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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 22122-36-7 with best quality

Cas:22122-36-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2(5H)-Furanone,3-methyl- 22122-36-7

Cas:22122-36-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

3-Methyl-2(5H)-Furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-methylfuran-2(5H)-one

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Other

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3-Methyl-2(5H)-furanone 5ml

Cas:22122-36-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3-Methyl-2(5H)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Manufacturers

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

3-Methyl-2(5h)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Methyl-2(5H)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3-Methyl-2(5H)-furanone CAS No.22122-36-7

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

3-METHYL-2(5H)-FURANONEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Other

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-methyl-2H-furan-5-one

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Other

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou KieRay Chem Co.,Ltd.

Hangzhou KieRaychem Co.,Ltd.is located in Yuhang District of Hangzhou City and specialized in the chemical product customization, development, sales, import and export. Current business is focused on fine chemicals, pharmaceutical materials and int

3-METHYL-2(5H)-FURANONE

Cas:22122-36-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 3-Methyl-2(5H)-furanone, CAS:22122-36-7 with the most competitive price and the best

3-Methyl-2(5H)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

3-Methyl-2(5H)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Sigma-Aldrich Chemie GmbH

3-Methyl-2(5H)-furanone (3-Methylfuran-2(5H)-one) has been synthesized in highest yield (77%) by employing ?-methyl-?- butyrolactone as starting reagent. Package:1, 5 g in glass bottle Application:3-Methyl-2(5H)-furanone is the suitable model compoun

3-Methyl-2(5H)-furanone

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

4-methyl-2H-furan-5-one

Cas:22122-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

carbon monoxide
201230-82-2

carbon monoxide

3-iodo-but-2-ene-1-ol
35761-83-2

3-iodo-but-2-ene-1-ol

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With potassium carbonate; hydrazine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 25℃; under 760 Torr; for 72h;100%
2,3-butadien-1-ol
18913-31-0

2,3-butadien-1-ol

carbon monoxide
201230-82-2

carbon monoxide

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With dodecacarbonyl-triangulo-triruthenium; triethylamine In 1,4-dioxane at 100℃; under 7600 Torr; for 8h;98%
3-methyl-3-(4-trimethylsilylphenylselenyl)-3H-dihydrofuran-2-one
850185-98-7

3-methyl-3-(4-trimethylsilylphenylselenyl)-3H-dihydrofuran-2-one

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With dihydrogen peroxide In dichloromethane at 0 - 20℃; for 0.75h;96%
allyl methacrylate
96-05-9

allyl methacrylate

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With C28H32Cl2N2ORu In toluene at 70℃; for 18h; Inert atmosphere;91%
α-bromomethyl-γ-butene lactone
58588-90-2

α-bromomethyl-γ-butene lactone

A

α-methylene-γ-butyrolactone
547-65-9

α-methylene-γ-butyrolactone

B

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With glucose dehydrogenase; D-glucose; NCR; nicotinamide adenine dinucleotide; NADH In dimethyl sulfoxide at 30℃; for 24h; Enzymatic reaction;A 91%
B 6%
With glucose dehydrogenase; D-glucose; Old Yellow Enzyme 3; nicotinamide adenine dinucleotide; NADH In dimethyl sulfoxide at 30℃; for 24h; Enzymatic reaction;A 8%
B 70%
With glucose dehydrogenase; D-glucose; Old Yellow Enzyme 3; nicotinamide adenine dinucleotide; NADH In dimethyl sulfoxide at 30℃; for 24h; Reagent/catalyst; Enzymatic reaction;
With glucose dehydrogenase; D-glucose; Old Yellow Enzyme 3; nicotinamide adenine dinucleotide; NADH In dimethyl sulfoxide at 30℃; for 24h; Enzymatic reaction;
α-methylene-γ-butyrolactone
547-65-9

α-methylene-γ-butyrolactone

4-Methyl-1-pentene
691-37-2

4-Methyl-1-pentene

A

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

B

dihydro-3-(3-methylbutylidene)furan-2(3H)-one
3021-23-6

dihydro-3-(3-methylbutylidene)furan-2(3H)-one

Conditions
ConditionsYield
With 2-chloro-1,3,2-benzodioxaborole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 40℃; for 14h;A n/a
B 87%
With chlorodicyclohexylphosphine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane-d2 at 40℃; for 14h;
4-Bromomethyl-3-methyl-oxetan-2-one

