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inquiryD-Threonine CAS No.: 632-20-2 H.S. Code: 2922491090 Synonyms:D-Threonine;(2R,3S)-2-Amino-3-hydroxybutyric acid;D-α-Amino-β-hydroxybutyric acid Molecular Formula: C4H9NO3 Molecular Weight: 119.12 Description: L-threonine is a
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inquirySichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality manageme
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Product Name: D-Threonine Synonyms: D-ALPHA-AMINO-BETA-HYDROXYBUTYRIC ACID;D-2-AMINO-3-HYDROXYBUTANOIC ACID;D-2-AMINO-3-HYDROXYBUTYRIC ACID;H-D-THR-OH;D-Threonine,(2R,3S)-2-Amino-3-hydroxybutyric acid, D-α-Amino-β-hydroxybutyric acid;(2
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inquiryProduct Product name D-Threonine Synonyms D-2-Amino-3-hydroxybutanoic acid CAS No. 632-20-2
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystalline powder or crystals Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Ap
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(2R,3R)-2-Benzyloxycarbonylamino-4,4,4-trichloro-3-hydroxy-butyric acid
D-Threonine
Conditions | Yield |
---|---|
With hydrogen; palladium dihydroxide In methanol under 760 Torr; for 3h; | 100% |
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride; water at 90℃; for 24h; | 98% |
Conditions | Yield |
---|---|
With sodium methylate at 25℃; for 4h; Yields of byproduct given; | A 96% B n/a |
With sodium methylate at 25℃; for 1h; Yield given; | A 93% B n/a |
D-Threonine
Conditions | Yield |
---|---|
With 3400 U whole cells In aq. phosphate buffer at 37℃; for 5h; pH=7; Enzymatic reaction; | 90.7% |
With L-threonine dehydratase Resolution of racemate; Enzymatic reaction; | n/a |
N-acetyl-D-threonine
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol | 85% |
With Agrobacterium tumefaciens C58 recombinant Atu3266 protein; water at 30℃; for 15h; pH=7.6; Enzymatic reaction; |
Acetic acid (1S,2R)-2-acetylamino-1-methyl-2-((S)-1-phenyl-ethylcarbamoyl)-ethyl ester
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 25h; Heating; | 74% |
Conditions | Yield |
---|---|
With hydrogen bromide |
N-chloroacetyl-L-threonine
D-Threonine
Conditions | Yield |
---|---|
Hydrolysis.mit Hilfe eines Enzym-Praeparats aus Nieren und Kochen des unveraendert zurueckbleibenden N-Chloracetyl-Ds-threonins mit 2n-HCl; |
N-(toluene-4-sulfonyl)-DS-threonine
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride |
N-benzoyl-Ds-threonine
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With hydrogen bromide |
N,N-phthaloyl-DL-threonine
D-Threonine
Conditions | Yield |
---|---|
With brucine |
Conditions | Yield |
---|---|
With hydrogen; Chiraphos-Ru Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
(3R,6S,1'S)-3-(1-Hydroxyethyl)-6-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine
A
L-valine
B
D-Threonine
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
D-threo (2S,3S) Ethyl 2-acetamido-3-hydroxybutyrate
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; |
acetaldehyde
A
D-Threonine
B
(2S,3S)-2-amino-3-hydroxybutanoic acid
C
L-threonine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium methylate; acetic acid 1) MeOH, rt, 2 h, 2) MeOH,reflux; Yield given. Multistep reaction. Yields of byproduct given; | |
With hydrogenchloride; triethylamine 1) MeOH, 2 months, rt, 2) MeOH, reflux; Yield given. Multistep reaction. Yields of byproduct given; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium methylate Product distribution; 1.) MeOH, 20 deg C, 1 h, 2.) H2O, reflux; other reagent; |
acetaldehyde
(S)-2-<(N-benzylprolyl)amino>acetophenone
glycine
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen sulfide; copper(II) sulfate; triethylamine Product distribution; various reaction conditions, stereoselectivity; |
acetaldehyde
glycine
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With (S)-15-formyl-14-hydroxy-2,8-dithia<9>(2,5)pyridinophane; hydroxide; zinc Product distribution; or propionaldehyde; | |
With zinc(II) nitrate; (R)-15-hydroxy-3,9-dithia-12-azabicyclo<9.2.2>pentadeca-11,13,14-triene-14-carboxyaldehyde; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In methanol; water at 35℃; pH 8.0; Title compound not separated from byproducts; | |
