As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryPanobinostat CAS No.:404950-80-7 Name: Panobinostat Synonyms: N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide Molecular Structure Molecular Formula: C21H23N3O2 M
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:404950-80-7
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inquiryPanobinostat CAS:404950-80-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:404950-80-7
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:404950-80-7
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inquirymedhylone,MEDAppearance:big crystal Storage:2-8 ℃ or Others Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according
We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:404950-80-7
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inquiryProduct Name: Panobinostat Synonyms: (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE;LBH-589;PANOBINOSTAT;2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)pheny
Cas:404950-80-7
Min.Order:1 Metric Ton
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inquiryProduct name: Panobinostat CAS No.:404950-80-7 Molecule Formula:C21H23N3O2 Molecule Weight:349.43 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS S
Cas:404950-80-7
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryPanobinostat Basic information Product Name: Panobinostat Synonyms: (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE;N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide;LBH-
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:404950-80-7
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Type:Trading Company
inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
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inquiry(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride
panobinostat
Conditions | Yield |
---|---|
Stage #1: (E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride With sodium hydroxide In methanol at -15 - -10℃; for 0.166667h; Stage #2: With hydroxylamine hydrochloride In methanol at -15 - -10℃; for 3.66667h; | 94.6% |
With hydroxylamine; potassium hydroxide In methanol at 0℃; for 4h; Inert atmosphere; | 73% |
With sodium hydroxide; hydroxylamine hydrochloride In water at 0℃; for 6h; | |
Stage #1: (E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]acrylic acid methyl ester hydrochloride With hydroxylamine; sodium hydroxide In ethanol; water at 0℃; Stage #2: With hydrogenchloride In water |
(E)-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylic acid methyl ester
panobinostat
Conditions | Yield |
---|---|
With hyydroxylamine methanol; potassium hydroxide at 20℃; for 4h; Inert atmosphere; | 62.5% |
With hydroxylamine; potassium hydroxide In methanol at 20℃; for 6h; | 62.5% |
panobinostat
Conditions | Yield |
---|---|
pH = 6.8 buffer; |
(E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylic acid
panobinostat
Conditions | Yield |
---|---|
Stage #1: (E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylic acid With hydroxylamine In methanol; water at -15 - 25℃; Stage #2: With hydrogenchloride In water pH=10.3 - 10.7; |
panobinostat
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; potassium hydroxide In propan-1-ol; ethylene glycol at -6℃; | 77.0 g |
2-methyltryptamine
panobinostat
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 2.2: 2 h / Inert atmosphere 3.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 2.2: 2 h / Inert atmosphere 3.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme |
phenylhydrazine
panobinostat
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 3.2: 2 h / Inert atmosphere 4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 3.2: 2 h / Inert atmosphere 4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: ethanol / 4.5 h / 35 - 40 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere 2.2: 6 h / 0 °C / Inert atmosphere 3.1: hydroxylamine; potassium hydroxide / methanol / 6 h / 20 °C View Scheme |
5-chloro-2-pentanone
panobinostat
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 3.2: 2 h / Inert atmosphere 4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: ethanol / 4.5 h / 40 °C / Inert atmosphere; Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere 3.2: 2 h / Inert atmosphere 4.1: hyydroxylamine methanol; potassium hydroxide / 4 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: ethanol / 4.5 h / 35 - 40 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere 2.2: 6 h / 0 °C / Inert atmosphere 3.1: hydroxylamine; potassium hydroxide / methanol / 6 h / 20 °C View Scheme |
panobinostat
methanesulfonic acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate
Conditions | Yield |
---|---|
In ethyl acetate at 50℃; | 98.3% |
In ethyl acetate at 50℃; Product distribution / selectivity; | 98.3% |
In ethyl acetate at 20 - 50℃; Product distribution / selectivity; | |
In ethyl acetate at 4 - 20℃; Product distribution / selectivity; |
panobinostat
L-Tartaric acid
Conditions | Yield |
---|---|
In ethanol at 60℃; for 2h; | 96.6% |
In ethanol at 60℃; Product distribution / selectivity; | 96.6% |
panobinostat
L-Tartaric acid