4-Bromomethyl-3-methyl-oxetan-2-one

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With silver nitrate In acetic acid Heating;59%
3-butenyl chloroformate
88986-45-2

3-butenyl chloroformate

A

α-methylene-γ-butyrolactone
547-65-9

α-methylene-γ-butyrolactone

B

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

C

bis(3-butenyl) carbonate
85120-17-8

bis(3-butenyl) carbonate

Conditions
ConditionsYield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In xylene at 130℃; for 16h; Yield given. Yields of byproduct given;A n/a
B n/a
C 49%
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In xylene at 130℃; for 16h; Yields of byproduct given;A n/a
B n/a
C 49%
2-chloro-3-hydroxy-2-methyl-γ-butyrolacton

2-chloro-3-hydroxy-2-methyl-γ-butyrolacton

A

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

B

3-hydroxy-2-methyl-γ-butyrolacton
87683-09-8

3-hydroxy-2-methyl-γ-butyrolacton

Conditions
ConditionsYield
With zinc In acetic acid for 0.5h;A 45%
B 36%
citraconic acid anhydride
616-02-4

citraconic acid anhydride

A

5-hydroxy-4-methyl-5H-furan-2-one
40834-42-2

5-hydroxy-4-methyl-5H-furan-2-one

B

4-methyl-2(5H)-furanone
6124-79-4

4-methyl-2(5H)-furanone

C

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran THF, 0 deg C, 45 min; room temperature, 45 min;A 5%
B 43%
C 5%
5-Benzenesulfinyl-3-methyl-dihydro-furan-2-one
78429-08-0

5-Benzenesulfinyl-3-methyl-dihydro-furan-2-one

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With pyridine for 3h; Heating;27%
LACTIC ACID
849585-22-4

LACTIC ACID

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
In water at 380℃; under 300030 Torr; for 0.0125h; Time;23%
citraconic acid anhydride
616-02-4

citraconic acid anhydride

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 6h;15%
Stage #1: citraconic acid anhydride With N-cyclohexyl-cyclohexanamine In methanol at -15 - 20℃; for 3.5h;
Stage #2: With carbonochloridic acid, butyl ester In dichloromethane at -12℃; for 12h;
Stage #3: With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 3h; Further stages.;
4,5-dihydro-3-hydroxy-3-methyl-2(3H)-furanone
1192-42-3

4,5-dihydro-3-hydroxy-3-methyl-2(3H)-furanone

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With phosphorus pentoxide
Multi-step reaction with 2 steps
1: pyridine, phosphorus tribromide / CHCl3 / 6 h / 0 °C
2: 80 percent / DBN / toluene / 0.5 h / Heating
View Scheme
citraconic acid anhydride
616-02-4

citraconic acid anhydride

A

4-methyl-2(5H)-furanone
6124-79-4

4-methyl-2(5H)-furanone

B

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate Yield given. Yields of byproduct given;
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h; Yield given. Yields of byproduct given;
With L-Selectride In tetrahydrofuran at -78 - 22℃; for 48h; Yield given. Yields of byproduct given;
3-butenyl chloroformate
88986-45-2

3-butenyl chloroformate

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
Yield given. Multistep reaction;
α-methyl-γ-butyrolactone trimethylsilyl ketene acetal
87532-06-7

α-methyl-γ-butyrolactone trimethylsilyl ketene acetal

A

α-methylene-γ-butyrolactone
547-65-9

α-methylene-γ-butyrolactone

B

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

C

3-methyltetrahydro-2-furanone
1679-47-6

3-methyltetrahydro-2-furanone

Conditions
ConditionsYield
With triethylamine hydrofluoride; lithium tert-butoxide CH2Cl2; Yield given. Multistep reaction. Yields of byproduct given;
With lead(IV) acetate; triethylamine hydrofluoride C2H2Cl2; Yield given. Multistep reaction. Yields of byproduct given;
With triethylamine hydrofluoride; lithium tert-butoxide C2H2Cl2; Yield given. Multistep reaction. Yields of byproduct given;
α-Methyl-α-(phenylthio)-γ-butyrolactone
72017-07-3

