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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Nimesulide Manufacturer/High quality/Best price/In stock

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ---------------------------------------------------------------------------------------------

High purity Various Specifications nimesulide CAS:51803-78-2

Cas:51803-78-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Nimesulide Cas 51803-78-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Store in 2-8℃ Package:25

Factory supply high quality Nimesulide Cas 51803-78-2 with reasonable price

Cas:51803-78-2

Min.Order:25 Kilogram

FOB Price: $42.0 / 45.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Nimesulide

Cas:51803-78-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Nimesulide 51803-78-2 GMP Manufacturer

Cas:51803-78-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Nimesulide

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nimesulide

Cas:51803-78-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Nimesulide Basic information Product Name: Nimesulide Synonyms: nimed;4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE;MESULID;AULIN;FANSIDOL;CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD);CETIRIZI

TIANFU-CHEM CAS:51803-78-2 Nimesulide

Cas:51803-78-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 51803-78-2 Nimesulide

Cas:51803-78-2

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 51803-78-2 with best quality

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Nimesulide/ LIDE PHARMA- Factory supply / Best price

Cas:51803-78-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

product Name Nimesulide Alias nimed;4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE;CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD);CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHO

Nimesulide CAS:51803-78-2

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Applications Lithium hydride is used as condensation agent, reducing agent, alkylation reagent and desiccant in organic synthesis, and is also a good hydrogen storage material Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned

Hot Sell 99% High Putiry Nimesulide CAS 51803-78-2

Cas:51803-78-2

Min.Order:10 Gram

FOB Price: $1500.0 / 2000.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Nimesulide 51803-78-2

Cas:51803-78-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Nimesulide CAS 51803-78-2 nervous system drugs

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $82.0 / 98.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Nimesulide CAS:51803-78-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Nimesulide CAS:51803-78-2

Cas:51803-78-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

FANSIDOL Powder USP Standard

Cas:51803-78-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Nimesulide

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Nimesulide

Cas:51803-78-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nimesulide

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Factory Supply Nimesulide CAS 51803-78-2 with Fast Shipment

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Nimesulide cas 51803-78-2 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Nimesulide cas 51803-78-2

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nimesulide

Cas:51803-78-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Nimesulide CAS 51803-78-2 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pr

Nimesulide CAS 51803-78-2

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali

Nimesulide

Cas:51803-78-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Nimesulide

Cas:51803-78-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Yellow Needle-Like Crystals Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Lab

Nimesulide

Cas:51803-78-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Nimesulide

Cas:51803-78-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Nimesulide CAS No.:51803-78-2 Molecule Formula:C13H12N2O5S Molecule Weight:308.31 Purity: 99% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECI

High Quality Nimesulide in stock

Cas:51803-78-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

sodium N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate

sodium N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
With hydrogenchloride In water pH=~ 2;100%
1-amino-2-phenoxy-4-nitrobenzene
5422-92-4

1-amino-2-phenoxy-4-nitrobenzene

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
Stage #1: 1-amino-2-phenoxy-4-nitrobenzene; methanesulfonyl chloride With triethylamine In dichloromethane at 20℃; for 23h; Cooling with ice;
Stage #2: With sodium hydroxide In water for 16h; Reflux;
74.3%
nimesulide radical anion

nimesulide radical anion

A

nimesulide
51803-78-2

nimesulide

B

4-nitrosonimesulide

4-nitrosonimesulide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 25℃; pH=9.0; Kinetics; Disproportionation;
N-(2-Phenoxyphenyl)-methansulfonamid
51765-51-6

N-(2-Phenoxyphenyl)-methansulfonamid

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
With sulfuric acid; nitric acid; acetic acid for 1h; Activation energy; Temperature;
2-Amino-5-nitrophenol
121-88-0

