Product name: ALOVUDINE Cas No: 25526-93-6 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it investe
Cas:25526-93-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:25526-93-6
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:25526-93-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:25526-93-6
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:25526-93-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:25526-93-6
Min.Order:1 Kilogram
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:25526-93-6
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:25526-93-6
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:25526-93-6
Min.Order:100 Milligram
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Type:Lab/Research institutions
inquiryName 3'-Deoxy-3'-fluorothymidine Molecular Structure Molecular Formula C10H13FN2O4 Molecular Weight
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:25526-93-6
Min.Order:0 Metric Ton
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:25526-93-6
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry3'-Deoxy-3'-fluorothymidinecAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates,
Product name: Alovudine CAS No.:25526-93-6 Molecule Formula:C10H13FN2O4 Molecule Weight:244.22 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPEC
Cas:25526-93-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:25526-93-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:25526-93-6
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:25526-93-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
Cas:25526-93-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryCHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s
Cas:25526-93-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai
Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:25526-93-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
good quality and cheap priceAppearance:powder Package:1kg,5kg,25kg Application:as raw material Transportation:by sea/air/courier
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
alovudine
Conditions | Yield |
---|---|
With hydrogenchloride In acetonitrile at 45℃; for 0.166667h; | 97% |
With hydrogenchloride In water; dimethyl sulfoxide at 175℃; for 0.0166667h; | |
With hydrogenchloride In acetonitrile |
1-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)-4-methoxy-5-methyl-2(1H)-pyrimidinone
alovudine
Conditions | Yield |
---|---|
With Dowex 50 In ethanol; water | 93% |
1-(2-chloro-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)thymine
alovudine
Conditions | Yield |
---|---|
With azobisisobutyronitrile; tri-n-butyl-tin hydride In 1,4-dioxane for 2h; Heating; | 90% |
Benzoic acid (2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
alovudine
Conditions | Yield |
---|---|
With ammonia In methanol for 18h; Ambient temperature; | 85% |
5'-O-Acetyl-3'-desoxy-3'-fluor-thymidin
alovudine
Conditions | Yield |
---|---|
With sodium methylate In methanol | 85% |
Conditions | Yield |
---|---|
In methanol | 85% |
5'-O-trityl-2,3'-anhydrothymidine
A
3'-Fluoro-5'-O-trityl-deoxythymidine
B
alovudine
Conditions | Yield |
---|---|
With hydrogen fluoride; diethylaluminum fluoride In 1,2-dimethoxyethane; n-heptane at 65℃; for 4h; | A 65% B 44% |
3'-Fluoro-5'-O-trityl-deoxythymidine
alovudine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol; chloroform at 40℃; for 0.333333h; | 64% |
With acetic acid at 90℃; | |
With acetic acid at 25℃; for 3h; | 1.28 g |
Benzoic acid (2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
A
1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine
B
alovudine
Conditions | Yield |
---|---|
Stage #1: Benzoic acid (2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester With azobisisobutyronitrile; tri-n-butyl-tin hydride In 1,4-dioxane for 2h; Heating; Stage #2: With ammonia In methanol at 20℃; for 24h; | A 27% B 55% |
1-<2,3-Dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-α/β-D-erythro-pentofuranosy>-5-methyl-2,4(1H,3H)-pyrimidinedione
alovudine
Conditions | Yield |
---|---|
With ammonia In methanol for 24h; Ambient temperature; | 50% |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.5h; Ambient temperature; | A 20% B 44% |
1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine
A
3'-deoxy-3'-fluoro-5'-O-mesylthymidine
B
alovudine
Conditions | Yield |
---|---|
With triethylamine tris(hydrogen fluoride) at 150℃; for 1.5h; | A 19% B 5% |
2,3'-anhydrothymidine
alovudine
Conditions | Yield |
