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Chengdu Baishixing Science and Technology Industry Co., Ltd.

The area of Chengdu Baishixing is 35,000 square metre , the staff members are 88, our output value is over 120 millions per year. Baishiying cooporates with Life Science Academy of Wuhan University to develop amino acids series products.We have pro

D-Threonine

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

D-Threonine Manufacturer/High quality/Best price/In stock

Cas:632-20-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality D-Threonine supplier in China

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Applic

Factory supply D-Threonine Cas 632-20-2 with high quality and best price

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

D-Threonine CAS No.: 632-20-2 H.S. Code: 2922491090 Synonyms:D-Threonine;(2R,3S)-2-Amino-3-hydroxybutyric acid;D-α-Amino-β-hydroxybutyric acid Molecular Formula: C4H9NO3 Molecular Weight: 119.12 Description: L-threonine is a

D-Threonine from China

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply D-Threonine

Cas:632-20-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% D-Threonine 632-20-2 GMP Manufacturer

Cas:632-20-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality manageme

D-Threonine

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

D-Threonine

Cas:632-20-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: D-Threonine Synonyms: D-ALPHA-AMINO-BETA-HYDROXYBUTYRIC ACID;D-2-AMINO-3-HYDROXYBUTANOIC ACID;D-2-AMINO-3-HYDROXYBUTYRIC ACID;H-D-THR-OH;D-Threonine,(2R,3S)-2-Amino-3-hydroxybutyric acid, D-α-Amino-β-hydroxybutyric acid;(2

632-20-2 D-Threonine

Cas:632-20-2

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

D-Threonine CAS 632-20-2

Cas:632-20-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 632-20-2 with best quality

Cas:632-20-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 632-20-2 D-Threonine

Cas:632-20-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Product name D-Threonine Synonyms D-2-Amino-3-hydroxybutanoic acid CAS No. 632-20-2

D-Threonine 632-20-2

Cas:632-20-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

D-threonine manufacturer/supplier

Cas:632-20-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

D-Threonine 632-20-2

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

D-Threonine 99%

Cas:632-20-2

Min.Order:1 Kilogram

FOB Price: $85.0 / 98.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical i

D-Threonine/632-20-2/D-Threonine Manufacturer

Cas:632-20-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:632-20-2

Cas:632-20-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales D-Threonine CAS 632-20-2

Cas:632-20-2

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

D-Threonine

Cas:632-20-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

D-THREONINE

Cas:632-20-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

D-Threonine

Cas:632-20-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

D-Threonine/High quality/Best price

Cas:632-20-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

D-Threonine Manufacturer/High quality/Best price/In stock

Cas:632-20-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

D-Threonine

Cas:632-20-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder or crystals Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Ap

D-Threonine

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

D-Threonine Manufacturer/High quality/Best price/In stock

Cas:632-20-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

D-(+)-Threonine

Cas:632-20-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2R,3R)-2-Benzyloxycarbonylamino-4,4,4-trichloro-3-hydroxy-butyric acid
134936-33-7, 137787-32-7, 137787-33-8

(2R,3R)-2-Benzyloxycarbonylamino-4,4,4-trichloro-3-hydroxy-butyric acid

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogen; palladium dihydroxide In methanol under 760 Torr; for 3h;100%
tert-butyl (2R,3S)-2-[N-(tert-butoxycarbonyl)amino]-3-(trichloroacetoxy)butanoate

tert-butyl (2R,3S)-2-[N-(tert-butoxycarbonyl)amino]-3-(trichloroacetoxy)butanoate

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride; water at 90℃; for 24h;98%
acetaldehyde
75-07-0

acetaldehyde

(R)-AFCMT-(GlyGly)Cu(II)

(R)-AFCMT-(GlyGly)Cu(II)

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

Conditions
ConditionsYield
With sodium methylate at 25℃; for 4h; Yields of byproduct given;A 96%
B n/a
With sodium methylate at 25℃; for 1h; Yield given;A 93%
B n/a
Conditions
ConditionsYield
With 3400 U whole cells In aq. phosphate buffer at 37℃; for 5h; pH=7; Enzymatic reaction;90.7%
With L-threonine dehydratase Resolution of racemate; Enzymatic reaction;n/a
N-acetyl-D-threonine
197302-88-8

