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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder ha

Methyldienedione

Cas:5173-46-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF 19-Norandrosta-4,9-diene-3,17-dione / Estra-4,9-diene-3,17-dione 5173-46-6

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Estra-4,9-diene-3,17-dione Cas 5173-46-6 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Storage:Refrigerator Package:1kg/foil

Reliable chemical supplier Estra-4,9-diene-3,17-dione Cas 5173-46-6 with factory price and high quality

Cas:5173-46-6

Min.Order:1 Kilogram

FOB Price: $85.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Estra-4,9-diene-3,17-dione CAS No.:5173-46-6 Name: Estra-4,9-diene-3,17-dione Synonyms: 19-Norandrosta-4,9-diene-3,17-dione Molecular Structure Molecular Formula: C19H20O2

High purity Estra-4,9-diene-3,17-dione CAS No.:5173-46-6

Cas:5173-46-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:1

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Estra-4,9-diene-3,17-dione CAS NO.5173-46-6

Cas:5173-46-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4,9-Estradiene-3,17-dione

Cas:5173-46-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Estra-4,9-diene-3,17-dione The alias:4,9-ESTRADIEN-3,17-DIONE;4,9-ESTRADIENE-3,17-DIONE; CAS NO:5173-46-6 EINECS NO:610-717-6 Molecular formula:C18H22O2 Molecular weight:270.37 Product Quality 12 years of chemical raw materials Matur

Estra-4,9-diene-3,17-dione/CAS:5173-46-6/with favorable price

Cas:5173-46-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

CAS: 5173-46-6 EINECS: 610-717-6 Chemical formula: C18H22O2 Molecular weight: 270.37 InchI: InchI=1/C18H22O2/c1-18-9-8-14-13-5-3-12 (19) 10-11 (13) 2-4-15 (14) 16 (18) 6-7-17 (18) 20/h10,15-16H, 2-9H2,1H3 Density: 1.16 ± 0.1 g/cm3 (Predicted)

Estra-4,9-diene-3,17-dione 5173-46-6

Cas:5173-46-6

Min.Order:5 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM-Estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 5173-46-6 with best quality

Cas:5173-46-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Estra-4,9-diene-3,17-dione/ LIDE PHARMA- Factory supply / Best price

Cas:5173-46-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Estra-4,9-diene-3,17-dione For Steroid Hormone Raw Materials

Cas:5173-46-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Estra-4,9-diene-3,17-dione 5173-46-6

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Estra-4,9-diene-3,17-dione CAS:5173-46-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Estra-4,9-diene-3,17-dione CAS:5173-46-6

Cas:5173-46-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

Estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:5173-46-6

Cas:5173-46-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Estra-4,9-diene-3,17-dione CAS 5173-46-6 AKS

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Top Quality Safe Fast Shipping Free Customs Estra-4,9-diene-3,17-dione CAS 5173-46-6

Cas:5173-46-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Estra-4,9-Diene-3,17-Dione

Cas:5173-46-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Main Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA can be suppli

98% Estra-4,9-diene-3,17-dione low price supplier

Cas:5173-46-6

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

ESTRA-4,9-DIENE-3.17-DIONE

Cas:5173-46-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

ESTRA-4,9-DIENE-3.17-DIONE

Cas:5173-46-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Estra-4,9-diene-3,17-dione

Cas:5173-46-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName:High purity Estra-4,9-diene-3,17-dione... CasNo:5173-46-6 Molecular Formula:C19H20O2 Appearance:detailed see specifications Application:Estra-4,9-diene-3,17-dione CAS No.:517... DeliveryTime:Check with us according to inquiry qua... P

Competitive Prices Widely used Estra-4,9-diene-3,17-dione CAS No.5173-46-6

Cas:5173-46-6

Min.Order:1 Metric Ton

FOB Price: $3.0 / 6.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Estra-4,9-Diene-3,17-Dione

