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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy High Grade Reliable Quality 2537-48-6 On Stock

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Diethyl cyanomethylphosphonate TOP1 supplier

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name Diethyl cyanomethylphosphonate CAS

Diethyl cyanomethylphosphonate

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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m

Diethyl cyanomethylphosphonate

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl Cyanomethylphosphonate

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Diethyl cyanomethylphosphonate

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Diethyl cyanomethylphosphonate

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Chemwill Asia Co., Ltd.

CHemwill -- Diethyl cyanomethylphosphonate

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--2537-48-6--High purity Diethyl cyanomethylphosphonate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established sta

TIANFUCHEM--2537-48-6--High purity Diethyl cyanomethylphosphonate in stock

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 2537-48-6 with competitive price

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 2537-48-6 ,Diethyl cyanomethylphosphonate

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Henan Sinotech Import&Export Corporation

1. Characteristics Item Specification CAS 2537-48-6 Appearance Transparent liquid 2. Application: It can be used as intermediate in organic syn

Diethyl cyanomethylphosphonate CAS: 2537-48-6

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonicacid, P-(cyanomethyl)-, diethyl ester 2537-48-6

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Qingdao Beluga Import and Export Co., LTD

Diethyl cyanomethylphosphonate CAS: 2537-48-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or

Diethyl cyanomethylphosphonate CAS: 2537-48-6

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2537-48-6

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Diethyl cyanomethylphosphonate

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl Cyanomethylphosphonate

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Diethyl cyanomethylphosphonate

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cyanomethylphosphonic acid diethyl ester~Diethyl phosphonoacetonitrile

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Diethyl cyanomethylphosphonate

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Diethyl cyanomethylphosphonate

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Diethyl cyanomethylphosphonate

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Diethyl cyanomethylphosphonate

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Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Best price 2537-48-6 best quality Diethyl cyanomethylphosphonate

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Siwei Development Group Ltd.

Product name: Diethyl Cyanomethyl Phosphonate CAS No.:2537-48-6 Molecule Formula:C6H12NO3P Molecule Weight:177.14 Purity: 99.0% Package: 200kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard

High Quality Diethyl Cyanomethyl Phosphonate in stock

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Diethyl cyanomethylphosphonate

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Diethylcyanomethylphosphonate

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Shanghai Minstar Chemical Co., Ltd

Product Name: Diethyl cyanomethylphosphonate Synonyms: (Cyanomethyl)diethoxyphosphine oxide;2-(Diethylphosphonyl)acetonitrile;Diethyl cyanomethanephosphonate;Phosphonic acid, (cyanomethyl)-, diethyl ester;Cyanomethylphosphonic acid diethyl este

Diethyl cyanomethylphosphonate 2537-48-6 C6H12NO3P

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Diethyl cyanomethylphosphonate

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Synthetic route

chloroacetonitrile
107-14-2

chloroacetonitrile

triethyl phosphite
122-52-1

triethyl phosphite

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

Conditions
ConditionsYield
at 150℃; for 4h;99%
at 150℃; for 2h;92%
for 3h; Arbusov reaction; Heating;85%
cyanomethyl bromide
590-17-0

cyanomethyl bromide

triethyl phosphite
122-52-1

triethyl phosphite

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

Conditions
ConditionsYield
for 0.0333333h; Michaelis-Arbuzov reaction; microwave irradiation;95%
diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

acetonitrile
75-05-8

acetonitrile

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

Conditions
ConditionsYield
Stage #1: acetonitrile With lithium hexamethyldisilazane In tetrahydrofuran; hexane at -78℃; for 0.5h; Metallation;
Stage #2: diethyl chlorophosphate In tetrahydrofuran at -78 - 0℃; for 0.25h; Substitution;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane Hydrolysis; Further stages.;
88%
With lithium diisopropyl amide 1.) THF, -30 deg C, 0.5 h, 2.) -30 deg C, 5 h; Yield given. Multistep reaction;
With lithium diisopropyl amide 1.) THF, -80 deg C, 15 min, 2.) THF, from -80 deg C to 0 deg C, 1 h; Multistep reaction;
chloroacetonitrile
107-14-2