N-acetyl-D-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride In methanol85%
With Agrobacterium tumefaciens C58 recombinant Atu3266 protein; water at 30℃; for 15h; pH=7.6; Enzymatic reaction;
Acetic acid (1S,2R)-2-acetylamino-1-methyl-2-((S)-1-phenyl-ethylcarbamoyl)-ethyl ester
205534-30-1

Acetic acid (1S,2R)-2-acetylamino-1-methyl-2-((S)-1-phenyl-ethylcarbamoyl)-ethyl ester

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride In methanol for 25h; Heating;74%
N-formyl-O-methyl-Ds-threonine
7505-36-4

N-formyl-O-methyl-Ds-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogen bromide
N-chloroacetyl-L-threonine
153893-46-0

N-chloroacetyl-L-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
Hydrolysis.mit Hilfe eines Enzym-Praeparats aus Nieren und Kochen des unveraendert zurueckbleibenden N-Chloracetyl-Ds-threonins mit 2n-HCl;
N-(toluene-4-sulfonyl)-DS-threonine
43188-50-7

N-(toluene-4-sulfonyl)-DS-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride
N-benzoyl-Ds-threonine
906324-06-9

N-benzoyl-Ds-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride
N-(4-nitro-benzoyl)-Ds-threonine
7402-25-7

N-(4-nitro-benzoyl)-Ds-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogen bromide
N,N-phthaloyl-DL-threonine
87068-79-9

N,N-phthaloyl-DL-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With brucine
DL-threonine
80-68-2

DL-threonine

A

D-Threonine
632-20-2

D-Threonine

B

L-threonine
72-19-5

L-threonine

methyl 2-acetamido-3-oxobutanoate
98432-01-0

methyl 2-acetamido-3-oxobutanoate

A

D-Threonine
632-20-2

D-Threonine

B

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With hydrogen; Chiraphos-Ru Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(3R,6S,1'S)-3-(1-Hydroxyethyl)-6-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine
87378-29-8

(3R,6S,1'S)-3-(1-Hydroxyethyl)-6-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine

A

L-valine
72-18-4

L-valine

B

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given;
D-threo (2S,3S) Ethyl 2-acetamido-3-hydroxybutyrate
111492-38-7

D-threo (2S,3S) Ethyl 2-acetamido-3-hydroxybutyrate

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;
nickelous 2-[(E)-[[2-[(2S)-1-benzylpyrrolidine-2-carbonyl]azanidylphenyl]-phenylmethylene]amino]acetate

nickelous 2-[(E)-[[2-[(2S)-1-benzylpyrrolidine-2-carbonyl]azanidylphenyl]-phenylmethylene]amino]acetate

acetaldehyde
75-07-0

acetaldehyde

A

D-Threonine
632-20-2

D-Threonine

B

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

C

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate; acetic acid 1) MeOH, rt, 2 h, 2) MeOH,reflux; Yield given. Multistep reaction. Yields of byproduct given;
With hydrogenchloride; triethylamine 1) MeOH, 2 months, rt, 2) MeOH, reflux; Yield given. Multistep reaction. Yields of byproduct given;
acetaldehyde
75-07-0

acetaldehyde

Nickel(II); {[1-(2-{[1-((S)-1-benzyl-pyrrolidin-2-yl)-1-hydroxy-meth-(Z)-ylidene]-amino}-phenyl)-meth-(Z)-ylidene]-amino}-acetate

Nickel(II); {[1-(2-{[1-((S)-1-benzyl-pyrrolidin-2-yl)-1-hydroxy-meth-(Z)-ylidene]-amino}-phenyl)-meth-(Z)-ylidene]-amino}-acetate

