3-(4-(methylsulfonyl)phenyl)pyridine
202409-81-2

2-bromo-5-chloro-3-(4-(methylsulfonyl)phenyl)pyridine

(6-methylpyridin-3-yl)boronic acid
659742-21-9

(6-methylpyridin-3-yl)boronic acid

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); cesium fluoride In 1,4-dioxane for 20h; Concentration; Suzuki Coupling; Inert atmosphere; Reflux;55%
3-bromo-5-chloro-6'-methyl-2,3'-bipyridine

3-bromo-5-chloro-6'-methyl-2,3'-bipyridine

4-methanesulphonylphenylboronic acid
149104-88-1

4-methanesulphonylphenylboronic acid

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane at 100℃;54%
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

3-anilido-2-chloro-acrolein

3-anilido-2-chloro-acrolein

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With ammonium acetate In propionic acid Heating;47%
(2Z,4Z)-4-Chloro-5-dimethylamino-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-penta-2,4-dien-1-one

(2Z,4Z)-4-Chloro-5-dimethylamino-2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-penta-2,4-dien-1-one

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran for 3h; Heating;8.42 g
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 46.5 g / isopropyl acetate / 60 °C
2: 46.5 g / isopropyl acetate / 60 - 65 °C
3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
4: 24.91 g / aq. HCl / 25 - 45 °C
5: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
6: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
7: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 46.5 g / isopropyl acetate / 60 °C
2: 46.5 g / isopropyl acetate / 60 - 65 °C
3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
4: 24.91 g / aq. HCl / 25 - 45 °C
5: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 5 steps
1: 46.5 g / isopropyl acetate / 60 °C
2: 46.5 g / isopropyl acetate / 60 - 65 °C
3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
4: 24.91 g / aq. HCl / 25 - 45 °C
5: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
4: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 2 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
4-(methylsulfonyl)phenylacetic acid
90536-66-6

4-(methylsulfonyl)phenylacetic acid

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
4: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 2 steps
1: 58 percent / t-BuMgCl / tetrahydrofuran / 50 °C
2: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C
2: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
3: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
4: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
5: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C
2: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
3: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C
2: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
3: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
221615-72-1

1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
4: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
2: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 2 steps
1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C
2: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
2: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
3: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: t-BuOK / tetrahydrofuran / 0.75 h / 25 °C
2: TFA; AcOH / tetrahydrofuran / 0.75 h / 25 - 30 °C
3: aq. NH3 / tetrahydrofuran / 5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 30 - 55 °C / Large scale
1.2: Large scale
2.1: sodium hydroxide; water / 25 - 35 °C
View Scheme
[1-(6-Methyl-pyridin-3-yl)-meth-(E)-ylidene]-phenyl-amine

[1-(6-Methyl-pyridin-3-yl)-meth-(E)-ylidene]-phenyl-amine

etoricoxib
202409-33-4

etoricoxib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 46.5 g / isopropyl acetate / 60 - 65 °C
2: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
3: 24.91 g / aq. HCl / 25 - 45 °C
4: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
5: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C
6: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 46.5 g / isopropyl acetate / 60 - 65 °C
2: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
3: 24.91 g / aq. HCl / 25 - 45 °C
4: 62 percent / NH4OAc / propionic acid / 125 °C
View Scheme
Multi-step reaction with 4 steps
1: 46.5 g / isopropyl acetate / 60 - 65 °C
2: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C
3: 24.91 g / aq. HCl / 25 - 45 °C
4: 47 percent / NH4OAc / propionic acid / Heating
View Scheme
2-(1-cyclohexenyl)ethylamine
3399-73-3

2-(1-cyclohexenyl)ethylamine

etoricoxib
202409-33-4

etoricoxib

N-(2-(cyclohex-1-en-1-yl)ethyl)-6'-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3'-bipyridin]-5-amine

N-(2-(cyclohex-1-en-1-yl)ethyl)-6'-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3'-bipyridin]-5-amine

Conditions
ConditionsYield
With C47H70BrO4PPdSi; sodium t-butanolate In tetrahydrofuran at 20℃; for 1h; Schlenk technique; Inert atmosphere; Sealed tube;97%

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