Cas:5173-46-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

ESTRA-4,9-DIENE-3.17-DIONE

Cas:5173-46-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Intermediate Estra-4,9-diene-3,17-dione Powder CAS 5173-46-6

Cas:5173-46-6

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Synthetic route

17β-hydroxyestra-4,9-dien-3-one
6218-29-7

17β-hydroxyestra-4,9-dien-3-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With tetrapropylammonium perruthennate for 3h;98%
With Jones reagent In acetone at 0℃; Jones Oxidation;97%
With tert.-butylhydroperoxide; 3 A molecular sieve; zircornium(IV) n-propoxide In dichloromethane for 17h;90%
estra-4,9-diene-3,17-dione
2503-06-2

estra-4,9-diene-3,17-dione

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 0.75h; Reflux;61%
With toluene-4-sulfonic acid
With phosphoric acid In dichloromethane; water
C17H24O4

C17H24O4

A

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

B

estra-4,9-diene-3,17-dione
2503-06-2

estra-4,9-diene-3,17-dione

Conditions
ConditionsYield
With piperdinium acetate In toluene for 16h; Reflux;A 36.4%
B 36.6%
(3aS,7aS)-4-(3,7-Dioxo-octyl)-7a-methyl-hexahydro-indene-1,5-dione
33383-89-0, 40013-34-1, 40013-38-5, 65166-16-7

(3aS,7aS)-4-(3,7-Dioxo-octyl)-7a-methyl-hexahydro-indene-1,5-dione

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With piperdinium acetate
Multi-step reaction with 2 steps
1: piperidine*AcOH
2: TsOH
View Scheme
3S,6aS,3-(4-oxo-1-pentyl)-6a-methyl-1,2,3,5,6,6a-hexahydrocyclopenta[f][1]benzopyran-7(8H)-one
36668-14-1

3S,6aS,3-(4-oxo-1-pentyl)-6a-methyl-1,2,3,5,6,6a-hexahydrocyclopenta[f][1]benzopyran-7(8H)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: piperidine*AcOH
View Scheme
Multi-step reaction with 3 steps
2: piperidine*AcOH
3: TsOH
View Scheme
10β-hydroxy-19-norandrost-4-ene-3,17-dione
5189-96-8

10β-hydroxy-19-norandrost-4-ene-3,17-dione

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid In dichloromethane; isopropyl alcohol
(+)-3,3-dimethylpropylenedioxy-4,5-seco-estr-9-ene-5,17-dione

(+)-3,3-dimethylpropylenedioxy-4,5-seco-estr-9-ene-5,17-dione

(+)-4,5-seco-estr-9-ene-3,5,17-trione
10582-53-3

(+)-4,5-seco-estr-9-ene-3,5,17-trione

potassium tert-butylate
865-47-4

potassium tert-butylate

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With sodium chloride; sodium acetate; acetic acid In hexane; water; acetone; toluene; tert-butyl alcohol
3-(tert-butyldimethylsilyloxy)-3a-methyl-6-(3-oxobutyl)-3,3a,4,5,8,9,9a,9b-octaammon-1H-cyclopentadiene[a]naphthalene-7(2Η)-one

3-(tert-butyldimethylsilyloxy)-3a-methyl-6-(3-oxobutyl)-3,3a,4,5,8,9,9a,9b-octaammon-1H-cyclopentadiene[a]naphthalene-7(2Η)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
3: Jones reagent / acetone / 0 °C
View Scheme
C24H38O2Si

C24H38O2Si

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: Jones reagent / acetone / 0 °C
View Scheme
(S)-Halos-Parish ketone
17553-86-5

