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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Panobinostat Manufacturer/High quality/Best price/In stock

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Panobinostat CAS No.:404950-80-7 Name: Panobinostat Synonyms: N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide Molecular Structure Molecular Formula: C21H23N3O2 M

High purity Panobinostat CAS No.:404950-80-7

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Panobinostat 404950-80-7 GMP Manufacturer

Cas:404950-80-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)-ethylamino)-methyl)-phenyl)-acrylamide

Cas:404950-80-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Panobinostat CAS 404950-80-7

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 404950-80-7 with best quality

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Panobinostat Manufacturer 404950-80-7 For Anticancer

Cas:404950-80-7

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Propenamide,N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- 404950-80-7

Cas:404950-80-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Animal Pharmaceuticals, Panobinostat CAS:404950-80-7

Cas:404950-80-7

Min.Order:1 Gram

FOB Price: $79.0 / 84.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Panobinostat CAS:404950-80-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Panobinostat CAS:404950-80-7

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Propenamide,N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Cas:404950-80-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Propenamide,N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Cas:404950-80-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Panobinostat

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $13.0 / 15.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Panobinostat

Cas:404950-80-7

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

buy MEDHYLONE

Cas:404950-80-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Panobinostat 404950-80-7

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Bromo-6-methoxypyridine

Cas:404950-80-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Propenamide,N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Cas:404950-80-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Panobinostat

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High Purity Medhylone

Cas:404950-80-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

medhylone,MEDAppearance:big crystal Storage:2-8 ℃ or Others Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according

medhylone,MED

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

buy MEDHYLONE

Cas:404950-80-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: Panobinostat Synonyms: (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE;LBH-589;PANOBINOSTAT;2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)pheny

TIANFUCHEM-- Panobinostat

Cas:404950-80-7

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Panobinostat CAS No.:404950-80-7 Molecule Formula:C21H23N3O2 Molecule Weight:349.43 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS S

Best Quality Panobinostat with good supplier

Cas:404950-80-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Panobinostat USP/EP/BP

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Shanghai Minstar Chemical Co., Ltd

Panobinostat Basic information Product Name: Panobinostat Synonyms: (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE;N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide;LBH-

Panobinostat

Cas:404950-80-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

buy MEDHYLONE

Cas:404950-80-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide

Cas:404950-80-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride
441741-66-8

(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
Stage #1: (E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride With sodium hydroxide In methanol at -15 - -10℃; for 0.166667h;
Stage #2: With hydroxylamine hydrochloride In methanol at -15 - -10℃; for 3.66667h;
94.6%
With hydroxylamine; potassium hydroxide In methanol at 0℃; for 4h; Inert atmosphere;73%
With sodium hydroxide; hydroxylamine hydrochloride In water at 0℃; for 6h;
Stage #1: (E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride With hydroxylamine; sodium hydroxide In ethanol; water at 0℃;
Stage #2: With hydrogenchloride In water
(E)-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylic acid methyl ester
441741-65-7

(E)-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylic acid methyl ester

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
With hyydroxylamine methanol; potassium hydroxide at 20℃; for 4h; Inert atmosphere;62.5%
With hydroxylamine; potassium hydroxide In methanol at 20℃; for 6h;62.5%
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
pH = 6.8 buffer;
(E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylic acid
960058-93-9

(E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylic acid

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
Stage #1: (E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylic acid With hydroxylamine In methanol; water at -15 - 25℃;
Stage #2: With hydrogenchloride In water pH=10.3 - 10.7;
methyl (2E)-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoate hydrochloride

methyl (2E)-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoate hydrochloride

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
With hydroxylamine hydrochloride; potassium hydroxide In propan-1-ol; ethylene glycol at -6℃;77.0 g
2-methyltryptamine
2731-06-8

2-methyltryptamine

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
2.2: 2 h / Inert atmosphere
3.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
2.2: 2 h / Inert atmosphere
3.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
phenylhydrazine
100-63-0

phenylhydrazine

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol / 4.5 h / 35 - 40 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.2: 6 h / 0 °C / Inert atmosphere
3.1: hydroxylamine; potassium hydroxide / methanol / 6 h / 20 °C
View Scheme
5-chloro-2-pentanone
5891-21-4

