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Senova Pharma

Commercial production supplying from grams to tons, with technical documents support, and audit and inspection support High purity, optimized stable process Appearance:yellow crystal Storage:Sealed in dry,Room Temperature Package:standard package

Sunitinib Intermediate

Cas:253870-02-9

Min.Order:10 Gram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid supplier in China

Cas:253870-02-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Off-white or white crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceut

Nanjing Yuance Industry&Trade Co., Ltd.

Purity 99% with good quality Competitive price Fast delivery Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $0.98 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 253870-02-9 with competitive price

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS Number 253870-02-9 Product Name 5- Formyl-2,4-dimethyl-1h-pyrrole-3-carboxylic Acid Synonyms 5-formyl-2,4-dimethylpyrrole-3-

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS: 253870-02-9

Cas:253870-02-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

FOB Price: $23.0 / 35.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS NO 253870-02-9

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-9

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS:253870-02-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializi

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS:253870-02-9

Cas:253870-02-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1715.html Product Name 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS No

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Gram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid

Cas:253870-02-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Gram

FOB Price: $53.0

Type:Trading Company

inquiry

Wuhan BJM Pharm Inc.

We have two factories in Dezhou , Shandong and Xianning, Hubei. The factory covers an area of 48,000 square meters with the building area of 26,000 square meters. We are specialized in the manufacture of pharmaceutical intermediates and cosmetic addi

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid CAS No:253870-02-9 Sunitinib internediate

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:253870-02-9

Sunitinib intermediate 253870-02-9

Cas:253870-02-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Nanjing Fred Technology Co.,Ltd.

5-formyl-2,4-dimethyl-1H-pyrr-ole-3-carboxylic acid is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:off-white solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/

5-formyl-2,4-dimethyl-1H-pyrr-ole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Sunitinib interMediate 253870-02-9

Cas:253870-02-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 253870-02-9 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Cas:253870-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol; water Reflux;99%
With potassium hydroxide In methanol; water at 70℃;97%
With methanol; water; potassium hydroxide at 100℃; for 2h;94%
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

A

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

B

5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene-methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid

5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene-methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid

Conditions
ConditionsYield
With potassium hydroxide In methanol; waterA 93%
B n/a
With potassium hydroxide In methanol; waterA 93%
B n/a
With potassium hydroxide In methanol; waterA 93%
B n/a
benzyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
37059-18-0

benzyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol; ethanol at 20℃; for 5h;93%
With palladium on activated charcoal; hydrogen; triethylamine In methanol; ethanol under 760.051 Torr; for 5h;93%
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
86770-31-2

2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / TFA
2: 93 percent / aq. KOH / methanol
View Scheme
Multi-step reaction with 2 steps
1: 81 percent / TFA / -5 - 20 °C
2: 90 percent / aq. KOH / methanol / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C
2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
2.2: 25 - 30 °C / pH 12 - 13
3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
View Scheme
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
1.2: 25 - 30 °C / pH 12 - 13
2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
View Scheme
Multi-step reaction with 2 steps
1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
2: water; potassium hydroxide / methanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: trichlorophosphate / dichloromethane / 1.25 h / 4 °C / Reflux
1.2: 10 °C
2.1: potassium hydroxide / water / 5 h / Reflux
2.2: pH 4
View Scheme
3,5-dimethyl-1H-pyrrole-2, 4-dicarboxylic acid 2-tert-butyl ester 4-benzyl ester
89909-48-8

3,5-dimethyl-1H-pyrrole-2, 4-dicarboxylic acid 2-tert-butyl ester 4-benzyl ester

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water; ethanol / 4 h / 0 - 65 °C
2.1: trichlorophosphate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / Reflux
2.3: 1 h / Reflux
3.1: palladium on activated charcoal; hydrogen; triethylamine / methanol; ethanol / 5 h / 760.05 Torr
View Scheme
benzyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
37059-10-2

benzyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trichlorophosphate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / Reflux
1.3: 1 h / Reflux
2.1: palladium on activated charcoal; hydrogen; triethylamine / methanol; ethanol / 5 h / 760.05 Torr
View Scheme
diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate
2436-79-5