(S)-Halos-Parish ketone

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: sodium tetrahydroborate / ethanol / 4 h / -15 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 3 h / 50 °C
3.2: 2 h
4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
5.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
6.1: sodium methylate / methanol / 1.5 h / Reflux
7.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
7.2: 17 h / 20 °C
8.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
9.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
11.1: Jones reagent / acetone / 0 °C
View Scheme
Multi-step reaction with 11 steps
1.1: sodium tetrahydroborate / ethanol / 4 h / -15 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
3.2: 17 h / 20 °C
4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
5.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
6.1: sodium methylate / methanol / 1.5 h / Reflux
7.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
7.2: 17 h / 20 °C
8.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
9.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
11.1: Jones reagent / acetone / 0 °C
View Scheme
(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one
16271-49-1

(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 3 h / 50 °C
2.2: 2 h
3.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
4.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
5.1: sodium methylate / methanol / 1.5 h / Reflux
6.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
6.2: 17 h / 20 °C
7.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
8.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
10.1: Jones reagent / acetone / 0 °C
View Scheme
Multi-step reaction with 10 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
2.2: 17 h / 20 °C
3.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
4.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
5.1: sodium methylate / methanol / 1.5 h / Reflux
6.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
6.2: 17 h / 20 °C
7.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
8.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
10.1: Jones reagent / acetone / 0 °C
View Scheme
(1S,7aS)-1-((tert-butyldimethylsilyl)oxy)-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one
149789-99-1, 126541-53-5

(1S,7aS)-1-((tert-butyldimethylsilyl)oxy)-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 3 h / 50 °C
1.2: 2 h
2.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
3.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
4.1: sodium methylate / methanol / 1.5 h / Reflux
5.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
5.2: 17 h / 20 °C
6.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
7.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
9.1: Jones reagent / acetone / 0 °C
View Scheme
Multi-step reaction with 9 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
1.2: 17 h / 20 °C
2.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
3.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
4.1: sodium methylate / methanol / 1.5 h / Reflux
5.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
5.2: 17 h / 20 °C
6.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
7.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
9.1: Jones reagent / acetone / 0 °C
View Scheme
1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(2-(2-methyl-1,3-dioxolane-2-yl)ethyl)-2,3,5,6,7,7a-tetrahydro-1H-inden-5(6H)-one
1092775-41-1

1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(2-(2-methyl-1,3-dioxolane-2-yl)ethyl)-2,3,5,6,7,7a-tetrahydro-1H-inden-5(6H)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
2.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
3.1: sodium methylate / methanol / 1.5 h / Reflux
4.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
4.2: 17 h / 20 °C
5.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
6.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
8.1: Jones reagent / acetone / 0 °C
View Scheme
1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)hexahydro-1H-inden-5(6)-one

1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)hexahydro-1H-inden-5(6)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
2.1: sodium methylate / methanol / 1.5 h / Reflux
3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
3.2: 17 h / 20 °C
4.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
5.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
7.1: Jones reagent / acetone / 0 °C
View Scheme
1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(3-oxobutyl)hexahydro-1H-inden-5(6)-one

1-(tert-butyldimethylsilyloxy)-7a-methyl-4-(3-oxobutyl)hexahydro-1H-inden-5(6)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium methylate / methanol / 1.5 h / Reflux
2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
2.2: 17 h / 20 °C
3.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
4.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
6.1: Jones reagent / acetone / 0 °C
View Scheme
3-(tert-butyldimethylsilyloxy)-3a-methyl-3,3a,4,5,8,9,9a,9b-octahydro-1H-cyclopenta[a]naphthalene-7(2H)-one

3-(tert-butyldimethylsilyloxy)-3a-methyl-3,3a,4,5,8,9,9a,9b-octahydro-1H-cyclopenta[a]naphthalene-7(2H)-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
1.2: 17 h / 20 °C
2.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
3.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
5.1: Jones reagent / acetone / 0 °C
View Scheme
<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one
95935-96-9

<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
2: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
4: Jones reagent / acetone / 0 °C
View Scheme
C12H16O3

