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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-[1-Hydroxy-2-(2, 4, 5-trifluorophenyl)-4, 6-dionethylidene]-2, 2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione 764667-64-3

Cas:764667-64-3

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

99% PureCAS 764667-64-3 with best price

Cas:764667-64-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione CAS764667-64-3

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,3-Dioxane-4,6-dione,5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl- 764667-64-3

Cas:764667-64-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione CAS:764667-64-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of ch

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione CAS:764667-64-3

Cas:764667-64-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,3-Dioxane-4,6-dione,5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-1-Hydroxy-2-(2,4,5-Trifluorophenyl)Ethylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM - 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione/High quality/Best price

Cas:764667-64-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-1-Hydroxy-2-(2,4,5-Trifluorophenyl)Ethylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione

Cas:764667-64-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 5-1-Hydroxy-2-(2,4,5-Trifluorophenyl)Ethylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS No.: 764667-64-3 Molecule Formula:C14H11F3O5 Molecule Weight:316.23 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Stan

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM - 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl- 1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM - 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU-CHEM - 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU-CHEM - 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1,3-Dioxane-4,6-dione,5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

5-1-Hydroxy-2-(2,4,5-Trifluorophenyl)Ethylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione

Cas:764667-64-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Synthetic route

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 45℃; for 3h;95%
With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20 - 50℃;94%
With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 45 - 55℃;94%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

2-(2,4,5-trifluorophenyl)acetyl chloride
1176895-65-0

2-(2,4,5-trifluorophenyl)acetyl chloride

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
With collidine In dichloromethane at -5 - 0℃; for 4h; Product distribution / selectivity; Inert atmosphere;
Stage #1: cycl-isopropylidene malonate; 2-(2,4,5-trifluorophenyl)acetyl chloride In dichloromethane at -5 - 30℃; for 4h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water at 0 - 5℃; Product distribution / selectivity;
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 - 25 °C
2.1: dichloromethane / 4 h / -5 - 30 °C / Inert atmosphere
2.2: 0 - 5 °C
View Scheme
2-oxo-2-(2,4,5-trifluorophenyl)acetamide

2-oxo-2-(2,4,5-trifluorophenyl)acetamide

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 5 h / 70 °C / Inert atmosphere
2: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
3: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
(2,4,5-trifluorophenyl)oxoacetic acid

(2,4,5-trifluorophenyl)oxoacetic acid

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
2: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium fluoride; tetraphenylphosphonium bromide; 18-crown-6 ether / 1,2-dichloro-benzene / 15 h / 120 - 130 °C / Inert atmosphere
2: 1,2-dichloro-benzene / 140 °C
3: potassium fluoride / 1,2-dichloro-benzene / 7 h / 110 °C / Inert atmosphere
4: sulfuric acid; sodium chloride / water / 8 h / 20 °C / Inert atmosphere
5: hydrogenchloride / water / 5 h / 70 °C / Inert atmosphere
6: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
7: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
2-chloro-4,5-difluorobenzoyl fluoride

2-chloro-4,5-difluorobenzoyl fluoride

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1,2-dichloro-benzene / 140 °C
2: potassium fluoride / 1,2-dichloro-benzene / 7 h / 110 °C / Inert atmosphere
3: sulfuric acid; sodium chloride / water / 8 h / 20 °C / Inert atmosphere
4: hydrogenchloride / water / 5 h / 70 °C / Inert atmosphere
5: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
6: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
2,4,5-trifluorobenzoyl fluoride

2,4,5-trifluorobenzoyl fluoride

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium fluoride / 1,2-dichloro-benzene / 7 h / 110 °C / Inert atmosphere
2: sulfuric acid; sodium chloride / water / 8 h / 20 °C / Inert atmosphere
3: hydrogenchloride / water / 5 h / 70 °C / Inert atmosphere
4: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
5: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
2,4,5-trifluorobenzene-1-carbonyl cyanide

2,4,5-trifluorobenzene-1-carbonyl cyanide

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; sodium chloride / water / 8 h / 20 °C / Inert atmosphere
2: hydrogenchloride / water / 5 h / 70 °C / Inert atmosphere
3: phosphonic Acid; iodine; methanesulfonic acid / 24 h / 110 °C
4: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / N,N-dimethyl acetamide / 3 h / 5 - 40 °C / Inert atmosphere
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
764667-65-4

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione

Conditions
ConditionsYield
With 4-methyl-morpholine In ethyl acetate for 6h; Reflux;98.1%
With N-ethyl-N,N-diisopropylamine In Isopropyl acetate at 85℃; for 4h;93.3%
With N-ethyl-N,N-diisopropylamine In Isopropyl acetate at 85℃; for 3.5h;92%
propan-1-ol
71-23-8

propan-1-ol

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

3-oxo-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

3-oxo-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 51℃; Kinetics;97%
In N,N-dimethyl acetamide at 51℃;97%
aniline
62-53-3

aniline

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluorophenyl)-3-oxo-N-phenylbutanamide

