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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 2,3-dicyanopropionate Manufacturer/High quality/Best price/In stock

Cas:40497-11-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 2,3-Dicyano Propionate with high purity

Cas:40497-11-8

Min.Order:1 Kilogram

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity ethyl 2,3-dicyanopropionate CAS:40497-11-8

Cas:40497-11-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 2,3-Dicyano Propionate

Cas:40497-11-8

Min.Order:1

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Type:Other

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Wuhan Kemi-Works Chemical Co., Ltd

Name:Ethyl 2,3-dicyanopropionate Synonyms :2,3-dicyanopropionate ethyl ester CAS. 40497-11-8 1.We have been specializing in special fine chemical for long, with strong R&D strength. 2.ISO9001. 3.We have been cooperating with oversea f

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Kilogram

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Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Ethyl 2, 3-Dicyanopropionate

Cas:40497-11-8

Min.Order:1 Metric Ton

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Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb

Ethyl 2,3-Dicyanopropionate

Cas:40497-11-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

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Chemwill Asia Co., Ltd.

CHemwill -- Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

High Quality Best Price Ethyl 2,3-dicyanopropionate Basic information Product Name: Ethyl 2,3-dicyanopropionate Synonyms: ETHYL 2,3-DICYANOPROPIONATE;2,3-Dicyanobenzoic acid,ethyl este

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 40497-11-8 with best quality

Cas:40497-11-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: Ethyl 2,3-dicyanopropionate Synonyms: ETHYL 2,3-DICYANOPROPIONATE;2,3-Dicyanobenzoic acid,ethyl ester;2,3-Ethyldicyanopropionate;ethyl 2,3-dicyanopropanoate;2,3-Dicyanopropionate

Ethyl 2,3-dicyanopropionate CAS: 40497-11-8

Cas:40497-11-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his products from many recent effective packing ways;

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Propanoic acid,2,3-dicyano-, ethyl ester 40497-11-8

Cas:40497-11-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:40497-11-8

Cas:40497-11-8

Min.Order:0

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

ethyl 2,3-dicyanopropanoate cas:40497-11-8

Cas:40497-11-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Ethyl 2,3-dicyanopropionate CAS NO.40497-11-8 CAS NO.40497-11

Cas:40497-11-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 2,3-Dicyano Propionate

Cas:40497-11-8

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:0 Metric Ton

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 2,3-DICYANOPROPIONATE

Cas:40497-11-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Propanoic acid,2,3-dicyano-, ethyl ester

Cas:40497-11-8

Min.Order:0

Negotiable

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Kilogram

Negotiable

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Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl 2,3-dicyanopropionate CAS: 40497-11-8 MF: C7H8N2O2 MW: 152.15 EINECS: 609-836-6 Mol File: 40497-11-8.mol Ethyl 2,3-dicyanopropionate Structure Ethyl 2,3-dicyanopropionate Chemical Properties Boiling point 1

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Gram

Negotiable

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Siwei Development Group Ltd.

Product name: Ethyl 2,3-Dicyanopropionate CAS No.:40497-11-8 Molecule Formula:C7H8N2O2 Molecule Weight:152.15 Purity: 99.0% Package: 200kg/drum Description:Colorless to pale yellow oily liquid Manufacture Standards:Enterprise Standard

High Quality Ethyl 2,3-Dicyanopropionate

Cas:40497-11-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Gram

Negotiable

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:0

Negotiable

Type:Manufacturers

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Ethyl 2,3-dicyanopropionate

Cas:40497-11-8

Min.Order:1 Metric Ton

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Synthetic route

sodium cyanide
773837-37-9

sodium cyanide

formaldehyd
50-00-0

formaldehyd

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Stage #1: sodium cyanide; formaldehyd In N,N-dimethyl-formamide for 2h; Reflux;
Stage #2: ethyl 2-cyanoacetate In N,N-dimethyl-formamide at 28 - 30℃; for 4h; Temperature;
98.5%
With 2-amino-3-hydroxypyridine; 2-Amino-2-methylpropane-1,3-diol; diethyl malonate In dimethyl sulfoxide at 20℃; for 20h; Temperature; Reagent/catalyst;97.2%
Stage #1: sodium cyanide; formaldehyd In ethanol at 5 - 10℃; for 4h;
Stage #2: With hydrogenchloride In ethanol at 5 - 10℃;
Stage #3: ethyl 2-cyanoacetate With ethanol; sodium at 5 - 30℃; for 10h; Product distribution / selectivity;
75.2%
In ethanol; dichloromethane for 0.666667h; Reflux;63%
With tetrabutylammomium bromide In dichloromethane; water at 10 - 90℃; Reagent/catalyst; Solvent;81.21 g
sodium cyanide
773837-37-9