5-chloro-2-pentanone

panobinostat
404950-80-7

panobinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol / 4.5 h / 35 - 40 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.2: 6 h / 0 °C / Inert atmosphere
3.1: hydroxylamine; potassium hydroxide / methanol / 6 h / 20 °C
View Scheme
panobinostat
404950-80-7

panobinostat

methanesulfonic acid
75-75-2

methanesulfonic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate
960055-60-1

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate

Conditions
ConditionsYield
In ethyl acetate at 50℃;98.3%
In ethyl acetate at 50℃; Product distribution / selectivity;98.3%
In ethyl acetate at 20 - 50℃; Product distribution / selectivity;
In ethyl acetate at 4 - 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

L-Tartaric acid
87-69-4

L-Tartaric acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

Conditions
ConditionsYield
In ethanol at 60℃; for 2h;96.6%
In ethanol at 60℃; Product distribution / selectivity;96.6%
panobinostat
404950-80-7

panobinostat

L-Tartaric acid
87-69-4

L-Tartaric acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-L-tartarate

Conditions
ConditionsYield
In ethanol at 0 - 60℃; Product distribution / selectivity; Cooling with ice;96.6%
panobinostat
404950-80-7

panobinostat

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hydrochloride
960055-52-1

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water96.2%
With hydrogenchloride In ethanol; water at 60℃; Product distribution / selectivity;
With hydrogenchloride In ethyl acetate at 20℃; Product distribution / selectivity;
LACTIC ACID
849585-22-4

LACTIC ACID

panobinostat
404950-80-7

panobinostat

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylamide DL-lactate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylamide DL-lactate

Conditions
ConditionsYield
In water at 60 - 90℃;91%
panobinostat
404950-80-7

panobinostat

maleic acid
110-16-7

maleic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide maleate
960055-57-6

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide maleate

Conditions
ConditionsYield
In acetone at 45℃;90.5%
In acetone at 0 - 45℃; Product distribution / selectivity; Cooling with ice;90.5%
In isopropyl alcohol at 60℃; Product distribution / selectivity;
In acetone at 60℃; Product distribution / selectivity;
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity;
LACTIC ACID
849585-22-4

LACTIC ACID

panobinostat
404950-80-7

panobinostat

panobinostat lactate
960055-56-5

panobinostat lactate

Conditions
ConditionsYield
In water; acetone at 0 - 20℃; Product distribution / selectivity; Cooling with ice;86.2%
In isopropyl alcohol at 4℃; Product distribution / selectivity;
formaldehyd
50-00-0

formaldehyd

panobinostat
404950-80-7

panobinostat

(E)-N-hydroxy-3-(4-((methyl(2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide

(E)-N-hydroxy-3-(4-((methyl(2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In methanol; dichloromethane at 20℃; for 3h; Inert atmosphere;45%
panobinostat
404950-80-7

panobinostat

(SP-4-2)-dichlorido(cyclohexane-1R,2R-diamine)-platinum(II)

(SP-4-2)-dichlorido(cyclohexane-1R,2R-diamine)-platinum(II)

[PtII((1R,2R)-(–)-1,2-diaminocyclohexane)((E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide-2H)]

[PtII((1R,2R)-(–)-1,2-diaminocyclohexane)((E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide-2H)]

Conditions
ConditionsYield
Stage #1: (SP-4-2)-dichlorido(cyclohexane-1R,2R-diamine)-platinum(II) With silver nitrate In water at 20℃; Darkness;
Stage #2: panobinostat In water; N,N-dimethyl-formamide at 20℃; for 24h;
18%
panobinostat
404950-80-7

panobinostat

acetic acid
64-19-7

acetic acid

acetone
67-64-1

acetone

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide acetate acetone solvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide acetate acetone solvate

Conditions
ConditionsYield
at 20℃;
panobinostat
404950-80-7

panobinostat

acetic acid
64-19-7

acetic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide acetate
960055-50-9

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide acetate

Conditions
ConditionsYield
In isopropyl alcohol at 60℃; Product distribution / selectivity;
In ethyl acetate at 60℃; Product distribution / selectivity;
In acetone at 4 - 20℃; Product distribution / selectivity;
In acetone at 4 - 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

ethanol
64-17-5

ethanol

benzoic acid
65-85-0

benzoic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate ethanol hemisolvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate ethanol hemisolvate

