As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:675-20-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:675-20-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:675-20-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:675-20-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Beluga chemical professional supply High quality 2-Piperidone CAS 675-20-7 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and
Cas:675-20-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:675-20-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:675-20-7
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $60.0 / 80.0
Type:Lab/Research institutions
inquiryProduct Name: 2-Piperidone Synonyms: VALEROLACTAM;piperidin-2-one;D-VALEROLACTAM;DELTA-VALEROLACTAM;ALPHA-PIPERIDONE;6-VALEROLACTAM;2-PIPERIDONE;2-PIPERIDINONE CAS: 675-20-7 MF: C5H9NO MW: 99.13 EINECS: 211-622-9 Product Categories: Bu
Cas:675-20-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali
Cas:675-20-7
Min.Order:1 Kilogram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:675-20-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:675-20-7
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white or light yellow powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: 2-Piperidone CAS No.:675-20-7 Molecule Formula:C5H9NO Molecule Weight:99.13 Purity: 99.0% Package: 25kg/drum Description:Light yellow crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:675-20-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Conditions | Yield |
---|---|
Stage #1: 2-hydroxypyridin With palladium 10% on activated carbon; hydrogen; acetic acid at 24 - 28℃; for 15h; Stage #2: In methanol | 100% |
With nickel-copper at 200 - 235℃; under 29420.3 Torr; Hydrogenation; | |
With 1,4-dioxane; palladium at 55℃; Hydrogenation; | |
With ethanol; nickel under 36775.4 - 73550.8 Torr; Hydrogenation; | |
With C33H49ClNRh; hydrogen In 2,2,2-trifluoroethanol; water at 70℃; under 7500.75 Torr; for 24h; Autoclave; | 99 %Chromat. |
Conditions | Yield |
---|---|
With aluminium trichloride at 40℃; for 0.5h; Rearrangement; | 100% |
With tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide In acetonitrile for 0.5h; Beckmann Rearrangement; Molecular sieve; Reflux; | 96% |
With silica gel; caesium carbonate; N-tosylimidazole In N,N-dimethyl-formamide for 2h; Beckmann rearrangement; Reflux; | 88% |
Conditions | Yield |
---|---|
With silica gel In toluene for 1.5h; Heating; | 99% |
With tris(2,2,2-trifluoroethyl) borate In acetonitrile at 80℃; for 5h; Reagent/catalyst; | 99% |
With 14C2H7N*14H(1+)*2H2O*2O(2-)*2Zr(4+)*O122P4W34(18-) In dimethyl sulfoxide at 70℃; for 24h; | 99% |
piperidin-2-one
Conditions | Yield |
---|---|
With acetic acid at 105℃; for 5h; | 98% |
2-oxopiperidine-1-carboxylic acid tert-butyl ester
piperidin-2-one
Conditions | Yield |
---|---|
With water at 100℃; for 0.5h; | 97% |
With silica gel; ytterbium(III) triflate In neat (no solvent) at 40℃; for 6h; | 96% |
In acetonitrile at 300℃; under 75007.5 Torr; | 95% |
With copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 50℃; for 18h; Sealed tube; | 94% |
N-benzyloxycarbonyl-2-piperidone
piperidin-2-one
Conditions | Yield |
---|---|
Stage #1: N-benzyloxycarbonyl-2-piperidone With diethylaluminium chloride In hexane; dichloromethane at -78℃; for 0.166667h; Stage #2: With methyl-phenyl-thioether In hexane; dichloromethane at 25℃; for 1h; | 97% |
N-cyclohexyl-2-thiazolinylsulfenamide
5-aminopentanoic acid
piperidin-2-one
Conditions | Yield |
---|---|
With triphenylphosphine | 96% |
Conditions | Yield |
---|---|
With Rh(trop2N)(PPh3); methacrylic acid methyl ester In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; | 96% |
With dichloro(benzene)ruthenium(II) dimer; sodium hydride; acetonitrile; 1,3-di(propan-2-yl)-1H-imidazol-3-ium bromide In toluene for 36h; Inert atmosphere; Reflux; | 94% |
With sodium hydride; dichloro(benzene)ruthenium(II) dimer; acetonitrile; 1,3-di(propan-2-yl)-1H-imidazol-3-ium bromide In toluene for 36h; Conversion of starting material; Inert atmosphere; Reflux; | 94% |
Conditions | Yield |
---|---|
