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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

5,6-Dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 6052-73-9 with competitive price

Cas:6052-73-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2(1H)-Pyridinone,5,6-dihydro- 6052-73-9

Cas:6052-73-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

5,6-DIHYDROPYRIDIN-2(1H)-ONE

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

5,6-dihydro-1H-pyridin-2-one CAS:6052-73-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

5,6-dihydro-1H-pyridin-2-one CAS:6052-73-9

Cas:6052-73-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5,6-dihydro-2(1H)-Pyridinone

Cas:6052-73-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

5,6-dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2(1H)-Pyridinone, 5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

5,6-dihydro-1H-pyridin-2-one CAS No.6052-73-9

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

1,2,5,6-tetrahydropyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

best seller Application:API

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

best seller Application:API

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

5,6-dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SAGECHEM LIMITED

2(1H)-Pyridinone,5,6-dihydro-

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

5,6-Dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

6052-73-9

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Scochem Technology Co., Ltd.

High quality suppliers Application:healing drugs

5,6-dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

5,6-dihydro-1H-pyridin-2-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

5,6-Dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

5,6-Dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:0

Negotiable

Type:Other

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

5,6-Dihydropyridin-2(1H)-one

Cas:6052-73-9

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
128372-89-4

6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0℃; for 1h; Inert atmosphere;98%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;72%
With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;
3-(phenylselanyl)-1-(trimethylsilyl)piperidin-2-one

3-(phenylselanyl)-1-(trimethylsilyl)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With dihydrogen peroxide In tetrahydrofuran at 0 - 20℃; for 2h;97.7%
In tetrahydrofuran at 0 - 20℃; for 2h;0.55 g
(E)-N-(but-3-en-1-yl)but-2-enamide

(E)-N-(but-3-en-1-yl)but-2-enamide

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 2h; Reflux;94%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 40℃; for 2h;56%
3-(phenylthio)piperidin-2-one
104261-03-2

3-(phenylthio)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Stage #1: 3-(phenylthio)piperidin-2-one With sodium hydrogencarbonate In dichloromethane for 0.166667h;
Stage #2: With 3-chloro-benzenecarboperoxoic acid for 1h; Further stages.;
90%
Stage #1: 3-(phenylthio)piperidin-2-one With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 2h;
Stage #2: In toluene for 1h; Reflux;
80%
Multi-step reaction with 2 steps
1: m-CPBA, aq.NaHCO3 / CH2Cl2 / 1 h / 0 °C
2: 1.17 g / benzene / 1 h / Heating
View Scheme
N-(but-3-en-1-yl)prop-2-enamide
1415686-28-0

N-(but-3-en-1-yl)prop-2-enamide

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In toluene at 85 - 90℃; for 7h;75%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 6h; Grubbs Olefin Metathesis; Reflux;70%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 6h; Reflux;70%
2-oxopiperidin-3-yl dimethyldithiocarbamate

2-oxopiperidin-3-yl dimethyldithiocarbamate

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
at 260℃; under 1 Torr;68%
1-(perfluorobenzoyl)-5,6-dihydropyridin-2(1H)-one

1-(perfluorobenzoyl)-5,6-dihydropyridin-2(1H)-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With lithium hydroxide monohydrate In tetrahydrofuran at 50℃; for 4h;68%
(E)-2,4-pentadienoic acid
21651-12-7

(E)-2,4-pentadienoic acid

A

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

B

1,6-dihydropyridin-2(3H)-one
61892-77-1

1,6-dihydropyridin-2(3H)-one

Conditions
ConditionsYield
With ammonia Yield given. Yields of byproduct given;
3-Benzenesulfonyl-piperidin-2-one

3-Benzenesulfonyl-piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
In benzene for 1h; Heating;1.17 g
3-(Phenylselenenyl)-2-piperidinone

3-(Phenylselenenyl)-2-piperidinone

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With dihydrogen peroxide In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) 25 deg C, 1.5 h; Yield given;
1-(trimethylsilyl)piperidin-2-one
3553-93-3

1-(trimethylsilyl)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran; hexane / 1.) -50 deg C, 45 min, 2.) -78 deg C, 7 h
2: 50percent H2O2 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 1.5 h
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -50 °C / Inert atmosphere
1.2: 7 h / -78 °C / Inert atmosphere
2.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
1-(methoxymethyl)-3-(phenylthio)piperidin-2-one
1026076-90-3

1-(methoxymethyl)-3-(phenylthio)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 78 percent / conc.HCl / ethanol / 6 h / Heating
2: m-CPBA, aq.NaHCO3 / CH2Cl2 / 1 h / 0 °C
3: 1.17 g / benzene / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / ethanol; water / 6 h / Reflux
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
2.2: 1 h / Reflux
View Scheme
C2HF3O2*C11H8F5NO2

