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Yangzhou Qinyuan Pharmatech Co.,Ltd

Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Fluoro-1,3-Dihydro-Indol-2-One supplier in China

Cas:56341-41-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 5-Fluoro-2-oxindole CAS number 56341-41-4 Assay ≥98% Appearance Yellowish crystalline Capacity 200mt/year Application Pharmaceutical interme

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Maufacturer supply 5-Fluoro-2-oxindole CAS 56341-41-4 at reasonable price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/

Maufacturer supply 5-Fluoro-2-oxindole CAS 56341-41-4 at reasonable price

Cas:56341-41-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Nanjing Yuance Industry&Trade Co., Ltd.

Purity 98% with good quality Competitive price Fast delivery Prompt shipment Appearance:Light yellow crystalline Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

5-Fluoro-1,3-dihydro-indol-2-one

Cas:56341-41-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

56341-41-4 5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 56341-41-4 5-Fluoro-2-oxindole Manufacturer

Cas:56341-41-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 56341-41-4 5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 56341-41-4 with fast shipping

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 5-Fluoro-2-oxindole Appearance Light Yellow Crystalline CAS NO. 56341-41-4 Molecular Formula C8H6FNO Molecular Weight 151.14

5-Fluoro-2-oxindole CAS: 56341-41-4

Cas:56341-41-4

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Think Chemical Co. Ltd

Product: Sunitinib Intermrdiate Chemical name:5-Fluoro-2-Oxindole Batch NO: 20210331 Analysis Date: 2021-03-31 Expiry Date: 2023-03-30 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research

5-Fluoro-2-Oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $640.0 / 660.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

5-Fluoro-2-oxindole CAS NO 56341-41-4

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Fluoro-2-oxindole 56341-41-4

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

5-Fluoro-2-oxindole with CAS:56341-41-4

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $468.0 / 549.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Fluoro-2-oxindole CAS:56341-41-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

5-Fluoro-2-oxindole CAS:56341-41-4

Cas:56341-41-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

5-Fluoro-2-oxindole CAS NO.56341-41-4

Cas:56341-41-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-Fluorooxindole

Cas:56341-41-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan BJM Pharm Inc.

Wuhan BJM Pharm Inc. was found in 2013, located in Hubei Province, where has long history, rich culture, convenient traffic, beautiful environment and preferential policy. We have two factories in Dezhou , Shandong and Xianning, Hubei. The factory c

5-Fluoro-2-oxindole cas:56341-41-4

Cas:56341-41-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

5-Fluoro-2-oxindole is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to light brown solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:Pharma

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

5-Fluoro-2-oxindole 56341-41-4

Cas:56341-41-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 56341-41-4 5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name 5-Fluoro-2-oxindole Synonyms 5-Fluorooxindole Molecular Structure Molecular Formula C

5-Fluoro-2-oxindole

Cas:56341-41-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

5-Fluorooxindole

Cas:56341-41-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h;
Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;
81.9%
5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
389571-36-2

5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux;92.1%
Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h;
Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h;
chloroacetyl chloride
79-04-9

chloroacetyl chloride

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent);88%
methyl 2-(5-fluoro-2-nitrophenyl)acetate
29640-99-1

methyl 2-(5-fluoro-2-nitrophenyl)acetate

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With iron In acetic acid at 100℃; for 1h;87%
1,3-dihydro-1-hydroxyindole-2-one
18108-55-9

1,3-dihydro-1-hydroxyindole-2-one

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h;81%
5-fluoro-3-hydrazonoindolin-2-one
283584-52-1

5-fluoro-3-hydrazonoindolin-2-one

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 5h; Reflux;80.4%
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere;
With sodium ethanolate
4'-fluoroacetanilide
351-83-7

4'-fluoroacetanilide

ethyl iodoacetae
623-48-3

ethyl iodoacetae

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;78%
(5-Fluoro-2-nitro-phenyl)-acetic Acid
29640-98-0

(5-Fluoro-2-nitro-phenyl)-acetic Acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2;76%
(E)-5-fluoro-3-hydrazonoindolin-2-one

(E)-5-fluoro-3-hydrazonoindolin-2-one

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 6h; Reflux;73.6%
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide
356068-89-8

(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
In water73%
In water73%
With hydrogenchloride In water at 20℃; for 12h; pH=3;73%
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide
356068-89-8