2-Amino-5-nitrophenol

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic acid / Reflux
2.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 72 h / 20 °C / Molecular sieve
3.1: hydrazine hydrate / methanol / 6 h / Reflux
4.1: triethylamine / dichloromethane / 23 h / 20 °C / Cooling with ice
4.2: 16 h / Reflux
View Scheme
2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione
117346-07-3

2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 72 h / 20 °C / Molecular sieve
2.1: hydrazine hydrate / methanol / 6 h / Reflux
3.1: triethylamine / dichloromethane / 23 h / 20 °C / Cooling with ice
3.2: 16 h / Reflux
View Scheme
2-(4-nitro-2-phenoxyphenyl)isoindoline-1,3-dione

2-(4-nitro-2-phenoxyphenyl)isoindoline-1,3-dione

nimesulide
51803-78-2

nimesulide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / methanol / 6 h / Reflux
2.1: triethylamine / dichloromethane / 23 h / 20 °C / Cooling with ice
2.2: 16 h / Reflux
View Scheme
nimesulide
51803-78-2

nimesulide

N-(4-amino-2-phenoxy phenyl) methanesulfonamide
51765-60-7

N-(4-amino-2-phenoxy phenyl) methanesulfonamide

Conditions
ConditionsYield
With 5% Pd(II)/C(eggshell); hydrogen In ethyl acetate at 27℃; for 3h;100%
With hydrogenchloride; tin In water at 90℃; for 3h;100%
With hydrogen; palladium on activated charcoal In ethanol Ambient temperature;97%
nimesulide
51803-78-2

nimesulide

methyl iodide
74-88-4

methyl iodide

N-Methyl-N-(4-nitro-2-phenoxy-phenyl)-methanesulfonamide
51765-67-4

N-Methyl-N-(4-nitro-2-phenoxy-phenyl)-methanesulfonamide

Conditions
ConditionsYield
Stage #1: nimesulide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;
99%
With potassium carbonate In acetonitrile for 5h;77%
nimesulide
51803-78-2

nimesulide

C13H10(2)H2N2O5S

C13H10(2)H2N2O5S

Conditions
ConditionsYield
With [(1,5-cyclooctadiene)Ir(1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)(PPh3)]PF6; deuterium In dichloromethane at 20℃; for 2h; Sealed tube;96%
tetrafluoroboric acid diethyl ether
67969-82-8

tetrafluoroboric acid diethyl ether

nimesulide
51803-78-2

nimesulide

2,3,7,8-tetrafluorothianthrene-S-oxide

2,3,7,8-tetrafluorothianthrene-S-oxide

C25H15F4N2O5S3(1+)*BF4(1-)

C25H15F4N2O5S3(1+)*BF4(1-)

Conditions
ConditionsYield
With 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride In acetonitrile at 0 - 25℃; regioselective reaction;93%
tetrafluoroboric acid diethyl ether
67969-82-8

tetrafluoroboric acid diethyl ether

sodium tetrafluoroborate
13755-29-8

sodium tetrafluoroborate

nimesulide
51803-78-2

nimesulide

2,3,7,8-tetrafluorothianthrene-S-oxide

2,3,7,8-tetrafluorothianthrene-S-oxide

C25H15F4N2O5S3(1+)*BF4(1-)

C25H15F4N2O5S3(1+)*BF4(1-)

Conditions
ConditionsYield
Stage #1: tetrafluoroboric acid diethyl ether; nimesulide; 2,3,7,8-tetrafluorothianthrene-S-oxide With trifluoroacetic anhydride In acetonitrile at 0 - 25℃; for 3h; Sealed tube;
Stage #2: sodium tetrafluoroborate In dichloromethane; water
93%
nimesulide
51803-78-2

nimesulide

silver nitrate

silver nitrate

Conditions
ConditionsYield
With KOH In water ligand, AgNO3, and KOH (1:1.1:1.1 molar ratio), stirred at room temp. for 1 h; ppt. filtered off, washed (water), dried (P2O5), elem. anal.;89%
nimesulide
51803-78-2

nimesulide

benzyl bromide
100-39-0

benzyl bromide

N-benzyl-N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

N-benzyl-N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;88%
nimesulide
51803-78-2

nimesulide

propargyl bromide
106-96-7

propargyl bromide

C16H14N2O5S
1601552-74-2

C16H14N2O5S

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;85%
Stage #1: nimesulide With potassium carbonate In acetone at 20℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In acetone at 20℃; for 24h; Inert atmosphere;
80.6%
4-Phenyl-1-butene
768-56-9

