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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ramipril Manufacturer/High quality/Best price/In stock

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ramipril Manufacturer/High quality

Cas:87333-19-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:2-8°C Packag

Manufacturer supply Ramipril CAS 87333-19-5 with good quality

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $730.0 / 890.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ramipril

Cas:87333-19-5

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Ramipril 87333-19-5 GMP Manufacturer

Cas:87333-19-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ramipril

Cas:87333-19-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU-CHEM--Ramipril

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Ramipril Powder, CAS 87333-19-5

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 87333-19-5 with competitive price

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ramipril Manufacturer/High quality

Cas:87333-19-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ramipril/ LIDE PHARMA- Factory supply / Best price

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers

CAS 87333-19-5 Purity Raw Ramipril Powder to Treat High Blood Pressure

Cas:87333-19-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ramipril 87333-19-5

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei TNJ chemical industry co.,ltd

Good products, good service. We have professional sales team working on sales service for 15 years. Good products can win good market but can not stand long without good service. We have strict sales regulation and service procedure to make sure yo

TNJ Ramipril

Cas:87333-19-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Ramipril Synonyms: PRAMACE;RAMIPRIL;RAMACE;UNIPRIL;TRITACE;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;cyclopenta(b)pyrrole-2-carboxylicacid,octahydro-1-(2-((1-(ethoxycarbonyl)-3-p;[2S,3AS,6AS]-1-[(2S)-2-[

Ramipril 87333-19-5 EP9.0 large in supply

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Cardiovascular Agents,Ramipril CAS:87333-19-5

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $52.4 / 58.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ramipril CAS:87333-19-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Ramipril CAS:87333-19-5

Cas:87333-19-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ramipril

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Ramipril CAS87333-19-5

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:87333-19-5

Cas:87333-19-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Ramipril CAS 87333-19-5 Factory Supply Manufactory

Cas:87333-19-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Ramipril CAS: 87333-19-5 Specification Items Specifications Results Appearance White or almost white crystalline powder White crystalline powder Specific rotation +32°~+38° +34.5° Pa

Factory supply Ramipril

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Ramipril

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Ramipril manufacturer with low price

Cas:87333-19-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ramipril

Cas:87333-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Ramipril

Cas:87333-19-5

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

HOE-498 Ramipril 87333-19-5

Cas:87333-19-5

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ramipril

Cas:87333-19-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Ramipril CAS 87333-19-5 with Best Price

Cas:87333-19-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ramipril

Cas:87333-19-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester
87269-88-3

2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol at 0 - 10℃; under 1838.94 - 2206.73 Torr;95%
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 760.051 Torr; for 1.5h; Product distribution / selectivity;80%
With hydrogen; 3% Pd/C In ethanol at 20 - 25℃; under 760.051 Torr; for 1 - 3h; Product distribution / selectivity;78%
(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid monohydrate

(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid monohydrate

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
at 40℃; under 2 Torr; for 10 - 12h; Product distribution / selectivity;94%
N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride
114192-42-6

N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid
109428-53-7

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Stage #1: (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid With sodium ethanolate; triethylamine In ethanol at -40℃;
Stage #2: N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride In ethanol; dichloromethane at -50 - 20℃; for 1.08333h;
Stage #3: With hydrogenchloride In water pH=4.2; Acidic aqueous solution;
88%
C8H13NO2*(x)ClH

C8H13NO2*(x)ClH

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
With sodium hydroxide In water at 10 - 15℃; pH=8.5 - 9.5;74%
benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride
87269-87-2, 87679-25-2, 88547-79-9, 93779-29-4, 94569-19-4, 138877-09-5

benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
With acetic acid; triethylamine In ethyl acetate at 5 - 20℃; for 4h;74%
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine / CH2Cl2 / 0.75 h
1.2: 45 percent / CH2Cl2 / 2.5 h / 25 - 30 °C
2.1: triethylamine / CH2Cl2 / 4 h / -15 - -10 °C
3.1: hydrogen / Pd/C
View Scheme
N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanine-2'-benzothiazolylthio ester
124492-03-1

N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanine-2'-benzothiazolylthio ester

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / CH2Cl2 / 4 h / -15 - -10 °C
2: hydrogen / Pd/C
View Scheme
ethyl (E)-4-oxo-4-phenyl-2-butenoate
15121-89-8

ethyl (E)-4-oxo-4-phenyl-2-butenoate

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) 2N NaOH, 2.) N(C2H5)3 / 1.) methylene chloride, 2.) ethanol, 2 h
2: 90 percent / H2, 1.6percent H2SO4 / 10percent Pd/C / acetic acid / 7 h / 30002.4 Torr / Ambient temperature
3: 95 percent / K2CO3, 25percent ethylmethylphosphinic anhydride / H2O; CH2Cl2
4: H2 / 10percent Pd/C / methanol / 0.5 h / 750.06 - 3750.3 Torr / Ambient temperature
View Scheme
benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride
87269-87-2, 87679-25-2, 88547-79-9, 93779-29-4, 94569-19-4, 138877-09-5

benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / K2CO3, 25percent ethylmethylphosphinic anhydride / H2O; CH2Cl2
2: H2 / 10percent Pd/C / methanol / 0.5 h / 750.06 - 3750.3 Torr / Ambient temperature
View Scheme
(1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeurebenzylester-hydrochlorid
87269-87-2, 87679-25-2, 88547-79-9, 93779-29-4, 94569-19-4, 138877-09-5