C12H16O3

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / ethylene dibromide; tetrahydrofuran / 2 h / Reflux
1.2: 1.5 h / Cooling with ice
2.1: Jones reagent / acetone / 0.5 h / 0 - 20 °C
3.1: piperdinium acetate / toluene / 16 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium / ethylene dibromide; tetrahydrofuran / 2 h / Reflux
1.2: 1.5 h / Cooling with ice
2.1: Jones reagent / acetone / 0.5 h / 0 - 20 °C
3.1: piperdinium acetate / toluene / 16 h / Reflux
4.1: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
View Scheme
1-chloro-4-(1,3-dioxolane)-n-pentane
5978-08-5

1-chloro-4-(1,3-dioxolane)-n-pentane

A

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

B

estra-4,9-diene-3,17-dione
2503-06-2

estra-4,9-diene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / ethylene dibromide; tetrahydrofuran / 2 h / Reflux
1.2: 1.5 h / Cooling with ice
2.1: Jones reagent / acetone / 0.5 h / 0 - 20 °C
3.1: piperdinium acetate / toluene / 16 h / Reflux
View Scheme
C19H30O5

C19H30O5

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Jones reagent / acetone / 0.5 h / 0 - 20 °C
2: piperdinium acetate / toluene / 16 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: Jones reagent / acetone / 0.5 h / 0 - 20 °C
2: piperdinium acetate / toluene / 16 h / Reflux
3: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
View Scheme
C23H34O4

C23H34O4

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Stage #1: C23H34O4 With hydrogenchloride In water; acetone for 3h; Reflux;
Stage #2: With potassium tert-butylate In isopropyl alcohol; toluene for 2h; Reagent/catalyst; Solvent; Reflux;
67.1 g
methanol
67-56-1

methanol

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

3,3-dimethoxy-estra-5(10),9(11)-diene-17-one
10109-76-9

3,3-dimethoxy-estra-5(10),9(11)-diene-17-one

Conditions
ConditionsYield
With acetyl chloride at -20℃; for 2h;97.5%
With tetrachlorosilane In hexane at 2 - 10℃; Product distribution / selectivity; Industry scale;
With acetyl chloride In hexane at 5 - 20℃; Product distribution / selectivity; Industry scale;
tetrachlorosilane In hexane at 2 - 15℃; for 1 - 1.5h; Product distribution / selectivity;
acetyl chloride In hexane at 5 - 20℃; for 1.35h; Product distribution / selectivity;
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

2-hydroxy-2-methylpropanenitrile
75-86-5

2-hydroxy-2-methylpropanenitrile

C19H23NO2

C19H23NO2

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 30 - 35℃; for 20h; Reagent/catalyst; Time; Solvent;95.1%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C21H30O2Si

C21H30O2Si

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -40 - 20℃; for 0.666667h; Reagent/catalyst; Temperature; Industrial scale;87.5%
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

17β-hydroxyestra-4,9-dien-3-one
6218-29-7

17β-hydroxyestra-4,9-dien-3-one

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate In dichloromethane at -78℃; for 5h;87%
With zygowilliopsis sp. WY7905 In aq. phosphate buffer at 30℃; for 24h; pH=8; Enzymatic reaction; stereoselective reaction;61%
With sodium borohydrid; acetic acid In tetrahydrofuran; methanol
With sodium borohydrid; acetic acid In tetrahydrofuran; methanol
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

ethylene glycol
107-21-1

ethylene glycol

C20H26O3

C20H26O3

Conditions
ConditionsYield
With hydrogenchloride In water for 1h; Reflux; Green chemistry;80%
methanol
67-56-1

methanol

4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C20H28O3

C20H28O3

Conditions
ConditionsYield
With hydrogenchloride In water for 1h; Reagent/catalyst; Solvent; Reflux; Green chemistry;77%
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

ethylene glycol
107-21-1

ethylene glycol

3,3:17,17-bis(ethylenedioxy)-estra-5(10),9(11)-diene
57905-07-4

3,3:17,17-bis(ethylenedioxy)-estra-5(10),9(11)-diene

Conditions
ConditionsYield
With pyridine hydrochloride; sodium 1.) heptane, reflux, 2.) MeOH, 15 min; Yield given. Multistep reaction;
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