chloroacetonitrile

triethyl phosphite
122-52-1

triethyl phosphite

A

chloroethane
75-00-3

chloroethane

B

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

Conditions
ConditionsYield
at 140 - 180℃;A n/a
B 84.5%
methanol
67-56-1

methanol

diazo-cyanomethylphosphonic acid diethyl ester
59463-50-2

diazo-cyanomethylphosphonic acid diethyl ester

A

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

B

diethyl ((cyanomethoxy)methyl)phosphonate
59463-48-8

diethyl ((cyanomethoxy)methyl)phosphonate

Conditions
ConditionsYield
In water for 3h; Irradiation; Sealed tube; Cooling with ice;A 66%
B 11%
diethyl cyanomethylphosphonate potassium salt

diethyl cyanomethylphosphonate potassium salt

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

Conditions
ConditionsYield
With ethyl 4-nitrobenzoate In dimethyl sulfoxide at 24.9℃; Equilibrium constant;
1-cyano-1-(diethoxyphosphoryl)-2-[(6-methylpyrid-2-yl)amino]-2-(trifluoromethyl)ethylene

1-cyano-1-(diethoxyphosphoryl)-2-[(6-methylpyrid-2-yl)amino]-2-(trifluoromethyl)ethylene

A

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

B

2,2,2-trifluoro-N-(6-methyl-2-pyridinyl)acetamide
334711-70-5

2,2,2-trifluoro-N-(6-methyl-2-pyridinyl)acetamide

Conditions
ConditionsYield
With air
2,3-dichloroquinoxaline
2213-63-0

2,3-dichloroquinoxaline

(2-amino-2-thioxoethyl)phosphonic acid diethyl ester
77679-10-8

(2-amino-2-thioxoethyl)phosphonic acid diethyl ester

A

2-chloro-3-[(3-chloro-2-quinoxalinyl)-thio]quinoxaline
1062508-50-2

2-chloro-3-[(3-chloro-2-quinoxalinyl)-thio]quinoxaline

B

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

furfural
98-01-1

furfural

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

(E)-3-(2-furyl)acrylonitrile
6125-63-9

(E)-3-(2-furyl)acrylonitrile

Conditions
ConditionsYield
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.666667h;100%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: furfural In tetrahydrofuran at 28℃;
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: furfural In tetrahydrofuran; mineral oil at 0 - 25℃; for 2h;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

7-Methoxy-1-tetralone
6836-19-7

7-Methoxy-1-tetralone

(7-methoxy-3,4-dihydro-2H-naphthalene-1-ylidene)acetonitrile
127299-26-7

(7-methoxy-3,4-dihydro-2H-naphthalene-1-ylidene)acetonitrile

Conditions
ConditionsYield
With sodium methylate In methanol at -20 - -10℃; for 24h; Reagent/catalyst; Wittig Rearrangement;100%
Stage #1: diethyl 1-cyanomethylphosphonate With potassium hydroxide In dimethyl sulfoxide at 15 - 25℃; for 1h; Industry scale;
Stage #2: 7-Methoxy-1-tetralone In tetrahydrofuran; dimethyl sulfoxide at 15 - 25℃; for 2.5h; Product distribution / selectivity;
95%
Stage #1: 7-Methoxy-1-tetralone With sodium hydride In 1,2-dimethoxyethane at 15℃; for 0.5h;
Stage #2: diethyl 1-cyanomethylphosphonate In monoethylene glycol diethyl ether at 10 - 15℃;
89%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

benzaldehyde
100-52-7

benzaldehyde

cinnamic nitrile
1885-38-7

cinnamic nitrile

Conditions
ConditionsYield
With caesium carbonate at 20℃; for 24h; Horner reaction;100%
With sodium hydride 1.) THF, RT, 20 min, 2.) THF, RT, 72 h; Multistep reaction;
In tetrahydrofuran at 0℃; for 3h; Yield given;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester

