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hangzhou verychem science and technology co.ltd

Product name: ALOVUDINE Cas No: 25526-93-6 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it investe

ALOVUDINE,manufacturer,99.0%min

Cas:25526-93-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3'-Deoxy-3'-fluorothymidine Manufacturer/High quality/Best price/In stock

Cas:25526-93-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

3'-Deoxy-3'-fluorothymidine CAS:25526-93-6

Cas:25526-93-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 25526-93-6 with best quality

Cas:25526-93-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Thymidine,3'-deoxy-3'-fluoro- 25526-93-6

Cas:25526-93-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality 3'-Deoxy-3'-fluorothymidine CAS 25526-93-6 For research Use only

Cas:25526-93-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Thymidine,3'-deoxy-3'-fluoro-

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Alovudine 25526-93-6

Cas:25526-93-6

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name 3'-Deoxy-3'-fluorothymidine Molecular Structure Molecular Formula C10H13FN2O4 Molecular Weight

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Thymidine, 3'-deoxy-3'-fluoro-

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Alovudine

Cas:25526-93-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Thymidine,3'-deoxy-3'-fluoro-

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3'-Fluoro-3'-deoxythymidine CAS NO.25526-93-6

Cas:25526-93-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3'-Deoxy-3'-fluorothymidinecAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates,

3'-Deoxy-3'-fluorothymidinec

Cas:25526-93-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: Alovudine CAS No.:25526-93-6 Molecule Formula:C10H13FN2O4 Molecule Weight:244.22 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPEC

High Quality Alovudine on stock

Cas:25526-93-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Thymidine,3'-deoxy-3'-fluoro-

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Alovudine

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s

25526-93-6manufacturer/high quality/in stock

Cas:25526-93-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3'-Deoxy-3'-fluorothymidinec

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

ALOVUDINE

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

3-Deoxy-3-fluorothymidine

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Thymidine,3'-deoxy-3'-fluoro-

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

good quality and cheap priceAppearance:powder Package:1kg,5kg,25kg Application:as raw material Transportation:by sea/air/courier

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3'-Deoxy-3'-fluorothymidine

Cas:25526-93-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluorothymidine

5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluorothymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile at 45℃; for 0.166667h;97%
With hydrogenchloride In water; dimethyl sulfoxide at 175℃; for 0.0166667h;
With hydrogenchloride In acetonitrile
1-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)-4-methoxy-5-methyl-2(1H)-pyrimidinone
145688-92-2

1-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)-4-methoxy-5-methyl-2(1H)-pyrimidinone

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With Dowex 50 In ethanol; water93%
1-(2-chloro-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)thymine
585540-19-8

1-(2-chloro-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)thymine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With azobisisobutyronitrile; tri-n-butyl-tin hydride In 1,4-dioxane for 2h; Heating;90%
Benzoic acid (2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
152711-06-3

Benzoic acid (2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With ammonia In methanol for 18h; Ambient temperature;85%
5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin
51247-07-5

5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With sodium methylate In methanol85%
NaOMe powder

NaOMe powder

5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin
51247-07-5

5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
In methanol85%
5'-O-trityl-2,3'-anhydrothymidine
25442-42-6

5'-O-trityl-2,3'-anhydrothymidine

A

3'-Fluoro-5'-O-trityl-deoxythymidine
135197-63-6

3'-Fluoro-5'-O-trityl-deoxythymidine

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With hydrogen fluoride; diethylaluminum fluoride In 1,2-dimethoxyethane; n-heptane at 65℃; for 4h;A 65%
B 44%
3'-Fluoro-5'-O-trityl-deoxythymidine
135197-63-6

3'-Fluoro-5'-O-trityl-deoxythymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol; chloroform at 40℃; for 0.333333h;64%
With acetic acid at 90℃;
With acetic acid at 25℃; for 3h;1.28 g
Benzoic acid (2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
585540-13-2