4-Phenyl-1-butene

nimesulide
51803-78-2

nimesulide

N-(2-phenoxy-4-((1-phenylbutyl)amino)phenyl)methanesulfonamide

N-(2-phenoxy-4-((1-phenylbutyl)amino)phenyl)methanesulfonamide

Conditions
ConditionsYield
With nickel(II) iodide; 6,6'-dimethyl-2,2'-bipyridine; (dimethoxy)methylsilane In N,N-dimethyl acetamide at 0 - 50℃; for 12.1667h; Inert atmosphere; Sealed tube; regioselective reaction;83%
nimesulide
51803-78-2

nimesulide

4-nitro-2-phenoxymethanesulfonanilide sodium salt

4-nitro-2-phenoxymethanesulfonanilide sodium salt

Conditions
ConditionsYield
With sodium In tetrahydrofuran for 4h; Heating;79%
With sodium hydroxide In water at 45℃; for 1h; Temperature;
methanol
67-56-1

methanol

nimesulide
51803-78-2

nimesulide

N-(4-(dimethylamino)-2-phenoxyphenyl)methanesulfonamide

N-(4-(dimethylamino)-2-phenoxyphenyl)methanesulfonamide

Conditions
ConditionsYield
With aluminum (III) chloride; water In acetonitrile at 20℃; Irradiation;78%
With palladium 10% on activated carbon; potassium tert-butylate at 150℃; for 60h;
formaldehyd
50-00-0

formaldehyd

nimesulide
51803-78-2

nimesulide

N-(4-(methylamino)-2-phenoxyphenyl)methanesulfonamide

N-(4-(methylamino)-2-phenoxyphenyl)methanesulfonamide

Conditions
ConditionsYield
With hydrogen In 1,4-dioxane at 60℃; under 7500.75 Torr; for 24h; Autoclave;77%
nimesulide
51803-78-2

nimesulide

N-methyl-O-((4-nitrophenyl)sulfonyl)hydroxylammonium trifluoromethanesulfonate

N-methyl-O-((4-nitrophenyl)sulfonyl)hydroxylammonium trifluoromethanesulfonate

A

N-(2-(4-(methylamino)phenoxy)-4-nitrophenyl)methanesulfonamide

N-(2-(4-(methylamino)phenoxy)-4-nitrophenyl)methanesulfonamide

B

N-(2-(2-(methylamino)phenoxy)-4-nitrophenyl)methanesulfonamide

N-(2-(2-(methylamino)phenoxy)-4-nitrophenyl)methanesulfonamide

Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate at 40℃; for 16h; regioselective reaction;A 64%
B 10%
nimesulide
51803-78-2

nimesulide

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-methyl-N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)benzenesulfonamide

4-methyl-N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)benzenesulfonamide

Conditions
ConditionsYield
With sodium carbonate In water at 35℃; pH=8 - 10;56%
2-chloromethyl-1H-benzimidazole
4857-04-9

2-chloromethyl-1H-benzimidazole

nimesulide
51803-78-2

nimesulide

N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Conditions
ConditionsYield
Stage #1: nimesulide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 2-chloromethyl-1H-benzimidazole In N,N-dimethyl-formamide at 25 - 60℃;
56%
2-nitrochalcone
53744-31-3, 7473-93-0