4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.666667h; Inert atmosphere;100%
With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.666667h; Inert atmosphere;100%
With lithium bromide In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

(4E,6E)-5-Methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienal
219130-11-7

(4E,6E)-5-Methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienal

(2E,6E,8E)-7-Methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienenitrile

(2E,6E,8E)-7-Methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienenitrile

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

1-naphthaldehyde
66-77-3

1-naphthaldehyde

3-(1-naphthyl)acrylonitrile
111686-30-7

3-(1-naphthyl)acrylonitrile

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; Wadsworth-Emmons reaction;100%
With potassium carbonate for 0.25h; Ambient temperature;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3,3'-difluorobenzophenone
345-70-0

3,3'-difluorobenzophenone

3,3'-bis(3-fluorophenyl)acrylonitrile
170019-08-6

3,3'-bis(3-fluorophenyl)acrylonitrile

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide100%
With sodium hydride In N,N-dimethyl-formamide Horner-Emmons coupling;100%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.416667h;
Stage #2: 3,3'-difluorobenzophenone In tetrahydrofuran; mineral oil at 80℃; Cooling with ice;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

N-(4-methoxybenzylidene)-p-toluenesulfonamide
14674-38-5

N-(4-methoxybenzylidene)-p-toluenesulfonamide

diethyl [(E)-1-cyano-2-(4-methoxyphenyl)ethenyl]phosphonate
36315-64-7

diethyl [(E)-1-cyano-2-(4-methoxyphenyl)ethenyl]phosphonate

Conditions
ConditionsYield
With dimethyl sulfoxide at 20℃; for 1h; Knoevenagel condensation; Inert atmosphere; Molecular sieve; optical yield given as %de; stereoselective reaction;100%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.0333333h; Condensation;81%
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In dimethyl sulfoxide Knoevenagel type condensation;
Stage #2: N-(4-methoxybenzylidene)-p-toluenesulfonamide In dimethyl sulfoxide at 20℃; Kinetics;
3-methoxy-4-(phenylmethoxy)benzaldehyde
2426-87-1

3-methoxy-4-(phenylmethoxy)benzaldehyde

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

4-benzyloxy-3-methoxy-β-cyanostyrene

4-benzyloxy-3-methoxy-β-cyanostyrene

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0℃; for 1.5h;100%
4-methyl-pent-3-en-2-one
141-79-7

4-methyl-pent-3-en-2-one

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3,5-Dimethyl-2,4-hexadienenitrile
54354-52-8

3,5-Dimethyl-2,4-hexadienenitrile

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -60 - 20℃;100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3,5-dimethoxybenzaldehdye
7311-34-4

3,5-dimethoxybenzaldehdye

3-(3,5-dimethoxyphenyl)acrylonitrile
153507-02-9

3-(3,5-dimethoxyphenyl)acrylonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 0.25h;
Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 20℃; for 17h;
100%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 28℃;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

1-[(1-methylcyclopropyl)sulfonyl]azetidin-3-one
1187594-26-8

1-[(1-methylcyclopropyl)sulfonyl]azetidin-3-one

2-(1-((1-methylcyclopropyl)sulfonyl)azetidin-3-ylidene)acetonitrile
1187594-27-9

2-(1-((1-methylcyclopropyl)sulfonyl)azetidin-3-ylidene)acetonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #2: 1-[(1-methylcyclopropyl)sulfonyl]azetidin-3-one In tetrahydrofuran; mineral oil at 20℃; for 16h;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

5,5-dichloro-4-oxo-1-(p-toluenesulfonyl)-4,5,6,7,-tetrahydroindole

5,5-dichloro-4-oxo-1-(p-toluenesulfonyl)-4,5,6,7,-tetrahydroindole

2-(5,5-dichloro-6,7-dihydro-1-tosyl-1H-indol-4(5H)-ylidene)acetonitrile
1236306-10-7