Benzoic acid (2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

A

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine
116209-63-3

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Stage #1: Benzoic acid (2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester With azobisisobutyronitrile; tri-n-butyl-tin hydride In 1,4-dioxane for 2h; Heating;
Stage #2: With ammonia In methanol at 20℃; for 24h;
A 27%
B 55%
1-<2,3-Dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-α/β-D-erythro-pentofuranosy>-5-methyl-2,4(1H,3H)-pyrimidinedione
129468-52-6, 129468-53-7

1-<2,3-Dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-α/β-D-erythro-pentofuranosy>-5-methyl-2,4(1H,3H)-pyrimidinedione

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With ammonia In methanol for 24h; Ambient temperature;50%
[(2R,3S)-3-Fluoro-5-(5-methyl-2,4-bis-trimethylsilanyloxy-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-methanol

[(2R,3S)-3-Fluoro-5-(5-methyl-2,4-bis-trimethylsilanyloxy-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-methanol

A

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine
116209-63-3

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.5h; Ambient temperature;A 20%
B 44%
1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine
15981-86-9

1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine

A

3'-deoxy-3'-fluoro-5'-O-mesylthymidine
51247-06-4

3'-deoxy-3'-fluoro-5'-O-mesylthymidine

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride) at 150℃; for 1.5h;A 19%
B 5%
2,3'-anhydrothymidine
15981-92-7

2,3'-anhydrothymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With hydrogen fluoride; diisobutylaluminium hydride In tetrahydrofuran; 1,2-dimethoxyethane at 65℃; for 4h;17%
(+)-trans-(5R,6R)-5-bromo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine

(+)-trans-(5R,6R)-5-bromo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With GLUTATHIONE In various solvent(s) at 37℃; for 0.5h; Mechanism; other 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidines;10%
2,2-Dimethyl-propionic acid (2R,3S)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
134614-83-8, 134614-84-9

2,2-Dimethyl-propionic acid (2R,3S)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

A

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine
116209-63-3

1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With potassium hydroxide In ethanol Yield given. Yields of byproduct given;
1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine
15981-86-9

1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With aluminum(III) fluoride; sodium hydroxide; hydrogen fluoride 1) DMF, 75 min, 100 deg C, 2) EtOH, 20 min, reflux; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: 19 percent / trishydrogenefluoride triethylamine / 1.5 h / 150 °C
2: 0.1 N NaOCH3 / methanol
View Scheme
Multi-step reaction with 2 steps
1: 29.5 percent / dimethylformamide / 1.25 h / 110 °C
2: 0.1 N NaOCH3 / methanol
View Scheme
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine
42214-24-4

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine

A

stavudin
3056-17-5

stavudin

B

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride; acetic acid 1.) THF, RT, 32 h, 2.) 110 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;
With diethylamino-sulfur trifluoride; acetic acid 1.) THF, benzene, 2 h, 2.) 100 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;
3'-deoxy-3'-fluoro-5'-O-mesylthymidine
51247-06-4

3'-deoxy-3'-fluoro-5'-O-mesylthymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
With sodium methylate In methanol Yield given;
1-[(2R,4S,5R)-4-Fluoro-5-(2-methyl-4-oxo-4H-benzo[1,3]dioxin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

1-[(2R,4S,5R)-4-Fluoro-5-(2-methyl-4-oxo-4H-benzo[1,3]dioxin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

A

alovudine
25526-93-6

alovudine

B

5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin
51247-07-5

5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin

Conditions
ConditionsYield
With growth medium RPMI 1640 at 37℃; for 19h; Product distribution;
3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester

3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester

alovudine
25526-93-6

alovudine

thymidine
50-89-5

thymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multistep reaction.;39 mg
3-N-tert-butoxycarbonyl-(5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-3'-O-(4-nitrobenzenesulfonyl)-β-D-threo-pentofuranosyl)thymine

3-N-tert-butoxycarbonyl-(5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-3'-O-(4-nitrobenzenesulfonyl)-β-D-threo-pentofuranosyl)thymine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium fluoride; Kryptofix / acetonitrile
View Scheme
5'-O-tert-butyldiphenylsilyl-3'-O-methanesulfonylthymidine
139212-95-6

