high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:873697-71-3
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:873697-71-3
Min.Order:1
Negotiable
Type:Other
inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
Cas:873697-71-3
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:873697-71-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOMecaMtiv Mecarbil CAS:873697-71-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter
Cas:873697-71-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:873697-71-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:873697-71-3
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:873697-71-3
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:873697-71-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:873697-71-3
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:873697-71-3
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:873697-71-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:873697-71-3
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
Cas:873697-71-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:873697-71-3
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
Cas:873697-71-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Omecamtiv mecarbil (CK-1827452)/873697-71-3/high purity 99% in stock Application:Omecamtiv mecarbil (CK-1827452)/873697-71-3/high purity 99% in stock
Cas:873697-71-3
Min.Order:0
Negotiable
Type:Other
inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white to yellow powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Omecamtiv mecarbil (CK-1827452)/873697-71-3/high purity 99% in stockAppearance:white or off-white powder Storage:keep away from heat,sparks and flames Package:100g/bag 1kg/bag 10kg/bag 100kg/bag Application:pharmaceutical research Transportation:By e
Cas:873697-71-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry5-isocyanato-2-methylpyridine
methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
In acetone at 20℃; Heating/reflux; | 86% |
In acetone at 20℃; Heating / reflux; | 86% |
In acetone at 20℃; for 6.65h; Heating / reflux; | 86% |
In acetone at 20℃; Heating / reflux; | 73% |
In acetone for 6.5h; Heating / reflux; | 73% |
methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
phenyl (6-methylpyridin-3-yl)carbamate hydrochloride
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetonitrile at 57℃; for 21h; Industrial scale; | 82% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 55℃; for 18h; | 47 g |
5-Amino-2-methylpyridine
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
In toluene at 80℃; for 15h; Inert atmosphere; | 81% |
methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetonitrile | 80% |
5-isocyanato-2-methylpyridine
tert-butyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
In acetone at 20℃; for 5.65h; Heating / reflux; | 73% |
5-bromo-2-methylpyridine
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 2 h / 85 °C / Inert atmosphere 2: hydrogenchloride; palladium on carbon; hydrogen / methanol; water / 20 h / 20 °C / 760.05 Torr 3: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / Inert atmosphere; Heating View Scheme |
methyl piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.25 h / 20 °C / Inert atmosphere 2: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / Inert atmosphere; Heating View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride; palladium on carbon; hydrogen / methanol; water / 20 h / 20 °C / 760.05 Torr 2: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / Inert atmosphere; Heating View Scheme |
(2-methylpyridin-5-yl)urea
methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
With t-BuBrettPhos; palladium diacetate; caesium carbonate In tetrahydrofuran; water Inert atmosphere; Heating; | 253 mg |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; triethylamine / toluene / 16 h / 120 °C / Inert atmosphere 3: toluene / 15 h / 80 °C / Inert atmosphere View Scheme |
methyl piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; triethylamine / toluene / 16 h / 120 °C / Inert atmosphere 3: toluene / 15 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: phosphoric acid / water; tert-butyl methyl ether / 6 h / 20 - 40 °C / Industrial scale 2: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 4: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 4 steps 1: phosphoric acid / water; tert-butyl methyl ether / 6 h / 20 - 40 °C / Industrial scale 2: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 4: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; triethylamine / toluene / 16 h / 120 °C / Inert atmosphere 2: toluene / 15 h / 80 °C / Inert atmosphere View Scheme |
5-Amino-2-methylpyridine
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetonitrile / 7 h / 20 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran View Scheme |
2-methyl-5-nitropyridine
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen; 5%-palladium/activated carbon / 50 - 60 °C / 3375.34 Torr 2: acetonitrile / 7 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran View Scheme |
2-fluoro-3-nitrotoluene