(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

A

5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

B

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
In waterA 73%
B n/a
In waterA 73%
B n/a
N'-(2-amino-5-fluorobenzylidene)-4-methylbenzenesulfonohydrazide

N'-(2-amino-5-fluorobenzylidene)-4-methylbenzenesulfonohydrazide

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h;55%
2-chloro-N-(4-fluorophenyl)acetamide
351-04-2

2-chloro-N-(4-fluorophenyl)acetamide

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With aluminium trichloride at 220 - 225℃; for 0.5h;54%
With aluminum (III) chloride at 220℃; for 1h;
3,3-dibromo-5-fluoro-2-oxindole
113423-50-0

3,3-dibromo-5-fluoro-2-oxindole

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With acetic acid; zinc Ambient temperature;
(2-tert-Butoxycarbonylamino-5-fluoro-phenyl)-acetic acid
138343-99-4

(2-tert-Butoxycarbonylamino-5-fluoro-phenyl)-acetic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 0.25h; Heating; Yield given;
4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / AlCl3 / 0.5 h / 220 - 225 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 60 - 70 °C
2.1: sulfuric acid / 80 - 90 °C
3.1: sulfuric acid; water
4.1: hydrazine hydrate / ethanol / Reflux
4.2: Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / dichloromethane / 20 °C
2: aluminum (III) chloride / 1 h / 220 °C
View Scheme
2,4-Difluoronitrobenzene
446-35-5

2,4-Difluoronitrobenzene

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1) NaH / 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h
2: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C
3: 87 percent / Fe powder / acetic acid / 1 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium methylate / N,N-dimethyl acetamide / 10 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 20 °C
3: hydrogenchloride / water; methanol / 2 h / Inert atmosphere; Reflux
View Scheme
dimethyl 2-(5-fluoro-2-nitrophenyl)malonate
147124-34-3

dimethyl 2-(5-fluoro-2-nitrophenyl)malonate

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C
2: 87 percent / Fe powder / acetic acid / 1 h / 100 °C
View Scheme
4-fluor-2-methylaniline
452-71-1

4-fluor-2-methylaniline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / Heating
2: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min
3: 10percent HCl / ethanol / 0.25 h / Heating
View Scheme
tert-butyl (4-fluoro-2-methylphenyl)carbamate
129822-40-8

tert-butyl (4-fluoro-2-methylphenyl)carbamate

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min
2: 10percent HCl / ethanol / 0.25 h / Heating
View Scheme
5-fluoro-1H-indole
399-52-0

5-fluoro-1H-indole

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / pyridinium bromide perbromide / 2-methyl-propan-2-ol / 20 h / 25 °C
2: Zn, AcOH / Ambient temperature
View Scheme
glacial acid

glacial acid

(5-Fluoro-2-nitro-phenyl)-acetic Acid
29640-98-0

(5-Fluoro-2-nitro-phenyl)-acetic Acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-fluoro-3-methylthiooxindole

5-fluoro-3-methylthiooxindole

tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

methylthioacetic acid ethyl ester
4455-13-4

methylthioacetic acid ethyl ester

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water
5-fluoro-3-methylthio-2-oxindole

5-fluoro-3-methylthio-2-oxindole

tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

methylthioacetic acid ethyl ester
4455-13-4

methylthioacetic acid ethyl ester

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water
C8H5FN2O
1261152-93-5

C8H5FN2O

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid; water
2.1: hydrazine hydrate / ethanol / Reflux
2.2: Reflux
View Scheme
N-(4-fluorophenyl)-2-(hydroxyimino) acetamide
351-09-7

N-(4-fluorophenyl)-2-(hydroxyimino) acetamide

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / 80 - 90 °C
2.1: sulfuric acid; water
3.1: hydrazine hydrate / ethanol / Reflux
3.2: Reflux
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / 1 h / 50 - 70 °C
2: hydrazine hydrate / ethanol / 0.5 h / Inert atmosphere; Reflux
3: potassium tert-butylate / ethanol / 2 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 0.17 h / Inert atmosphere
2: titanium tetrachloride; zinc / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / water / 50 - 75 °C
2: hydrazine hydrate / water / 6 h / 140 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 2 h / 60 - 90 °C
2: hydrazine hydrate / water; ethanol / 10 h / 100 °C
View Scheme
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