5'-O-tert-butyldiphenylsilyl-3'-O-methanesulfonylthymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating
2: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C
3: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C
4: 1.28 g / aq. AcOH / 3 h / 25 °C
View Scheme
5'-O-tert-butyldiphenylsilylthymidine
101527-40-6

5'-O-tert-butyldiphenylsilylthymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 9.65 g / 0 - 25 °C
2: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating
3: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C
4: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C
5: 1.28 g / aq. AcOH / 3 h / 25 °C
View Scheme
threothymidine
16053-52-4

threothymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C
2: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C
3: 1.28 g / aq. AcOH / 3 h / 25 °C
View Scheme
thymidine
50-89-5

thymidine

o-xylyl halide

o-xylyl halide

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: pyridine / 25 °C
2: 9.65 g / 0 - 25 °C
3: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating
4: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C
5: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C
6: 1.28 g / aq. AcOH / 3 h / 25 °C
View Scheme
5'-O-trityldeoxyxylothymidine
55612-11-8

5'-O-trityldeoxyxylothymidine

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C
2: 1.28 g / aq. AcOH / 3 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: DAST; pyridine / CH2Cl2
2: aq. AcOH / 90 °C
View Scheme
Multi-step reaction with 3 steps
1: 86 percent / pyridine / 1.) 22 h, 2.) rt, 3 h
2: 57 percent / KF, 18-crown-6 ether / dimethylformamide / 1 h / 100 °C
3: 64 percent / p-toluenesulfonic acid / CHCl3; methanol / 0.33 h / 40 °C
View Scheme
Multi-step reaction with 2 steps
1: diethylamino sulfur trifluoride (DAST) / CH2Cl2 / 1 h / Ambient temperature
2: 64 percent / p-toluenesulfonic acid / CHCl3; methanol / 0.33 h / 40 °C
View Scheme
methyl 3-deoxy-5-O-benzoyl-3-fluoro-2-O-tosyl-β-D-arabinofuranoside
133776-09-7

methyl 3-deoxy-5-O-benzoyl-3-fluoro-2-O-tosyl-β-D-arabinofuranoside

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating
2.1: trimethylsilyl triflate
2.2: 49 percent / acetonitrile / 5 h / Heating
3.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
3.2: 55 percent / NH3 / methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating
2.1: trimethylsilyl triflate
2.2: 49 percent / acetonitrile / 5 h / Heating
3.1: 55 percent / NH3 / methanol / 24 h / 20 °C
4.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
View Scheme
methyl 5-O-benzyl-2-O-tosyl-3-fluoro-3-deoxy-β-D-arabino-furanoside
126716-24-3

methyl 5-O-benzyl-2-O-tosyl-3-fluoro-3-deoxy-β-D-arabino-furanoside

alovudine
25526-93-6

alovudine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating
2.1: H2 / Pd/C / ethanol / 18 h / 20 °C
3.1: 0.42 g / pyridine / 18 h / 20 °C
4.1: trimethylsilyl triflate
4.2: 49 percent / acetonitrile / 5 h / Heating
5.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
5.2: 55 percent / NH3 / methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating
2.1: H2 / Pd/C / ethanol / 18 h / 20 °C
3.1: 0.42 g / pyridine / 18 h / 20 °C
4.1: trimethylsilyl triflate
4.2: 49 percent / acetonitrile / 5 h / Heating
5.1: 55 percent / NH3 / methanol / 24 h / 20 °C
6.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: H2 / Pd/C / ethanol / 18 h / 20 °C
1.2: 71 percent / pyridine / 18 h / 20 °C
2.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating
3.1: trimethylsilyl triflate
3.2: 49 percent / acetonitrile / 5 h / Heating
4.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
4.2: 55 percent / NH3 / methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: H2 / Pd/C / ethanol / 18 h / 20 °C
1.2: 71 percent / pyridine / 18 h / 20 °C
2.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating
3.1: trimethylsilyl triflate
3.2: 49 percent / acetonitrile / 5 h / Heating
4.1: 55 percent / NH3 / methanol / 24 h / 20 °C
5.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating
View Scheme
C19H26BN2O4(1+)*CF3O3S(1-)

