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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystalline powder Conforms Solublility To comply

High purity Various Specifications Cyclosporine A CAS:59865-13-3

Cas:59865-13-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&D b

Cyclosporin A/ LIDE PHARMA- Factory supply / Best price

Cas:59865-13-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Josun International Limited

Dear Friend, welcome you choose us ! And thank you very much for trust! We are one professional APIs and Chemicals supplier, we can provide you with good price and good service, ================================================== Pls see

High Quality Cyclosporin A /Ciclosporin USP EP

Cas:59865-13-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Afine Chemicals Limited

Appearance:white powder Storage:cool dry Package:5kg or 25kgs drum Application:API Transportation:Air express Port:Shanghai, hangzhou, Beijing, etc

Cyclosporin A

Cas:59865-13-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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GUANGZHOU MEDCAN PHARMATECH LTD

1.Assay:99.6% 2.Appearance:A white crystalline powder 3.With competitive price Appearance:white crystalline powder Storage:storage in ambient temperature Package:5-25KG/drum or bag Application:Active pharmaceutical ingredients 59865-13-3 Transpo

Cyclosporine A

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $1269.0 / 1300.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Cyclosporin A Manufacturer/High quality/Best price/In stock

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Loss on drying 2.0%max Heavy metals 0.002% max Boiling Point(°C) 1293.8°C at 760 mmHg Flash Point(°C) 736.3°C

CAS:59865-13-3 Cyclosporin A

Cas:59865-13-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Cyclosporin A manufacturer/supplier

Cas:59865-13-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Cyclosporin A Cas 59865-13-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store in 2-8℃ Package:100g,1kg/foi

High quality Cyclosporin A Cas 59865-13-3 with favorable price and good service

Cas:59865-13-3

Min.Order:100 Gram

FOB Price: $1.5 / 3.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Cyclosporine A[59865-13-3] , Ciclosporin Name Cyclosporin A Synonyms Antibiotic S 7481F1; Cyclosporine HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corp

Cyclosporine A Ciclosporin EP9.0

Cas:59865-13-3

Min.Order:100 Gram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cyclosporin A

Cas:59865-13-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Cyclosporin A 59865-13-3 GMP Manufacturer

Cas:59865-13-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Cyclosporin A

Cas:59865-13-3

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Cyclosporin A

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Pribolab PTE.LTD

Accurate valued; NRM, HPLC, Lc-MS/MS methods valued and certified, ensure the accurate purity; All the standards attached COA and MSDS; More than 80 kinds of mycotoxin standards can be provided; Competitive price; Professional technical team to

STD#9211 Cyclosporin A in acetonitrile

Cas:59865-13-3

Min.Order:1 Milliliter

FOB Price: $2.0 / 5.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

Cyclosporin A sandimmune factory supply

Cas:59865-13-3

Min.Order:1 Gram

FOB Price: $10.5 / 12.5

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general

TIANFU-CHEM CAS NO.59865-13-3 Cyclosporin A

Cas:59865-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Cyclosporin A cas 59865-13-3

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $48.0 / 58.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 59865-13-3 with best quality

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t

Cyclosporin A

Cas:59865-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

English name:CYCLOSPORINE Latin name:CICLOSPORINUM Chemical name:Cyclosporin; Restasis; Cyclosporine A; cyclosporin A; Antibiotic S 7481F1; 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methy

Cyclosporina

Cas:59865-13-3

Min.Order:500 Gram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

ol27-400 CAS NO.:59865-13-3

Cas:59865-13-3

Min.Order:1 Gram

FOB Price: $4.0 / 5.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Cyclosporin A Raw Powder Immunosuppressor Pharma Grade CAS 59865-13-3

Cas:59865-13-3

Min.Order:10 Gram

Negotiable

Type:Other

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Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Cyclosporin A at Factory Price

Cas:59865-13-3

Min.Order:25 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cyclosporin A 59865-13-3

Cas:59865-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white crystalline powder Storage:Store in seale

High Quality Cyclosporin A / Ciclosporin USP EP 59865-13-3 CAS

Cas:59865-13-3

Min.Order:500 Gram

Negotiable

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply Cyclosporin A CAS 59865-13-3

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Hot Sell Ciclosporin A Cyclosporin CAS 59865-13-3