3-bromoazulene-1-carbaldehyde
42081-15-2

3-bromoazulene-1-carbaldehyde

(3E)-3-(((4Z,6Z,8E)-1-bromoazulen-3-yl)methylene)-5-fluoroindolin-2-one
1022916-57-9

(3E)-3-(((4Z,6Z,8E)-1-bromoazulen-3-yl)methylene)-5-fluoroindolin-2-one

Conditions
ConditionsYield
With piperidine In ethanol for 2h; Heating / reflux;100%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
452105-33-8

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;98%
With pyrrolidine In ethanol for 3h; Reflux;98.2%
With piperidine In ethanol Inert atmosphere;90%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

formic acid ethyl ester
109-94-4

formic acid ethyl ester

5-fluoro-3-formyl-1H-indole-2-one

5-fluoro-3-formyl-1H-indole-2-one

Conditions
ConditionsYield
With sodium methylate In methanol Reflux;98%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

1,5-diphenyl-1,4-pentadiene-3-one
538-58-9

1,5-diphenyl-1,4-pentadiene-3-one

5'-fluoro-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione
1374637-27-0

5'-fluoro-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione

Conditions
ConditionsYield
With Boc-D-Phg-OH; 9-amino-9-deoxy-epiquinine In toluene at 40℃; for 72h; Air; optical yield given as %ee; enantioselective reaction;98%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib
557795-19-4

sunitinib

Conditions
ConditionsYield
With piperidine In toluene for 3h; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux;97.3%
With piperidine In toluene for 3h; Reagent/catalyst; Solvent; Reflux;97.3%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3.5h; Aldol Condensation; Darkness; Inert atmosphere;94%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
356068-93-4

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 5-fluoroindol-2(3H)-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 5h; Reflux;
Stage #2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With trimethylsilyl trifluoromethanesulfonate
97%
pyrrolidine In ethanol for 3h; Heating / reflux;96%
With pyrrolidine In ethanol for 3h; Heating / reflux;96%
3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde
40236-20-2

3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(3Z)-[(3,5-dimethyl-4-nitro-1-hydropyrrol-2-yl)methylene]-5-fluoro-indol-2-one

(3Z)-[(3,5-dimethyl-4-nitro-1-hydropyrrol-2-yl)methylene]-5-fluoro-indol-2-one

Conditions
ConditionsYield
With pyrrolidine In ethanol Reflux;96%
With pyrrolidine In ethanol Reflux;96%
With pyrrolidine In ethanol Reflux;96%
With piperidine In ethanol Knoevenagel condensation; Heating;87%
With pyrrolidine In ethanol Reflux;
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

3-iodo-1H-indazole-6-carbaldehyde
944904-42-1

3-iodo-1H-indazole-6-carbaldehyde

(E)-5-fluoro-3-((3-iodo-1H-indazol-6-yl)methylene)indolin-2-one

(E)-5-fluoro-3-((3-iodo-1H-indazol-6-yl)methylene)indolin-2-one

Conditions
ConditionsYield
With piperidine In methanol at 60℃; for 3h;96%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
1194048-25-3

5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-[13C]methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-[13C]methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;95%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

malononitrile
109-77-3

malononitrile

2-(5-fluoro-2-oxoindolin-3-ylidene)malononitrile
116719-42-7

2-(5-fluoro-2-oxoindolin-3-ylidene)malononitrile

Conditions
ConditionsYield
With iron(III) chloride hexahydrate; oxygen In N,N-dimethyl-formamide at 50℃; for 4h; Green chemistry;95%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

methyl 2-oxobutanoate
3952-66-7

methyl 2-oxobutanoate

C13H14FNO4

C13H14FNO4

Conditions
ConditionsYield
With piperidine In methanol at 0 - 20℃; for 24h;93%
6-fluoro-1H-indole-3-carbaldehyde
2795-41-7

6-fluoro-1H-indole-3-carbaldehyde

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(Z)-5-fluoro-3-((5-fluoro-1H-indol-3-yl)methylene)indolin-2-one
1350703-09-1

(Z)-5-fluoro-3-((5-fluoro-1H-indol-3-yl)methylene)indolin-2-one

Conditions
ConditionsYield
With piperidine In methanol for 5h; Reflux;92%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2,6-dimethyl-1-chlorobenzene
6781-98-2

2,6-dimethyl-1-chlorobenzene

C16H14FNO
1426306-74-2

C16H14FNO

Conditions
ConditionsYield
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique;92%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2-bromo-4-methoxybenzaldehyde
43192-31-0