2-(5,5-dichloro-6,7-dihydro-1-tosyl-1H-indol-4(5H)-ylidene)acetonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 5,5-dichloro-4-oxo-1-(p-toluenesulfonyl)-4,5,6,7,-tetrahydroindole In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

tert-butyl 3-formylpyrrolidine-1-carboxylate
59379-02-1

tert-butyl 3-formylpyrrolidine-1-carboxylate

tert-butyl 3-[(E)-2-cyanoethenyl]pyrrolidine-1-carboxylate

tert-butyl 3-[(E)-2-cyanoethenyl]pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 2h;
Stage #2: tert-butyl 3-formylpyrrolidine-1-carboxylate In tetrahydrofuran at 0 - 20℃; for 16h;
100%
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 12h;86.1%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

2-cyclopentylacetaldehyde
5623-81-4

2-cyclopentylacetaldehyde

4-cyclopentylbut-2-enenitrile
1269823-36-0

4-cyclopentylbut-2-enenitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h;
Stage #2: 2-cyclopentylacetaldehyde In tetrahydrofuran; mineral oil at 20℃;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

4-N,N-di-n-butylamino-2-methoxybenzaldehyde
103893-16-9

4-N,N-di-n-butylamino-2-methoxybenzaldehyde

3-(4-dibutylamino-2-methoxyphenyl)acrylonitrile
1267604-90-9

3-(4-dibutylamino-2-methoxyphenyl)acrylonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran for 0.416667h; Cooling with ice;
Stage #2: 4-N,N-di-n-butylamino-2-methoxybenzaldehyde In tetrahydrofuran for 1h;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

C12H16N2O

C12H16N2O

C14H17N3

C14H17N3

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In tetrahydrofuran at 5 - 20℃; for 1h; Inert atmosphere;
Stage #2: C12H16N2O In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

lithium ethyl cyanomethylphosphonate

lithium ethyl cyanomethylphosphonate

Conditions
ConditionsYield
With lithium bromide at 100℃; for 70h;100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde
1208005-62-2

7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde

(E)-3-(7-(diethylamino)-9,9-dimethyl-9H-fluoren-2-yl)acrylonitrile

(E)-3-(7-(diethylamino)-9,9-dimethyl-9H-fluoren-2-yl)acrylonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: 7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde In tetrahydrofuran at 20℃; for 4h;
100%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: 7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde In tetrahydrofuran; mineral oil at 20℃; for 4h;
100%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

C19H34O4Si

C19H34O4Si

C21H35NO3Si

C21H35NO3Si

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h;
Stage #2: C19H34O4Si In tetrahydrofuran; hexane at 0 - 20℃; Wittig-Horner Reaction;
100%
cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

2-<4,4-(ethylenedioxy)cyclohexylidene>acetonitrile
124499-35-0

2-<4,4-(ethylenedioxy)cyclohexylidene>acetonitrile

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride In tetrahydrofuran; paraffin for 12h;99%
Stage #1: diethyl 1-cyanomethylphosphonate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride In tetrahydrofuran for 0.416667h; Inert atmosphere;
Stage #2: cyclohexanedione monoethylene ketal at 20℃; for 3h;
96%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran
Stage #2: cyclohexanedione monoethylene ketal With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran
95%
2-(1,3-dithian-2-yl)-2-methylpropanal
64872-91-9

2-(1,3-dithian-2-yl)-2-methylpropanal

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

(E)-4-(1,3-dithian-2-yl)-4-methylpent-2-enenitrile
139745-78-1

(E)-4-(1,3-dithian-2-yl)-4-methylpent-2-enenitrile

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran99%
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 45 min; 2.) -78 deg C, 2 h; RT, 2 h;99%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