17-hydroxy-estra-4,9-dien-3-one

17-hydroxy-estra-4,9-dien-3-one

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; methanol at -10℃;
With sodium tetrahydroborate In methanol; water for 0.5h; Cooling with ice;
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

ethylene deltenone
5571-36-8

ethylene deltenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol
5490-76-6

(8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene
137532-55-9

3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-ethyne
91934-95-1

3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-ethyne

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(8S,11R,13S,14S,17S)-11-(4-Dimethylamino-phenyl)-17-hydroxy-13-methyl-17-phenylethynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

(8S,11R,13S,14S,17S)-11-(4-Dimethylamino-phenyl)-17-hydroxy-13-methyl-17-phenylethynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: H2SO4 / acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(8S,11R,13S,14S,17R)-11-(4-Dimethylamino-phenyl)-17-[2-(4-dimethylamino-phenyl)-ethyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

(8S,11R,13S,14S,17R)-11-(4-Dimethylamino-phenyl)-17-[2-(4-dimethylamino-phenyl)-ethyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: 1.) H2, 2.) H2SO4 / 1.) Pd/C / 1.) DMF, 2.) acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C29H34O6
173387-69-4

C29H34O6

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C30H36O6
173387-77-4

C30H36O6

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(11β,17α)-11,21-bis[4-(dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-dien-20-yn-3-one

(11β,17α)-11,21-bis[4-(dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-dien-20-yn-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: H2SO4 / acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C36H43NO4
91934-88-2

C36H43NO4

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(11β,17α)-11-[4-(dimethylamino)phenyl]-17-hydroxy-21-[4-(methylsulfonyl)phenyl]-19-norpregna-4,9-dien-20-yn-3-one

(11β,17α)-11-[4-(dimethylamino)phenyl]-17-hydroxy-21-[4-(methylsulfonyl)phenyl]-19-norpregna-4,9-dien-20-yn-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: H2SO4 / acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C38H48N2O4
162607-85-4

C38H48N2O4

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

(11β,17α)-11-(1,3-benzodioxol-5-yl)-21-[4-(methylsulfonyl)phenyl]-17-hydroxy-19-norpregna-4,9-dien-20-yn-3-one

(11β,17α)-11-(1,3-benzodioxol-5-yl)-21-[4-(methylsulfonyl)phenyl]-17-hydroxy-19-norpregna-4,9-dien-20-yn-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: H2SO4 / acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

1-[4-[(11β,17α)-11-(2,3-dihydro-1,4-benzodioxin-6-yl)-17-hydroxy-3-oxo-19-nor-pregna-4,9-dien-20-yn-21-yl)phenyl]-2 pyrrolidinone

1-[4-[(11β,17α)-11-(2,3-dihydro-1,4-benzodioxin-6-yl)-17-hydroxy-3-oxo-19-nor-pregna-4,9-dien-20-yn-21-yl)phenyl]-2 pyrrolidinone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
7: H2SO4 / acetone
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C37H45NO6S
196881-37-5

C37H45NO6S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
View Scheme
4,9-Androstadiene-3,17-dione
5173-46-6

4,9-Androstadiene-3,17-dione

C36H40O8S
196881-38-6

C36H40O8S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaBH4 / tetrahydrofuran; methanol / -10 °C
2: 1.) (EtO)3CH, pTsOH, 2.) pyridinium chlorochromate / 2.) CH2Cl2
3: KOtBu / tetrahydrofuran
4: H2O2, trifluoroacetophenone, Py / CH2Cl2
5: Mg, CuCl
6: CuI, Pd(OAc)2, PPh3 / various solvent(s) / Heating
View Scheme

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