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate Product distribution; 1.) MeOH, 20 deg C, 1 h, 2.) H2O, reflux; other reagent;
acetaldehyde
75-07-0

acetaldehyde

(S)-2-<(N-benzylprolyl)amino>acetophenone
82704-15-2

(S)-2-<(N-benzylprolyl)amino>acetophenone

glycine
56-40-6

glycine

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen sulfide; copper(II) sulfate; triethylamine Product distribution; various reaction conditions, stereoselectivity;
acetaldehyde
75-07-0

acetaldehyde

glycine
56-40-6

glycine

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With (S)-15-formyl-14-hydroxy-2,8-dithia<9>(2,5)pyridinophane; hydroxide; zinc Product distribution; or propionaldehyde;
With zinc(II) nitrate; (R)-15-hydroxy-3,9-dithia-12-azabicyclo<9.2.2>pentadeca-11,13,14-triene-14-carboxyaldehyde; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In methanol; water at 35℃; pH 8.0; Title compound not separated from byproducts;
Yield given. Multistep reaction;
With zinc(II) nitrate; (S)-15-hydroxy-6,6-bis<<4'-<(dimethylamino)methyl>benzyl>thio>-3,9-dithia-12-azabicyclo<9.2.2>pentadeca-11,13,14-triene-14-carboxyaldehyde; sodium acetate In methanol; water at 35℃; pH 5.0; Title compound not separated from byproducts;
With 5-(4-Me2NCH2C6H4S-)-3-HO-5,6,7,8-H4-quinoline-4-carbaldehyde; copper dichloride In ethanol; water at 40℃; pH=4.0; Product distribution; Further Variations:; Reagents; pH-values;
acetaldehyde
75-07-0

acetaldehyde

C21H21N3O3(2-)*Cu(2+)

C21H21N3O3(2-)*Cu(2+)

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(S)-2-{(N-benzyl-2-pyrrolidinyl)carbonylamino}benzaldehyde
82704-14-1

(S)-2-{(N-benzyl-2-pyrrolidinyl)carbonylamino}benzaldehyde

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given;
acetaldehyde
75-07-0

acetaldehyde

C22H23N3O3(2-)*Cu(2+)

C22H23N3O3(2-)*Cu(2+)

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(S)-2-<(N-benzylprolyl)amino>acetophenone
82704-15-2

(S)-2-<(N-benzylprolyl)amino>acetophenone

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given;
acetaldehyde
75-07-0

acetaldehyde

C23H25N3O3(2-)*Cu(2+)

C23H25N3O3(2-)*Cu(2+)

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(S)-1-Benzyl-piperidine-2-carboxylic acid (2-acetyl-phenyl)-amide
82704-16-3

(S)-1-Benzyl-piperidine-2-carboxylic acid (2-acetyl-phenyl)-amide

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given;
acetaldehyde
75-07-0

acetaldehyde

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With hydrogenchloride; triethylamine 1.) MeOH, 20 deg C, 1 h, 2.) H2O, reflux; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
1-((S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-ethanol
87378-29-8, 87421-18-9

1-((S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-ethanol

A

L-valine
72-18-4

L-valine

B

D-Threonine
632-20-2

D-Threonine

C

D-allo-threonine
24830-94-2

D-allo-threonine

Conditions
ConditionsYield
With hydrogenchloride 1) 2 h, r. t., 2) 1 h reflux; Yield given. Title compound not separated from byproducts;
(4R,5S)-5-methyl-2-oxooxazolidine-4-carboxylic acid
122871-70-9

(4R,5S)-5-methyl-2-oxooxazolidine-4-carboxylic acid

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With hydrogenchloride at 110℃; for 36h; Yield given;
acetaldehyde
75-07-0

acetaldehyde

{[1-(15-Hydroxy-3,9-dithia-12-aza-bicyclo[9.2.2]pentadeca-1(14),11(15),12-trien-14-yl)-meth-(E)-ylidene]-amino}-acetic acid

{[1-(15-Hydroxy-3,9-dithia-12-aza-bicyclo[9.2.2]pentadeca-1(14),11(15),12-trien-14-yl)-meth-(E)-ylidene]-amino}-acetic acid

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With sodium hydroxide; zinc(II) cation; sodium hydrogencarbonate 2) aq. MeOH, r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
acetaldehyde
75-07-0

acetaldehyde

{[1-(15-Hydroxy-3,9-dithia-12-aza-bicyclo[9.2.2]pentadeca-1(14),11(15),12-trien-14-yl)-meth-(E)-ylidene]-amino}-acetic acid