sodium cyanide

ethyl 2-cyanoacrylate
7085-85-0

ethyl 2-cyanoacrylate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Stage #1: sodium cyanide In isopropyl alcohol at 30℃; for 4h;
Stage #2: ethyl-2-cyanoacrilate With methanesulfonic acid In isopropyl alcohol at 20 - 25℃; for 6h; Solvent; Reagent/catalyst; Temperature;
86%
Stage #1: sodium cyanide; ethyl-2-cyanoacrilate With methanesulfonic acid In isopropyl alcohol at 20 - 25℃; for 6h;
Stage #2: With hydrogenchloride In isopropyl alcohol at 10℃; Product distribution / selectivity;
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

ethyl (E)-3-[(4-methylphenyl)sulfonyl]-2-propenoate
117659-25-3

ethyl (E)-3-[(4-methylphenyl)sulfonyl]-2-propenoate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; acetonitrile at 20℃; for 2h; Michael Addition; Inert atmosphere;83%
formaldehyd
50-00-0

formaldehyd

potassium cyanide
151-50-8

potassium cyanide

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
With water In dimethyl sulfoxide at 20℃; for 15h;80%
In ethanol
glycolonitrile
107-16-4

glycolonitrile

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Stage #1: ethyl 2-cyanoacetate With sodium ethanolate In ethanol for 0.5h;
Stage #2: glycolonitrile In ethanol at 5 - 30℃; for 8h;
Stage #3: In ethanol; water at 5 - 10℃; pH=4.45;
79.6%
Stage #1: ethyl 2-cyanoacetate With sodium ethanolate; sodium In ethanol for 0.5h;
Stage #2: glycolonitrile In ethanol at 5 - 30℃; for 8h;
79.6%
With potassium carbonate In N,N-dimethyl-formamide at 15 - 25℃; Product distribution / selectivity;77%
With sodium ethanolate In ethanol for 1h; Heating;
Stage #1: ethyl 2-cyanoacetate With ethanol; sodium for 0.5h;
Stage #2: glycolonitrile In ethanol at 5 - 30℃; for 8h;
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
With paraformaldehyde In ethanol; water77%
ethanol
64-17-5

ethanol

sodium cyanoacetic acid ethyl ester
18852-51-2

sodium cyanoacetic acid ethyl ester

glycolonitrile
107-16-4

glycolonitrile

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
in kaltem Alkohol;
sodium cyanoacetic acid ethyl ester
18852-51-2

sodium cyanoacetic acid ethyl ester

glycolonitrile
107-16-4

glycolonitrile

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
With ethanol
diethyl sulfate
64-67-5

diethyl sulfate

carbon dioxide
124-38-9

carbon dioxide

tetraethylammoniumcyanide
13435-20-6

tetraethylammoniumcyanide

acrylonitrile
107-13-1

acrylonitrile

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
(i), (ii) /BRN= 605310/, (iii) /BRN= 1209714/; Multistep reaction;
potassium cyanide
151-50-8

potassium cyanide

Ethyl 2-bromopropionate
535-11-5, 41978-69-2

Ethyl 2-bromopropionate

A

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

B

α-cyano-propionic acid ester

α-cyano-propionic acid ester

Conditions
ConditionsYield
With ethanol
ethanedinitrile
460-19-5

ethanedinitrile

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Stage #1: ethanedinitrile; ethyl 2-cyanoacetate With potassium carbonate In DMF (N,N-dimethyl-formamide); water at 30℃; for 1.5h;
Stage #2: at 20℃;
ethyl acrylate
140-88-5

ethyl acrylate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iodine / dichloromethane / 48 h / 20 °C / Inert atmosphere
1.2: 3 h / 0 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
View Scheme
diethyl malonate
105-53-3

diethyl malonate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanol / 3 h / 10 °C
1.2: 1 h / 0 °C
1.3: 1 h / 0 - 10 °C
2.1: ammonia / toluene / 2 h / 80 °C / 750.08 Torr / Inert atmosphere; Autoclave
3.1: 1,4-diaza-bicyclo[2.2.2]octane; phosgene / 5 h / 100 °C
View Scheme
ethyl 2-amido-3-cyanopropionate

ethyl 2-amido-3-cyanopropionate

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; phosgene at 100℃; for 5h; Concentration;134.5 g
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2,6-dichloro-4-(trifluoromethyl)aniline
24279-39-8