Cas:59865-13-3

Min.Order:1 Kilogram

FOB Price: $1430.0 / 1500.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Cyclosporin A CAS 59865-13-3 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China a

High quality Cyclosporin A CAS 59865-13-3

Cas:59865-13-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

H-D-Ala-MeLeu-MeLeu-MeVal-MeBmt-Abu-Sar-MeLeu-Val-MeLeu-Ala-SH

H-D-Ala-MeLeu-MeLeu-MeVal-MeBmt-Abu-Sar-MeLeu-Val-MeLeu-Ala-SH

cyclosporin A
59865-13-3

cyclosporin A

Conditions
ConditionsYield
With Cyclohexyl isocyanide; benzotriazol-1-ol In tetrahydrofuran; dichloromethane at 23℃; for 24h; Inert atmosphere;55%
C117H209N41O23
324077-04-5

C117H209N41O23

A

C55H98N30O11

C55H98N30O11

B

cyclosporin A
59865-13-3

cyclosporin A

Conditions
ConditionsYield
pH=7.4; Reactivity;
7,8-Secocyclosporin-7-carboxylic acid

7,8-Secocyclosporin-7-carboxylic acid

cyclosporin A
59865-13-3

cyclosporin A

Conditions
ConditionsYield
With Cyclohexyl isocyanide; benzotriazol-1-ol In tetrahydrofuran at 70℃; for 16h; Inert atmosphere; Microwave irradiation;6.4 mg
C67H121N11O15

C67H121N11O15

cyclosporin A
59865-13-3

cyclosporin A

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 1 h / -20 °C
2: Cyclohexyl isocyanide; benzotriazol-1-ol / tetrahydrofuran; dichloromethane / 20 h / 70 °C / Inert atmosphere; Microwave irradiation
View Scheme
C62H113N11O13

C62H113N11O13

cyclosporin A
59865-13-3

cyclosporin A

Conditions
ConditionsYield
With Cyclohexyl isocyanide; benzotriazol-1-ol In tetrahydrofuran; dichloromethane at 70℃; for 20h; Inert atmosphere; Microwave irradiation;8.6 mg
cyclosporin A
59865-13-3

cyclosporin A

acetic anhydride
108-24-7

acetic anhydride

O-acetyl-cyclosporin A
83602-41-9

O-acetyl-cyclosporin A

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;100%
With dmap at 20℃;96%
With dmap In dichloromethane at 20℃;95%
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

cyclosporin A
59865-13-3

cyclosporin A

C71H131N11O12Si

C71H131N11O12Si

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 20℃; for 12h;100%
vinyl benzoate
583-04-0

vinyl benzoate

cyclosporin A
59865-13-3

cyclosporin A

A

benzoic acid 6-(5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacont-2-yl)-6-hydroxy-5-methyl-hex-2-enyl ester

benzoic acid 6-(5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacont-2-yl)-6-hydroxy-5-methyl-hex-2-enyl ester

B

benzoylated-MeBMT-CsA

benzoylated-MeBMT-CsA

Conditions
ConditionsYield
With 1,3-dimesityl-4,5-dihydroimidazol-2-ylidenetricyclohexylphos; phine benzylidene ruthenium dichloride In dichloromethane at 45℃; for 12h; Title compound not separated from byproducts;A n/a
B 99%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 45℃; Title compound not separated from byproducts;
S-(4-vinylphenyl) thioacetate
23939-49-3

S-(4-vinylphenyl) thioacetate

cyclosporin A
59865-13-3

cyclosporin A

C69H115N11O13S

C69H115N11O13S

Conditions
ConditionsYield
(1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium In dichloromethane for 16h; Heating / reflux;98%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

cyclosporin A
59865-13-3

cyclosporin A

C66H117N11O14

C66H117N11O14

Conditions
ConditionsYield
(1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium In dichloromethane for 16h; Heating / reflux;93%
With Hoveyda-Grubbs catalyst second generation In 1,2-dichloro-ethane at 70℃; for 4h; Inert atmosphere; Sealed tube; Microwave irradiation;
With Hoveyda-Grubbs catalyst second generation In 1,2-dichloro-ethane at 23 - 70℃; for 4h; Inert atmosphere; Sealed tube;
cyclosporin A
59865-13-3