With sodium azide; sulfuric acid; silica gel at 60℃; for 0.416667h; Schmidt reaction; | 95% |
With acetylhydroxamic acid; sulfuric acid In acetonitrile at 80℃; under 1292.9 Torr; for 0.133333h; Microwave irradiation; | 87% |
With hydroxylamine hydrochloride at 120℃; for 6h; Beckmann rearrangement; neat (no solvent); | 80% |
piperidin-2-one
Conditions | Yield |
---|---|
With methanesulfonic acid In toluene for 6h; Heating; | 95% |
Conditions | Yield |
---|---|
With RuCl2[PPh2(CH2)4PPh2][2-(H2NCH2)C5H4N]; potassium hydroxide In toluene for 16h; Inert atmosphere; Reflux; | A 7% B 93% |
With dodecacarbonyl-triangulo-triruthenium; N–phenyl–2–(dicyclohexylphosphino)pyrrole In cyclohexane at 140℃; for 21h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Autoclave; |
piperidin-2-one
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; bis(trichloromethyl) carbonate; potassium hydroxide In water; acetonitrile at 60℃; for 0.00277778h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h; | 92% |
N-benzyloxycarbonyl-5-aminovaleric acid succinimide ester
piperidin-2-one
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate | 91% |
5-azidopentanamide
piperidin-2-one
Conditions | Yield |
---|---|
Stage #1: 5-azidopentanamide With triphenylphosphine In tetrahydrofuran at 20℃; for 1h; Stage #2: With water In tetrahydrofuran for 24h; Reflux; | 91% |
With tri-n-butyl-tin hydride In toluene for 24h; Reflux; | 84% |
piperidin-2-one
Conditions | Yield |
---|---|
With trifluoroacetic acid In chloroform at 25℃; for 2h; | 88% |
5-chloro-valeric acid
A
piperidine
B
piperidin-2-one
C
1-pentanamine
D
N-butylamine
Conditions | Yield |
---|---|
Stage #1: 5-chloro-valeric acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry; | A 85% B 9% C 2% D 2% |
Conditions | Yield |
---|---|
With 5.4 wt% Au/CeO2; water; oxygen In diethylene glycol dimethyl ether at 160℃; under 760.051 Torr; for 2.5h; Catalytic behavior; Schlenk technique; | 83% |
With water; oxygen at 100℃; under 760.051 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Time; Green chemistry; | 80% |
With oxygen; gold on silica dioxide In toluene at 100℃; for 100h; | 60% |
Conditions | Yield |
---|---|
In methanol Irradiation (UV/VIS); anaerobic irradiation 1h with visible light at 20°C; analyzing products by GLC; | A 83% B 3% |
In benzene Irradiation (UV/VIS); anaerobic irradiation 1h with visible light at 20°C; analyzing products by GLC; | A 76% B 2% |
In water Irradiation (UV/VIS); anaerobic irradiation 1h with visible light in single-compartment vesicle of N,N-dihexadecyl-Nα-(6-(trimethylammonio)hexanoyl)-L-alaninamide bromide at 20°C; phosphate-borate buffer; analyzing products by GLC; | A 63% B 24% |
piperidin-2-one
Conditions | Yield |
---|---|
With platinum(IV) oxide; carbon monoxide; hydrogen In methanol at 25℃; for 72h; Autoclave; Inert atmosphere; | 80% |
ethyl 5-azidovalerate
piperidin-2-one
Conditions | Yield |
---|---|
With water; triphenylphosphine In tetrahydrofuran for 12h; Ambient temperature; | 77% |
Conditions | Yield |
---|---|
With acetylhydroxamic acid; sulfuric acid In acetonitrile for 8h; Reflux; | A 75% B 6% |
With ammonium hydroxide; molecular sieve; dihydrogen peroxide at 79.9℃; for 5h; other catalyst; further ketones; |
piperidin-2-one
Conditions | Yield |
---|---|
With ammonium hydroxide; hydrogen; nickel In water at 70℃; under 25857.4 Torr; for 3.5h; | 74% |
Cyclopentylmethylketoxim
piperidin-2-one
Conditions | Yield |
---|---|
With sulfonated polymeric solid acid H-PDVB-SO3H In benzonitrile at 130℃; for 1h; Beckmann Rearrangement; | 74% |
1-(trimethylsilyl)piperidin-2-one
Ethyl 2-bromopropionate
A
piperidin-2-one
B
trimethylsilyl bromide
D
ethyl acrylate
Conditions | Yield |
---|---|
at 155 - 180℃; for 3h; Yields of byproduct given; | A n/a B n/a C 73% D n/a |
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; Trimethylacetic acid In tetrahydrofuran at 0 - 20℃; for 0.166667h; Deamination; | 73% |
((E)-1-Propenyl)-piperidin-2-one
piperidin-2-one
Conditions | Yield |
---|---|
