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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 2,2-Difluorobenzodioxole-5-carboxaldehyde CAS 656-42-8 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its inter

Factory supply 2,2-Difluorobenzodioxole-5-carboxaldehyde CAS 656-42-8 with fast delivery

Cas:656-42-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM 2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2,2-Difluorobenzodioxole-5-carboxaldehyde 656-42-8

Cas:656-42-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 656-42-8 with competitive price

Cas:656-42-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--High purity 2,2-Difluorobenzodioxole-5-carboxaldehyde factory price

Cas:656-42-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1,3-Benzodioxole-5-carboxaldehyde,2,2-difluoro-

Cas:656-42-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,2-Difluorobenzodioxole-5-carboxaldehyde CAS:656-42-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

2,2-Difluorobenzodioxole-5-carboxaldehyde CAS:656-42-8

Cas:656-42-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,3-Benzodioxole-5-carboxaldehyde,2,2-difluoro-

Cas:656-42-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,2-Difluoro-5-formylbenzodioxole

Cas:656-42-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,3-Benzodioxole-5-carboxaldehyde,2,2-difluoro-

Cas:656-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,2-Difluorobenzodioxole-5-carboxaldehyde /High quality/Best price

Cas:656-42-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,2-Difluoro-5-formylbenzodioxole

Cas:656-42-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2,2-Difluorobenzodioxole-5-carboxaldehyde Chemical Properties Boiling point 202-203 °C(lit.) density 1.422 g/mL at 25 °C(lit.) refractive index n20/D 1.5000(lit.) Fp 205 °F storage temp. Keep in dark place,Sealed in dr

2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--High purity 2,2-Difluorobenzodioxole-5-carboxaldehyde factory price

Cas:656-42-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

656-42-8 Appearance:95%+ Package:R&D,Pilot run Application:656-42-8 Transportation:per client require Port:Express ,Air, Sea

1,3-Benzodioxole-5-carboxaldehyde,2,2-difluoro-

Cas:656-42-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--High purity 2,2-Difluorobenzodioxole-5-carboxaldehyde factory price

Cas:656-42-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--High purity 2,2-Difluorobenzodioxole-5-carboxaldehyde factory price

Cas:656-42-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2,2-Difluorobenzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2,2-Difluoro-5-formylbenzodioxole

Cas:656-42-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--High purity 2,2-Difluorobenzodioxole-5-carboxaldehyde factory price

Cas:656-42-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Cas:656-42-8

Min.Order:0

Negotiable

Type:Trading Company

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hangzhou verychem science and technology co.ltd

Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested two pharmaceutical raw material production plants, one researching company, and several

2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde cas no. 656-42-8 98%

Cas:656-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde

Cas:656-42-8

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

2-thioxobenzo[d][1,3]dioxole-5-carbaldehyde
1269252-03-0

2-thioxobenzo[d][1,3]dioxole-5-carbaldehyde

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Conditions
ConditionsYield
With bromine trifluoride In CFCl3; chloroform at 0℃; for 0.0166667h;95%
5-dichloromethyl-2,2-difluorobenzo-(1,3)-dioxole
149045-78-3

5-dichloromethyl-2,2-difluorobenzo-(1,3)-dioxole

hexamethylenetetramine
100-97-0

hexamethylenetetramine

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Conditions
ConditionsYield
With hydrogenchloride In water
5-bromo-2,2-difluoro-2H-1,3-benzodioxole
33070-32-5

5-bromo-2,2-difluoro-2H-1,3-benzodioxole

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Conditions
ConditionsYield
Stage #1: 5-bromo-2,2-difluoro-2H-1,3-benzodioxole With n-butyllithium In tetrahydrofuran for 0.166667h; Cooling with acetone-dry ice;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 2h; Cooling with acetone-dry ice;
Stage #3: With water; ammonium chloride In tetrahydrofuran
Stage #1: 5-bromo-2,2-difluoro-2H-1,3-benzodioxole With isopropylmagnesium chloride In tetrahydrofuran at -10 - 0℃; for 5h; Inert atmosphere; Large scale;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -25℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;
28.6 g
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / water / 2 h / 0 °C
2: bromine trifluoride / CFCl3; chloroform / 0.02 h / 0 °C
View Scheme
2,2-difluoro-1,3-benzodioxole
1583-59-1

