Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryPurity: 98% up Storage:room temprature Package:25kg/drum Application:Etoricoxib intermediate Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiryStock products, own laboratory Storage:Inert atmosphere,Room Temperature Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryMelting Point:111-113℃ Boiling Point:426.7±40.0 °C(Predicted) PKA:3.84±0.10(Predicted) PSA:55.26000 Density:1.17±0.1 g/cm3(Predicted) LogP:3.53730 Storage Temp.:Inert atmosphere,Room Temperature XLogP3:3 Hydr
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inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiry1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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Type:Manufacturers
inquiryKONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for
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inquiryMethyl 6-methylnicotinate
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
With tert-butylmagnesium chloride In tetrahydrofuran at 65 - 70℃; for 1h; Reagent/catalyst; Temperature; | 87.7% |
N-methoxy-N-methyl-6-methylnicotinamide
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
In tetrahydrofuran; toluene at -10℃; for 1h; | 80% |
Methyl 6-methylnicotinate
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
With tert-butylmagnesium chloride In tetrahydrofuran at 65 - 70℃; for 1h; | 78.5% |
1-(chloromethyl)-4-methylthiobenzene
N-methoxy-N-methyl-6-methylnicotinamide
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Stage #1: 1-(chloromethyl)-4-methylthiobenzene With magnesium In tetrahydrofuran; toluene for 3 - 4h; Stage #2: N-methoxy-N-methyl-6-methylnicotinamide In toluene at -20℃; for 1.5h; | 76% |
With magnesium; ethylene dibromide In tetrahydrofuran; toluene at 36℃; | 62% |
Methyl 6-methylnicotinate
2-(4-(methylthio)phenyl)acetic acid
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
With tert-butylmagnesium chloride In tetrahydrofuran at 65 - 70℃; for 1h; | 72% |
Stage #1: 2-(4-(methylthio)phenyl)acetic acid With tert-butylmagnesium chloride In tetrahydrofuran at 60℃; for 1h; Flow reactor; Stage #2: Methyl 6-methylnicotinate In tetrahydrofuran at 60℃; for 1h; Flow reactor; Stage #3: With hydrogenchloride In water; toluene Temperature; Flow reactor; |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
In tetrahydrofuran; toluene at -20 - -10℃; for 1h; Temperature; Inert atmosphere; | 60% |
Methyl 6-methylnicotinate
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: i-PrMgCl / toluene; tetrahydrofuran / 0.5 h / -10 °C 2: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene / 0.67 h / Reflux 1.2: Reflux 2.1: hydrogenchloride; water; acetic acid / 40 °C / Reflux 2.2: 0.17 h / 0 - 5 °C / pH 7 - 7.2 View Scheme | |
Multi-step reaction with 2 steps 1: sodium methylate / toluene / 0.67 h / 25 - 30 °C / pH 5.2-6.2 / Reflux 2: hydrogenchloride / toluene; water; acetic acid / 20 °C / pH 6.9-7.1 View Scheme | |
Multi-step reaction with 2 steps 1: isopropylmagnesium chloride / toluene; tetrahydrofuran / 0.5 h / -20 - -10 °C / Inert atmosphere 2: toluene; tetrahydrofuran / 1 h / -20 - -10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: isopropylmagnesium chloride / toluene; tetrahydrofuran / 0.5 h / -20 - -10 °C / Inert atmosphere 2: diethyl ether / -10 - 0 °C View Scheme |
2-[4-(methylsulfanyl)phenyl]acetonitrile
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: toluene / 0.67 h / Reflux 1.2: Reflux 2.1: hydrogenchloride; water; acetic acid / 40 °C / Reflux 2.2: 0.17 h / 0 - 5 °C / pH 7 - 7.2 View Scheme | |
Multi-step reaction with 2 steps 1: sodium methylate / toluene / 0.67 h / 25 - 30 °C / pH 5.2-6.2 / Reflux 2: hydrogenchloride / toluene; water; acetic acid / 20 °C / pH 6.9-7.1 View Scheme |
1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone With hydrogenchloride; water; acetic acid at 40℃; Reflux; Stage #2: With ammonia In water at 0 - 5℃; for 0.166667h; pH=7 - 7.2; Product distribution / selectivity; | |
With hydrogenchloride In water; acetic acid; toluene at 20℃; pH=6.9-7.1; Concentration; Reagent/catalyst; Solvent; Time; Temperature; | 5.2 g |
Methyl 6-methylnicotinate
2-[4-(methylsulfanyl)phenyl]acetonitrile
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Stage #1: Methyl 6-methylnicotinate; 2-[4-(methylsulfanyl)phenyl]acetonitrile With hydrogenchloride; sodium methylate In water; toluene at 25 - 30℃; pH=5.2-6.2; Reflux; Stage #2: With hydrogenchloride In water; acetic acid; toluene at 40 - 50℃; Reflux; |
6-methyl-nicotinoyl chloride
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hexamethyldisilazane / diethyl ether 2: toluene; tetrahydrofuran / 1 h / -20 - -10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / water; dichloromethane / 0.5 h / 15 - 25 °C 2: diethyl ether / -10 - 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / water; dichloromethane / 0.5 h / 15 - 25 °C 2: toluene; tetrahydrofuran / 1 h / -20 - -10 °C / Inert atmosphere View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