α-Methyl-α-(phenylthio)-γ-butyrolactone

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With sodium periodate 1) aq. methanol, r.t.; 2) toluene, reflux, 0.5 h; Yield given. Multistep reaction;
4-Benzenesulfonyl-3-methyl-dihydro-furan-2-one

4-Benzenesulfonyl-3-methyl-dihydro-furan-2-one

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 1h; Yield given;
ethyl 4-acetoxy-4-chloro-2-hydroxy-2-methylbutanoate
80350-42-1

ethyl 4-acetoxy-4-chloro-2-hydroxy-2-methylbutanoate

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 4h; Heating;
Acetic acid (E)-1-acetoxy-3-methyl-4-oxo-but-2-enyl ester
85030-54-2

Acetic acid (E)-1-acetoxy-3-methyl-4-oxo-but-2-enyl ester

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetic acid Heating;
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

2-bromo-4-methyl-2H-furan-5-one
59488-94-7

2-bromo-4-methyl-2H-furan-5-one

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 78℃; for 1.5h;100%
With N-Bromosuccinimide; dibenzoyl peroxide In dichloromethane for 3h; Reflux; Dean-Stark;68%
With N-Bromosuccinimide; Perbenzoic acid In tetrachloromethane for 8h; Heating;0.330 g
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

triisopropyl((3-methylfuran-2-yl)oxy)silane
176041-42-2

triisopropyl((3-methylfuran-2-yl)oxy)silane

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;99%
With triethylamine In dichloromethane at 20℃; for 1.5h;99%
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;95%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

thioacetic acid
507-09-5

thioacetic acid

cis-4-acetylthio-3-methyl-4,5-dihydro-2(3H)-furanone

cis-4-acetylthio-3-methyl-4,5-dihydro-2(3H)-furanone

Conditions
ConditionsYield
With triethylamine at 50℃; for 72h;95%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

Allyl chloroformate
2937-50-0

Allyl chloroformate

3-methylfuran-2-yl prop-2-en-1-yl carbonate
1402611-71-5

3-methylfuran-2-yl prop-2-en-1-yl carbonate

Conditions
ConditionsYield
Stage #1: 3-methyl-5H-furan-2-one With sodium hexamethyldisilazane In tetrahydrofuran at -60℃; Inert atmosphere;
Stage #2: Allyl chloroformate In tetrahydrofuran Inert atmosphere;
94%
Stage #1: 3-methyl-5H-furan-2-one With sodium hexamethyldisilazane In tetrahydrofuran at -60℃; Inert atmosphere;
Stage #2: Allyl chloroformate In tetrahydrofuran at -60℃; for 0.333333h; Inert atmosphere;
92%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

3,4-dibromo-3-methyldihydrofuran-2-one

3,4-dibromo-3-methyldihydrofuran-2-one

Conditions
ConditionsYield
With bromine In dichloromethane at -10℃; for 2h;93%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

methyl 2-nitroacetate
2483-57-0

methyl 2-nitroacetate

((3R,4S)-4-Methyl-5-oxo-tetrahydro-furan-3-yl)-nitro-acetic acid methyl ester

((3R,4S)-4-Methyl-5-oxo-tetrahydro-furan-3-yl)-nitro-acetic acid methyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 60℃; for 12h; Michael addition;91%
thiobenzoic acid
98-91-9

thiobenzoic acid

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

cis-4-benzoylthio-3-methyl-4,5-dihydro-2(3H)-furanone

cis-4-benzoylthio-3-methyl-4,5-dihydro-2(3H)-furanone

Conditions
ConditionsYield
With triethylamine at 50℃; for 48h;90%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

tert-butyl(dimethyl)[(3-methylfuran-2-yl)oxy]silane
131497-06-8

tert-butyl(dimethyl)[(3-methylfuran-2-yl)oxy]silane

Conditions
ConditionsYield
With triethylamine In diethyl ether at 0℃; for 3h;88.5%
With triethylamine In dichloromethane at 0 - 23℃; for 21h;86%
Silylation;
2,2-dimethyl-5-nitro-1,3-dioxane
4064-87-3

2,2-dimethyl-5-nitro-1,3-dioxane

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

trans-4-(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)-dihydro-3-methyl-2(3H)-furanone

trans-4-(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)-dihydro-3-methyl-2(3H)-furanone

