117836-26-7

Basic information

• Product Name: (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester
• Synonyms: (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester;(2S,5S)-1-benzyl 2-methyl 5-hydroxypiperidine-1,2-dicarboxylate
• CAS NO: 117836-26-7
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol File: 117836-26-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.272
• CAS DataBase Reference: (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester(117836-26-7)
• EPA Substance Registry System: (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester(117836-26-7)

Safety Data

• Hazardous Substances Data: 117836-26-7(Hazardous Substances Data)

Usage

Description

(2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester is a piperidine derivative, a heterocyclic organic compound with diverse biological activities. It is a methyl benzyl ester of a piperidine dicarboxylic acid, featuring a hydroxy group at the 5th position. (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester is known for its potential as a neurotransmitter modulator and therapeutic agent, warranting further research into its pharmacological and physiological effects.

Uses

Used in Pharmaceutical Industry:
(2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester is used as a potential therapeutic agent for its diverse biological activities. Its role as a neurotransmitter modulator makes it a candidate for the development of treatments targeting neurological disorders and other conditions that may benefit from modulation of neurotransmission.
Used in Research Applications:
In the field of scientific research, (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester serves as a valuable compound for studying the structure-activity relationships of piperidine derivatives. This aids in understanding their interactions with biological targets and contributes to the advancement of drug discovery and development processes.

Upstream product

• 117836-24-5 (S)-5-(tert-Butyl-dimethyl-silanyloxy)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 117836-22-3 (S)-5-Trimethylsilanyloxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 65427-31-8 (S)-2-Benzyloxycarbonylamino-6-chloro-5-oxo-hexanoic acid methyl ester 
• 15366-19-5 methyl (S)-2-benzyloxycarbonylamino-6-diazo-5-oxohexanoate 
• 5672-83-3 Z-L-GluOMe 
• 23632-67-9 (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid 
• 117836-16-5 (S)-2-Benzyloxycarbonylamino-6-chloro-5-hydroxy-hexanoic acid methyl ester 
• 117836-18-7 (S)-2-Benzyloxycarbonylamino-6-chloro-5-trimethylsilanyloxy-hexanoic acid methyl ester 
• 117836-20-1 (S)-2-Benzyloxycarbonylamino-5-(tert-butyl-dimethyl-silanyloxy)-6-chloro-hexanoic acid methyl ester 
• 117836-15-4 (S)-2-Benzyloxycarbonylamino-5-ethoxycarbonyloxy-5-oxo-pentanoic acid methyl ester 
• 72180-34-8 (S)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 117836-13-2 (S)-5-Oxo-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 13907-82-9 N²-benzyloxycarbonyl-L-glutamine methyl ester 

Downstream Products

• 107476-23-3 3-Oxo-2-oxa-5-aza-bicyclo[2.2.2]octane-5-carboxylic acid benzyl ester 
• 117836-27-8 (2S,5R)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 917507-80-3 (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid 
• 695183-75-6 (2S,5S)-5-hydroxypiperidin-2-carboxylic acid methyl ester 
• 865178-80-9 methyl (2S,5S)-5-O-methylsulfonyl-N-(benzyloxycarbonyl)pipecolate 
• 865178-81-0 methyl (2S,5R)-5-azido-N-(benzyloxycarbonyl)pipecolate 
• 865178-82-1 methyl (2S,5R)-5-(tert-butoxycarbonylamino)-1-N-(benzyloxycarbonyl)pipecolate 
• 865178-85-4 (2S,5R)-5-(tert-butoxycarbonylamino)-1-N-(thyminylacetyl)pipecolic acid 
• 865178-84-3 methyl (2S,5R)-5-(tert-butoxycarbonylamino)-1-N-(thyminylacetyl)pipecolate 
• 695183-59-6 1-[2-(N-tert-butoxycarbonylamino)ethyl]-5-(R)-(N₃-benzoylthymin-1-yl)-2-(S)-pipecolic acid methyl ester 
• 63088-78-8 (2S,5R)-5-hydroxypiperidine-2-carboxylic acid 

Relevant articles and documents

MANUFACTURING METHOD OF (2S,5S)-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID AS WELL AS MANUFACTURING INTERMEDIATE OF THE SAME AND METHOD FOR MANUFACTURING THE SAME

PROBLEM TO BE SOLVED: To provide synthesis methods of 5-hydroxy-6-methoxypiperidine-2-carboxylic acid derivatives and 5-oxopiperidine-2-carboxylic acid derivatives more safely than ever by using inexpensive raw ingredients. SOLUTION: In the provided method, a compound expressed by the following formula [X] is manufactured from a compound expressed by the following formula [I] through steps (1) through (9) [either steps (4) and (5) or steps (6) and (7) in the case of steps (4) through (7)]. COPYRIGHT: (C)2015,JPOandINPIT

CHIRAL SYNTHESIS OF 5-HYDROXY-(L)-PIPECOLIC ACIDS FROM (L)-GLUTAMIC ACID

A stereo- and enantio-specific synthesis of the naturally occuring cis-5-hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L)-glutamic acid; the key step involves cyclisation of a protected chlorohydrin, and also gives access to trans-5-hydroxy-(L)-pipecolic acid.