2,6-dichloro-4-(trifluoromethyl)aniline

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Conditions
ConditionsYield
Stage #1: 2,6-dichloro-4-(trifluoromethyl)aniline With nitrosylsulfuric acid; acetic acid at 5 - 50℃; for 11h; Large scale;
Stage #2: ethyl 2,3-dicyanopropanoate In water at 10 - 30℃; for 20h; Large scale;
95%
Stage #1: 2,6-dichloro-4-(trifluoromethyl)aniline With nitrosylsulfuric acid; sulfuric acid In hexane at 10 - 30℃;
Stage #2: ethyl 2,3-dicyanopropanoate In hexane at 0 - 30℃; for 6h; Solvent;
95.2%
Stage #1: 2,6-dichloro-4-(trifluoromethyl)aniline With hydrogenchloride; sulfuric acid In water; toluene at 30 - 40℃; for 1.5h; Green chemistry;
Stage #2: With sodium nitrite In water; toluene at 15 - 20℃; for 1h; Green chemistry;
Stage #3: ethyl 2,3-dicyanopropanoate In water; toluene at 10 - 25℃; for 12h; Temperature; Green chemistry;
90%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

4-chloro-aniline
106-47-8

4-chloro-aniline

5-amino-1-(4-chlorophenyl)-1H-pyrazole-3-carbonitrile

5-amino-1-(4-chlorophenyl)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonium hydroxide In ethanol; water at 20℃; for 4h; pH=9 - 10;
93.6%
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonia In dichloromethane; water at 20℃;
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2,6-dichloro-4-trifluoromethylaniline-13C

2,6-dichloro-4-trifluoromethylaniline-13C

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethyl)pyrazole-13C6

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethyl)pyrazole-13C6

Conditions
ConditionsYield
Stage #1: 2,6-dichloro-4-trifluoromethylaniline-13C With sulfuric acid; acetic acid; sodium nitrite at 55℃; for 0.75h; Cooling;
Stage #2: ethyl 2,3-dicyanopropanoate With acetic acid at 10℃; for 0.25h;
91.4%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2,3-dicyanopropionamide
98024-59-0

2,3-dicyanopropionamide

Conditions
ConditionsYield
With ammonium hydroxide at 0℃; for 4h;85%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

4-phenoxyphenylboronic acid
51067-38-0

4-phenoxyphenylboronic acid

ethyl 2,5-bis(4-phenoxyphenyl)-1H-pyrrole-3-carboxylate

ethyl 2,5-bis(4-phenoxyphenyl)-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With [2,2]bipyridinyl; palladium(II) trifluoroacetate; 2,2,2-trifluoroacetic acid ammonia; trifluoroacetic acid In tetrahydrofuran; water at 80℃; for 48h; Schlenk technique;83%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2,4-Difluor-benzoldiazonium-chlorid
90802-25-8

2,4-Difluor-benzoldiazonium-chlorid

5-amino-1-(2,4-difluorophenyl)-3-cyano-1H-pyrazole

5-amino-1-(2,4-difluorophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
for 2h;81%
Stage #1: ethyl 2,3-dicyanopropanoate; 2,4-Difluor-benzoldiazonium-chlorid for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
58.8%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

4-bromo-aniline
106-40-1

4-bromo-aniline

5-amino-1-(4-bromophenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-bromophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-bromo-aniline With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate In ethanol; water at 20℃; for 4h; pH=9 - 10;
80.3%
Stage #1: 4-bromo-aniline With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonia In dichloromethane; water at 20℃;
Stage #1: 4-bromo-aniline With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

p-chlorobenzenediazonium chloride
2028-74-2

p-chlorobenzenediazonium chloride

5-amino-1-(4-chlorophenyl)-1H-pyrazole-3-carbonitrile

5-amino-1-(4-chlorophenyl)-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
for 2h;79.6%
Stage #1: ethyl 2,3-dicyanopropanoate; p-chlorobenzenediazonium chloride for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
72.6%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

benzene diazonium chloride
100-34-5

benzene diazonium chloride

5-amino-1-phenyl-1H-pyrazole-3-carbonitrile

5-amino-1-phenyl-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
for 2h;78.8%
Stage #1: ethyl 2,3-dicyanopropanoate; benzene diazonium chloride for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
66.8%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

p-toluidine
106-49-0

p-toluidine

5-amino-1-(4-methylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-methylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonium hydroxide In ethanol; water at 20℃; for 4h; pH=9 - 10;
78.2%
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonia In ethanol; water at 20℃; for 4h; pH=9 - 10;
60.5%
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonia In dichloromethane; water at 20℃;
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2-fluorobenzenediazonium chloride
53559-92-5

2-fluorobenzenediazonium chloride

5-amino-1-(2-fluorophenyl)-3-cyano-1H-pyrazole

5-amino-1-(2-fluorophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
for 2h;78%
Stage #1: ethyl 2,3-dicyanopropanoate; 2-fluorobenzenediazonium chloride for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
67.3%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