Yield given. Multistep reaction; | |
With zinc(II) nitrate; (S)-15-hydroxy-6,6-bis<<4'-<(dimethylamino)methyl>benzyl>thio>-3,9-dithia-12-azabicyclo<9.2.2>pentadeca-11,13,14-triene-14-carboxyaldehyde; sodium acetate In methanol; water at 35℃; pH 5.0; Title compound not separated from byproducts; | |
With 5-(4-Me2NCH2C6H4S-)-3-HO-5,6,7,8-H4-quinoline-4-carbaldehyde; copper dichloride In ethanol; water at 40℃; pH=4.0; Product distribution; Further Variations:; Reagents; pH-values; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(S)-2-{(N-benzyl-2-pyrrolidinyl)carbonylamino}benzaldehyde
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(S)-2-<(N-benzylprolyl)amino>acetophenone
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(S)-1-Benzyl-piperidine-2-carboxylic acid (2-acetyl-phenyl)-amide
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine 1.) MeOH, 20 deg C, 1 h, 2.) H2O, reflux; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
1-((S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-ethanol
A
L-valine
B
D-Threonine
C
D-allo-threonine
Conditions | Yield |
---|---|
With hydrogenchloride 1) 2 h, r. t., 2) 1 h reflux; Yield given. Title compound not separated from byproducts; |
(4R,5S)-5-methyl-2-oxooxazolidine-4-carboxylic acid
D-Threonine
Conditions | Yield |
---|---|
With hydrogenchloride at 110℃; for 36h; Yield given; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With sodium hydroxide; zinc(II) cation; sodium hydrogencarbonate 2) aq. MeOH, r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; |
acetaldehyde
A
D-Threonine
B
D-allo-threonine
C
(2S,3S)-2-amino-3-hydroxybutanoic acid
D
L-threonine
Conditions | Yield |
---|---|
With sodium hydroxide; zinc(II) cation; sodium hydrogencarbonate 2) aq. MeOH, r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With D-threonine aldolase; pyridoxal 5'-phosphate; diothiothreitol In water at 14 - 37℃; Product distribution; Kinetics; effect of additives and reaction time, pH effect; | |
With recombinant D-threonine aldolase from the green alga Chlamydomonas reinhardtii In aq. buffer at 70℃; pH=8.4; Catalytic behavior; Kinetics; pH-value; Temperature; Enzymatic reaction; | A n/a B n/a |
With 4-morpholineethanesulfonic acid; pyridoxal 5'-phosphate; D-threonine aldolase from Delftia sp. RIT313 cloned and expressed in Escherichia coli BL21; sodium hydroxide; manganese(ll) chloride In water at 25℃; for 0.5h; pH=6; Kinetics; Temperature; Time; pH-value; Aldol Addition; Enzymatic reaction; stereoselective reaction; |
O-phospho-D-threonine
D-Threonine
Conditions | Yield |
---|---|
With alkaline phosphatase In water at 37℃; for 24h; | 8.0 % Chromat. |
Conditions | Yield |
---|---|
With hydrogenchloride at 20℃; Heating / reflux; | 100% |
With thionyl chloride for 1h; Reflux; | 100% |
With thionyl chloride at 60℃; for 3h; | 71% |
D-Threonine
di-tert-butyl dicarbonate
(2R,3S)-2-tert-butoxycarbonylamino-3-hydroxybutyric acid
Conditions | Yield |
---|---|
With sodium hydroxide In water; tert-butyl alcohol at 20℃; for 23h; | 100% |
With sodium hydrogencarbonate In methanol; water at 20℃; for 36h; Inert atmosphere; | 95% |
With sodium carbonate In tetrahydrofuran; water | 87% |
methanol
D-Threonine
(2R,3S)-2-amino-3-hydroxy-butyric acid methyl ester hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride Heating; | 100% |
With thionyl chloride at 25℃; for 48h; Esterification; | 100% |
With hydrogenchloride at 20℃; for 5h; | 100% |
D-Threonine
(fluorenylmethoxy)carbonyl chloride
(((9H-fluoren-9-yl)methoxy)carbonyl)-D-threonine
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane | 100% |
Conditions | Yield |
---|---|
In toluene at 140℃; for 24h; Dean-Stark; Schlenk technique; Inert atmosphere; | 100% |
In benzene for 42h; Heating; |
methanol
D-Threonine
di-tert-butyl dicarbonate
tert-butyldimethylsilyl chloride
methyl (2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoate
Conditions | Yield |
---|---|
Stage #1: methanol; D-Threonine With thionyl chloride for 2h; Heating; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 2.5h; Stage #3: tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 10h; | 100% |
(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol
2,2'-dipyridyl carbonate
D-Threonine