Conditions
ConditionsYield
In water at 20℃; Product distribution / selectivity;
at 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

isopropyl alcohol
67-63-0

isopropyl alcohol

benzoic acid
65-85-0

benzoic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate 2-propanol hemisolvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate 2-propanol hemisolvate

Conditions
ConditionsYield
In water at 20℃; Product distribution / selectivity;
at 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

benzoic acid
65-85-0

benzoic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate
960055-51-0

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate

Conditions
ConditionsYield
In acetone at 20℃;
In ethanol; water at 4 - 20℃; Product distribution / selectivity;
In ethanol; water at 4 - 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

citric acid
77-92-9

citric acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemicitrate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemicitrate

Conditions
ConditionsYield
In water; isopropyl alcohol at 60℃; Product distribution / selectivity;
In ethanol at 60℃; Product distribution / selectivity;
In water; acetone at 60℃; Product distribution / selectivity;
In acetone at 20 - 60℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-fumarate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-fumarate

Conditions
ConditionsYield
In ethanol at 20℃;
In water; isopropyl alcohol at 20 - 60℃; Product distribution / selectivity;
In isopropyl alcohol at 20℃; Product distribution / selectivity;
In ethanol; water at 20 - 60℃; Product distribution / selectivity;
In ethanol at 4 - 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

2,5-dihydroxybenzoic acid.
490-79-9

2,5-dihydroxybenzoic acid.

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide gentisate
960055-55-4

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide gentisate

Conditions
ConditionsYield
In ethanol; water at 60℃;
In ethanol; water at 4 - 60℃;
LACTIC ACID
849585-22-4

LACTIC ACID

panobinostat
404950-80-7

panobinostat

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate
960055-68-9

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate

Conditions
ConditionsYield
In isopropyl alcohol at 4 - 20℃; Product distribution / selectivity;
In acetone at 4 - 20℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

malic acid
617-48-1

malic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-malate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-malate

Conditions
ConditionsYield
In ethanol; water at 20 - 60℃; Product distribution / selectivity;
In isopropyl alcohol at 60℃; Product distribution / selectivity;
In ethanol at 60℃; Product distribution / selectivity;
In ethanol; water at 4 - 60℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

malonic acid
141-82-2

malonic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-malonate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-malonate

Conditions
ConditionsYield
In ethanol at 60℃; Product distribution / selectivity;
In isopropyl alcohol at 60℃; Product distribution / selectivity;
In acetone at 20 - 60℃; Product distribution / selectivity;
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

ethanol
64-17-5

ethanol

phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate ethanol hemisolvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate ethanol hemisolvate

Conditions
ConditionsYield
at 20℃;
panobinostat
404950-80-7

panobinostat

phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

isopropyl alcohol
67-63-0

isopropyl alcohol

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate isopropanol hemisolvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate isopropanol hemisolvate

Conditions
ConditionsYield
at 20℃;
panobinostat
404950-80-7

panobinostat

phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate
960055-62-3

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate

Conditions
ConditionsYield
In acetone at 20 - 60℃; Product distribution / selectivity;
In ethyl acetate at 20 - 60℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

propionic acid
802294-64-0

propionic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide propionate isopropanol hemisolvate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide propionate isopropanol hemisolvate

Conditions
ConditionsYield
at 60℃;
panobinostat
404950-80-7

panobinostat

propionic acid
802294-64-0

propionic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide propionate
960055-63-4

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide propionate

Conditions
ConditionsYield
In acetone at 60℃; Product distribution / selectivity;
In ethyl acetate at 60℃; Product distribution / selectivity;
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity;
panobinostat
404950-80-7

panobinostat

isopropyl alcohol
67-63-0

isopropyl alcohol

1.5C3H8O*C21H23N3O2*H2O4S

1.5C3H8O*C21H23N3O2*H2O4S

Conditions
ConditionsYield
With sulfuric acid at 60℃;
panobinostat
404950-80-7

panobinostat

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide sulfate
960055-65-6

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide sulfate

Conditions
ConditionsYield
With sulfuric acid In ethyl acetate at 20℃;
panobinostat
404950-80-7

panobinostat

succinic acid
110-15-6

succinic acid

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-succinate

N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hemi-succinate

Conditions
ConditionsYield
In ethanol; water at 60℃; Product distribution / selectivity;
In ethanol at 20 - 60℃; Product distribution / selectivity;
In ethanol; water at 4 - 60℃; Product distribution / selectivity;

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