Conditions
ConditionsYield
With 1,1,3,3-tetramethylguanidine In acetonitrile at 17℃; for 48h;85%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

2-nitropropane
79-46-9

2-nitropropane

trans-3-methyldihydro-4-<2-(2-nitropropyl)>-2(3H)-furanone

trans-3-methyldihydro-4-<2-(2-nitropropyl)>-2(3H)-furanone

Conditions
ConditionsYield
With 1,1,3,3-tetramethylguanidine at 17℃; for 48h;85%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

(5S)-5-((R)-hydroxy(4-fluorophenyl)methyl)-3-methylfuran-2(5H)-one

(5S)-5-((R)-hydroxy(4-fluorophenyl)methyl)-3-methylfuran-2(5H)-one

Conditions
ConditionsYield
Stage #1: 3-methyl-5H-furan-2-one; 4-fluorobenzaldehyde With N,O-bis-(trimethylsilyl)-acetamide; N-(3',5'-di-tert-butylbenzyl)quininium bromide; sodium 4-methoxyphenolate In tetrahydrofuran at -78℃; for 5h; Aldol Addition; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0℃; for 0.5h; Inert atmosphere; Schlenk technique; enantioselective reaction;
82%
Nitroethane
79-24-3

Nitroethane

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

(3R,4S)-3-Methyl-4-(1-nitro-ethyl)-dihydro-furan-2-one

(3R,4S)-3-Methyl-4-(1-nitro-ethyl)-dihydro-furan-2-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 24h; Michael addition;78%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

trimethylsilyl trifluoromethanesulfonate
27607-77-8

trimethylsilyl trifluoromethanesulfonate

2-trimethylsilyloxy-3-methylfurane
61550-03-6

2-trimethylsilyloxy-3-methylfurane

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;78%
With triethylamine In dichloromethane at 20℃; for 1.5h; Cooling with ice; Inert atmosphere;78%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

(6S,7R,8S)-8-triisopropylsilyloxy-1-azabicyclo[5.3.0]decane-6-carbaldehyde

(6S,7R,8S)-8-triisopropylsilyloxy-1-azabicyclo[5.3.0]decane-6-carbaldehyde

(6S,7R,8S)-6-{[(1S)-hydroxy-(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]methyl}-8-triisopropylsilyloxy-1-azabicyclo[5.3.0]decane

(6S,7R,8S)-6-{[(1S)-hydroxy-(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]methyl}-8-triisopropylsilyloxy-1-azabicyclo[5.3.0]decane

Conditions
ConditionsYield
Stage #1: 3-methyl-5H-furan-2-one With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6S,7R,8S)-8-triisopropylsilyloxy-1-azabicyclo[5.3.0]decane-6-carbaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; diastereoselective reaction;
78%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

3,6-dimethoxyl-2-methylbenzaldehyde
121625-00-1

3,6-dimethoxyl-2-methylbenzaldehyde

C15H18O5

C15H18O5

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In chloroform for 0.5h; Reagent/catalyst; Inert atmosphere; UV-irradiation;78%
4-tetrahydropyranyloxybutanal
54911-85-2

4-tetrahydropyranyloxybutanal

3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

5-[1-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)butyl]-3-methylfuran-2-(5H)-one
1038587-97-1

5-[1-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)butyl]-3-methylfuran-2-(5H)-one

Conditions
ConditionsYield
Stage #1: 3-methyl-5H-furan-2-one With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 4-tetrahydropyranyloxybutanal In tetrahydrofuran at -78 - 20℃; for 2h; Further stages.;
76%
3-methyl-5H-furan-2-one
22122-36-7

3-methyl-5H-furan-2-one

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(5S)-5-((R)-hydroxy(4-chlorophenyl)methyl)-3-methylfuran-2(5H)-one

(5S)-5-((R)-hydroxy(4-chlorophenyl)methyl)-3-methylfuran-2(5H)-one

Conditions
ConditionsYield
Stage #1: 3-methyl-5H-furan-2-one; 4-chlorobenzaldehyde With N,O-bis-(trimethylsilyl)-acetamide; N-(3',5'-di-tert-butylbenzyl)quininium bromide; sodium 4-methoxyphenolate In tetrahydrofuran at -78℃; for 5h; Aldol Addition; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0℃; for 0.5h; Inert atmosphere; Schlenk technique; enantioselective reaction;
75%

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