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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate supplier in China

Cas:41162-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply Dimethyl (2-oxo-4-phenylbutyl)phosphonate CAS 41162-19-0 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its int

Factory supply Dimethyl (2-oxo-4-phenylbutyl)phosphonate CAS 41162-19-0 with fast delivery

Cas:41162-19-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

1-dimethoxyphosphoryl-4-phenylbutan-2-one

Cas:41162-19-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:white crystalline powder Storage:Sealed, dry, m

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dimethyl (2-oxo-4-phenylbutyl)-phosphonate

Cas:41162-19-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

41162-19-0

Cas:41162-19-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 41162-19-0 with competitive price

Cas:41162-19-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 41162-19-0 Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-(2-oxo-4-phenylbutyl)-, dimethyl ester 41162-19-0

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Empagliflozin CAS:864070-44-0Dimethyl (2-oxo-4-phenylbutyl)phosphonate CAS:41162-19-0Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

Dimethyl (2-oxo-4-phenylbutyl)phosphonate CAS:41162-19-0

Cas:41162-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-(2-oxo-4-phenylbutyl)-, dimethyl ester

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Kemi-Works Chemical Co., Ltd

Name:Dimethyl(2-oxo-4-phenylbutyl)phosphonate CAS.41162-19-0 1.We have been specializing in special fine chemical for long, with strong R&D strength. 2.ISO9001. 3.We have been cooperating with oversea from Europe, USA, Korea, Japan

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: BMP;Dimethyl(2-oxo-4-phenylbutyl)phosphonate CAS No.: 41162-19-0 Chemical name: Dimethyl(2-oxo-4-phenylbutyl)phosphonate85%;Dimethyl-(2-Oxo-4-Phemylbutyl) Phosphaonte;DIMETHYL (2-OXO-4-PHENYLBUTYL)PHOSPHONATE;DIMETHYL-[4-PHEN

BMP;Dimethyl(2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

Dimethyl (2-oxo-4-phenylbutyl)phosphonate CAS:41162-19-0 Specification Item Specification Appearance Pale Yellow to Light Yellow Liquid Assay 98%min Density 1.152±0.06 g/cm3(Predicted)

Factory Supply Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Phosphonic acid,P-(2-oxo-4-phenylbutyl)-, dimethyl ester

Cas:41162-19-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate

Cas:41162-19-0

Min.Order:0

Negotiable

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Dimethyl(2-oxo-4-phenylbutyl)phosphonate 41162-19-0

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

DiMethyl (2-Oxo-4-phenybutyl)phospate 41162-19-0

Cas:41162-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DIMETHYL-(2-OXO-4-PHENYLBUTYL)PHOSPHONATE

Cas:41162-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(1-Acetoxyethyl)-3-ethyl-5-methylpyrazine

Cas:41162-19-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate

Cas:41162-19-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:clear yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Phar

Phosphonic acid,P-(2-oxo-4-phenylbutyl)-, dimethyl ester

Cas:41162-19-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Dimethyl(2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Cas:41162-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

3-phenylpropanoic acid methyl ester
103-25-3

3-phenylpropanoic acid methyl ester

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 3-phenylpropanoic acid methyl ester In tetrahydrofuran at -78℃; for 1h;
98%
With n-butyllithium In tetrahydrofuran at -78 - 0℃; Inert atmosphere;98%
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: 3-phenylpropanoic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃;
97%
ethyl dihydrocinnamate
2021-28-5

ethyl dihydrocinnamate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran at 5 - 20℃; Inert atmosphere;95%
With n-butyllithium 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 30 min; Multistep reaction;
With n-butyllithium In tetrahydrofuran; diethyl ether; hexane; water; acetic acid
Stage #1: dimethyl methane phosphonate With n-hexyllithium In tetrahydrofuran; hexane at -80℃; Inert atmosphere;
Stage #2: ethyl dihydrocinnamate In tetrahydrofuran; hexane at 20℃; Inert atmosphere;
Stage #3: With water In tetrahydrofuran; hexane at 20℃;
With n-butyllithium In tetrahydrofuran; hexane
argon

argon

1-iodo-4-phenylbutan-2-one
352276-27-8

1-iodo-4-phenylbutan-2-one

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
With phosphorous acid trimethyl ester In acetonitrile85%
1-iodo-4-phenylbutan-2-one
352276-27-8