cyclosporin A

acetic anhydride
108-24-7

acetic anhydride

MeBmt(OAc)-CsA

MeBmt(OAc)-CsA

Conditions
ConditionsYield
With dmap at 20℃; for 18h;92%
p-vinyl-N-t-butoxycarbonylbenzylamine
150814-00-9

p-vinyl-N-t-butoxycarbonylbenzylamine

cyclosporin A
59865-13-3

cyclosporin A

C73H124N12O14
1245657-05-9

C73H124N12O14

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 55℃; for 20h; Cross Metathesis;91%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane Reflux;
cyclosporin A
59865-13-3

cyclosporin A

tert-butylpent-4-enyloxydimethylsilane
127154-84-1

tert-butylpent-4-enyloxydimethylsilane

A

C70H129N11O13Si

C70H129N11O13Si

B

TBSO-pentenyl-MeBmt-CsA

TBSO-pentenyl-MeBmt-CsA

Conditions
ConditionsYield
With 1,3-dimesityl-4,5-dihydroimidazol-2-ylidenetricyclohexylphos; phine benzylidene ruthenium dichloride In dichloromethane at 45℃; for 22h; Title compound not separated from byproducts;A n/a
B 90%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 45℃; Title compound not separated from byproducts;
tetradecanedioyl dichloride
21646-49-1

tetradecanedioyl dichloride

cyclosporin A
59865-13-3

cyclosporin A

C76H135N11O15

C76H135N11O15

Conditions
ConditionsYield
Stage #1: tetradecanedioyl dichloride; cyclosporin A With dmap at 20℃; for 48h;
Stage #2: With water; sodium hydroxide at 20℃; for 1h;
90%
cyclosporin A
59865-13-3

cyclosporin A

N-succinimidyl 4-pentenoic acid ester
331754-32-6

N-succinimidyl 4-pentenoic acid ester

A

C68H116N12O16

C68H116N12O16

B

C68H116N12O16

C68H116N12O16

Conditions
ConditionsYield
With 1,3-dimesityl-4,5-dihydroimidazol-2-ylidenetricyclohexylphos; phine benzylidene ruthenium dichloride In dichloromethane for 22h; Heating; Title compound not separated from byproducts;A n/a
B 89%
cyclosporin A
59865-13-3

cyclosporin A

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

cyclosporine A chloroacetate ester
141749-42-0

cyclosporine A chloroacetate ester

Conditions
ConditionsYield
With pyridine at 5 - 20℃; for 17h;88.3%
Bromoform
75-25-2

Bromoform

cyclosporin A
59865-13-3

cyclosporin A

C63H111Br2N11O12

C63H111Br2N11O12

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 20℃; for 120h;87%
methyl 4-vinylbenzoate
1076-96-6

methyl 4-vinylbenzoate

cyclosporin A
59865-13-3

cyclosporin A

C69H115N11O14

C69H115N11O14

Conditions
ConditionsYield
With Hoveyda-Grubbs catalyst second generation In dichloromethane at 60℃; for 48h;86.4%
1,12-dodecanedioyl dichloride
4834-98-4

1,12-dodecanedioyl dichloride

cyclosporin A
59865-13-3

cyclosporin A

C74H131N11O15

C74H131N11O15

Conditions
ConditionsYield
Stage #1: 1,12-dodecanedioyl dichloride; cyclosporin A With dmap at 20℃; for 48h;
Stage #2: With water; sodium hydroxide at 20℃; for 1h;
84%
cyclosporin A
59865-13-3

cyclosporin A

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

α-chloroacetyl cyclosporin A derivative

α-chloroacetyl cyclosporin A derivative

Conditions
ConditionsYield
With pyridine at 50℃; for 16h;83%
cyclosporin A
59865-13-3

cyclosporin A

suberoyl chloride
10027-07-3

suberoyl chloride

C70H123N11O15

C70H123N11O15

Conditions
ConditionsYield
Stage #1: cyclosporin A; suberoyl chloride With dmap at 20℃; for 48h;
Stage #2: With water; sodium hydroxide at 20℃; for 1h;
82%
cyclosporin A
59865-13-3

cyclosporin A

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R)-1,4-dihydroxy-2-methylbutyl)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
116408-18-5