In diethyl ether at -10 - 0℃; Temperature; |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone With methanesulfonic acid; acetic acid at 5 - 10℃; Stage #2: With dihydrogen peroxide at 5 - 25℃; for 6h; | 97.5% |
With sodium tungstate; dihydrogen peroxide In methanol at 40 - 50℃; for 2h; Temperature; Concentration; | 92% |
With sodium tungstate; dihydrogen peroxide In methanol; sulfuric acid at 55℃; | 89% |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone; (Z)-N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.75h; Stage #2: With hydroxylamine hydrochloride; acetic acid; trifluoroacetic acid In tetrahydrofuran; water for 5h; Heating; Further stages.; | 82% |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone With potassium tert-butylate In tetrahydrofuran at 20℃; Stage #2: vinamidinium hexafluorophosphate With acetic acid; trifluoroacetic acid at 20℃; Stage #3: With ammonium hydroxide for 6h; Heating; | 74% |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
2-chloromalonaldehyde
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
Conditions | Yield |
---|---|
With ammonium acetate; propionic acid at 130℃; for 16h; Temperature; Reagent/catalyst; | 68% |
2-chloro-3-acetoxyacrolein
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
Conditions | Yield |
---|---|
With ammonium acetate; propionic acid at 130℃; for 16h; Reagent/catalyst; | 45% |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 25℃; for 0.75h; Alkylation; |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tBuOK / tetrahydrofuran / 20 °C 1.2: AcOH; TFA / 20 °C 1.3: 74 percent / aq. NH3 / 6 h / Heating 2.1: 84 percent / m-CPBA / CH2Cl2; H2O / 0.67 h / -20 °C 3.1: (CF3CO)2O; 2,6-lutidine / acetonitrile / 1 h / -10 °C View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-6'-methyl-3-(4-(methylsulfinyl)phenyl)-2,3'-bipyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tBuOK / tetrahydrofuran / 20 °C 1.2: AcOH; TFA / 20 °C 1.3: 74 percent / aq. NH3 / 6 h / Heating 2.1: 84 percent / m-CPBA / CH2Cl2; H2O / 0.67 h / -20 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium tert-butylate / tetrahydrofuran / 20 °C 2: acetic acid; trifluoroacetic acid 3: ammonium hydroxide / water 4: uranyl(VI) acetate dihydrate; phosphoric acid; oxygen / water; acetonitrile / 12 h / 20 °C / 760.05 Torr / Schlenk technique; Irradiation View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
thiobutyric acid S-[4-(5-chloro-6'-methyl-[2,3']bipyridinyl-3-yl)phenyl] ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tBuOK / tetrahydrofuran / 20 °C 1.2: AcOH; TFA / 20 °C 1.3: 74 percent / aq. NH3 / 6 h / Heating 2.1: 84 percent / m-CPBA / CH2Cl2; H2O / 0.67 h / -20 °C 3.1: (CF3CO)2O; 2,6-lutidine / acetonitrile / 1 h / -10 °C 4.1: 32 mg / pyridine / CH2Cl2 / 0.5 h / 0 - 20 °C View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
etoricoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C 4: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: 62 percent / NH4OAc / propionic acid / 125 °C View Scheme | |
Multi-step reaction with 2 steps 1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: 47 percent / NH4OAc / propionic acid / Heating View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: t-BuOK / tetrahydrofuran / 0.75 h / 25 °C 2: TFA; AcOH / tetrahydrofuran / 0.75 h / 25 - 30 °C 3: aq. NH3 / tetrahydrofuran / 5 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 20 °C 2: acetic acid; trifluoroacetic acid 3: ammonium hydroxide / water View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: t-BuOK / tetrahydrofuran / 0.75 h / 25 °C 2: TFA; AcOH / tetrahydrofuran / 0.75 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 20 °C 2: acetic acid; trifluoroacetic acid View Scheme |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone With potassium tert-butylate In isopropyl alcohol at 5 - 8℃; for 4.5h; Stage #2: N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V) In isopropyl alcohol at 5 - 8℃; Product distribution / selectivity; | |
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone With potassium tert-butylate In isopropyl alcohol at 5 - 8℃; Stage #2: N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V) In isopropyl alcohol | 7.3 g |
1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone
5-chloro-3-(4-methylthiophenyl)-6'-methyl-[2,3']bipyridine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propionic acid; ammonium acetate / 16 h / 130 °C 2: hydrogenchloride / tert-butyl methyl ether View Scheme | |
Multi-step reaction with 2 steps 1: propionic acid; ammonium acetate / 16 h / 130 °C 2: hydrogenchloride / tert-butyl methyl ether View Scheme |
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