{[1-(15-Hydroxy-3,9-dithia-12-aza-bicyclo[9.2.2]pentadeca-1(14),11(15),12-trien-14-yl)-meth-(E)-ylidene]-amino}-acetic acid

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

C

(2S,3S)-2-amino-3-hydroxybutanoic acid
28954-12-3

(2S,3S)-2-amino-3-hydroxybutanoic acid

D

L-threonine
72-19-5

L-threonine

Conditions
ConditionsYield
With sodium hydroxide; zinc(II) cation; sodium hydrogencarbonate 2) aq. MeOH, r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
acetaldehyde
75-07-0

acetaldehyde

glycine
56-40-6

glycine

A

D-Threonine
632-20-2

D-Threonine

B

D-allo-threonine
24830-94-2

D-allo-threonine

Conditions
ConditionsYield
With D-threonine aldolase; pyridoxal 5'-phosphate; diothiothreitol In water at 14 - 37℃; Product distribution; Kinetics; effect of additives and reaction time, pH effect;
With recombinant D-threonine aldolase from the green alga Chlamydomonas reinhardtii In aq. buffer at 70℃; pH=8.4; Catalytic behavior; Kinetics; pH-value; Temperature; Enzymatic reaction;A n/a
B n/a
With 4-morpholineethanesulfonic acid; pyridoxal 5'-phosphate; D-threonine aldolase from Delftia sp. RIT313 cloned and expressed in Escherichia coli BL21; sodium hydroxide; manganese(ll) chloride In water at 25℃; for 0.5h; pH=6; Kinetics; Temperature; Time; pH-value; Aldol Addition; Enzymatic reaction; stereoselective reaction;
O-phospho-D-threonine
96193-69-0

O-phospho-D-threonine

D-Threonine
632-20-2

D-Threonine

Conditions
ConditionsYield
With alkaline phosphatase In water at 37℃; for 24h;8.0 % Chromat.
methanol
67-56-1

methanol

D-Threonine
632-20-2

D-Threonine

D-threonine methyl ester
82679-55-8

D-threonine methyl ester

Conditions
ConditionsYield
With hydrogenchloride at 20℃; Heating / reflux;100%
With thionyl chloride for 1h; Reflux;100%
With thionyl chloride at 60℃; for 3h;71%
D-Threonine
632-20-2

D-Threonine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2R,3S)-2-tert-butoxycarbonylamino-3-hydroxybutyric acid
2592-18-9, 23082-29-3, 23082-30-6, 55674-67-4, 85979-33-5, 86748-77-8

(2R,3S)-2-tert-butoxycarbonylamino-3-hydroxybutyric acid

Conditions
ConditionsYield
With sodium hydroxide In water; tert-butyl alcohol at 20℃; for 23h;100%
With sodium hydrogencarbonate In methanol; water at 20℃; for 36h; Inert atmosphere;95%
With sodium carbonate In tetrahydrofuran; water87%
methanol
67-56-1

methanol

D-Threonine
632-20-2

D-Threonine

(2R,3S)-2-amino-3-hydroxy-butyric acid methyl ester hydrochloride
60538-15-0

(2R,3S)-2-amino-3-hydroxy-butyric acid methyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride Heating;100%
With thionyl chloride at 25℃; for 48h; Esterification;100%
With hydrogenchloride at 20℃; for 5h;100%
D-Threonine
632-20-2

D-Threonine

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

(((9H-fluoren-9-yl)methoxy)carbonyl)-D-threonine
157355-81-2

(((9H-fluoren-9-yl)methoxy)carbonyl)-D-threonine

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane100%
D-Threonine
632-20-2

D-Threonine

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

allyl alcohol
107-18-6

allyl alcohol

H-D-Thr-Oallyl p-tolunenesulfonate

H-D-Thr-Oallyl p-tolunenesulfonate

Conditions
ConditionsYield
In toluene at 140℃; for 24h; Dean-Stark; Schlenk technique; Inert atmosphere;100%
In benzene for 42h; Heating;
methanol
67-56-1

methanol

D-Threonine
632-20-2

D-Threonine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

methyl (2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoate
914799-28-3

methyl (2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoate

Conditions
ConditionsYield
Stage #1: methanol; D-Threonine With thionyl chloride for 2h; Heating;
Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 2.5h;
Stage #3: tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 10h;
100%
(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol
457889-46-2