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R)-1,4-dihydroxy-2-methylbutyl)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

Conditions
ConditionsYield
Stage #1: cyclosporin A With ozone In dichloromethane at -78℃; for 0.5h;
Stage #2: With sodium tetrahydroborate In methanol; dichloromethane at -78 - 20℃; Further stages.;
81%
Multi-step reaction with 2 steps
1.1: ozone / dichloromethane / 0.08 h / -78 °C
1.2: 2 h / -78 - 20 °C
2.1: sodium tetrahydroborate / methanol / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
sebacoyl chloride
111-19-3

sebacoyl chloride

cyclosporin A
59865-13-3

cyclosporin A

C72H127N11O15

C72H127N11O15

Conditions
ConditionsYield
Stage #1: sebacoyl chloride; cyclosporin A With dmap at 20℃; for 48h;
Stage #2: With water; sodium hydroxide at 20℃; for 1h;
81%
carbon dioxide
124-38-9

carbon dioxide

cyclosporin A
59865-13-3

cyclosporin A

[α-carboxy-sar]-3-cyclosporin

[α-carboxy-sar]-3-cyclosporin

Conditions
ConditionsYield
Stage #1: cyclosporin A With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran at -78℃; for 1.33333 - 1.41667h;
78%
cyclosporin A
59865-13-3

cyclosporin A

carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

chloromethylcarbonate-CsA
321526-67-4

chloromethylcarbonate-CsA

Conditions
ConditionsYield
With pyridine In dichloromethane; water at 0 - 20℃; for 21.5h;75%
carbon dioxide
124-38-9

carbon dioxide

cyclosporin A
59865-13-3

cyclosporin A

[α-methylene-Sar]-3-cyclosporin

[α-methylene-Sar]-3-cyclosporin

Conditions
ConditionsYield
Stage #1: carbon dioxide; cyclosporin A With lithium diisopropyl amide In tetrahydrofuran; hexane at -5℃; for 0.00338889h; Flow reactor;
Stage #2: With chloroacetyl chloride In tetrahydrofuran; hexane at -50 - 20℃; for 8h; Flow reactor;
65%
H2SiEt2
542-91-6

H2SiEt2

cyclosporin A
59865-13-3

cyclosporin A

C70H133N11O12Si2

C70H133N11O12Si2

Conditions
ConditionsYield
With 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; bis(pentafluorophenyl)borohydride In chloroform for 24h; Inert atmosphere; Sealed tube;62%
cyclosporin A
59865-13-3

cyclosporin A

3-Chloro-2-methylpropene
563-47-3

3-Chloro-2-methylpropene

C66H117N11O12

C66H117N11O12

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water55%
3-fluoropropene
818-92-8

3-fluoropropene

cyclosporin A
59865-13-3

cyclosporin A

C62H110FN11O12

C62H110FN11O12

Conditions
ConditionsYield
(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)(PCy3)Cl2Ru=CHPh In dichloromethane Heating / reflux;51.2%
3-fluoropropene
818-92-8

3-fluoropropene

cyclosporin A
59865-13-3

cyclosporin A

C62H110FN11O12

C62H110FN11O12

Conditions
ConditionsYield
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-yl-ene][benzylidine]ruthenium(IV)dichloride In dichloromethane Heating / reflux;51.2%
2-chloromethyl-3-chloroprop-1-ene
1871-57-4

2-chloromethyl-3-chloroprop-1-ene

cyclosporin A
59865-13-3

cyclosporin A

C66H116ClN11O12
158613-16-2

C66H116ClN11O12

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water50%
cyclosporin A
59865-13-3

cyclosporin A

[4’-hydroxy-N-methylleucine]4-cyclosporin A
107335-26-2

[4’-hydroxy-N-methylleucine]4-cyclosporin A

Conditions
ConditionsYield
With Sebekia benihana; water In ethanol50%
cyclosporin A
59865-13-3

cyclosporin A

methyl iodide
74-88-4

methyl iodide

A

C63H113N11O12

C63H113N11O12

B

C63H113N11O12

C63H113N11O12

Conditions
ConditionsYield
Stage #1: cyclosporin A With lithium chloride; lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 0℃; for 2h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at -20℃; for 3h; Inert atmosphere;
A 50%
B 12%

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