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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory supply Latanoprost powder CAS 130209-82-4

Cas:130209-82-4

Min.Order:1 Gram

FOB Price: $300.0

Type:Trading Company

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hangzhou verychem science and technology co.ltd

Product name: Latanoprost Cas No: 130209-82-4 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it inve

Latanoprost,manufacturer,99.0%min

Cas:130209-82-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Latanoprost 130209-82-4 GMP Manufacturer

Cas:130209-82-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Latanoprost 130209-82-4

Cas:130209-82-4

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Qiuxian Yanjia Trading Co., Ltd

Advantages 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

High purity Latanoprost in stock cas 130209-82-4

Cas:130209-82-4

Min.Order:1 box

FOB Price: $190.0 / 220.0

Type:Trading Company

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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. Latanoprost is our regular products. Package:According to your demand Transportation:as requested Port:any port

Latanoprost

Cas:130209-82-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Latanoprost Manufacturer/High quality/Best price/In stock

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 130209-82-4 Latanoprost

Cas:130209-82-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Kono Chem Co.,Ltd

CAS No.: 130209-82-4 Other Names: XALATAN MF: C26H40O5, C26H40O5 EINECS No.: None Place of Origin: Shaanxi, China (Mainland) Type: small-molecule inhibitor

Latanoprost 99% powder

Cas:130209-82-4

Min.Order:1 Gram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Colorless or slightly yellow oily liquid Storage:-20°C Pa

High purity Latanoprost CAS 130209-82-4 supplied by manufacturer

Cas:130209-82-4

Min.Order:5 Metric Ton

FOB Price: $300.0 / 400.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Latanoprost CAS No.:130209-82-4 Name: Latanoprost Synonyms: Propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate Molecular Structure: Molecular Formula: C26H40O5

High purity Latanoprost CAS No.:130209-82-4

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:White or

Latanoprost (50 mg)

Cas:130209-82-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Latanoprost

Cas:130209-82-4

Min.Order:1

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Latanoprost manufacturer with low price

Cas:130209-82-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Latanoprost

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 130209-82-4 with best quality

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Latanoprost/ LIDE PHARMA- Factory supply / Best price

Cas:130209-82-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Chemical Name: Latanoprost Synonyms:XALATAN;ISOPROPYL (5Z, 9A,11A,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OATE;LATANOPROST;17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;9ALPHA,11ALPHA,15R-TRIHYDR

Latanoprost ,CAS 130209-82-4

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:pale yellow oil Storage:2-8℃ Package:10g/bottle Application:Prostaglandin Transportation:Express/Sea/Air Port:Any port in china

High Quality Latanoprost (free base) In Stock Lata prostaglandin

Cas:130209-82-4

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

High Purity Factory Supply Latanoprost Powder CAS 130209-82-4 for Prostaglandin

Cas:130209-82-4

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service Upbio is Specialized in APIs, chemical intermedia

Hotsale Latanoprost

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

(free base) 130209-82-4 cas shipping door to door 99.7% latanoprost

Cas:130209-82-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

130209-82-4 Latanoprost with best price

Cas:130209-82-4

Min.Order:1 Kilogram

FOB Price: $50.0 / 150.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Latanoprost CAS 130209-82-4 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China an

High quality Latanoprost CAS 130209-82-4

Cas:130209-82-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Latanoprost ,CAS 130209-82-4

Cas:130209-82-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Buy low price cheap Latanoprost for Treating Eyes in stock 2018

Cas:130209-82-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Latanoprost

Cas:130209-82-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

Quick Details CAS No.: 130209-82-4 Other Names: xa41; XALATAN; Xalata MF: C26H40O5 EINECS No.: 634-172-9 Place of Origin:, China (Mainlan

Latanoprost

Cas:130209-82-4

Min.Order:1 Gram

FOB Price: $300.0

Type:Trading Company

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Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of

Supply Latanoprost high quality Hot sale 99.0% Latanoprost price market

Cas:130209-82-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-iodo-propane
75-30-9

2-iodo-propane

latanoprost acid
41639-83-2

latanoprost acid

A

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

B

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone at 20℃; for 14h;A n/a
B 99.83%
latanoprost acid
41639-83-2

latanoprost acid

isopropyl alcohol
67-63-0

isopropyl alcohol

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With Lipase Novozym 435 at 30℃; for 18h; Enzymatic reaction;92%
Novozym 435 at 30℃; for 18h;92%
With 2-chloro-1,3-dimethyl imidazolium chloride; potassium tert-butylate; triethylamine at 0 - 70℃; for 2h;
isopropyl 11,15-bistetrahydropyranyloxy-13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2α

isopropyl 11,15-bistetrahydropyranyloxy-13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2α

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In methanol at 52℃; for 4h; Product distribution / selectivity;90%
pyridinium p-toluenesulfonate In methanol at 52℃; for 4h;90%
With pyridinium p-toluenesulfonate In dichloromethane at 40℃; Inert atmosphere;86.1%
With toluene-4-sulfonic acid In isopropyl alcohol at 40℃; for 5h;
With ethanol; pyridinium p-toluenesulfonate at 20 - 50℃; for 3h;
2-iodo-propane
75-30-9