C19H26BN2O4(1+)*CF3O3S(1-)

alovudine
25526-93-6

alovudine

C25H32BFN2O8

C25H32BFN2O8

Conditions
ConditionsYield
With dmap In tetrahydrofuran for 16h; Inert atmosphere; Reflux;99%
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
124482-92-4

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

alovudine
25526-93-6

alovudine

3'-fluoro-3'-deoxythymidine-5'-(2-cyanoethyl diisopropylamino) phosphoramidite
161006-80-0

3'-fluoro-3'-deoxythymidine-5'-(2-cyanoethyl diisopropylamino) phosphoramidite

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Ambient temperature;96%
alovudine
25526-93-6

alovudine

3'-fluoro-3'-deoxythymidine 5'-fluorophosphoridate

3'-fluoro-3'-deoxythymidine 5'-fluorophosphoridate

Conditions
ConditionsYield
With pyridine; bis(tri-n-butylammonium) phosphorofluoridate; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole In N,N-dimethyl-formamide at 20℃; for 0.25h;91%
With 2,4,6-triisopropylphenylsulfonyl chloride; fluorophosphoric acid tri-n-butylammonium salt In pyridine; N,N-dimethyl-formamide for 0.333333h; Ambient temperature;62%
N-myristoyl-Glu(OtBu)-OH
1365246-87-2

N-myristoyl-Glu(OtBu)-OH

alovudine
25526-93-6

alovudine

N-myristoyl-Glu(OtBu)-OFLT
1365246-88-3

N-myristoyl-Glu(OtBu)-OFLT

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h;91%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h;91%
tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

alovudine
25526-93-6

alovudine

3'-fluoro-5'-O-tert-butyldiphenylsilyl-3'-deoxythymidine
116195-70-1

3'-fluoro-5'-O-tert-butyldiphenylsilyl-3'-deoxythymidine

Conditions
ConditionsYield
With pyridine at 25℃;90%
2,5-dioxopyrrolidin-1-yl 7-(trifluoromethyl)quinoline-3-carboxylate

2,5-dioxopyrrolidin-1-yl 7-(trifluoromethyl)quinoline-3-carboxylate

alovudine
25526-93-6

alovudine

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 7-(trifluoromethyl)-quinoline-3-carboxylate

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 7-(trifluoromethyl)-quinoline-3-carboxylate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; Inert atmosphere;87%
alovudine
25526-93-6

alovudine

3'-fluoro-3'-deoxythymidine-5'-O-β-triphosphate
1314761-18-6

3'-fluoro-3'-deoxythymidine-5'-O-β-triphosphate

Conditions
ConditionsYield
Stage #1: alovudine With C15H26N4O6P3Pol; 5-(ethylthio)-1H-tetrazole In tetrahydrofuran; dimethyl sulfoxide
Stage #2: With tert.-butylhydroperoxide In tetrahydrofuran Further stages;
85%
2,5-dioxopyrrolidin-1-yl 7-methoxyquinoline-3-carboxylate

2,5-dioxopyrrolidin-1-yl 7-methoxyquinoline-3-carboxylate

alovudine
25526-93-6

alovudine

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 7-methoxyquinoline-3-carboxylate

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 7-methoxyquinoline-3-carboxylate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 80℃; for 72h; Inert atmosphere;82%
alovudine
25526-93-6

alovudine

phosphoric acid mono[3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahyrofuran-2-ylmethyl] ester
25520-83-6

phosphoric acid mono[3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahyrofuran-2-ylmethyl] ester

Conditions
ConditionsYield
With tris(p-nitrophenyl)phosphate at 50℃; Erwina herbicola 47/3 cells;81%
With trimethyl phosphite; trichlorophosphate
succinoyl dichloride
543-20-4

succinoyl dichloride

alovudine
25526-93-6

alovudine

di[5′-O-(3'-fluoro-2′,3′-dideoxythymidinyl)] 1,4-succinate

di[5′-O-(3'-fluoro-2′,3′-dideoxythymidinyl)] 1,4-succinate

Conditions
ConditionsYield
With dmap In benzene at 20℃;80%
3,4,5,6-tetrachlorophthalimide
1571-13-7