(1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeurebenzylester-hydrochlorid

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 67.8 g / 1.) 10percent NaOH 2.) 6N HCl / CH2Cl2; ethyl acetate
2: 95 percent / K2CO3, 25percent ethylmethylphosphinic anhydride / H2O; CH2Cl2
3: H2 / 10percent Pd/C / methanol / 0.5 h / 750.06 - 3750.3 Torr / Ambient temperature
View Scheme
(1'S,2S)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester
87269-98-5

(1'S,2S)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / H2, 1.6percent H2SO4 / 10percent Pd/C / acetic acid / 7 h / 30002.4 Torr / Ambient temperature
2: 95 percent / K2CO3, 25percent ethylmethylphosphinic anhydride / H2O; CH2Cl2
3: H2 / 10percent Pd/C / methanol / 0.5 h / 750.06 - 3750.3 Torr / Ambient temperature
View Scheme
N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine
87269-99-6

N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / K2CO3, 25percent ethylmethylphosphinic anhydride / H2O; CH2Cl2
2: H2 / 10percent Pd/C / methanol / 0.5 h / 750.06 - 3750.3 Torr / Ambient temperature
View Scheme
(1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeure-hydrochlorid
87269-86-1, 87758-19-8, 93779-30-7, 94062-51-8, 96893-64-0, 135214-81-2

(1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeure-hydrochlorid

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

A

ramipril
129939-63-5

ramipril

B

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid

(S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride
87269-86-1

(S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Stage #1: (2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid; (S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride With sodium hydroxide; hydrogenation catalyst In water at 20 - 25℃; pH=10 - 11;
Stage #2: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride In water at 20 - 25℃; for 3 - 4h; pH=10 - 11;
Stage #3: With hydrogenchloride In water at 15 - 20℃; for 2.5 - 2.75h; pH=4.4 - 5.2; Product distribution / selectivity;
benzyl (1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylate
93779-31-8

benzyl (1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylate

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; (chloromethylene)dimethyliminium chloride / N,N-dimethyl-formamide; dichloromethane / 0.42 h / -10 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere
View Scheme
(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride

(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / acetic acid / 40 - 60 °C / 3750.38 - 4500.45 Torr
2: thionyl chloride / 0 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
4: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride
87269-86-1

(S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / 0 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride
87269-87-2, 87679-25-2, 88547-79-9, 93779-29-4, 94569-19-4, 138877-09-5

benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
2: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid p-toluene sulfonic acid salt

(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid p-toluene sulfonic acid salt

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen / water / 55 - 60 °C / 4125.41 - 4500.45 Torr
2.1: water / 1 h / 15 - 55 °C
2.2: 0 - 5 °C
3.1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(±)-methyl 2-(acetylamino)-3-(2-oxocyclopentyl)-propionate
87269-85-0

(±)-methyl 2-(acetylamino)-3-(2-oxocyclopentyl)-propionate

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: immozyme alkaline serine endopeptidase; sodium carbonate / water / 20 h / 24 - 26 °C / pH 6.2 - 6.8 / Enzymatic reaction
2: hydrogenchloride / water / 3 h / Reflux
3: 5%-palladium/activated carbon; hydrogen / acetic acid / 40 - 60 °C / 3750.38 - 4500.45 Torr
4: thionyl chloride / 0 - 30 °C
5: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
6: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid p-toluene sulfonic acid salt

(2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid p-toluene sulfonic acid salt

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: water / 1 h / 15 - 55 °C
1.2: 0 - 5 °C
2.1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid
109428-53-7

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

Ramipril
87333-19-5

Ramipril

(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: water / Reflux
2.1: hydrogen / water / 55 - 60 °C / 4125.41 - 4500.45 Torr
3.1: water / 1 h / 15 - 55 °C
3.2: 0 - 5 °C
4.1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
5.1: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(+)-(2S)-acetylamino-3-(2-oxocyclopentyl)propionic acid

(+)-(2S)-acetylamino-3-(2-oxocyclopentyl)propionic acid

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / water / 3 h / Reflux
2: 5%-palladium/activated carbon; hydrogen / acetic acid / 40 - 60 °C / 3750.38 - 4500.45 Torr
3: thionyl chloride / 0 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / toluene / 1 h / 0 - 5 °C
5: 5%-palladium/activated carbon; hydrogen / ethanol / 20 - 22 °C / 2327.23 - 2585.81 Torr
View Scheme
(2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

(2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water; ethyl acetate / 0.08 h / 15 °C
1.2: 1.08 h / 20 °C
2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C / 760.05 Torr
View Scheme
(2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

(2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

Ramipril
87333-19-5

Ramipril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 h / -10 - -5 °C / Inert atmosphere
1.2: 0.01 h
2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C / 760.05 Torr
View Scheme
L-arginine
74-79-3