---|---|
With hydrogen fluoride; diisobutylaluminium hydride In tetrahydrofuran; 1,2-dimethoxyethane at 65℃; for 4h; | 17% |
alovudine
Conditions | Yield |
---|---|
With GLUTATHIONE In various solvent(s) at 37℃; for 0.5h; Mechanism; other 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidines; | 10% |
2,2-Dimethyl-propionic acid (2R,3S)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
A
1-(2,3-dideoxy-3-fluoro-α-D-erythro-pentofuranosyl)-thymine
B
alovudine
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol Yield given. Yields of byproduct given; |
1-(2,3'-Anhydro-5'-O-methylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl)thymine
alovudine
Conditions | Yield |
---|---|
With aluminum(III) fluoride; sodium hydroxide; hydrogen fluoride 1) DMF, 75 min, 100 deg C, 2) EtOH, 20 min, reflux; Yield given. Multistep reaction; | |
Multi-step reaction with 2 steps 1: 19 percent / trishydrogenefluoride triethylamine / 1.5 h / 150 °C 2: 0.1 N NaOCH3 / methanol View Scheme | |
Multi-step reaction with 2 steps 1: 29.5 percent / dimethylformamide / 1.25 h / 110 °C 2: 0.1 N NaOCH3 / methanol View Scheme |
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine
A
stavudin
B
alovudine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; acetic acid 1.) THF, RT, 32 h, 2.) 110 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given; | |
With diethylamino-sulfur trifluoride; acetic acid 1.) THF, benzene, 2 h, 2.) 100 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given; |
3'-deoxy-3'-fluoro-5'-O-mesylthymidine
alovudine
Conditions | Yield |
---|---|
With sodium methylate In methanol Yield given; |
Conditions | Yield |
---|---|
With growth medium RPMI 1640 at 37℃; for 19h; Product distribution; |
alovudine
thymidine
alovudine
Conditions | Yield |
---|---|
Multistep reaction.; | 39 mg |
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium fluoride; Kryptofix / acetonitrile View Scheme |
5'-O-tert-butyldiphenylsilyl-3'-O-methanesulfonylthymidine
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating 2: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 3: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 4: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme |
5'-O-tert-butyldiphenylsilylthymidine
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 9.65 g / 0 - 25 °C 2: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating 3: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 4: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 5: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme |
threothymidine
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 2: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 3: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: pyridine / 25 °C 2: 9.65 g / 0 - 25 °C 3: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating 4: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 5: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 6: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme |
5'-O-trityldeoxyxylothymidine
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 2: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: DAST; pyridine / CH2Cl2 2: aq. AcOH / 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: 86 percent / pyridine / 1.) 22 h, 2.) rt, 3 h 2: 57 percent / KF, 18-crown-6 ether / dimethylformamide / 1 h / 100 °C 3: 64 percent / p-toluenesulfonic acid / CHCl3; methanol / 0.33 h / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: diethylamino sulfur trifluoride (DAST) / CH2Cl2 / 1 h / Ambient temperature 2: 64 percent / p-toluenesulfonic acid / CHCl3; methanol / 0.33 h / 40 °C View Scheme |
methyl 3-deoxy-5-O-benzoyl-3-fluoro-2-O-tosyl-β-D-arabinofuranoside
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating 2.1: trimethylsilyl triflate 2.2: 49 percent / acetonitrile / 5 h / Heating 3.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating 3.2: 55 percent / NH3 / methanol / 24 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating 2.1: trimethylsilyl triflate 2.2: 49 percent / acetonitrile / 5 h / Heating 3.1: 55 percent / NH3 / methanol / 24 h / 20 °C 4.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating View Scheme |
methyl 5-O-benzyl-2-O-tosyl-3-fluoro-3-deoxy-β-D-arabino-furanoside