Conditions | Yield |
---|---|
In ethanol at 0 - 60℃; Product distribution / selectivity; Cooling with ice; | 96.6% |
panobinostat
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water | 96.2% |
With hydrogenchloride In ethanol; water at 60℃; Product distribution / selectivity; | |
With hydrogenchloride In ethyl acetate at 20℃; Product distribution / selectivity; |
LACTIC ACID
panobinostat
Conditions | Yield |
---|---|
In water at 60 - 90℃; | 91% |
panobinostat
maleic acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide maleate
Conditions | Yield |
---|---|
In acetone at 45℃; | 90.5% |
In acetone at 0 - 45℃; Product distribution / selectivity; Cooling with ice; | 90.5% |
In isopropyl alcohol at 60℃; Product distribution / selectivity; | |
In acetone at 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In water; acetone at 0 - 20℃; Product distribution / selectivity; Cooling with ice; | 86.2% |
In isopropyl alcohol at 4℃; Product distribution / selectivity; |
formaldehyd
panobinostat
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride In methanol; dichloromethane at 20℃; for 3h; Inert atmosphere; | 45% |
panobinostat
Conditions | Yield |
---|---|
Stage #1: (SP-4-2)-dichlorido(cyclohexane-1R,2R-diamine)-platinum(II) With silver nitrate In water at 20℃; Darkness; Stage #2: panobinostat In water; N,N-dimethyl-formamide at 20℃; for 24h; | 18% |
Conditions | Yield |
---|---|
at 20℃; |
panobinostat
acetic acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide acetate
Conditions | Yield |
---|---|
In isopropyl alcohol at 60℃; Product distribution / selectivity; | |
In ethyl acetate at 60℃; Product distribution / selectivity; | |
In acetone at 4 - 20℃; Product distribution / selectivity; | |
In acetone at 4 - 20℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In water at 20℃; Product distribution / selectivity; | |
at 20℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In water at 20℃; Product distribution / selectivity; | |
at 20℃; Product distribution / selectivity; |
panobinostat
benzoic acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide benzoate
Conditions | Yield |
---|---|
In acetone at 20℃; | |
In ethanol; water at 4 - 20℃; Product distribution / selectivity; | |
In ethanol; water at 4 - 20℃; Product distribution / selectivity; |
panobinostat
citric acid
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 60℃; Product distribution / selectivity; | |
In ethanol at 60℃; Product distribution / selectivity; | |
In water; acetone at 60℃; Product distribution / selectivity; | |
In acetone at 20 - 60℃; Product distribution / selectivity; |
panobinostat
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In ethanol at 20℃; | |
In water; isopropyl alcohol at 20 - 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 20℃; Product distribution / selectivity; | |
In ethanol; water at 20 - 60℃; Product distribution / selectivity; | |
In ethanol at 4 - 20℃; Product distribution / selectivity; |
panobinostat
2,5-dihydroxybenzoic acid.
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide gentisate
Conditions | Yield |
---|---|
In ethanol; water at 60℃; | |
In ethanol; water at 4 - 60℃; |
LACTIC ACID
panobinostat
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate
Conditions | Yield |
---|---|
In isopropyl alcohol at 4 - 20℃; Product distribution / selectivity; | |
In acetone at 4 - 20℃; Product distribution / selectivity; |
panobinostat
malic acid
Conditions | Yield |
---|---|
In ethanol; water at 20 - 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 60℃; Product distribution / selectivity; | |
In ethanol at 60℃; Product distribution / selectivity; | |
In ethanol; water at 4 - 60℃; Product distribution / selectivity; |
panobinostat
malonic acid
Conditions | Yield |
---|---|
In ethanol at 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 60℃; Product distribution / selectivity; | |
In acetone at 20 - 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
at 20℃; |
Conditions | Yield |
---|---|
at 20℃; |
panobinostat
phosphoric acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide phosphate
Conditions | Yield |
---|---|
In acetone at 20 - 60℃; Product distribution / selectivity; | |
In ethyl acetate at 20 - 60℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
at 60℃; |
panobinostat
propionic acid
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide propionate
Conditions | Yield |
---|---|
In acetone at 60℃; Product distribution / selectivity; | |
In ethyl acetate at 60℃; Product distribution / selectivity; | |
In isopropyl alcohol at 4 - 60℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With sulfuric acid at 60℃; |
panobinostat
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide sulfate
Conditions | Yield |
---|---|
With sulfuric acid In ethyl acetate at 20℃; |
panobinostat
succinic acid
Conditions | Yield |
---|---|
In ethanol; water at 60℃; Product distribution / selectivity; | |
In ethanol at 20 - 60℃; Product distribution / selectivity; | |
In ethanol; water at 4 - 60℃; Product distribution / selectivity; |
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