Stage #1: ((E)-1-Propenyl)-piperidin-2-one With ruthenium trichloride; sodium periodate In water; 1,2-dichloro-ethane Stage #2: With sodium hydrogencarbonate; sodium carbonate In water; 1,2-dichloro-ethane | 70% |
Multi-step reaction with 2 steps 1: NaIO4; aq. RuCl3 / 1,2-dichloro-ethane / 20 °C 2: 100 mg / aq. NaHCO3; Na2CO3 / acetone View Scheme |
methanol
N-chloro-δ-valerolactam
A
piperidin-2-one
B
6-methoxypiperidin-2-one
Conditions | Yield |
---|---|
for 0.25h; Irradiation; | A 5 % Chromat. B 69% |
piperidin-2-one
1-nitrosopiperidin-2-one
Conditions | Yield |
---|---|
With sodium acetate; dinitrogen tetraoxide In dichloromethane at -10℃; for 1h; | 100% |
With 3,3-dimethyl-2-nitroso-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide In 1,2-dichloro-ethane at 80℃; Sealed tube; | 93% |
With diethyl ether; nitrous anhydride unter Kuehlung; |
piperidin-2-one
chloral
1-(2,2,2-Trichloro-1-hydroxy-ethyl)-piperidin-2-one
Conditions | Yield |
---|---|
In benzene for 2h; Heating; | 100% |
piperidin-2-one
p-methoxybenzyl chloride
N-(4-Methoxybenzyl)-δ-valerolactam
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Reflux; Inert atmosphere; | 100% |
With sodium hydride In tetrahydrofuran for 23h; Heating; | 94% |
With sodium t-butanolate In dimethyl sulfoxide at 20℃; for 3h; | 78% |
With potassium hydroxide; tetrabutylammomium bromide In toluene for 8h; Heating; | 52% |
With tetrabutylammomium bromide; potassium hydroxide In toluene for 8h; Dean-Stark; | 28.8 g |
piperidin-2-one
benzenesulfonyl chloride
1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran; hexane at -78℃; for 4h; Inert atmosphere; | 100% |
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; | 94% |
With n-butyllithium 1.) THF, hexane, -60 deg C, 20 min, 2.) THF, hexane, from -60 deg C to 0 deg C, 2.5 h; Yield given. Multistep reaction; |
piperidin-2-one
ethyl acrylate
1-(2-ethoxycarbonylethyl)-2-piperidinone
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran Michael addition reaction; | 100% |
With tetraethoxy orthosilicate; cesium fluoride In neat (no solvent) at 25℃; for 0.166667h; Product distribution; Mechanism; variation of reaction time and amount of CsF; further α,β-unsaturated esters; further amides; presence of different solvents; | 98% |
With tetraethoxy orthosilicate; cesium fluoride In neat (no solvent) at 25℃; for 0.166667h; | 98% |
piperidin-2-one
bromoacetic acid tert-butyl ester
1-t-Butoxycarbonylmethyl-2-piperidone
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With sodium hydride In toluene at 0℃; for 1h; Metallation; Stage #2: bromoacetic acid tert-butyl ester at 20℃; for 10h; Alkylation; | 100% |
With P-tris(dimethylamino)-C-dimethylphosphonium ylide In tetrahydrofuran at -78 - 20℃; for 3h; Alkylation; | 71% |
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In tetrahydrofuran for 4h; Heating; | 100% |
piperidin-2-one
Methyl 4-(bromomethyl)benzoate
4-(2-oxopiperidinomethyl)benzoate
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: Methyl 4-(bromomethyl)benzoate In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
piperidin-2-one
di-tert-butyl dicarbonate
2-oxopiperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; for 0.166667h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at -78℃; for 0.5h; Further stages.; | 99% |
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; | 98% |
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With 3,3-dimethyldioxirane In acetone at 0 - 25℃; for 48h; | 99% |
With manganese(II) triflate; 4,4'-diamino-2,2'-bipyridyl; dihydrogen peroxide In acetone at 20℃; for 1h; Reagent/catalyst; | 98% |
With potassium peroxymonosulphate; water; potassium bromide In dichloromethane at 20℃; for 7h; Sealed tube; Irradiation; | 95% |
With oxygen; titanium(IV) oxide In water for 48h; Irradiation; | 0.9 mmol |
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With sodium hydride In tetrahydrofuran Stage #2: allyl bromide In tetrahydrofuran | 99% |
With sodium hydride In tetrahydrofuran at 20℃; | 92% |
With potassium hydride In tetrahydrofuran at 0 - 20℃; for 20h; | 89% |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene at 110℃; for 23h; | 99% |
Conditions | Yield |