alovudine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating 2.1: H2 / Pd/C / ethanol / 18 h / 20 °C 3.1: 0.42 g / pyridine / 18 h / 20 °C 4.1: trimethylsilyl triflate 4.2: 49 percent / acetonitrile / 5 h / Heating 5.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating 5.2: 55 percent / NH3 / methanol / 24 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating 2.1: H2 / Pd/C / ethanol / 18 h / 20 °C 3.1: 0.42 g / pyridine / 18 h / 20 °C 4.1: trimethylsilyl triflate 4.2: 49 percent / acetonitrile / 5 h / Heating 5.1: 55 percent / NH3 / methanol / 24 h / 20 °C 6.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: H2 / Pd/C / ethanol / 18 h / 20 °C 1.2: 71 percent / pyridine / 18 h / 20 °C 2.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating 3.1: trimethylsilyl triflate 3.2: 49 percent / acetonitrile / 5 h / Heating 4.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating 4.2: 55 percent / NH3 / methanol / 24 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: H2 / Pd/C / ethanol / 18 h / 20 °C 1.2: 71 percent / pyridine / 18 h / 20 °C 2.1: 72 percent / LiCl / dimethylsulfoxide / 2 h / Heating 3.1: trimethylsilyl triflate 3.2: 49 percent / acetonitrile / 5 h / Heating 4.1: 55 percent / NH3 / methanol / 24 h / 20 °C 5.1: 90 percent / tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating View Scheme |
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran for 16h; Inert atmosphere; Reflux; | 99% |
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
alovudine
3'-fluoro-3'-deoxythymidine-5'-(2-cyanoethyl diisopropylamino) phosphoramidite
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Ambient temperature; | 96% |
alovudine
Conditions | Yield |
---|---|
With pyridine; bis(tri-n-butylammonium) phosphorofluoridate; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole In N,N-dimethyl-formamide at 20℃; for 0.25h; | 91% |
With 2,4,6-triisopropylphenylsulfonyl chloride; fluorophosphoric acid tri-n-butylammonium salt In pyridine; N,N-dimethyl-formamide for 0.333333h; Ambient temperature; | 62% |
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h; | 91% |
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h; | 91% |
tert-butylchlorodiphenylsilane
alovudine
3'-fluoro-5'-O-tert-butyldiphenylsilyl-3'-deoxythymidine
Conditions | Yield |
---|---|
With pyridine at 25℃; | 90% |
alovudine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; Inert atmosphere; | 87% |
alovudine
3'-fluoro-3'-deoxythymidine-5'-O-β-triphosphate
Conditions | Yield |
---|---|
Stage #1: alovudine With C15H26N4O6P3Pol; 5-(ethylthio)-1H-tetrazole In tetrahydrofuran; dimethyl sulfoxide Stage #2: With tert.-butylhydroperoxide In tetrahydrofuran Further stages; | 85% |
alovudine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 80℃; for 72h; Inert atmosphere; | 82% |
alovudine
phosphoric acid mono[3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahyrofuran-2-ylmethyl] ester
Conditions | Yield |
---|---|
With tris(p-nitrophenyl)phosphate at 50℃; Erwina herbicola 47/3 cells; | 81% |
With trimethyl phosphite; trichlorophosphate |
succinoyl dichloride
alovudine
Conditions | Yield |
---|---|
With dmap In benzene at 20℃; | 80% |
3,4,5,6-tetrachlorophthalimide
alovudine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 96h; Inert atmosphere; | 80% |
alovudine
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 78% |
2,5-dioxopyrrolidin-1-yl quinoline-3-carboxylate
alovudine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 80℃; for 24h; Inert atmosphere; | 77% |
alovudine
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 76% |
alovudine
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 76% |
alovudine
chloromethylphosphonic dichloride
Conditions | Yield |
---|---|
With triethyl phosphate at 0℃; | 76% |
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 1H-imidazole-1-carboxylate
alovudine
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran for 3.5h; Inert atmosphere; Reflux; | 75% |
1,14-tetradecanedioic acid
alovudine
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; | 75% |
alovudine
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 72% |
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.333333h; Ambient temperature; | 70% |
succinic acid anhydride
alovudine
5'-O-(succinate)-3'-fluoro-2',3'-dideoxythymidine
Conditions | Yield |
---|---|
With pyridine at 20℃; | 70% |
With pyridine |
alovudine
Conditions | Yield |
---|---|
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide for 0.333333h; Ambient temperature; | 69% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 69% |
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