C2HF3O2*C11H8F5NO2

A

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

B

(3E,9E,15E)-1,7,13-Triaza-cyclooctadeca-3,9,15-triene-2,8,14-trione

(3E,9E,15E)-1,7,13-Triaza-cyclooctadeca-3,9,15-triene-2,8,14-trione

Conditions
ConditionsYield
With 4-methyl-morpholine In 1,4-dioxane at 80℃; for 18h;A 6 mg
B 36 mg
C8H13NO

C8H13NO

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride Grubbs Olefin Metathesis;
2-oxopiperidine-1-carboxylic acid tert-butyl ester
85908-96-9

2-oxopiperidine-1-carboxylic acid tert-butyl ester

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 1.5 h / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 3 h / 80 °C / Inert atmosphere
3.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C
3.1: toluene / 3 h / 80 °C
4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
View Scheme
N-(tert-butyloxycarbonyl)-3-(phenylthio)piperidine-2-one
358732-56-6

N-(tert-butyloxycarbonyl)-3-(phenylthio)piperidine-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 3 h / 80 °C / Inert atmosphere
2.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C
2: toluene / 3 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
View Scheme
piperidin-2-one
675-20-7

piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 1.5 h / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 3 h / 80 °C / Inert atmosphere
4.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 13 h / 0 - 20 °C
2: 2,5-di-tert-butyl-p-benzoquinone; palladium(II) trifluoroacetate; racemic methyl phenyl sulfoxide; zinc(II) trifluoroacetate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere; Sealed tube
3: lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / toluene / 4 h / Inert atmosphere
2.1: tetrahydrofuran / 0.75 h / -50 °C / Alkaline conditions; Enzymatic reaction
2.2: 7 h
3.1: tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / toluene / 4 h / 50 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -50 °C / Inert atmosphere
2.2: 7 h / -78 °C / Inert atmosphere
3.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / dichloromethane; tetrahydrofuran / 0.5 h / 0 °C
1.2: 3 h
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: hydrogenchloride / ethanol; water / 6 h / Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
4.2: 1 h / Reflux
View Scheme
1-(perfluorobenzoyl)piperidin-2-one

1-(perfluorobenzoyl)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2,5-di-tert-butyl-p-benzoquinone; palladium(II) trifluoroacetate; racemic methyl phenyl sulfoxide; zinc(II) trifluoroacetate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere; Sealed tube
2: lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 50 °C
View Scheme
1-(methoxymethyl)piperidin-2-one
50902-27-7

1-(methoxymethyl)piperidin-2-one

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: hydrogenchloride / ethanol; water / 6 h / Reflux
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
3.2: 1 h / Reflux
View Scheme
3-benzenesulfinyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

3-benzenesulfinyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 3 h / 80 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
View Scheme
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

cis-3,4-dihydroxy-2-piperidinone
139374-43-9

cis-3,4-dihydroxy-2-piperidinone

Conditions
ConditionsYield
osmium(VIII) oxide; 4-methylmorpholine N-oxide In tert-butyl alcohol Ambient temperature;100%
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tert-butyl alcohol for 27h; Ambient temperature;64 mg
[2-(hydroxymethyl)phenyl]dimethyl(4-fluorophenyl)silane
853955-70-1

[2-(hydroxymethyl)phenyl]dimethyl(4-fluorophenyl)silane

5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

(R)-4-(4-fluorophenyl)-2-piperidinone

(R)-4-(4-fluorophenyl)-2-piperidinone

Conditions
ConditionsYield
With potassium hydroxide; (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene; bis(ethylene)rhodium(I) chloride dimer In tetrahydrofuran at 50℃; for 12h;92%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

tris(4-chlorophenyl)boroxine
7519-91-7

tris(4-chlorophenyl)boroxine

(R)-4-(4-chlorophenyl)-2-piperidinone

(R)-4-(4-chlorophenyl)-2-piperidinone

Conditions
ConditionsYield
With (R)-2,2'-bis(diarylphosphino)-1,1'-binaphthyl; water; bis(ethylene)rhodium acetylacetonate In 1,4-dioxane at 60℃; for 12h;88%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

tris(4-fluorophenyl)boroxine
448-59-9

tris(4-fluorophenyl)boroxine

(R)-4-(4-fluorophenyl)-2-piperidinone

(R)-4-(4-fluorophenyl)-2-piperidinone

Conditions
ConditionsYield
With (R)-2,2'-bis(diphenylphosphino)-octahydro-1,1'-binaphthyl; water; bis(ethylene)rhodium acetylacetonate In 1,4-dioxane at 40℃; for 12h;84%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C13H11ClN2O

C13H11ClN2O

(E)-1-(3-(4-((1H-imidazol-1-yl)methyl)phenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

(E)-1-(3-(4-((1H-imidazol-1-yl)methyl)phenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran; mineral oil at -5 - 0℃; for 2h;
Stage #2: C13H11ClN2O In tetrahydrofuran; mineral oil for 21h;
82%
With triethylamine In tetrahydrofuran at 0℃; for 3h;
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

formic acid ethyl ester
109-94-4

formic acid ethyl ester

N-formyl-5,6-dihydropyridine-2(1H)-one

N-formyl-5,6-dihydropyridine-2(1H)-one

Conditions
ConditionsYield
With titanium tetrachloride; triethylamine In dichloromethane at 0℃; for 1h;76%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C23H24Cl2O7