2-iodo-propane

latanoprost acid
41639-83-2

latanoprost acid

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;84%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 14h;72%
With potassium carbonate In N,N-dimethyl-formamide at 50℃;68%
C41H64O8
856453-33-3

C41H64O8

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In methanol at 45℃; for 6h; Product distribution / selectivity;83.7%
pyridinium p-toluenesulfonate In methanol at 45℃; for 6h;83.7%
C39H46O7

C39H46O7

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Stage #1: C39H46O7 With hydrogen In ethyl acetate at 20℃; for 4h; Inert atmosphere;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 0℃; for 0.5h; Inert atmosphere;
Stage #3: With sodium tetrahydroborate In methanol; dichloromethane; water at 0℃; for 2.5h; Inert atmosphere;
83%
C26H38O5
141074-06-8

C26H38O5

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Stage #1: C26H38O5 With 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride In toluene at -70 - -20℃;
Stage #2: With hydrogenchloride In water; toluene
75%
2-iodo-propane
75-30-9

2-iodo-propane

latanoprost acid
41639-83-2

latanoprost acid

A

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

B

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

C

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone at 20℃; for 5.5 - 14.2167h; Product distribution / selectivity;A n/a
B n/a
C 63.2%
2-iodo-propane
75-30-9

2-iodo-propane

C23H32O4

C23H32O4

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Stage #1: C23H32O4 With sodium hydride In isopropyl alcohol; mineral oil at 20 - 35℃; for 18h;
Stage #2: 2-iodo-propane With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 18h;
49%
(3aR,4R,5R,6aS)-hexahydro-5-triethylsilyoxy-4-[5-phenyl-(3R)-3-triethylsilyloxy-pentanyl]-2H-cyclopenta[β]furan-2-one
477884-73-4

(3aR,4R,5R,6aS)-hexahydro-5-triethylsilyoxy-4-[5-phenyl-(3R)-3-triethylsilyloxy-pentanyl]-2H-cyclopenta[β]furan-2-one

A

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

B

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

C

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Purification / work up;A n/a
B n/a
C 45%
(-)-Corey lactone 5-(4-phenylbenzoate)
31752-99-5

(-)-Corey lactone 5-(4-phenylbenzoate)

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: DCC, phosphoric acid / 1,2-dimethoxy-ethane / a) 18 deg C, 30 min, b) RT, 2 h
2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h
3: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C
4: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
5: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
6: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
7: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
8: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
benzyl bromide
100-39-0

benzyl bromide

alcoholic potash

alcoholic potash

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1.) NaH, 2.) n-BuLi
2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h
3: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C
4: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
5: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
6: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
7: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
8: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
41639-72-9

(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C
2: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
3: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
4: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
5: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
6: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentenyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
41639-23-0

(1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentenyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
2: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
3: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
4: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
5: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
dimethyl (2-oxo-4-phenylbutyl)phosphonate

dimethyl (2-oxo-4-phenylbutyl)phosphonate

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h
2: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C
3: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
4: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
5: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
6: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
7: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-ol

(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-ol

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
2: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-one
145773-21-3

(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-one

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
2: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
3: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
145773-20-2

(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
2: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
3: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
4: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate
38754-71-1

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h
2: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C
3: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h
4: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature
5: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C
6: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h
7: 38 percent / DBU / acetone / 4 h / Ambient temperature
View Scheme
latanoprost acid
41639-83-2

latanoprost acid

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With caesium carbonate In water; N,N-dimethyl-formamide
C41H76O5Si3

C41H76O5Si3

C41H76O5Si3

C41H76O5Si3

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With hydrogenchloride; water In acetone at 0 - 25℃; pH=1 - 3;
C38H68O5Si2
477884-76-7

C38H68O5Si2

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 0.5h;
C38H68O5Si2
477884-76-7

C38H68O5Si2

C38H68O5Si2

C38H68O5Si2

A

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate

B

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 0.5h;
2-iodo-propane
75-30-9

2-iodo-propane

latanoprost L-arginine salt
1224443-39-3

latanoprost L-arginine salt

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
In methanol; water
In methanol; water
(Z)-isopropyl 7-((1R,2R,3R,5S)-3-(tert-butyldimethylsilyloxy)-2-((R)-3-(tert-butyldimethylsilyloxy)-5-phenylpentyl)-5-hydroxycyclopentyl)hept-5-enoate
474944-22-4

(Z)-isopropyl 7-((1R,2R,3R,5S)-3-(tert-butyldimethylsilyloxy)-2-((R)-3-(tert-butyldimethylsilyloxy)-5-phenylpentyl)-5-hydroxycyclopentyl)hept-5-enoate