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; potassium hydroxide / ethanol / 10 h / 50 - 60 °C
2.1: Inert atmosphere
3.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux
3.2: 0.5 h / Reflux
4.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide / water; ethanol / 2.5 h / Reflux
2.1: neat (no solvent) / 1.5 h / Heating
3.1: trichlorophosphate / dichloromethane / 0.5 h / 5 °C
3.2: 1.5 h / Reflux
4.1: sodium hydroxide / water; methanol / 4 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water; ethanol / 2 h / Reflux
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 120 °C
3: trichlorophosphate / 15 - 20 °C
4: potassium hydroxide; water / methanol / 3 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide / ethanol; water / 10 h / 50 °C
2.1: 0.08 h / 200 °C / Inert atmosphere
3.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C
3.2: 1.5 h / Reflux
4.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere
View Scheme
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester
5442-91-1

3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux
2.2: 0.5 h / Reflux
3.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: neat (no solvent) / 1.5 h / Heating
2.1: trichlorophosphate / dichloromethane / 0.5 h / 5 °C
2.2: 1.5 h / Reflux
3.1: sodium hydroxide / water; methanol / 4 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 120 °C
2: trichlorophosphate / 15 - 20 °C
3: potassium hydroxide; water / methanol / 3 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: 0.08 h / 200 °C / Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C
2.2: 1.5 h / Reflux
3.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere
View Scheme
morpholine
110-91-8

morpholine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

3,5-dimethyl-4-(morpholine-4-carbonyl)-1H-pyrrole-2-carbaldehyde
775322-41-3

3,5-dimethyl-4-(morpholine-4-carbonyl)-1H-pyrrole-2-carbaldehyde

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water; N,N-dimethyl-formamide at 20℃; for 12h;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

butan-1-ol
71-36-3

butan-1-ol

butyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
1440428-47-6

butyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Reflux;99%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoro-1-methyl-1,3-dihydroindol-2-one
41192-31-8

5-fluoro-1-methyl-1,3-dihydroindol-2-one

(Z)-5-((5-fluoro-1-methyl-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

(Z)-5-((5-fluoro-1-methyl-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With pyrrolidine In ethanol at 80℃; for 3h;99%
With pyrrolidine In ethanol for 3h; Reflux;84%
With pyrrolidine In ethanol for 3h; Reflux;84%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
452105-33-8

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;98%
With pyrrolidine In ethanol for 3h; Reflux;98.2%
With piperidine In ethanol Inert atmosphere;90%
piperidine
110-89-4

piperidine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

3,5-dimethyl-4-(piperidin-1-ylcarbonyl)-1H-pyrrole-2-carbaldehyde
1309935-11-2

3,5-dimethyl-4-(piperidin-1-ylcarbonyl)-1H-pyrrole-2-carbaldehyde

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; for 12h;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
356068-93-4

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 5-fluoroindol-2(3H)-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 5h; Reflux;
Stage #2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With trimethylsilyl trifluoromethanesulfonate
97%
pyrrolidine In ethanol for 3h; Heating / reflux;96%
With pyrrolidine In ethanol for 3h; Heating / reflux;96%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
1374685-40-1

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
356068-93-4

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole With 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile for 0.25h;
Stage #2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With trifluorormethanesulfonic acid
97%
With 1,1,1,3,3,3-hexamethyl-disilazane; trifluorormethanesulfonic acid In acetonitrile at 20 - 65℃; for 48h; Product distribution / selectivity;
1-(2-aminoethyl)piperidine
27578-60-5

1-(2-aminoethyl)piperidine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-formyl-2,4-dimethyl-N-(2-( piperidin-1-yl)-ethyl)-1H-pyrrole-3-carboxamide
1196888-04-6

5-formyl-2,4-dimethyl-N-(2-( piperidin-1-yl)-ethyl)-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide96%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 5 - 20℃;66%
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1-(2-aminoethyl)piperidine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
pyrrolidine
123-75-1

pyrrolidine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

3,5-dimethyl-4-( pyrrolidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde
1309935-10-1