C23H24Cl2O7

piperarborenine B

piperarborenine B

Conditions
ConditionsYield
In toluene at 20 - 80℃; for 12h; Inert atmosphere; Molecular sieve;75%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C16H9ClO5

C16H9ClO5

C21H15NO6

C21H15NO6

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 10h;75%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

1-chloro-5,6-dihydropyridin-2(1H)-one
1215765-27-7

1-chloro-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
With N-chloro-succinimide; potassium tert-butylate In tetrahydrofuran at 20℃; for 0.666667h; Inert atmosphere;74%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

p-phenylenediacrylic diacid dichloride
35288-49-4

p-phenylenediacrylic diacid dichloride

C22H20N2O4

C22H20N2O4

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h;
Stage #2: p-phenylenediacrylic diacid dichloride In tetrahydrofuran; hexane at -78℃; for 3h;
72%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

1-nosyl-5,6-dihydropyridin-2(1H)-one
1266568-91-5

1-nosyl-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 2-Nitrobenzenesulfonyl chloride In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;
71%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

2,2-diethoxy-ethanamine
645-36-3

2,2-diethoxy-ethanamine

5,6-Dihydroimidazo<1,2-a>pyridine

5,6-Dihydroimidazo<1,2-a>pyridine

Conditions
ConditionsYield
titanium tetrachloride In 1,3,5-trimethyl-benzene for 74h; Heating;68.9%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C19H31NO5

C19H31NO5

tert-butyl (E)-4-(2-methyl-3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)piperidine-1-carboxylate

tert-butyl (E)-4-(2-methyl-3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: C19H31NO5 In tetrahydrofuran at -78 - 20℃; for 1h;
67.8%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: C19H31NO5 In tetrahydrofuran at 20℃; for 1h;
67.8%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

chloroacetyl chloride
79-04-9

chloroacetyl chloride

1-(2-chloroacetyl)-5,6-dihydropyridin-2(1H)-one

1-(2-chloroacetyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;
Stage #2: chloroacetyl chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
65%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C13H14Cl3NO

C13H14Cl3NO

C18H20Cl2N2O2

C18H20Cl2N2O2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 10h;65%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

cinnamyl chloride
2687-12-9

cinnamyl chloride

1-cinnamoyl-5,6-dihydropyridin-2(1H)-one
1057962-70-5

1-cinnamoyl-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;
Stage #2: cinnamyl chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
64%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

mesitylenecarbonitrile oxide
2904-57-6

mesitylenecarbonitrile oxide

3-(2,4,6-trimethyl-phenyl)-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

3-(2,4,6-trimethyl-phenyl)-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

Conditions
ConditionsYield
In benzene at 20℃; for 504000h; Cycloaddition;62%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C10H11ClN2O

C10H11ClN2O

(E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

(E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: C10H11ClN2O With pivaloyl chloride; triethylamine In tetrahydrofuran at -20℃; for 0.75h;
Stage #2: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -70℃; for 1.75h;
53%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

(2E)-3-(3,5,6-trimethylpyrazin-2-yl)prop-2-enoic acid

(2E)-3-(3,5,6-trimethylpyrazin-2-yl)prop-2-enoic acid

(E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

(E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: (2E)-3-(3,5,6-trimethylpyrazin-2-yl)prop-2-enoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran; dichloromethane at -20℃;
Stage #2: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran for 1h;
53%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

(E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride

(E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride

(E)-1-(3-(5-methoxypyrimidin-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

(E)-1-(3-(5-methoxypyrimidin-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: (E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1h;
52.23%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: (E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1h;
52.23%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

benzohydroximoyl chloride
698-16-8

benzohydroximoyl chloride

3-phenyl-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

3-phenyl-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

Conditions
ConditionsYield
With triethylamine In benzene at 20℃; for 48h; Cycloaddition; dehydrochlorination;51%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

C19H31NO5

C19H31NO5

(Z)-tert-butyl 4-(2-methyl-3-oxo-3-(2-oxo-5,6-dihydropyridin-1(2H)-yl)prop-1-enyl)piperidine-1-carboxylate

(Z)-tert-butyl 4-(2-methyl-3-oxo-3-(2-oxo-5,6-dihydropyridin-1(2H)-yl)prop-1-enyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: C19H31NO5 In tetrahydrofuran at -78 - 20℃; for 1h;
49.6%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: C19H31NO5 In tetrahydrofuran at 20℃; for 1h;
49.6%
5,6-dihydro-2(1H)-pyridinone
6052-73-9

5,6-dihydro-2(1H)-pyridinone

(E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride

(E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride

(E)-1-(3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

(E)-1-(3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: (E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1.5h;
48.92%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: (E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride In tetrahydrofuran at -78℃; for 1.5h;
48.92%

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