2-nitrochalcone

nimesulide
51803-78-2

nimesulide

C28H23N3O4S

C28H23N3O4S

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; potassium carbonate In ethanol at 90℃; for 1h; Schlenk technique; Inert atmosphere;54%
nimesulide
51803-78-2

nimesulide

fenofibrate boronic acid

fenofibrate boronic acid

isopropyl 2-methyl-2-(4-(4-(N-(4-(methylsulfonamido)-3-phenoxyphenyl)sulfamoyl)benzoyl)phenoxy)propanoate

isopropyl 2-methyl-2-(4-(4-(N-(4-(methylsulfonamido)-3-phenoxyphenyl)sulfamoyl)benzoyl)phenoxy)propanoate

Conditions
ConditionsYield
With sodium metabisulfite; lithium phosphate; choline chloride In N,N-dimethyl-formamide at 130℃; for 10h; Inert atmosphere;50%
With sodium metabisulfite; lithium phosphate; choline chloride; water In N,N-dimethyl-formamide at 130℃; for 10h; Schlenk technique; Inert atmosphere;50%
nimesulide
51803-78-2

nimesulide

C13H10(3)H2N2O5S

C13H10(3)H2N2O5S

Conditions
ConditionsYield
With tritium; [(1,5-cyclooctadiene)Ir(1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)(PPh3)]PF6 In Isopropyl acetate at 20℃; for 4h;12%
nimesulide
51803-78-2

nimesulide

A

N-(4-amino-2-phenoxy phenyl) methanesulfonamide
51765-60-7

N-(4-amino-2-phenoxy phenyl) methanesulfonamide

B

4-Hydroxy-Nimesulide
109032-22-6

4-Hydroxy-Nimesulide

Conditions
ConditionsYield
With sodium tetrahydroborate; oxygen; Cl8-5,10,15,20-tetraphenylporphyrinatoiron(III) chloride at 25℃; for 2h;A 11 % Chromat.
B 4.5 % Chromat.
nimesulide
51803-78-2

nimesulide

A

N-(4-amino-2-phenoxy phenyl) methanesulfonamide
51765-60-7

N-(4-amino-2-phenoxy phenyl) methanesulfonamide

B

4-nitrosonimesulide

4-nitrosonimesulide

C

4-hydroxylamine nimesulide
503552-34-9

4-hydroxylamine nimesulide

Conditions
ConditionsYield
With sodium tetrahydroborate; meso-tetraphenylporphyrin iron(III) chloride In methanol; dichloromethane at 20℃; for 1h; Product distribution; Further Variations:; Catalysts;
nimesulide
51803-78-2

nimesulide

4-hydroxylamine nimesulide
503552-34-9

4-hydroxylamine nimesulide

Conditions
ConditionsYield
With ammonium chloride; zinc
nimesulide
51803-78-2

nimesulide

4-nitrosonimesulide

4-nitrosonimesulide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Zn; NH4Cl
2: potassium dichromate / 0 °C
View Scheme
nimesulide
51803-78-2

nimesulide

N-(4-Cyano-2-phenoxy-phenyl)-methanesulfonamide

N-(4-Cyano-2-phenoxy-phenyl)-methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature
2: 1.) NaNO2, aq. HCl, 2.) NaCN / 1.) 5 deg C, 2.) H2O, benzene, from 0 to 40 deg C, 1.5 h
View Scheme
nimesulide
51803-78-2

nimesulide

N-[2-Phenoxy-4-(1H-tetrazol-5-yl)-phenyl]-methanesulfonamide

N-[2-Phenoxy-4-(1H-tetrazol-5-yl)-phenyl]-methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature
2: 1.) NaNO2, aq. HCl, 2.) NaCN / 1.) 5 deg C, 2.) H2O, benzene, from 0 to 40 deg C, 1.5 h
3: 1.) Me3SnN3, 2.) silica gel / 1.) toluene, reflux, 24 h, 2.) MeOH, RT, 4 h
View Scheme

Raw Materials

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