2,2-difluoro-1,3-benzodioxole

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iron; bromine / 20 - 30 °C / Inert atmosphere; Large scale
2.1: isopropylmagnesium chloride / tetrahydrofuran / 5 h / -10 - 0 °C / Inert atmosphere; Large scale
2.2: 2 h / -25 °C / Inert atmosphere; Large scale
View Scheme
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxylate

tert-butyl 4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran at 0 - 20℃;99%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 16h;
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

(S)-N-[(1E)-(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2-methylpropane-2-sulfinamide

(S)-N-[(1E)-(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2-methylpropane-2-sulfinamide

Conditions
ConditionsYield
With copper(II) sulfate In dichloromethane at 18 - 25℃; for 16h; Inert atmosphere;95%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

toluene-4-sulfonic acid hydrazide
1576-35-8

toluene-4-sulfonic acid hydrazide

N'-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)-4-methylbenzenesulfonohydrazide

N'-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)-4-methylbenzenesulfonohydrazide

Conditions
ConditionsYield
In ethanol Reflux;88%
In methanol at 20℃; for 12h; Inert atmosphere; Sealed tube;
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

2,2-difluoro-5-vinylbenzo[d][1,3]dioxole

2,2-difluoro-5-vinylbenzo[d][1,3]dioxole

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.25h; Schlenk technique; Inert atmosphere;
Stage #2: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In tetrahydrofuran at 0 - 25℃; for 48h; Schlenk technique; Inert atmosphere;
85%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;
80%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;
76%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.25h; Schlenk technique; Inert atmosphere;
Stage #2: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In tetrahydrofuran at 0 - 20℃; Schlenk technique; Inert atmosphere;
50%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

2-heptylamine
123-82-0

2-heptylamine

C15H21F2NO2

C15H21F2NO2

Conditions
ConditionsYield
With triethylsilane; palladium on carbon; TPGS-750-M In water at 45℃; for 4h;85%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

methylmagnesium bromide
75-16-1

methylmagnesium bromide

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethan-1-ol
1009032-10-3

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethan-1-ol

Conditions
ConditionsYield
Stage #1: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde; methylmagnesium bromide In diethyl ether at 0 - 20℃; for 0.25 - 0.333333h;
Stage #2: With water at 0℃;
83.5%
piperazine
110-85-0

piperazine

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine
1093211-85-8

1-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine

Conditions
ConditionsYield
With hydrogen; 20% palladium hydroxide-activated charcoal In methanol; toluene at 20 - 70℃; under 760.051 Torr; for 36h;83%
Stage #1: piperazine; 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In methanol at 20℃; for 18h;
Stage #2: With 20% palladium hydroxide on charcoal; hydrogen In methanol at 70℃; under 760.051 Torr;
83%
Stage #1: piperazine; 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde In methanol at 20℃; for 18h; Inert atmosphere;
Stage #2: With 10 wt% Pd(OH)2 on carbon; hydrogen In methanol at 70℃; under 760.051 Torr;
83%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

cyclohexylamine
108-91-8

cyclohexylamine

N-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]cyclohexanamine
1443830-94-1

N-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]cyclohexanamine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In dichloromethane at 25℃; Molecular sieve;82%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid hydrazide
662157-81-5

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid hydrazide

2',4'-difluoro-4-hydroxy-N'-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylidene] biphenyl-3-carbohydrazide

2',4'-difluoro-4-hydroxy-N'-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylidene] biphenyl-3-carbohydrazide

Conditions
ConditionsYield
In ethanol for 2h; Reflux;82%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