(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol

2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

(2R,3S)-3-hydroxy-2-[[4-[4-(trifluoromethyl)-phenyl]-phenyl]-methoxycarbonylamino]-butanoic acid
1439368-11-2

(2R,3S)-3-hydroxy-2-[[4-[4-(trifluoromethyl)-phenyl]-phenyl]-methoxycarbonylamino]-butanoic acid

Conditions
ConditionsYield
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
100%
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
100%
Stage #1: (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.21 g
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

3-(4-hydroxymethyl-phenyl)thiophene
160278-20-6

3-(4-hydroxymethyl-phenyl)thiophene

(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid
1439368-16-7

(2R,3S)-3-hydroxy-2-[({[4-(thiophen-3-yl)phenyl]methoxy}carbonyl)amino]butanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
100%
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.188 g
Stage #1: 2,2'-dipyridyl carbonate; 3-(4-hydroxymethyl-phenyl)thiophene With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.188 g
methanol
67-56-1

methanol

D-Threonine
632-20-2

D-Threonine

D-threonine methyl ester hydrochloride

D-threonine methyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; thionyl chloride at 0℃; for 2h; Reflux;99%
With thionyl chloride at 0 - 20℃; for 24h;
D-Threonine
632-20-2

D-Threonine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoic acid
1126450-23-4

(2R,3S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsilyloxy)butanoic acid

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;98%
D-Threonine
632-20-2

D-Threonine

3-(2-bromoethyl)-2-chloro-4-fluorobenzonitrile
1182369-29-4

3-(2-bromoethyl)-2-chloro-4-fluorobenzonitrile

(2R,3S)-2-(3-chloro-4-cyano-2-vinyl-phenylamino)-3-hydroxy-butyric acid
1182369-30-7

(2R,3S)-2-(3-chloro-4-cyano-2-vinyl-phenylamino)-3-hydroxy-butyric acid

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20 - 85℃;97%
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

cyclohexanol
108-93-0

cyclohexanol

(2R,3S)-2-(((cyclohexyloxy)carbonyl)amino)-3-hydroxybutanoic acid
1439367-66-4

(2R,3S)-2-(((cyclohexyloxy)carbonyl)amino)-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
97%
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; dichloromethane; water at 20℃; for 15h; Inert atmosphere;
0.3 g
Stage #1: 2,2'-dipyridyl carbonate; cyclohexanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.3 g
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

4-cyclohexylphenylmethyl alcohol
208259-47-6

4-cyclohexylphenylmethyl alcohol

(2R,3S)-2-[{[(4-cyclohexylphenyl)methoxy]carbonyl}amino]-3-hydroxybutanoic acid
1439368-01-0

(2R,3S)-2-[{[(4-cyclohexylphenyl)methoxy]carbonyl}amino]-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
96%
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.32 g
Stage #1: 2,2'-dipyridyl carbonate; 4-cyclohexylphenylmethyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.32 g
D-Threonine
632-20-2

D-Threonine

(4-phenylphenyl)methyl pyridyl carbonate

(4-phenylphenyl)methyl pyridyl carbonate

(2R,3S)-3-hydroxy-2-[(4-phenylphenyl)methoxycarbonylamino]butanoic acid
1598377-15-1

(2R,3S)-3-hydroxy-2-[(4-phenylphenyl)methoxycarbonylamino]butanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;96%
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

2-decyn-1-ol
4117-14-0

2-decyn-1-ol

(2R,3S)-2-(dec-2-ynoxycarbonylamino)-3-hydroxybutanoic acid

(2R,3S)-2-(dec-2-ynoxycarbonylamino)-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; 2-decyn-1-ol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
96%
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

p-butylbenzyl alcohol
60834-63-1

p-butylbenzyl alcohol

(2R,3S)-2-({[(4-butylphenyl)methoxy]carbonyl}amino)-3-hydroxybutanoic acid

(2R,3S)-2-({[(4-butylphenyl)methoxy]carbonyl}amino)-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; p-butylbenzyl alcohol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
94%
piperonol
495-76-1

piperonol

2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

(2R,3S)-2-{[(2H-1,3-benzodioxol-5-ylmethoxy)carbonyl]amino}-3-hydroxybutanoic acid
1439368-05-4