2-bromo-4-methoxybenzaldehyde

3-(2-bromo-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one

3-(2-bromo-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one

Conditions
ConditionsYield
With piperidine In ethanol for 1.5h; Reflux;92%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-fluoro-1H-indole
399-52-0

5-fluoro-1H-indole

Conditions
ConditionsYield
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere;92%
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere;86%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

C18H22N4O4

C18H22N4O4

C34H30F2N6O4

C34H30F2N6O4

Conditions
ConditionsYield
Stage #1: C18H22N4O4 With triethylamine In chloroform at 0℃; for 0.166667h;
Stage #2: 5-fluoroindol-2(3H)-one In chloroform at 65℃; for 8h; Solvent; Temperature;
92%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

acetic anhydride
108-24-7

acetic anhydride

1,3-diacetyl-5-fluoro-1H-indol-2-yl acetate
1268630-22-3

1,3-diacetyl-5-fluoro-1H-indol-2-yl acetate

Conditions
ConditionsYield
With dmap at 150℃; for 2h;91%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

3-(4-methoxyphenyl)propynal
90696-21-2

3-(4-methoxyphenyl)propynal

A

C18H12FNO2

C18H12FNO2

C28H22FNO5

C28H22FNO5

Conditions
ConditionsYield
With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride In tetrahydrofuran at 20 - 65℃; for 2h; Molecular sieve; Inert atmosphere; optical yield given as %de; diastereoselective reaction;A 5%
B 91%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

C15H12FNO2
1426306-75-3

C15H12FNO2

Conditions
ConditionsYield
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique;91%
2-methylquinoline
91-63-4

2-methylquinoline

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-fluoro-3-hydroxy-3-(quinolin-2-ylmethyl)indolin-2-one

5-fluoro-3-hydroxy-3-(quinolin-2-ylmethyl)indolin-2-one

Conditions
ConditionsYield
With iron(II) acetate In N,N-dimethyl-formamide at 80℃; for 5h; Green chemistry;91%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-fluoroindoline-2-thione
73425-13-5

5-fluoroindoline-2-thione

Conditions
ConditionsYield
With tetraphosphorus decasulfide; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 4h;90%
With phosphorous (V) sulfide; sodium hydrogencarbonate In tetrahydrofuran for 3h; Ambient temperature;84%
Stage #1: 5-fluoroindol-2(3H)-one With tetraphosphorus decasulfide In tetrahydrofuran at 20℃; for 1h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran at 120℃; for 1h;
75%
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃;
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃;
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(R)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde
1130138-32-7

(R)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one
1130137-76-6

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Conditions
ConditionsYield
With piperidine In ethanol at 20 - 80℃; Darkness;90%
With piperidine In ethanol at 20 - 80℃; for 2h; Darkness;90%
With piperidine In ethanol at 20℃;
1-methyl-2-formyl-1H-benzimidazole
3012-80-4

1-methyl-2-formyl-1H-benzimidazole

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(E)-5-fluoro-3-((1-methyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-one

(E)-5-fluoro-3-((1-methyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-one

Conditions
ConditionsYield
With piperidine In ethanol Knoevenagel Condensation; Reflux; stereoselective reaction;90%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

C14H21NO5

C14H21NO5

C30H32FN3O7

C30H32FN3O7

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h;
Stage #2: 5-fluoroindol-2(3H)-one; C14H21NO5 With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;
90%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde
1239441-14-5

3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

(Z)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-fluoroindolin-2-one

(Z)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-fluoroindolin-2-one

Conditions
ConditionsYield
With piperidine In ethanol for 12h; Reflux;90%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

4-(4-formylphenoxy)-3-(trifluoromethyl)benzonitrile

4-(4-formylphenoxy)-3-(trifluoromethyl)benzonitrile

4-(4-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

4-(4-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

Conditions
ConditionsYield
With piperidine In ethanol at 60℃;90%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

ethyl 3-(2-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate
1235459-55-8

ethyl 3-(2-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate

(Z)-ethyl 3-{2-[(5-fluoro-2-oxoindolin-3-ylidene)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl}propanoate
1235458-09-9

(Z)-ethyl 3-{2-[(5-fluoro-2-oxoindolin-3-ylidene)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl}propanoate

Conditions
ConditionsYield
With piperidine In ethanol for 12h; Aldol condensation; Reflux;89%
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