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid / 8 h / 83 °C 1.2: 3 h / 40 °C 2.1: sodium hydroxide / water; toluene / 1 h / 20 °C 2.2: 15 °C / 3000.3 Torr 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid; sodium hydroxide / water / 18.5 h / 83 °C / Inert atmosphere; Industrial scale 1.2: 7.5 h / 40 °C / Industrial scale 2.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3.1: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid; sodium hydroxide / water / 18.5 h / 83 °C / Inert atmosphere; Industrial scale 1.2: 7.5 h / 40 °C / Industrial scale 2.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3.1: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 4 steps 1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid; sodium hydroxide / water / 18.5 h / 83 °C / Inert atmosphere; Industrial scale 2: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 4: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 4 steps 1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid; sodium hydroxide / water / 18.5 h / 83 °C / Inert atmosphere; Industrial scale 2: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 3: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 4: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water; toluene / 1 h / 20 °C 1.2: 15 °C / 3000.3 Torr 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide; acetic acid / 8 h / 83 °C 1.2: 3 h / 40 °C 2.1: sodium hydroxide / water; toluene / 1 h / 20 °C 2.2: 15 °C / 3000.3 Torr 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water; toluene / 0.25 h / Industrial scale 2: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; toluene / 0.25 h / Industrial scale 2: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 2: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 2: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
1-(bromomethyl)-2-fluoro-3- nitrobenzene
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 2: hydrogen; 5%-palladium/activated carbon / water; toluene; ethanol / 10 - 15 °C / 3102.97 Torr / Industrial scale 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / toluene; methanol / 7.5 h / 25 - 40 °C / Inert atmosphere; Industrial scale 2: hydrogen; 0.7% Pd/C / 5 h / 15 °C / 3102.97 Torr 3: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 21 h / 57 °C / Industrial scale View Scheme |
methyl 3-amino-2-fluoro-benzoate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22.25 h / 0 - 65 °C 2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 3.2: 16 h / 0 - 28 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 1 h / 5 - 28 °C 1.2: 2 h / 28 °C 2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 3.2: 16 h / 0 - 28 °C View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 2.2: 16 h / 0 - 28 °C View Scheme |
methyl piperazine-1-carboxylate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-(2-fluoro-3-(hydroxymethyl)phenyl)-3-(6-methylpyridin-3-yl)urea With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 28℃; for 3.25h; Stage #2: methyl piperazine-1-carboxylate With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 0 - 28℃; for 16h; |
methyl piperazine-1,3-carboxylate hydrochloride
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium hydroxide / dichloromethane / 1 h / 30 °C 2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 2.2: 16 h / 0 - 28 °C View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: water; sodium hydroxide / ethanol / 24.42 h / 30 - 100 °C 2.1: thionyl chloride; methanol / 16.17 h / 0 - 65 °C 3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 4.2: 16 h / 0 - 28 °C View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride; methanol / 16.17 h / 0 - 65 °C 2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 3.2: 16 h / 0 - 28 °C View Scheme |
5-Amino-2-methylpyridine
methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate
bis(trichloromethyl) carbonate
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate; bis(trichloromethyl) carbonate With triethylamine In dichloromethane at 5 - 28℃; for 1h; Stage #2: 5-Amino-2-methylpyridine In dichloromethane at 28℃; for 2h; |
3-amino-2-fluorobenzonitrile
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / 0 - 65 °C 2.1: water; sodium hydroxide / ethanol / 24.42 h / 30 - 100 °C 3.1: thionyl chloride; methanol / 16.17 h / 0 - 65 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 5.2: 16 h / 0 - 28 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: water; sodium hydroxide / 14 h / 30 - 100 °C 2.1: thionyl chloride / 16.5 h / 0 - 65 °C 3.1: triethylamine / dichloromethane / 1 h / 5 - 28 °C 3.2: 2 h / 28 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 5.2: 16 h / 0 - 28 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: water; sodium hydroxide / 14 h / 30 - 100 °C 2.1: thionyl chloride / 16.5 h / 0 - 65 °C 3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22.25 h / 0 - 65 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 5.2: 16 h / 0 - 28 °C View Scheme |
3-amino-2-fluoro benzoic acid
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / 16.5 h / 0 - 65 °C 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22.25 h / 0 - 65 °C 3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 4.2: 16 h / 0 - 28 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: thionyl chloride / 16.5 h / 0 - 65 °C 2.1: triethylamine / dichloromethane / 1 h / 5 - 28 °C 2.2: 2 h / 28 °C 3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2.5 h / 65 °C 4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.25 h / 0 - 28 °C 4.2: 16 h / 0 - 28 °C View Scheme |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
With hydrogenchloride; sulfuric acid In tetrahydrofuran; methanol at 50℃; for 4h; |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
Conditions | Yield |
---|---|
With sulfuric acid In acetone |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
ethanesulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; acetone |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; hexane; water; acetone; acetonitrile at 50℃; for 4h; | |
In tetrahydrofuran at 65℃; |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
maleic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water; acetone at 50℃; for 4h; Temperature; | |
In methanol at 65℃; Solvent; Temperature; |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
malonic acid
Conditions | Yield |
---|---|
In methanol at 50℃; |
methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate
methanesulfonic acid
Conditions | Yield |
---|---|
In methanol at 50℃; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View