4-(2,4,5-trifluorophenyl)-3-oxo-N-phenylbutanamide

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 50.8℃; Kinetics;92%
In N,N-dimethyl acetamide at 50.8℃;92%
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
486460-21-3

3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
764667-65-4

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 41.1℃; Kinetics; Further Variations:; Temperatures;91%
benzyl alcohol
100-51-6

benzyl alcohol

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

benzyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

benzyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
In toluene Reflux;90%
In acetonitrile at 80 - 84℃; for 24h; Inert atmosphere;81.6%
In acetonitrile for 2h; Reflux;
methanol
67-56-1

methanol

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
In toluene for 3h; Heating;88.7%
at 60 - 63℃;
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
With methanol at 60 - 63℃;85%
In methanol Reflux;
(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

tert-butyl 3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-but-2-enoate
1345822-93-6

tert-butyl 3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-but-2-enoate

Conditions
ConditionsYield
With acetic acid In tert-butyl alcohol at 30 - 82℃; for 8h;83%
C6H3(2)H4F3N4*ClH

C6H3(2)H4F3N4*ClH

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

C16H8(2)H4F6N4O2

C16H8(2)H4F6N4O2

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 80℃; for 2h; Temperature;82.72%
(R)-2-methylpropane-2-sulfinamide
196929-78-9

(R)-2-methylpropane-2-sulfinamide

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

C18H20F3NO5S

C18H20F3NO5S

Conditions
ConditionsYield
In acetonitrile at 65℃;81%
(R)-2-Ethyl-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester

(R)-2-Ethyl-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

8-methyl-5-oxo-7-(2,4,5-trifluoro-benzyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid ethyl ester

8-methyl-5-oxo-7-(2,4,5-trifluoro-benzyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride In 1,2-dichloro-ethane at 65℃; for 3h;80%
piperidine
110-89-4

piperidine

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

1-(1-piperidinyl)-4-(2,4,5-trifluorophenyl)-1,3-butanedione

1-(1-piperidinyl)-4-(2,4,5-trifluorophenyl)-1,3-butanedione

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 50.9℃; Kinetics;78%
In N,N-dimethyl acetamide at 50.9℃;78%
N,N-di(tert-butoxycarbonyl)hydroxylamine
85006-25-3

N,N-di(tert-butoxycarbonyl)hydroxylamine

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

C20H24F3NO7

C20H24F3NO7

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 50.8℃; Kinetics; Further Variations:; Temperatures;78%
In N,N-dimethyl acetamide at 50.8℃;78%
ethyl (R)-4,5-dihydrothiazole-4-carboxylate
206876-90-6

ethyl (R)-4,5-dihydrothiazole-4-carboxylate

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(2R,5S,6R)-7-Oxo-6-[2-(2,4,5-trifluoro-phenyl)-acetyl]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethyl ester

(2R,5S,6R)-7-Oxo-6-[2-(2,4,5-trifluoro-phenyl)-acetyl]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride In benzene Heating;41%
aniline hydrochloride
142-04-1

aniline hydrochloride

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluorophenyl)-3-oxo-N-phenylbutanamide

4-(2,4,5-trifluorophenyl)-3-oxo-N-phenylbutanamide

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 48.5℃; Kinetics;92 % Chromat.
N-benzylidenemethylamine
25521-74-8

N-benzylidenemethylamine

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

3-methyl-2-phenyl-6-(2,4,5-trifluoro-benzyl)-2,3-dihydro-[1,3]oxazin-4-one

3-methyl-2-phenyl-6-(2,4,5-trifluoro-benzyl)-2,3-dihydro-[1,3]oxazin-4-one

Conditions
ConditionsYield
In acetonitrile at 55℃; for 5h;
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: 60 - 63 °C
2.1: ammonium acetate / methanol / 60 - 63 °C
3.1: sulfuric acid / methanol / -10 - 0 °C
3.2: 2 h / -10 - 0 °C
3.3: pH 8 - 9
4.1: isopropyl alcohol / 3 h / 25 - 30 °C
5.1: sodium carbonate / water / pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 24 h / 80 - 84 °C / Inert atmosphere
2: salicylic acid; ammonium acetate; Ru(OAc)2((R)-dm-Segphos); hydrogen / 20 h / 40 - 80 °C / Green chemistry
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-73-9

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-16-6

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-17-7

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-18-8

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

C13H16F3N3O*HCl

C13H16F3N3O*HCl

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
7: 99 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-27-9

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
7: 85 percent / CH2Cl2 / 2 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester
939964-28-0

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
7: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-(2-benzoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-29-1

(R)-[3-(2-benzoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
7: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-[3-(2-benzoyltetrahydropyridazin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-30-4

(R)-[3-(2-benzoyltetrahydropyridazin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
7: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
939964-31-5

tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
6: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
7: 84 percent / Et3N / CH2Cl2 / 3 h / 20 °C
View Scheme
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