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
With hydrogenchloride; water In isopropyl alcohol at 25 - 30℃;
latanoprost acid
41639-83-2

latanoprost acid

isopropyl bromide
75-26-3

isopropyl bromide

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Stage #1: latanoprost acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone at 20 - 25℃; for 0.166667h;
Stage #2: isopropyl bromide In acetone for 0.5h;
tert-butyl[(1S)-3-iodo-1-phenethylpropyl]oxydimethylsilane
876953-73-0

tert-butyl[(1S)-3-iodo-1-phenethylpropyl]oxydimethylsilane

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / hexane; diethyl ether / 4 h / -78 °C / Inert atmosphere
1.2: 0.92 h / -78 - -50 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / 3 h / -78 °C
2.2: -50 °C
3.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 24 h / 20 - 40 °C
4.1: Grubbs catalyst first generation / dichloromethane / 18 h / 20 - 40 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride; ammonium hydrogen difluoride / tetrahydrofuran / 24 h / 20 - 40 °C
6.1: sodium hydride / isopropyl alcohol; mineral oil / 18 h / 20 - 35 °C
6.2: 18 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 4 h / -78 - -40 °C / Inert atmosphere; Schlenk technique
1.2: 0.5 h / -30 °C / Inert atmosphere; Schlenk technique
2.1: ozone / methanol; dichloromethane / -78 °C
2.2: -78 - 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere; Schlenk technique
4.2: 0 - 20 °C / Inert atmosphere; Schlenk technique
5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 4 h / -78 - -40 °C / Inert atmosphere; Schlenk technique
1.2: 0.5 h / -30 °C / Inert atmosphere; Schlenk technique
2.1: ozone / methanol; dichloromethane / -78 °C
2.2: -78 - 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
4.1: valerianate de potassium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique
4.2: 0 - 20 °C / Inert atmosphere; Schlenk technique
5.1: hydrogenchloride; water / tetrahydrofuran / 17 h / 20 °C
6.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / diethyl ether / 4 h / -78 - -40 °C / Inert atmosphere
1.2: 1 h / -78 - -20 °C / Inert atmosphere
2.1: ozone / methanol; dichloromethane / -78 °C
2.2: 3.25 h / -78 - 20 °C / Inert atmosphere
3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere
4.2: 1.5 h / 0 - 20 °C / Inert atmosphere
5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
View Scheme
C31H54O3Si2
1261926-67-3

C31H54O3Si2

latanoprost
130209-82-4

latanoprost

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / toluene / 3 h / -78 °C
1.2: -50 °C
2.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 24 h / 20 - 40 °C
3.1: Grubbs catalyst first generation / dichloromethane / 18 h / 20 - 40 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride; ammonium hydrogen difluoride / tetrahydrofuran / 24 h / 20 - 40 °C
5.1: sodium hydride / isopropyl alcohol; mineral oil / 18 h / 20 - 35 °C
5.2: 18 h / 20 °C
View Scheme
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

latanoprost
130209-82-4

latanoprost

(Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)cyclopentyl)hept-5-enoate

(Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)cyclopentyl)hept-5-enoate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;94%
latanoprost
130209-82-4

latanoprost

latanoprost acid
41639-83-2

latanoprost acid

Conditions
ConditionsYield
Stage #1: latanoprost With lithium hydroxide; water In tetrahydrofuran for 16h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
90%
butylboronic acid
4426-47-5

butylboronic acid

latanoprost
130209-82-4

latanoprost

(Z)-isopropyl 7-((1R,5S,6R,7R)-3-butyl-7-((R)-3-hydroxy-5-phenylpentyl)-2,4-dioxa-3-borabicyclo[3.2.1]octan-6-yl)hept-5-enoate

(Z)-isopropyl 7-((1R,5S,6R,7R)-3-butyl-7-((R)-3-hydroxy-5-phenylpentyl)-2,4-dioxa-3-borabicyclo[3.2.1]octan-6-yl)hept-5-enoate

Conditions
ConditionsYield
In dichloromethane at 45℃; for 20h; Inert atmosphere;80%
In dichloromethane at 45℃; for 22h; Inert atmosphere;
(S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionic acid

(S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionic acid

latanoprost
130209-82-4

latanoprost

C68H94O32

C68H94O32

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 28h; Inert atmosphere;60%
(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionic acid

(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionic acid

latanoprost
130209-82-4

latanoprost

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 48h; Inert atmosphere;54%
(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoic acid

(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoic acid

latanoprost
130209-82-4

latanoprost

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 48h; Inert atmosphere;37%
(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionyloxy]-propionic acid

(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-acetoxypropionyloxy)propionyloxy]propionyloxy}propionyloxy)propionyloxy]-propionic acid

latanoprost
130209-82-4

latanoprost

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

propan-2-yl (5Z)-7-[3,5-bis({[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy})-2-(3-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-(acetyloxy)propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}propanoyl]oxy}-5-phenylpentyl)cyclopentyl]hept-5-enoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 30℃; for 48h; Inert atmosphere;35%

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