6,6'-dideuterio-3,3'-dimethylbenzophenone
144617-64-1

6,6'-dideuterio-3,3'-dimethylbenzophenone

C17H13(2)H2N
144617-69-6

C17H13(2)H2N

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane99%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

cyclopentanone
120-92-3

cyclopentanone

cyclopentylideneacetonitrile
5732-88-7

cyclopentylideneacetonitrile

Conditions
ConditionsYield
With sodium hydride In diethyl ether at 20℃; Cooling with ice;99%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In N,N-dimethyl-formamide at 0℃;
Stage #2: cyclopentanone In N,N-dimethyl-formamide at 0 - 20℃;
89%
With potassium carbonate In water at 80℃; for 2.5h;88%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3-tetrahydropyran-2-yloxy-androst-5-en-17-one
19637-35-5

3-tetrahydropyran-2-yloxy-androst-5-en-17-one

20-carbonitrilopregna-5,17(20)diene 3β-tetrahydropyranyl ether

20-carbonitrilopregna-5,17(20)diene 3β-tetrahydropyranyl ether

Conditions
ConditionsYield
With sodium hydride Wittig-Horner reaction;99%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In 1,2-dimethoxyethane for 0.166667h; Heating;
Stage #2: 3-tetrahydropyran-2-yloxy-androst-5-en-17-one In 1,2-dimethoxyethane for 5h; Wittig-Horner reaction; Heating; Further stages.;
99%
5-Norbornene-2-carboxaldehyde
5453-80-5, 19926-90-0

5-Norbornene-2-carboxaldehyde

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

(E)-3-Bicyclo[2.2.1]hept-5-en-2-yl-acrylonitrile

(E)-3-Bicyclo[2.2.1]hept-5-en-2-yl-acrylonitrile

Conditions
ConditionsYield
With polymer-anchored quaternary trimethylammonium hydroxide In acetonitrile at 20℃; for 1h; Horner-Emmons olefination;99%
tert-butyl 3-oxoazetidine-1-carboxylate
398489-26-4

tert-butyl 3-oxoazetidine-1-carboxylate

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester
1153949-11-1

3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #2: tert-butyl 3-oxoazetidine-1-carboxylate In tetrahydrofuran; mineral oil Product distribution / selectivity;
99%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 0 - 20℃;
Stage #2: tert-butyl 3-oxoazetidine-1-carboxylate In tetrahydrofuran at 0℃;
Stage #3: With water In tetrahydrofuran
98%
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In tetrahydrofuran at 0 - 30℃;
Stage #2: tert-butyl 3-oxoazetidine-1-carboxylate In tetrahydrofuran at 0 - 30℃;
95%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

3-benzyloxy cyclobutanone
30830-27-4

3-benzyloxy cyclobutanone

2-(3-(benzyloxy)cyclobutylidene)acetonitrile
1187595-82-9

2-(3-(benzyloxy)cyclobutylidene)acetonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With triethylamine; lithium bromide In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: 3-benzyloxy cyclobutanone at 20℃; for 20h; Concentration;
99%
Stage #1: diethyl 1-cyanomethylphosphonate With triethylamine; lithium bromide In tetrahydrofuran at 10℃; for 1.5h; Inert atmosphere;
Stage #2: 3-benzyloxy cyclobutanone In tetrahydrofuran at 10℃; for 20h; Inert atmosphere;
91%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: 3-benzyloxy cyclobutanone In tetrahydrofuran at 20℃;
80%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: 3-benzyloxy cyclobutanone In tetrahydrofuran at 20℃; Inert atmosphere;
80%
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In tetrahydrofuran at 0 - 20℃;
Stage #2: 3-benzyloxy cyclobutanone In tetrahydrofuran at 0 - 20℃;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

(E)-β-[4-(2-nitrobenzenesulfonyloxy)phenyl]acrylonitrile

(E)-β-[4-(2-nitrobenzenesulfonyloxy)phenyl]acrylonitrile

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde; 2-Nitrobenzenesulfonyl chloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1.5h;
Stage #2: diethyl 1-cyanomethylphosphonate With lithium chloride at 20℃; for 24h; Inert atmosphere;
99%

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