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SHAANXI FUJIE PHARMACEUTICAL CO.,LTD

【annual production】The annual production capability of the factory can reach to fifty tons. 【superiority】 1.we are manufacture and our production workshop had passed China GMP. 2.we can give you lowest price and best quality. 3.Our government st

Reliable quality of on hot selling Enoxolone 471-53-4 global leader

Cas:471-53-4

Min.Order:20 Kilogram

FOB Price: $380.0 / 400.0

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white crystalline powder Complies Infrared Absorption

High purity Enoxolone (18-β-glycyrrhetinic acid) with high quality cas:471-53-4

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $300.0 / 410.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W

99% up GMP 18β-Glycyrrhetinic acid Enoxolone 471-53-4

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $825.0 / 1100.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Enoxolone supplier in China

Cas:471-53-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Best service,high quality and cheap price. Appearance:White crystal powder Storage:Dry place in sealed container Package:25kg/drum,1kg/bag Application:Mainly used in medicine, health food, tobacco, cosmetics raw materials or auxiliary materials, et

18-Beta-Glycyrrhetinic acid

Cas:471-53-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

high purity natral extract from licorice root Appearance:white powder Storage:keep away from moisture and strong heat Package:25kg/drum Application:pharma and cosmeic use Transportation:by air, by sea Port:Shanghai

Glycyrrhetinic acid

Cas:471-53-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professio

Glycyrrhetic Acid

Cas:471-53-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Enoxolone

Cas:471-53-4

Min.Order:1

Negotiable

Type:Other

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Kono Chem Co.,Ltd

Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Provin

18-Beta-Glycyrrhetinic acid

Cas:471-53-4

Min.Order:650 Kilogram

FOB Price: $500.0 / 555.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Enoxolone 471-53-4 ISO Producer

Cas:471-53-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 18β-Glycyrrhetinic Acid

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Enoxolone /manufacturer/high quality/in stock

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Glycyrrhetinic acid

Cas:471-53-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Chinese Name: Glycyrrhizic acid Chinese aliases: glycyrrhetinic acid; (3B, 20B) - 3-hydroxy-11-oxo-oleanolic-12-ene-29-acid; (3B, 20B) - 3-hydroxy-11-oxo-oleanolic-12-ene-29-acid; (3B, 20B) - hydroxy-11-oxo-oleanolic-12-ene-29-acid; (3B-hydroxy-11

Enoxolone/Cas:471-53-4 /99.9% High purity

Cas:471-53-4

Min.Order:100 Metric Ton

FOB Price: $4.0 / 6.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

CAS No.: 471-53-4 INCI Name: Glycyrrhetinic Acid Assay: Titr≥98% Efficacy:anti-inflammatory,anti-allergic,anti-aging and skin-whitening. Application:facial mask,skin cream,facial foam,etc. It is used in

471-53-4 Enoxolone

Cas:471-53-4

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

ProName: High purity Enoxolone (18-β-glycyrrhet... CasNo: 471-53-4 Molecular Formula: C30H46O4 Appearance: White or off-white crystalline powder Application: intermediate for organic synthesis DeliveryTime: Prompt PackAge: 25kg net/paper

18β-Glycyrrhetinic Acid 471-53-4

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Fair price CAS 471-53-4 with high quality products

Cas:471-53-4

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 471-53-4 Enoxolone

Cas:471-53-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

rodcut name Enoxolone Specification 99% Appearance White crystal powder CAS No. 471-53-4 MF C30H46O4 Appearance:White powder Storage:Store in cool and dry place, away from sun light

18-Beta-Glycyrrhetinic acid

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

18 beta Glycyrrhetinic Acid Plant Extract 1.CAS NO: 471-53-4 2.Purity: 98% 3.Molecular Formula: C30H46O4 4.Molecular Weight: 470.69 5. Appearance: white crystalline powder 6.Function: 1. It is mainly used in the dermatology field in c

High quality Enoxolone

Cas:471-53-4

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

GMP Factory Supply Glycyrrhetinic acid

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

18β-Glycyrrhetinic Acid

Cas:471-53-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

18β-Glycyrrhetinic Acid CAS: 471-53-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

18β-Glycyrrhetinic Acid CAS: 471-53-4

Cas:471-53-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Enoxolone

Cas:471-53-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

18β- Glycyrrhetinic Acid manufacturer with low price

Cas:471-53-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 471-53-4 18β-Glycyrrhetinic Acid