1-iodo-4-phenylbutan-2-one

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
In acetonitrile at 20℃; for 2.5h; Reflux; Inert atmosphere;60%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

benzyl chloride
100-44-7

benzyl chloride

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
(i) NaH, THF, (ii) nBuLi, hexane, (iii) /BRN= 471308/; Multistep reaction;
(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: H2 / 5 percent Pd/C / ethyl acetate
2.1: MeOH
3.1: N-BuLi / tetrahydrofuran / 0 °C
3.2: tetrahydrofuran
View Scheme
3-Phenylpropionic acid
501-52-0

3-Phenylpropionic acid

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: MeOH
2.1: N-BuLi / tetrahydrofuran / 0 °C
2.2: tetrahydrofuran
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid
2: n-butyllithium / tetrahydrofuran
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / 2 h / Reflux
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 2 h / Reflux
2: n-butyllithium / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
View Scheme
4-Phenyl-2-butanone
2550-26-7

4-Phenyl-2-butanone

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine / methanol / 2.83 h / -5 - 20 °C / Inert atmosphere
2: sodium iodide / acetone / 6 h / 20 °C / Inert atmosphere
3: acetonitrile / 2.5 h / 20 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: bromine / methanol / 4 h / 0 - 15 °C
2: sodium iodide / acetone / 12 h
3: acetonitrile / 3 h / 65 °C
View Scheme
Multi-step reaction with 2 steps
1: bromine; acetic acid / methanol / Inert atmosphere
2: acetonitrile / 3 h / 65 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: iodine; copper(II) oxide / methanol; dichloromethane / 15 h / 42 °C / Inert atmosphere
2: acetonitrile / 3 h / 65 °C / Inert atmosphere
View Scheme
1-bromo-4-phenylbutan-2-one
31984-10-8

1-bromo-4-phenylbutan-2-one

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 6 h / 20 °C / Inert atmosphere
2: acetonitrile / 2.5 h / 20 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 12 h
2: acetonitrile / 3 h / 65 °C
View Scheme
trimethyl phosphite
512-56-1

trimethyl phosphite

1-iodo-4-phenylbutan-2-one
352276-27-8

1-iodo-4-phenylbutan-2-one

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
In acetonitrile at 65℃; for 3h;73 g
In acetonitrile at 65℃; for 3h; Inert atmosphere;
trimethyl phosphite
512-56-1

trimethyl phosphite

1-bromo-4-phenylbutan-2-one
31984-10-8

1-bromo-4-phenylbutan-2-one

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
In acetonitrile at 65℃; for 3h; Inert atmosphere;72 g
4-Phenyl-1-butene
768-56-9

4-Phenyl-1-butene

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice
2: zinc(II) chloride / toluene / 4 h / 65 - 70 °C / Inert atmosphere
3: Jones reagent / acetone / 5 h / Cooling with ice
View Scheme
(2-hydroxy-4-phenyl-butyl)-phosphonic acid dimethyl ester

(2-hydroxy-4-phenyl-butyl)-phosphonic acid dimethyl ester

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Conditions
ConditionsYield
With Jones reagent In acetone for 5h; Cooling with ice;15.8 g
(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
64091-14-1

(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
1240483-13-9

(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde In tetrahydrofuran; mineral oil at 0℃;
93%
With triethylamine; lithium chloride In acetonitrile for 2h; Inert atmosphere;92%
(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
64091-14-1

(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

C24H34O4Si

C24H34O4Si

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde In tetrahydrofuran; mineral oil at 0℃; for 1.5h;
93%
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With potassium carbonate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde In tetrahydrofuran at -20℃; Reagent/catalyst; Inert atmosphere;
86%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(4E)-1,7-diphenylhept-4-en-3-one
79559-59-4

(4E)-1,7-diphenylhept-4-en-3-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With potassium carbonate In tetrahydrofuran at 20℃; for 0.666667h; Inert atmosphere;
Stage #2: 3-phenyl-propionaldehyde at 40℃; for 12h;
92%
With potassium hexamethylsilazane Multistep reaction;
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