5-amino-1-(4-trifluoromethoxyphenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-trifluoromethoxyphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethoxy)aniline With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonia In ethanol; water at 20℃; for 4h; pH=9 - 10;
77.4%
Stage #1: 4-(trifluoromethoxy)aniline With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

ethyl 2-(aminomethyl)-4-aminobutyrate dihydrochloride

ethyl 2-(aminomethyl)-4-aminobutyrate dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; platinum(IV) oxide In methanol under 2585.7 Torr; for 2h;77%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

5-amino-1-(3-methylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(3-methylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1-amino-3-methylbenzene With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonia In ethanol; water at 20℃; for 4h; pH=9 - 10;
76.2%
Stage #1: 1-amino-3-methylbenzene With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

p-methylbenzenediazonium chloride
2028-84-4

p-methylbenzenediazonium chloride

5-amino-1-(4-methylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-methylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
for 2h;75.8%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

3,4-dichlorobenzenediazonium chloride
50379-99-2

3,4-dichlorobenzenediazonium chloride

5-amino-1-(3,4-dichlorophenyl)-3-cyano-1H-pyrazole

5-amino-1-(3,4-dichlorophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
for 2h;75.3%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

(4-bromophenyl)diazonium chloride
2028-85-5

(4-bromophenyl)diazonium chloride

5-amino-1-(4-bromophenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-bromophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: ethyl 2,3-dicyanopropanoate; (4-bromophenyl)diazonium chloride for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
75.2%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

C7H2Cl2F3N2(1+)*Cl(1-)

C7H2Cl2F3N2(1+)*Cl(1-)

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
120068-79-3

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Conditions
ConditionsYield
for 2h;74.7%
Stage #1: ethyl 2,3-dicyanopropanoate; C7H2Cl2F3N2(1+)*Cl(1-) for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
48.8%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

2,6-Difluoro-benzenediazonium; chloride

2,6-Difluoro-benzenediazonium; chloride

5-amino-1-(2,3,4-trifluorophenyl)-3-cyano-1H-pyrazole

5-amino-1-(2,3,4-trifluorophenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: ethyl 2,3-dicyanopropanoate; 2,6-Difluoro-benzenediazonium; chloride for 2h;
Stage #2: With ammonium hydroxide at 20℃; for 2h; pH=9 - 10;
73.8%
2,6-dibromo-4-(trifluoromethoxy)aniline
88149-49-9

2,6-dibromo-4-(trifluoromethoxy)aniline

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

5-amino-1-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-1H-pyrazole-3-carbonitrile

5-amino-1-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-1H-pyrazole-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 2,6-dibromo-4-(trifluoromethoxy)aniline With sulfuric acid; acetic acid; sodium nitrite In water at 0 - 55℃; for 1h;
Stage #2: ethyl 2,3-dicyanopropanoate With acetic acid In water at 5 - 20℃; for 2h;
73%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

ethyl 2,3-dicarbamoylpropionate

ethyl 2,3-dicarbamoylpropionate

Conditions
ConditionsYield
Stage #1: ethyl 2,3-dicyanopropanoate With acetamide; acetic acid at 50℃; under 760.051 Torr; for 0.5h;
Stage #2: With tetrakis(acetonitrile)palladium(II) tetrafluoroborate at 50℃; under 2 Torr; for 2h;
72%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

5-amino-1-(4-trifluoromethylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-trifluoromethylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonia In ethanol; water at 20℃; for 4h; pH=9 - 10;
70.4%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonium hydroxide In ethanol; water at 20℃; for 4h; pH=9 - 10;
58.9%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonia In dichloromethane; water at 20℃;
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: ethyl 2,3-dicyanopropanoate at 20℃;
Stage #3: With ammonium hydroxide In dichloromethane at 20℃;
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

5-amino-1-(3-trifluoromethylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(3-trifluoromethylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylaniline With hydrogenchloride; sodium nitrite In ethanol; water for 0.5h; Cooling with ice;
Stage #2: ethyl 2,3-dicyanopropanoate With ammonia In ethanol; water at 20℃; for 4h; pH=9 - 10;
70.4%
ethyl 2,3-dicyanopropanoate
40497-11-8

ethyl 2,3-dicyanopropanoate

p-trifluorobenzene diazonium chloride
25102-84-5

p-trifluorobenzene diazonium chloride

5-amino-1-(4-trifluoromethylphenyl)-3-cyano-1H-pyrazole

5-amino-1-(4-trifluoromethylphenyl)-3-cyano-1H-pyrazole

Conditions
ConditionsYield
for 2h;70.4%

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