(2R,3S)-2-{[(2H-1,3-benzodioxol-5-ylmethoxy)carbonyl]amino}-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
92%
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.337 g
Stage #1: piperonol; 2,2'-dipyridyl carbonate With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.337 g
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

[4-(cyclohexoxy)-phenyl]-methanol
13485-84-2

[4-(cyclohexoxy)-phenyl]-methanol

(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid
1439368-20-3

(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
91%
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.214 g
Stage #1: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
0.214 g
D-Threonine
632-20-2

D-Threonine

4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride
59703-00-3

4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

C11H17N3O6

C11H17N3O6

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 11h; Reagent/catalyst; Solvent; Large scale;90.2%
D-Threonine
632-20-2

D-Threonine

pentyl chloroformate
638-41-5

pentyl chloroformate

(2R,3S)-3-hydroxy-2-{[(pentyloxy)carbonyl]amino}butanoic acid
1439367-11-9

(2R,3S)-3-hydroxy-2-{[(pentyloxy)carbonyl]amino}butanoic acid

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h;90%
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h;90%
With tetrabutylammomium bromide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 18h;90%
D-Threonine
632-20-2

D-Threonine

(1S,3E)-5-<(2,5-dioxo-1-pyrrolidinyl)oxy>-1-<(1R,2E)-1-methyl-3-phenyl-2-propenyl>-5-oxo-3-pentenyl-(2S)-<3-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoate
188346-51-2

(1S,3E)-5-<(2,5-dioxo-1-pyrrolidinyl)oxy>-1-<(1R,2E)-1-methyl-3-phenyl-2-propenyl>-5-oxo-3-pentenyl-(2S)-<3-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoate

N-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-D-threonine
240428-50-6

N-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-D-threonine

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide In N,N-dimethyl-formamide at 55 - 60℃;89%
D-Threonine
632-20-2

D-Threonine

2-phenylethyl pyridin-2-yl carbonate
458560-24-2

2-phenylethyl pyridin-2-yl carbonate

2-phenylethyl 2-oxopyridine-1-carboxylate
1439367-76-6

2-phenylethyl 2-oxopyridine-1-carboxylate

(2R,3S)-3-hydroxy-2-(phenethyloxycarbonylamino)-butanoic acid
1439367-77-7

(2R,3S)-3-hydroxy-2-(phenethyloxycarbonylamino)-butanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water89%
D-Threonine
632-20-2

D-Threonine

N-ethoxycarbonylphthalimide
22509-74-6

N-ethoxycarbonylphthalimide

(2R,3S)-N-Phthaloylthreonin
103239-32-3

(2R,3S)-N-Phthaloylthreonin

Conditions
ConditionsYield
With sodium carbonate In water88%
D-Threonine
632-20-2

D-Threonine

benzyl chloroformate
501-53-1

benzyl chloroformate

(2R,3S)-2-{[(benzyloxy)carbonyl]amino}-3-hydroxybutanoic acid
5618-95-1, 19728-63-3, 41151-16-0, 85995-53-5, 119221-16-8, 80384-27-6

(2R,3S)-2-{[(benzyloxy)carbonyl]amino}-3-hydroxybutanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; for 1.5h;85%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 1h;76%
With sodium hydrogencarbonate In tetrahydrofuran; water for 18h; Ambient temperature;
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

D-Threonine
632-20-2

D-Threonine

[4-(3-bromo-2-thienyl)phenyl]methanol

[4-(3-bromo-2-thienyl)phenyl]methanol

(2R,3S)-2-[({[4-(3-bromothiophen-2-yl)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

(2R,3S)-2-[({[4-(3-bromothiophen-2-yl)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Conditions
ConditionsYield
Stage #1: 2,2'-dipyridyl carbonate; [4-(3-bromo-2-thienyl)phenyl]methanol With dmap In dichloromethane at 20℃; for 15h; Inert atmosphere;
Stage #2: D-Threonine With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 15h;
85%

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