Cas:471-53-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:471-53-4

Cas:471-53-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

PRODUCT DETAILS

China Biggest Manufacturer factory sales Glycyrrhetinic Acid CAS 471-53-4

Cas:471-53-4

Min.Order:1000 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Gansu Yalan Pharmaceutical Co,.Ltd. is one of the top 18 enterprises medicine herbal pieces in China,The company has a complete production line of glycyrrhiza series products. The new factory can supply 400 tons of glycyrrhizin r

High purity Enoxolone (18-β-glycyrrhetinic acid) with high quality cas:471-53-4

Cas:471-53-4

Min.Order:100 Gram

FOB Price: $1.1 / 1.2

Type:Lab/Research institutions

inquiry

Synthetic route

glycyrrhizin
1405-86-3

glycyrrhizin

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With methanol; thionyl chloride at 0 - 20℃; for 9h; Reagent/catalyst; Inert atmosphere;90%
With hydrogenchloride; water In methanol at 90℃; for 20h;
With hydrogenchloride In water at 100℃; for 20h;
With sulfuric acid In methanol Reflux;250 mg
With methanol; sulfuric acid at 90℃; for 24h;
Conditions
ConditionsYield
With hydrogenchloride In water85%
Multi-step reaction with 2 steps
1: 18.4 percent / CHCl3; dimethylformamide / 72 h / Ambient temperature
2: 68.3 percent / 20percent H2SO4 / dioxane / 4 h
View Scheme
With hydrogenchloride In ethanol; water at 30 - 35℃; for 48h;0.53%
(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-D-glucopyranosiduronic acid

(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-D-glucopyranosiduronic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With hydrogenchloride In water; acetic acid at 100℃; for 1h;72%
With hydrogenchloride; water In chloroform for 6h; Reflux;13 mg
6',6''-dibenzyl-18β-glycyrrhizin
87918-97-6

6',6''-dibenzyl-18β-glycyrrhizin

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane for 4h;68.3%
β-glycyrrhizic acid monopotassium salt

β-glycyrrhizic acid monopotassium salt

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid In water at 100℃; for 8h; Hydrolysis;68.3%
Conditions
ConditionsYield
at 40℃; for 3h; 15percent aq. solution of β-glucuronidase, acetate buffer 4.6;48%
With β-glucuronidase In water at 40℃; for 3h; Rate constant; Kinetics; Product distribution; acetate buffer 4.6; other temp., other pH, other time;48.08%

A

3β-hydroxy-12-oxoolean-30-oic acid

3β-hydroxy-12-oxoolean-30-oic acid

B

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
Stage #1: 11-deoxyglycyrrhetinic acid With ozone In methanol; dichloromethane at -60℃;
Stage #2: With acetic acid; zinc In methanol; dichloromethane at 0℃; for 1h; Further stages.;
A 42%
B n/a
Conditions
ConditionsYield
With potassium hydroxide
methanol
67-56-1

methanol

apioglycyrrhizin
121709-66-8

apioglycyrrhizin

A

methyl glucoside of D-glucurono-6,3-lactone
135414-74-3

methyl glucoside of D-glucurono-6,3-lactone

B

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With hydrogenchloride the structure was confirmed;
methanol
67-56-1

methanol

araboglycyrrhizin
121687-83-0

araboglycyrrhizin

A

methyl glucoside of D-glucurono-6,3-lactone
135414-74-3

methyl glucoside of D-glucurono-6,3-lactone

B

enoxolone
471-53-4

enoxolone

C

methyl α,β-L-arabinopyranoside
449173-64-2

methyl α,β-L-arabinopyranoside

Conditions
ConditionsYield
the structure was confirmed;
glycyrrhizin
1405-86-3

glycyrrhizin

A

enoxolone
471-53-4

enoxolone

B

D-glucuronyl-β-1,2-D-glucuronic acid

D-glucuronyl-β-1,2-D-glucuronic acid

Conditions
ConditionsYield
With glycyrrhizinic acid hydrolase at 40℃; pH 5.0, acetate buffer;
1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid
34096-83-8

1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With luminal contents in rat colon In phosphate buffer at 37℃; pH=7.4; Kinetics; Hydrolysis;
ammonium salt of/the/ glycyrrhizinic acid

ammonium salt of/the/ glycyrrhizinic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid
With hydrogenchloride at 50℃;
With sulfuric acid at 130 - 155℃; unter Druck;
glycyrrhizinic acid

glycyrrhizinic acid

enoxolone
471-53-4

enoxolone

monoammonium salt of/the/ glycyrrhizinic acid

monoammonium salt of/the/ glycyrrhizinic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid
With β-glucuronidase
potassium salt of/the/ glycyrrhizinic acid

potassium salt of/the/ glycyrrhizinic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid
With hydrogenchloride at 50℃;
With sulfuric acid at 130 - 155℃; unter Druck;
glycyrrhizic acid

glycyrrhizic acid

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With sulfuric acid In methanol Reflux;
glycyrrhizin
1405-86-3

glycyrrhizin

A

enoxolone
471-53-4

enoxolone

B

1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid
34096-83-8

1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid

Conditions
ConditionsYield
With water at 100 - 140℃; under 52505.3 Torr; Kinetics; Thermodynamic data; Green chemistry;
C38H49NO6