---|---|
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 8h; | 99% |
With potassium phosphate; copper(l) iodide; N-Methyl-L-proline Methyl Ester In dimethyl sulfoxide at 110℃; for 5h; Goldberg reaction; Inert atmosphere; | 81% |
With potassium carbonate In neat (no solvent) at 120℃; for 20h; Catalytic behavior; Green chemistry; | 75% |
piperidin-2-one
propargyl bromide
A
N-propargyl δ-valerolactam
B
N-(1,2-propadienyl)valerolactam
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In tetrahydrofuran for 4h; Heating; | A n/a B 99% |
piperidin-2-one
Benzyloxyacetyl chloride
1-(2-(benzyloxy)acetyl)piperidin-2-one
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With pyridine; dmap In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: Benzyloxyacetyl chloride In dichloromethane at 50℃; for 16h; Inert atmosphere; | 99% |
With pyridine In toluene for 12h; Heating; | 2.95 g |
piperidin-2-one
3-chloro-4-fluorobenzyl bromide
1-(3-chloro-4-fluorobenzyl)piperidin-2-one
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In tert-butyl methyl ether; water at 20 - 30℃; for 0.5h; Inert atmosphere; Large scale; Stage #2: 3-chloro-4-fluorobenzyl bromide In tert-butyl methyl ether; water at 20 - 30℃; for 0.5h; Inert atmosphere; Large scale; | 99% |
Stage #1: piperidin-2-one With tert-butyl methyl ether; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water at 20 - 30℃; for 0.5h; Inert atmosphere; Large scale; Stage #2: 3-chloro-4-fluorobenzyl bromide In water at 20 - 30℃; Inert atmosphere; Large scale; | 99% |
Stage #1: piperidin-2-one; tetrabutylammonium sulfate In tert-butyl methyl ether at 20℃; for 0.0833333h; Stage #2: 3-chloro-4-fluorobenzyl bromide With sodium hydroxide In tert-butyl methyl ether; water at 20 - 30℃; for 4h; | |
Stage #1: piperidin-2-one With sodium hydride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0℃; for 0.583333h; Stage #2: 3-chloro-4-fluorobenzyl bromide In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 20℃; | |
Stage #1: piperidin-2-one With sodium hydride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0℃; for 0.583333h; Stage #2: 3-chloro-4-fluorobenzyl bromide In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 20℃; |
piperidin-2-one
4-[(4,5-dichloro-1,3-thiazol-2-yl)oxy]-2,5-dimethylaniline
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With trichlorophosphate In toluene at 20℃; for 2h; Stage #2: 4-[(4,5-dichloro-1,3-thiazol-2-yl)oxy]-2,5-dimethylaniline In toluene for 5h; Heating / reflux; Stage #3: With sodium hydroxide In water; toluene | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride; water at 90℃; for 24h; | 98% |
With water; hydrogen cation |
piperidin-2-one
(E)-3-phenylpropenal
1-(3-phenylpropionyl)-2-piperidone
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one; (E)-3-phenylpropenal With Shvo's Catalyst In toluene at 100℃; for 24h; Inert atmosphere; Stage #2: With hydrogen In toluene at 100℃; under 760.051 Torr; for 5h; | 98% |
piperidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 130℃; for 0.25h; Buchwald-Hartwig Coupling; Inert atmosphere; Microwave irradiation; | 98% |
piperidin-2-one
benzyl chloride
ethyl iodide
3-ethyl-1-(phenylmethyl)-2-piperidinone
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 1h; Inert atmosphere; Stage #2: ethyl iodide In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #3: benzyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 3h; Inert atmosphere; | 98% |
piperidin-2-one
bromoethyl-2-benzyl ether
1-(2-(benzyloxy)ethyl)piperidin-2-one
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran 1.) 0 deg C; 2.) heating; | 97% |
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -78 - 20℃; | 97% |
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #2: benzyl bromide In tetrahydrofuran; hexane at -78 - 20℃; | 97% |
With n-butyllithium In tetrahydrofuran at -78 - 20℃; | 97% |
piperidin-2-one
2-(ethylthio)acetyl chloride
1-ethylsulfenylacetylpiperidin-2-one
Conditions | Yield |
---|---|
In benzene for 12h; Heating; | 97% |
Heating; | |
In benzene |
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