35364-15-9 Usage
Description
1-(2-Amino-5-hydroxyphenyl)propan-1-one is a synthetic intermediate with a unique chemical structure that features an amino and hydroxyl group attached to a phenyl ring, connected to a propanone moiety. 1-(2-Amino-5-hydroxyphenyl)propan-1-one plays a crucial role in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
1-(2-Amino-5-hydroxyphenyl)propan-1-one is used as a synthetic intermediate for the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10-tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione. This intermediate is essential for the synthesis of irinotecan and other camptothecin analogs, which are potent anticancer agents.
Additionally, 1-(2-Amino-5-hydroxyphenyl)propan-1-one is used in the synthesis of E-ring-modified (RS)-camptothecin analogs. These analogs serve as antitumor agents, contributing to the development of novel cancer treatments.
Preparation
Obtained by UV-irradiation of 3-ethyl-2,1-benzisoxazole in 66% sulfuric acid for 90 min at 80–90° Also prepared from 2-nitro-5-hydroxybenzaldehyde (five steps) or from p-anisidine.
Check Digit Verification of cas no
The CAS Registry Mumber 35364-15-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,3,6 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 35364-15:
(7*3)+(6*5)+(5*3)+(4*6)+(3*4)+(2*1)+(1*5)=109
109 % 10 = 9
So 35364-15-9 is a valid CAS Registry Number.
35364-15-9Relevant articles and documents
PROCESS FOR PREPARATION OF 2-AMINO-5-HYDROXY PROPIOPHENONE
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, (2020/07/31)
The present invention relates to a process for preparation of 2-Amino-5-hydroxypropiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).
A novel and practical synthesis of 2-amino-5-hydroxypropiophenone
Xiong, Xiao-Dong,Chen, Wen-Xue,Kuang, Yun-Yan,Chen, Fen-Er
experimental part, p. 423 - 427 (2009/12/24)
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METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES
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Page/Page column 5; 11, (2010/11/25)
The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.