C38H49NO6

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; manganese; 2.9-dimethyl-1,10-phenanthroline; carbon dioxide In N,N-dimethyl-formamide at 20℃; under 2585.81 Torr; for 20h; Sealed tube; chemoselective reaction;
Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;100%
With potassium carbonate In acetone at 20℃; for 12h;95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h;94%
enoxolone
471-53-4

enoxolone

O-benzyl-N,N'-dicyclohexylisourea
6738-17-6

O-benzyl-N,N'-dicyclohexylisourea

benzyl (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate
51984-75-9

benzyl (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate

Conditions
ConditionsYield
In chloroform for 5h; Heating;99%
Conditions
ConditionsYield
In methanol; diethyl ether at 0℃;99%
In tetrahydrofuran; diethyl ether for 0.833333h;89.7%
In diethyl ether; dichloromethane83%
Conditions
ConditionsYield
In methanol; diethyl ether at 0 - 20℃; for 2h;99%
In diethyl ether at 20℃; for 1h;98%
In methanol; hexane; toluene at 20℃; for 0.5h;91%
In methanol; diethyl ether
enoxolone
471-53-4

enoxolone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(3β)-3-[(methylsulfonyl)oxy]-11-oxo-olean-12-en-30-oic acid
1326599-59-0

(3β)-3-[(methylsulfonyl)oxy]-11-oxo-olean-12-en-30-oic acid

Conditions
ConditionsYield
With pyridine at 20℃; for 70h;99%
With triethylamine In dichloromethane at 4℃; for 3h;65.7%
enoxolone
471-53-4

enoxolone

phenyl isocyanate
103-71-9

phenyl isocyanate

3-phenylcarbamoyl-18β-glycyrrhetinic acid

3-phenylcarbamoyl-18β-glycyrrhetinic acid

Conditions
ConditionsYield
With triethylamine In toluene at 110℃; for 2h;99%
Conditions
ConditionsYield
With pyridine at 20℃; for 16h;98%
With pyridine; dmap at 20℃; for 2h;98.2%
for 1.5h; Reflux;96.4%
enoxolone
471-53-4

enoxolone

3,11-dioxoolean-12-en-30-oic acid
6184-16-3, 7020-50-0, 146236-29-5

3,11-dioxoolean-12-en-30-oic acid

Conditions
ConditionsYield
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; for 1h;98%
With Jones reagent In acetone at 0℃; for 1.5h;96.25%
With Jones reagent In acetone at 0℃; for 2h;96%
enoxolone
471-53-4

enoxolone

S-(1-butyn-3-yl)-O-methyl xanthate

S-(1-butyn-3-yl)-O-methyl xanthate

Conditions
ConditionsYield
In toluene Heating;98%
enoxolone
471-53-4

enoxolone

prenyl bromide
870-63-3

prenyl bromide

18β-glycyrrhetinic acid 30-prenyl ester

18β-glycyrrhetinic acid 30-prenyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 50℃; for 4h;98%
enoxolone
471-53-4

enoxolone

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid
109278-66-2

(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions
ConditionsYield
In ethyl acetate at 130℃; for 1h;98%
enoxolone
471-53-4

enoxolone

oxymatrine

oxymatrine

C30H46O4*C15H24N2O2

C30H46O4*C15H24N2O2

Conditions
ConditionsYield
In ethanol at 50℃; Solvent; Temperature;97.8%
enoxolone
471-53-4

enoxolone

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

C44H64O13

C44H64O13

Conditions
ConditionsYield
With Aliquat 336; potassium carbonate In dichloromethane; water for 48h; Ambient temperature;97%
3-bromo-4-fluoro-benzyl chloride
78239-72-2

3-bromo-4-fluoro-benzyl chloride

enoxolone
471-53-4

enoxolone

3-(3-bromo-4-fluoro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

3-(3-bromo-4-fluoro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;97%
enoxolone
471-53-4

enoxolone

1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

3-(3-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

3-(3-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;97%
enoxolone
471-53-4

enoxolone

4-chlorophenacetyl chloride
25026-34-0

4-chlorophenacetyl chloride

(3β)‐(2‐(4‐chlorophenyl)acetoxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