3,5-dimethyl-4-( pyrrolidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; for 12h;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-hydroxy-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

5-hydroxy-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

(Z)-5-((5-hydroxy-4,6-dimethyl-2-oxo-1H-pyrrolo[2,3-b]pyridin-3(2H)-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

(Z)-5-((5-hydroxy-4,6-dimethyl-2-oxo-1H-pyrrolo[2,3-b]pyridin-3(2H)-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Knoevenagel Condensation; Reflux;93%
methanol
67-56-1

methanol

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

methyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
58298-68-3

methyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Reflux; Inert atmosphere;92%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

octanol
111-87-5

octanol

octyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
1440428-48-7

octyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Reflux;90%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

methyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
58298-68-3

methyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone at 23℃; for 12h;90%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

C14H21NO5

C14H21NO5

C30H32FN3O7

C30H32FN3O7

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h;
Stage #2: 5-fluoroindol-2(3H)-one; C14H21NO5 With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;
90%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

ethylenediamine
107-15-3

ethylenediamine

C18H22N4O4

C18H22N4O4

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 6h; Reagent/catalyst; Solvent; Temperature;90%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

cyclohexylamine
108-91-8

cyclohexylamine

N-cyclohexyl-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-cyclohexyl-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;89%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-[(2,6-dichlorobenzyl)sulfonyl]-1,3-dihydro-2H-indol-2-one
477573-39-0

5-[(2,6-dichlorobenzyl)sulfonyl]-1,3-dihydro-2H-indol-2-one

(Z)-5-[{5-(2,6-dichlorobenzylsulfonyl)-2-oxoindolin-3-ylidene}methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
477574-82-6

(Z)-5-[{5-(2,6-dichlorobenzylsulfonyl)-2-oxoindolin-3-ylidene}methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With piperidine In ethanol at 80℃;87%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h;86.3%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide84%
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: N,N-diethylethylenediamine With triethylamine In N,N-dimethyl-formamide at 20℃;
80%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N,N-diethylhydrazine
616-40-0

N,N-diethylhydrazine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h;86.3%
2-oxoindole
59-48-3

2-oxoindole

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine
108342-87-6, 120029-97-2, 120030-03-7

N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine

C42H57N3O11

C42H57N3O11

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h;
Stage #2: 2-oxoindole; N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;
86%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

phenol
108-95-2

phenol

phenyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
1440428-49-8

phenyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Reflux;83%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde
251356-81-7

3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide82%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 5 - 20℃;66%
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.0833333h;
Stage #2: 1-methyl-piperazine at 20℃; for 24h;
Stage #3: With sodium hydroxide In water; N,N-dimethyl-formamide for 0.5h;
40%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5‑formyl‑2,4‑dimethyl‑1H‑pyrrole‑3‑carboxylic acid (2‑morpholin‑4‑yl‑ethyl)amide
515821-26-8

5‑formyl‑2,4‑dimethyl‑1H‑pyrrole‑3‑carboxylic acid (2‑morpholin‑4‑yl‑ethyl)amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;82%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 5 - 20℃;66%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

C26H45NO5

C26H45NO5

C42H56FN3O7

C42H56FN3O7

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h;
Stage #2: 5-fluoroindol-2(3H)-one; C26H45NO5 With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;
82%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
1440428-46-5

isopropyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Reflux;80%
5-bromo-2-indolin-2-one
20870-78-4

5-bromo-2-indolin-2-one

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine
108342-87-6, 120029-97-2, 120030-03-7

N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine

C42H56BrN3O8

C42H56BrN3O8

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h;
Stage #2: 5-bromo-2-indolin-2-one; N-[2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl]amine With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;
80%
pyrrolidine
123-75-1

pyrrolidine

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
356068-93-4

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In ethanol; water; acetone79%
With hydrogenchloride; acetic acid In ethanol; water; acetone79%
With hydrogenchloride; acetic acid In ethanol; water; acetone79%

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