(1S,3S,4R)-4-[(3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methylidene-octahydro-1H-inden-5-yl]-3-(hydroxymethyl)-4-methylcyclohexan-1-ol

(1S,3S,4R)-4-[(3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methylidene-octahydro-1H-inden-5-yl]-3-(hydroxymethyl)-4-methylcyclohexan-1-ol

(1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylamino)methyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol

(1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylamino)methyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol

Conditions
ConditionsYield
Stage #1: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde; (1S,3S,4R)-4-[(3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methylidene-octahydro-1H-inden-5-yl]-3-(hydroxymethyl)-4-methylcyclohexan-1-ol In methanol for 0.5h; Reflux; Inert atmosphere;
Stage #2: With methanol; sodium tetrahydroborate at 20℃; Inert atmosphere;
81%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

N-methyl-N-tosylpropiolamide

N-methyl-N-tosylpropiolamide

(±)-(4R,5R)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-2-methyl-4-(p-tolyl)isothiazolidin-3-one 1,1-dioxide

(±)-(4R,5R)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-2-methyl-4-(p-tolyl)isothiazolidin-3-one 1,1-dioxide

Conditions
ConditionsYield
With eosin Y disodium salt In acetonitrile at 80℃; for 48h; Smiles Aromatic Rearrangement; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation; diastereoselective reaction;80%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

(2,2-difluoro-1,3-benzodioxol-5-yl)methanol
72768-97-9

(2,2-difluoro-1,3-benzodioxol-5-yl)methanol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20 - 30℃; for 3.5h; Reagent/catalyst; Inert atmosphere; Large scale;77.7%
With methanol; sodium tetrahydroborate
tetrahydrofuran-2,4-dione
4971-56-6

tetrahydrofuran-2,4-dione

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1,10-phenanthroline-5-amine
54258-41-2

1,10-phenanthroline-5-amine

(9aR,13S)-13-((3,4-difluoromethylenedioxy)phenyl)-9a-hydroxy-9a,10,12a,13-tetrahydrofuro[3,4-b]pyrido[3,2-f][1,10]phenanthrolin-12(9H)-one

(9aR,13S)-13-((3,4-difluoromethylenedioxy)phenyl)-9a-hydroxy-9a,10,12a,13-tetrahydrofuro[3,4-b]pyrido[3,2-f][1,10]phenanthrolin-12(9H)-one

Conditions
ConditionsYield
In ethanol Reflux;77%
1-Phenylprop-1-yne
673-32-5

1-Phenylprop-1-yne

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-4-phenylbut-3-yn-1-ol

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-4-phenylbut-3-yn-1-ol

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; (1,2,3,4,5-pentamethylcyclopentadienyl)(tetrahydrofuran)dicarbonyliron(II) tetrafluoroborate; boron trifluoride diethyl etherate In toluene at 100℃; for 24h;76%
4-hydroxy-2(5H)-furanone
541-57-1

4-hydroxy-2(5H)-furanone

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

9-(2,2-difluoro-1,3-benzodioxol-5-yl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one
867069-17-8

9-(2,2-difluoro-1,3-benzodioxol-5-yl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one

Conditions
ConditionsYield
Inert atmosphere; Reflux;75%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-(trimethylsilyloxy)acetonitrile

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-(trimethylsilyloxy)acetonitrile

Conditions
ConditionsYield
Stage #1: 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde With zinc(II) iodide In dichloromethane at 10 - 15℃;
Stage #2: trimethylsilyl cyanide In dichloromethane at 20℃; for 1h;
75%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1,10-phenanthroline-5,6-dione
27318-90-7

1,10-phenanthroline-5,6-dione

2-(3',3'-difluoro-3,4-methylenedioxyphenyl)imidazo[4,5-f][1,10]phenanthroline
1187485-75-1

2-(3',3'-difluoro-3,4-methylenedioxyphenyl)imidazo[4,5-f][1,10]phenanthroline

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 2h; Reflux;74%
With ammonium acetate; acetic acid for 2h; Reflux;74%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

