27298-75-5

Basic information

• Product Name: 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-
• Synonyms: 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-;[(3-Hydroxymethyl-2,2,5,5-tetramethylpyrrolizino)oxy]radical;[[3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolizino]oxy]radical;[3-(Hydroxymethyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy]radical;[3-(Hydroxymethyl)-2,2,5,5-tetramethyl-1-pyrrolidyloxy]radical;[3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolizinooxy]radical;HM-PROXYL;3-(HydroxyMethyl)-2,2,5,5-tetraMethyl-
• CAS NO: 27298-75-5
• Molecular Formula: C₉H₁₈NO₂
• Molecular Weight: 0
• Product Categories: Heterocycles;Nitric Oxide Reagents;Spin Labeling Compounds;Heterocycles, Nitric Oxide Reagents, Spin Labeling Compounds
• Mol File: 27298-75-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 112-113°C
• Boiling Point: 257.302°C at 760 mmHg
• Flash Point: 108.361°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: -20°C Freezer
• Stability: Store Under Argon
• CAS DataBase Reference: 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-(27298-75-5)
• EPA Substance Registry System: 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-(27298-75-5)

Safety Data

• Hazardous Substances Data: 27298-75-5(Hazardous Substances Data)

Usage

Description

1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethylis a chemical compound with the chemical properties of a yellow solid. It is also known as 3-(HydroxyMethyl)-1-oxy-2,2,5,5-tetramethylpyrrolidine and is a derivative of hydroxytetramethylpiperidine. 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethylhas been found to have significant applications in the field of medicine, particularly in neoplastic diseases.

Uses

Used in Pharmaceutical Industry:
1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethylis used as a reactive spin label for drug resistance reversal in neoplastic diseases. Its application reason is that it can help overcome the resistance of cancer cells to certain treatments, making them more susceptible to therapeutic interventions.
Used in Drug Resistance Reversal:
In the field of oncology, 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethylis used as a compound for drug resistance reversal in neoplastic diseases. The application reason is that it can potentially enhance the effectiveness of existing cancer treatments by reducing the resistance of cancer cells to these therapies, thus improving patient outcomes.

InChI:InChI=1/C9H19NO2/c1-8(2)5-7(6-11)9(3,4)10(8)12/h7,11-12H,5-6H2,1-4H3

Upstream product

• 69588-78-9 C₁₅H₁₃Cl₅NO₃ 
• 46147-15-3 3-carboxy proxyl 
• 76893-15-7 C₁₅H₁₃F₅NO₃ 
• 145671-05-2 3-((ethoxycarbonyloxy)carbonyl)-2,2,5,5-tetramethylpyrrolidin-1-oxyl 
• 2154-67-8 3-carboxy-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy 
• 2154-68-9 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 78151-24-3 2,2,5,5-tetramethyl-3-p-toluenesulfonyloxy-2,3,4,5-tetrahydropyrrole-1-oxyl 
• 54606-49-4 3-Methylamino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy 
• 78140-52-0 2,2,5,5-tetramethyl-3-isothiocyanatomethylpyrrolidine-1-oxyl 
• 78140-46-2 C₂₇H₃₂N₂OP 
• 76893-20-4 C₁₅H₂₀N₅O₅ 
• 78280-10-1 copper 5-(2-((((2,2,5,5-tetramethyl-1-oxypyrrolidin-3-yl)methylene)oxy)carbonyl)phenyl)-10,15,20-tritolylporphyrin 
• 77629-60-8 copper(II) trans-meso-tetraphenyl-1-[3-(O-(3-methylene-2,2,5,5-tetramethylpirrolidinyl-1-oxy))acrylic ester]porphyrin 

Relevant articles and documents

A Rhodopsin Pigment Containing a Spin-Labeled Retinal

A retinal derivative containing a nitroxide group has been synthesized and a photosensitive pigment formed between the 9-cis isomer and bovine opsin.The pigment is stable to hydroxylamine and 11-cis-retinal.The electron spin resonance spectrum of the pigment in suspension shows that the nitroxide is strongly immobilized (τ > 10-7 s), is inaccessible to small hydrophilic reagents, and is not highly oriented within the membrane.The electron spin resonance spectrum of detergent-solubilized pigment is highly sensitive to the nature of the detergent, the digitonin and CHAPS solubilized pigment showing spectra most closely resembling the spectrum of pigment in suspension.These data are consistant with the ring portion of the retinal chromophore being deep within the membrane in a hydrophobic environment.

Synthesis and evaluation of β-galactosidase-targeting spin-label probe: 5-o-β-d-galactosyl-5-hydroxy-1,1,3,3-tetramethylisoindoline-2-oxyl

In this study, 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, and 5-hydroxy-1,1,3,3-tetra-methylisoindoline-2-oxyl O-galactosides (PG, TG, and IG) were synthesized. Moreover, their reduction reactivi

2,2,5,5-tetrasubstituted-pyrrolidine-1-oxyl compounds useful as MRI agents

Nitroxides useful as MRI enhancing agents are of the formula STR1 wherein R1, R2, R3 and R4 each are alkyl of 1-4 carbon atoms; and R is --alk--COO- M+ or --B--N+ (Alk)3 Hal- in which alk is alkylene of 1-8 carbon atoms, B is a divalent bond or alkylene of 1-8 carbon atoms, M+ is an ammonium or metal ion, Alk is alkyl of 1-8 carbon atoms or a corresponding alkyl group substituted by a free or esterified hydroxy group, and Hal- is Cl-, Br- or I-.