1,7-diphenyl-4-heptene-3-one
79559-59-4

1,7-diphenyl-4-heptene-3-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With potassium carbonate In tetrahydrofuran at 20℃; for 0.666667h; Inert atmosphere;
Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran at 40℃; for 12h;
92%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate
38754-71-1

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
41639-72-9

(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With potassium carbonate In isopropyl alcohol at 25℃; for 0.5h; Horner-Wadsworth-Emmons Olefination;
Stage #2: (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate In isopropyl alcohol at 25℃; for 5h; Temperature; Horner-Wadsworth-Emmons Olefination;
91%
With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at -15℃;70%
With sodium hydride 1.) THF, 90 min, 2.) THF, 30 min; Multistep reaction;
With sodium hydroxide In dichloromethane; water at 0 - 5℃; for 1.5h; Product distribution / selectivity;
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

Corey aldehyde
62961-72-2

Corey aldehyde

(3aR,4R,5R,6aS)-5-hydroxy-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one

(3aR,4R,5R,6aS)-5-hydroxy-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: Corey aldehyde In tetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Temperature; Inert atmosphere;
88%
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;
Stage #2: Corey aldehyde In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;
(S)-1-(2-oxoethyl)but-3-enyl acrylate

(S)-1-(2-oxoethyl)but-3-enyl acrylate

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(4S,6E)-8-oxo-10-phenyldeca-1,6-dien-4-yl prop-2-enoate

(4S,6E)-8-oxo-10-phenyldeca-1,6-dien-4-yl prop-2-enoate

Conditions
ConditionsYield
With sodium hexamethyldisilazane at 0℃; for 12h; Horner-Wadsworth-Emmons olefination;87%
C8H13NO3
1092078-92-6

C8H13NO3

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

C18H23NO3
1092078-93-7

C18H23NO3

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In tetrahydrofuran at 20℃; for 1h; Horner-Wadsworth-Emmons olefination;
Stage #2: C8H13NO3 In tetrahydrofuran at 20℃; for 1h; Horner-Wadsworth-Emmons olefination;
86%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one
39746-01-5

(1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one

(3aR,4R,5R,6aS)-2-oxo-4-((1E)-3-oxo-5-phenylpent-1-en-1-yl)-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate
55076-60-3

(3aR,4R,5R,6aS)-2-oxo-4-((1E)-3-oxo-5-phenylpent-1-en-1-yl)-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at -15℃;
Stage #2: (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one In acetonitrile at -15℃; Wittig Reaction;
84.7%
With triethylamine; lithium chloride In tetrahydrofuran; dichloromethane at 0℃; for 2h; Horner-Wadsworth-Emmons Olefination; Cooling with ice;73%
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hexamethyldisilazane In 1,2-dimethoxyethane Metallation;
Stage #2: (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one In 1,2-dimethoxyethane Condensation;
With n-butyllithium In tetrahydrofuran; hexane; dichloromethane; acetic acid
With triethylamine; lithium chloride In dichloromethane at 0℃; for 2h; Horner-Emmons reaction;
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

2,2-dihydroxyacetic acid
563-96-2

2,2-dihydroxyacetic acid

(E)-4-oxo-6-phenylhex-2-enoic acid

(E)-4-oxo-6-phenylhex-2-enoic acid

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at -20℃; for 2h; Horner-Wadsworth-Emmons Olefination; stereoselective reaction;83%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

2-dibenzylamino-5-oxo-pentanoic acid benzyl ester
850209-99-3

2-dibenzylamino-5-oxo-pentanoic acid benzyl ester

(S,E)-benzyl 2-(dibenzylamino)-7-oxo-9-phenylnon-5-enoate
1379764-51-8

(S,E)-benzyl 2-(dibenzylamino)-7-oxo-9-phenylnon-5-enoate

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 20℃; Horner-Wadsworth-Emmons olefination; Inert atmosphere;
Stage #2: 2-dibenzylamino-5-oxo-pentanoic acid benzyl ester In acetonitrile at 20℃; Horner-Wadsworth-Emmons olefination; Inert atmosphere;
80%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