(3β)‐(2‐(4‐chlorophenyl)acetoxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions
ConditionsYield
With triethylamine In ethyl acetate for 24h; Reflux;97%
enoxolone
471-53-4

enoxolone

chloroacetyl chloride
79-04-9

chloroacetyl chloride

(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid
109278-66-2

(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 4h;96.2%
Stage #1: enoxolone; chloroacetyl chloride With triethylamine In tetrahydrofuran at 25℃; for 12h;
Stage #2: With hydrogenchloride In dichloromethane; water
45.3%
enoxolone
471-53-4

enoxolone

allyl bromide
106-95-6

allyl bromide

(3β,18β,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid allyl ester
31467-24-0

(3β,18β,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid allyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 50℃; for 4h;96%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;84.2%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 24.1667h;69%
N-BOC-1,2-diaminoethane
57260-73-8

N-BOC-1,2-diaminoethane

enoxolone
471-53-4

enoxolone

N-[2-(tert-butoxycarbonylamino)ethyl]glycyrrhetinamide
1334318-59-0

N-[2-(tert-butoxycarbonylamino)ethyl]glycyrrhetinamide

Conditions
ConditionsYield
Stage #1: enoxolone With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: N-BOC-1,2-diaminoethane In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
96%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 10h;90%
Stage #1: enoxolone With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N-BOC-1,2-diaminoethane In N,N-dimethyl-formamide at 0 - 20℃;
64%
enoxolone
471-53-4

enoxolone

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate
1612838-71-7

1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile for 0.333333h; Reflux;95.8%
With hydrogenchloride In water for 3.5h; Reflux;90%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;27%
With piperazine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20℃;
enoxolone
471-53-4

enoxolone

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate
1612838-71-7

1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate

Conditions
ConditionsYield
Stage #1: enoxolone; benzotriazol-1-ol With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 0.333333h;
Stage #2: 1-t-Butoxycarbonylpiperazine In dichloromethane for 24h; Reflux;
95.8%
Conditions
ConditionsYield
With hydrogenchloride; zinc amalgam In 1,4-dioxane; water for 5h; Clemmensen Reduction; Cooling;95%
With hydrogenchloride; mercury dichloride; zinc In 1,4-dioxane; water90%
With platinum(IV) oxide; hydrogen In acetic acid87.6%
enoxolone
471-53-4

enoxolone

11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picene-3,14-diol
77397-93-4

11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picene-3,14-diol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 60 - 70℃; for 4h;95%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran at 0 - 20℃;63%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran
With lithium aluminium tetrahydride In tetrahydrofuran at 60℃;
enoxolone
471-53-4

enoxolone

(3β,18β,20β)-3,11-dihydroxyoleana-12-en-29-oic acid

(3β,18β,20β)-3,11-dihydroxyoleana-12-en-29-oic acid

Conditions
ConditionsYield
With sodium tetrahydroborate; sodium hydroxide In tetrahydrofuran; water for 24h; Reflux;95%
With sodium tetrahydroborate; sodium hydroxide In tetrahydrofuran; water for 4h; Reflux;80%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran; water for 4h; Reduction; Heating;
enoxolone
471-53-4

enoxolone

4-Fluorobenzyl bromide
459-46-1

4-Fluorobenzyl bromide

10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-eicosahydropicene-2-carboxylic acid 4-fluorobenzyl ester

10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-eicosahydropicene-2-carboxylic acid 4-fluorobenzyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;95%
enoxolone
471-53-4

enoxolone

methyllithium
917-54-4

methyllithium

3β-hydroxy-11-methylene-18β-olean-12-en-30-oic acid

3β-hydroxy-11-methylene-18β-olean-12-en-30-oic acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; diethyl ether at 20℃; for 1h;95%
1-bromo-butane
109-65-9

1-bromo-butane

enoxolone
471-53-4

enoxolone

butyl 3β-hydroxy-11-oxo-olean-12-en-30-oate
1375691-79-4

butyl 3β-hydroxy-11-oxo-olean-12-en-30-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h;95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;85.8%
enoxolone
471-53-4

enoxolone

1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

3-(4-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

3-(4-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;95%
enoxolone
471-53-4

enoxolone

p-bromobenzyl chloride
589-17-3

p-bromobenzyl chloride

3-(4-bromo-benzyloxy)-11-oxoolean-12-ene-29-oic acid

3-(4-bromo-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;95%
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