[1-(6-ethyl-4,4-dimethyI-1,2,3,4-tetrahydro-quinolin-7-yl)-ethyl]-carbamic acid tert-butyl ester
1254928-30-7

[1-(6-ethyl-4,4-dimethyI-1,2,3,4-tetrahydro-quinolin-7-yl)-ethyl]-carbamic acid tert-butyl ester

{1-[1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-6-ethyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl]-ethyl}-carbamic acid tert-butyl ester
1254928-67-0

{1-[1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-6-ethyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With sodium cyanoborohydride In tetrahydrofuran at 65℃; for 20h; sealed tube;74%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

3,4-(difluoromethylenedioxy)-6-nitrobenzaldehyde
294619-51-5

3,4-(difluoromethylenedioxy)-6-nitrobenzaldehyde

Conditions
ConditionsYield
With nitric acid; trifluoroacetic acid In dichloromethane at -60 - 4℃; Nitration;73%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

(2,2-difluorobenzo-1,3-dioxol-5-yl)methyl 2,2-difluorobenzo-1,3-dioxole-5-carboxylate
1219810-39-5

(2,2-difluorobenzo-1,3-dioxol-5-yl)methyl 2,2-difluorobenzo-1,3-dioxole-5-carboxylate

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium formate; cyclohexyldiphenylphosphine In 1,4-dioxane at 80℃; for 20h; Tishchenko reaction; Inert atmosphere;73%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

1-(2,2-difluorobenzo[1,3]dioxan-5-yl)ethanone oxime
146322-07-8

1-(2,2-difluorobenzo[1,3]dioxan-5-yl)ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In methanol at 20℃; for 6h;72%
pyrrolidine
123-75-1

pyrrolidine

4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

C21H17F2NO5

C21H17F2NO5

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;71%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

4-Phenyl-1-butene
768-56-9

4-Phenyl-1-butene

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-methyl-4-phenylbutan-1-ol

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-methyl-4-phenylbutan-1-ol

Conditions
ConditionsYield
With chromium chloride; (±)N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II); phenylsilane; 1-fluoro-2,4,6-trimethylpyridin-1-ium tetrafluoroborate In tetrahydrofuran; acetonitrile at 22℃; for 24h; Inert atmosphere; chemoselective reaction;71%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

malonic acid
141-82-2

malonic acid

3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acrylic acid
721-13-1

3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acrylic acid

Conditions
ConditionsYield
With piperidine; pyridine for 3h; Heating / reflux;70%
With piperidine In pyridine for 3h; Heating / reflux;70%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

malonic acid
141-82-2

malonic acid

3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acrylic acid
387350-55-2

3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acrylic acid

Conditions
ConditionsYield
With pyridine; piperidine for 3h; Knoevenagel Condensation; Heating / reflux;70%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

2-bromoprop-1-ene
557-93-7

2-bromoprop-1-ene

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)butan-1-one

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)butan-1-one

Conditions
ConditionsYield
With acetylacetonatodicarbonylrhodium(l); potassium formate; potassium carbonate; triphenylphosphine In 1,2-dimethoxyethane at 130℃; for 16h; Inert atmosphere; Sealed tube;66%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; Inert atmosphere;64%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

2-[(2-carboxyacetyl)amino]benzoic acid
53947-84-5

2-[(2-carboxyacetyl)amino]benzoic acid

(E)-2-[[3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]amino]benzoic acid

(E)-2-[[3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]amino]benzoic acid

Conditions
ConditionsYield
With piperidine In toluene for 0.5h; Knoevenagel Condensation; Dean-Stark; Reflux;62%
2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde
656-42-8

2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde

sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

5-(2,2-difluorovinyl)-2,2-difluorobenzo[d][1,3]dioxole

5-(2,2-difluorovinyl)-2,2-difluorobenzo[d][1,3]dioxole

Conditions
ConditionsYield
With triphenylphosphine In N,N-dimethyl-formamide at 100℃; Inert atmosphere;62%

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