ethyl 2-((1R,2S,3R)-3-(dimethyl(phenyl)silyl)-2-formyl-5-oxocyclopentyl)acetate

ethyl 2-((1R,2S,3R)-3-(dimethyl(phenyl)silyl)-2-formyl-5-oxocyclopentyl)acetate

ethyl 2-((1R,2R,3R)-3-(dimethyl(phenyl)silyl)-5-oxo-2-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentyl)acetate

ethyl 2-((1R,2R,3R)-3-(dimethyl(phenyl)silyl)-5-oxo-2-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentyl)acetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 20℃; for 6h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;73%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(3aR,4R,5R,6aS)-5-((tert-butyldiphenylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde

(3aR,4R,5R,6aS)-5-((tert-butyldiphenylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde

(3aR,4R,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-((E)-3-oxo-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one
1395619-06-3

(3aR,4R,5R,6aS)-5-(tert-butyldiphenylsilyloxy)-4-((E)-3-oxo-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With triethylamine; lithium chloride In tetrahydrofuran at -10℃; for 1.5h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: (3aR,4R,5R,6aS)-5-((tert-butyldiphenylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde In tetrahydrofuran at -10℃; for 2.41667h; Inert atmosphere;
72%
C30H34O7

C30H34O7

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

4-[(Z)-7-isopropoxy-7-oxohept-2-enyl]-5-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentane-1,3-diyl dibenzoate

4-[(Z)-7-isopropoxy-7-oxohept-2-enyl]-5-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentane-1,3-diyl dibenzoate

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In 1,2-dimethoxyethane at -5 - 25℃; Inert atmosphere;
Stage #2: C30H34O7 In 1,2-dimethoxyethane at -5 - 25℃; Wittig reaction; Inert atmosphere;
70%
[(S)-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl) acetaldehyde]

[(S)-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl) acetaldehyde]

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

sodium hydride
7646-69-7

sodium hydride

(6R)-(4-oxo-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one

(6R)-(4-oxo-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate; sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: [(S)-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl) acetaldehyde] In tetrahydrofuran; mineral oil at -78℃; for 1h; Inert atmosphere;
66%
[(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]
163074-98-4

[(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

C25H26O4

C25H26O4

Conditions
ConditionsYield
With triethylamine; lithium chloride In tetrahydrofuran at -18 - -10℃; for 25h; Horner-Wadsworth-Emmons Olefination;65%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

2-(trimethylsilyl)phenyl trifluoromethanesulfonate
88284-48-4

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

dimethyl 2-(3-phenylpropanoyl)benzylphosphonate
1170736-73-8

dimethyl 2-(3-phenylpropanoyl)benzylphosphonate

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate; 2-(trimethylsilyl)phenyl trifluoromethanesulfonate With cesium fluoride In tetrahydrofuran at 60℃; for 67h; Inert atmosphere;
Stage #2: With silica gel In tetrahydrofuran; ethyl acetate
65%
(Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate

(Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

4-[(Z)-7-isopropoxy-7-oxohept-2-enyl]-5-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentane-1,3-diyl dibenzoate

4-[(Z)-7-isopropoxy-7-oxohept-2-enyl]-5-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentane-1,3-diyl dibenzoate

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With sodium hydride In 1,2-dimethoxyethane at -5 - 25℃; for 1.25h; Wittig reaction; Inert atmosphere;
Stage #2: (Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate In 1,2-dimethoxyethane at -5 - 25℃; for 2h; Wittig reaction; Inert atmosphere;
65%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(1-diazo-2-oxo-4-phenylbutyl)phosphonic acid dimethyl ester.

(1-diazo-2-oxo-4-phenylbutyl)phosphonic acid dimethyl ester.