L-arginine

Ramipril
87333-19-5

Ramipril

ramipril-(L)-arginine

ramipril-(L)-arginine

Conditions
ConditionsYield
In water; isopropyl alcohol at 20℃; for 0.5h;98%
In butanone for 0.5h; Product distribution / selectivity; Heating / reflux;
Ramipril
87333-19-5

Ramipril

(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid monohydrate

(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid monohydrate

Conditions
ConditionsYield
With water In di-isopropyl ether for 1 - 1.5h; Product distribution / selectivity;86%
With water for 1 - 1.5h; Product distribution / selectivity;86%
With water In formaldehyde diethyl acetal for 1 - 1.5h; Product distribution / selectivity;85%
Ramipril
87333-19-5

Ramipril

tert-butylamine
75-64-9

tert-butylamine

ramipril tert-butylamine salt
1028843-42-6

ramipril tert-butylamine salt

Conditions
ConditionsYield
In water; ethyl acetate at 20 - 40℃;79%
In ethyl acetate at 10℃; for 1h;67%
In ethyl acetate at 50 - 70℃;
Ramipril
87333-19-5

Ramipril

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

ramipril tris(hydroxymethyl)aminomethane salt
1187092-62-1

ramipril tris(hydroxymethyl)aminomethane salt

Conditions
ConditionsYield
In ethanol; water at 20 - 40℃;75%
1,1-Diphenylethylene
530-48-3

1,1-Diphenylethylene

Ramipril
87333-19-5

Ramipril

3-((2S,3aS,6aS)-1-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)octahydrocyclopenta[b]pyrrol-2-yl)-2,2-diphenylpropanoic acid

3-((2S,3aS,6aS)-1-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)octahydrocyclopenta[b]pyrrol-2-yl)-2,2-diphenylpropanoic acid

Conditions
ConditionsYield
With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; cesium fluoride In N,N-dimethyl acetamide at 25 - 30℃; for 8h; Irradiation; Inert atmosphere; Schlenk technique; Molecular sieve; regioselective reaction;72%
Ramipril
87333-19-5

Ramipril

C23H38N2O5

C23H38N2O5

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen; acetic acid In ethanol at 30℃; under 1292.9 - 1551.49 Torr; for 24h; Temperature;66%
Ramipril
87333-19-5

Ramipril

ramipril-ammonia
1028843-43-7

ramipril-ammonia

Conditions
ConditionsYield
With ammonia In ethanol; ethyl acetate at 32.5 - 37.5℃; for 1h;57%
benzyl bicyclo[1.1.0]butane-1-carboxylate

benzyl bicyclo[1.1.0]butane-1-carboxylate

Ramipril
87333-19-5

Ramipril

benzyl 3-((3aR,6aR)-1-(((R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-D-alanyl)octahydrocyclopenta[b]pyrrol-2-yl)cyclobutane-1-carboxylate

benzyl 3-((3aR,6aR)-1-(((R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-D-alanyl)octahydrocyclopenta[b]pyrrol-2-yl)cyclobutane-1-carboxylate

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; caesium carbonate In N,N-dimethyl acetamide; water for 24h; Sealed tube; Irradiation; Inert atmosphere;31%
Ramipril
87333-19-5

Ramipril

ramiprilate
87269-97-4

ramiprilate

Conditions
ConditionsYield
at 37℃; esterase from various rat tissue homogenates or plasma;
With porcine liver esterase In phosphate buffer at 37℃; pH=8.6;
Stage #1: Ramipril With sodium hydroxide In methanol; water at 60℃; for 0.0833333h;
Stage #2: In methanol; water Acidic conditions;
With recombinant human carboxylesterase 1; water In aq. phosphate buffer at 37℃; for 0.133333h; Kinetics; Enzymatic reaction;
Ramipril
87333-19-5

Ramipril

ramipril diketopiperazine

ramipril diketopiperazine

Conditions
ConditionsYield
In isopropyl alcohol Heating; Yield given;
Stage #1: Ramipril With hydrogenchloride; water In methanol at 80℃; for 30h;
Stage #2: In methanol Acidic conditions;
L-lysine
56-87-1

L-lysine

Ramipril
87333-19-5

Ramipril

ramipril-(L)-lysine

ramipril-(L)-lysine

Conditions
ConditionsYield
In butanone for 0.5h; Heating / reflux;
Ramipril
87333-19-5

Ramipril

(2S,3aS,6aS)-1[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 1-ethyl ester sodium salt
934623-96-8

(2S,3aS,6aS)-1[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 1-ethyl ester sodium salt

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 20℃; for 1h;
Ramipril
87333-19-5

Ramipril

ramipril hemicalcium

ramipril hemicalcium

Conditions
ConditionsYield
With calcium hydroxide In butanone for 1h; Heating / reflux;
Ramipril
87333-19-5

Ramipril

(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
103129-81-3

(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

ramipril-amlodipine salt
1029898-76-7

ramipril-amlodipine salt

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 0.0333333h;
Ramipril
87333-19-5

Ramipril

amlodipine
103129-82-4

amlodipine

ramipril-amlodipine salt
1029898-78-9

ramipril-amlodipine salt

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 0.0333333h;

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