3,4,5,6-tetrachlorophthalimide

alovudine
25526-93-6

alovudine

5'-(4,5,6,7-tetrachloroisoindole-1,3-dione-2-yl)-5',3'-dideoxy-3'-fluorothymidine

5'-(4,5,6,7-tetrachloroisoindole-1,3-dione-2-yl)-5',3'-dideoxy-3'-fluorothymidine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 96h; Inert atmosphere;80%
Tributyl-amine; compound with difluoromethyl-phosphonic acid

Tributyl-amine; compound with difluoromethyl-phosphonic acid

alovudine
25526-93-6

alovudine

Difluoromethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Difluoromethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature;78%
2,5-dioxopyrrolidin-1-yl quinoline-3-carboxylate
127369-50-0

2,5-dioxopyrrolidin-1-yl quinoline-3-carboxylate

alovudine
25526-93-6

alovudine

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl quinoline-3-carboxylate

((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl quinoline-3-carboxylate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 80℃; for 24h; Inert atmosphere;77%
Tributyl-amine; compound with fluoromethyl-phosphonic acid

Tributyl-amine; compound with fluoromethyl-phosphonic acid

alovudine
25526-93-6

alovudine

Fluoromethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Fluoromethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature;76%
Tributyl-amine; compound with iodomethyl-phosphonic acid

Tributyl-amine; compound with iodomethyl-phosphonic acid

alovudine
25526-93-6

alovudine

Iodomethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Iodomethyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature;76%
alovudine
25526-93-6

alovudine

chloromethylphosphonic dichloride
1983-26-2

chloromethylphosphonic dichloride

3'-fluoro-3'-deoxythymidine-5'-chloromethylphosphonate

3'-fluoro-3'-deoxythymidine-5'-chloromethylphosphonate

Conditions
ConditionsYield
With triethyl phosphate at 0℃;76%
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 1H-imidazole-1-carboxylate
1262015-14-4

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 1H-imidazole-1-carboxylate

alovudine
25526-93-6

alovudine

C24H30BFN2O8

C24H30BFN2O8

Conditions
ConditionsYield
With dmap In tetrahydrofuran for 3.5h; Inert atmosphere; Reflux;75%
1,14-tetradecanedioic acid
821-38-5

1,14-tetradecanedioic acid

alovudine
25526-93-6

alovudine

3'-fluoro-2′,3′-dideoxy-5'-O-(13-carboxyltridecanoate)thymidine

3'-fluoro-2′,3′-dideoxy-5'-O-(13-carboxyltridecanoate)thymidine

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h;75%
Tributyl-amine; compound with vinyl-phosphonic acid

Tributyl-amine; compound with vinyl-phosphonic acid

alovudine
25526-93-6

alovudine

Vinyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Vinyl-phosphonic acid mono-[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature;72%
C12H27N*C3H7O5P

C12H27N*C3H7O5P

alovudine
25526-93-6

alovudine

C13H18FN2O8P

C13H18FN2O8P

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.333333h; Ambient temperature;70%
succinic acid anhydride
108-30-5

succinic acid anhydride

alovudine
25526-93-6

alovudine

5'-O-(succinate)-3'-fluoro-2',3'-dideoxythymidine
1099829-97-6

5'-O-(succinate)-3'-fluoro-2',3'-dideoxythymidine

Conditions
ConditionsYield
With pyridine at 20℃;70%
With pyridine
Tributyl-amine; compound with acetic acid phosphonomethyl ester

Tributyl-amine; compound with acetic acid phosphonomethyl ester

alovudine
25526-93-6

alovudine

Acetic acid [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphorylmethyl ester

Acetic acid [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphorylmethyl ester

Conditions
ConditionsYield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.333333h; Ambient temperature;69%
2-fluoroethyl bromide
762-49-2

2-fluoroethyl bromide

alovudine
25526-93-6

alovudine

C12H16F2N2O4
887113-64-6

C12H16F2N2O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;69%

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