Conditions
ConditionsYield
With 4-toluenesulfonyl azide; potassium carbonate63%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(-)-7α-triethylsilyloxy-6β-formyl-cis-2-oxabicyclo<3.3.0>octan-3-one
128948-10-7

(-)-7α-triethylsilyloxy-6β-formyl-cis-2-oxabicyclo<3.3.0>octan-3-one

C24H34O4Si

C24H34O4Si

Conditions
ConditionsYield
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With triethylamine; lithium chloride In tetrahydrofuran at -15 - -5℃;
Stage #2: (-)-7α-triethylsilyloxy-6β-formyl-cis-2-oxabicyclo<3.3.0>octan-3-one In tetrahydrofuran for 1h;
51%
Stage #1: dimethyl(2-oxo-4-phenylbutyl)phosphonate With lithium hydroxide monohydrate In tert-butyl methyl ether at 20℃; for 1h;
Stage #2: (-)-7α-triethylsilyloxy-6β-formyl-cis-2-oxabicyclo<3.3.0>octan-3-one In tert-butyl methyl ether; water at 5℃; for 0.916667h; Wittig-Horner Reaction;
27.5 g
With lithium hydroxide monohydrate In tert-butyl methyl ether at 5℃; for 0.75h; Wittig-Horner Reaction; Inert atmosphere;
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

A

(E)-6,6,6-trifluoro-1,5-diphenylhex-4-en-3-one

(E)-6,6,6-trifluoro-1,5-diphenylhex-4-en-3-one

B

(Z)-6,6,6-trifluoro-1,5-diphenylhex-4-en-3-one

(Z)-6,6,6-trifluoro-1,5-diphenylhex-4-en-3-one

Conditions
ConditionsYield
Stage #1: ethyl trifluoroacetate,; phenylmagnesium bromide In diethyl ether; water at -80 - 0℃; for 2h; Inert atmosphere;
Stage #2: dimethyl(2-oxo-4-phenylbutyl)phosphonate With triethylamine; lithium bromide In tetrahydrofuran; diethyl ether; water at 0 - 40℃; for 5.16h; Inert atmosphere;
A 51%
B 4%
[(S)-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl) acetaldehyde]

[(S)-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl) acetaldehyde]

dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(6R)-(4-oxo-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one

(6R)-(4-oxo-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Horner-Wadsworth-Emmons reaction;20%
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

methyl <1α,2α(Z),3α,4α>-7-<3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate
104596-33-0

methyl <1α,2α(Z),3α,4α>-7-<3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate

(Z)-7-[(1S,2R,3S,4R)-3-((E)-3-Oxo-5-phenyl-pent-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

(Z)-7-[(1S,2R,3S,4R)-3-((E)-3-Oxo-5-phenyl-pent-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Conditions
ConditionsYield
With sodium hydride 1.) DME, 2.) 23 deg C; Multistep reaction;
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

<1α,2β(5Z),3β,4α>-7-<5,6-exo-epoxy-3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid methyl ester

<1α,2β(5Z),3β,4α>-7-<5,6-exo-epoxy-3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid methyl ester

(Z)-7-[(1S,2S,4R,5R,6R,7S)-7-((E)-3-Oxo-5-phenyl-pent-1-enyl)-3,8-dioxa-tricyclo[3.2.1.02,4]oct-6-yl]-hept-5-enoic acid methyl ester

(Z)-7-[(1S,2S,4R,5R,6R,7S)-7-((E)-3-Oxo-5-phenyl-pent-1-enyl)-3,8-dioxa-tricyclo[3.2.1.02,4]oct-6-yl]-hept-5-enoic acid methyl ester

Conditions
ConditionsYield
With triethylamine; lithium bromide 1.) CH2Cl2, 25 deg C, 15 min, 2.) 25 deg C, overnight; Multistep reaction;
dimethyl(2-oxo-4-phenylbutyl)phosphonate
41162-19-0

dimethyl(2-oxo-4-phenylbutyl)phosphonate

(Z)-7-((1R,2S,3R,5S)-3,5-Dihydroxy-2-hydroxymethyl-cyclopentyl)-hept-5-enoic acid isopropyl ester
177616-22-7

(Z)-7-((1R,2S,3R,5S)-3,5-Dihydroxy-2-hydroxymethyl-cyclopentyl)-hept-5-enoic acid isopropyl ester

15-keto-17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester
130209-77-7

15-keto-17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester

Conditions
ConditionsYield
With aluminium trichloride; 3 A molecular sieve; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; lithium chloride; phenylboronic acid Yield given. Multistep reaction;
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