(2R,3S)-3-hydroxy-2-[[4-[4-(trifluoromethyl)-phenyl]-phenyl]-methoxycarbonylamino]-butanoic acid
Conditions | Yield |
---|---|
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 100% |
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 100% |
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.21 g |
2,2'-dipyridyl carbonate
D-Threonine
3-(4-hydroxymethyl-phenyl)thiophene
(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 100% |
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.188 g |
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.188 g |
Conditions | Yield |
---|---|
With hydrogenchloride; thionyl chloride at 0℃; for 2h; Reflux; | 99% |
With thionyl chloride at 0 - 20℃; for 24h; |
D-Threonine
tert-butyldimethylsilyl chloride
(2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoic acid
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; | 98% |
D-Threonine
3-(2-bromoethyl)-2-chloro-4-fluorobenzonitrile
(2R,3S)-2-(3-chloro-4-cyano-2-vinyl-phenylamino)-3-hydroxy-butyric acid
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20 - 85℃; | 97% |
2,2'-dipyridyl carbonate
D-Threonine
cyclohexanol
(2R,3S)-2-(((cyclohexyloxy)carbonyl)amino)-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 97% |
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; dichloromethane; water at 20℃; for 15h; Inert atmosphere; | 0.3 g |
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.3 g |
2,2'-dipyridyl carbonate
D-Threonine
4-cyclohexylphenylmethyl alcohol
(2R,3S)-2-[{[(4-cyclohexylphenyl)methoxy]carbonyl}amino]-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 96% |
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.32 g |
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.32 g |
D-Threonine
(2R,3S)-3-hydroxy-2-[(4-phenylphenyl)methoxycarbonylamino]butanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 96% |
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; 2-decyn-1-ol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 96% |
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; p-butylbenzyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 94% |
piperonol
2,2'-dipyridyl carbonate
D-Threonine
(2R,3S)-2-{[(2H-1,3-benzodioxol-5-ylmethoxy)carbonyl]amino}-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 92% |
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.337 g |
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.337 g |
2,2'-dipyridyl carbonate
D-Threonine
[4-(cyclohexoxy)-phenyl]-methanol
(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 91% |
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.214 g |
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 0.214 g |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 11h; Reagent/catalyst; Solvent; Large scale; | 90.2% |
D-Threonine
pentyl chloroformate
(2R,3S)-3-hydroxy-2-{[(pentyloxy)carbonyl]amino}butanoic acid
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h; | 90% |
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h; | 90% |
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h; | 90% |
D-Threonine
(1S,3E)-5-<(2,5-dioxo-1-pyrrolidinyl)oxy>-1-<(1R,2E)-1-methyl-3-phenyl-2-propenyl>-5-oxo-3-pentenyl-(2S)-<3-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoate
N-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-D-threonine
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide In N,N-dimethyl-formamide at 55 - 60℃; | 89% |
D-Threonine
2-phenylethyl pyridin-2-yl carbonate
2-phenylethyl 2-oxopyridine-1-carboxylate
(2R,3S)-3-hydroxy-2-(phenethyloxycarbonylamino)-butanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water | 89% |
Conditions | Yield |
---|---|
With sodium carbonate In water | 88% |
D-Threonine
benzyl chloroformate
(2R,3S)-2-{[(benzyloxy)carbonyl]amino}-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; for 1.5h; | 85% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 1h; | 76% |
With sodium hydrogencarbonate In tetrahydrofuran; water for 18h; Ambient temperature; |
Conditions | Yield |
---|---|
Stage #1: 2,2'-dipyridyl carbonate; [4-(3-bromo-2-thienyl)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere; Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h; | 85% |
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